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| 1 | 中国上海汉族人群IgA缺乏症的研究显示文摘目的:通过对中国汉族人群(上海地区献血人群n=61624)Ig AD大规模的调查,一方面筛选出Ig AD者,将他们作为供者建立上海Ig AD稀有血型资料库,为相同稀有血型患者提供配合安全的血液制品,预防和规避免疫性输血过敏反应的发生。同时调查中国汉族人群Ig AD发生频率,研究比较这些Ig AD者的疾病相关风险基因与白种人Ig AD者、与中国汉族正常献血者的遗传差异。方法:筛选61 624名中国汉族献血者,调查Ig AD者、统计Ig AD发生率,观察其免疫球蛋白Ig M及Ig G亚型的表达量,HLA-DR/DQ基因定型并比较中华造血干细胞捐献者资料库相关基因频率。结果:中国汉族人群Ig AD发生频率约为1∶2 000(31/61 624)。Ig AD者血清Ig G水平高于正常值,无Ig G亚型缺失,3人有抗Ig A抗体。2/3 Ig AD献血者携带有白种人Ig AD者的遗传单倍体DRB1*0301-DQB1*0201,DRB1*0701-DQB1*0202和DRB1*0102-DQB1*0501,其频率显著高于中华造血干细胞捐献者资料库数据。结论:中国汉族人群Ig AD频率显著低于白种人。三分之二的Ig AD献血者携带白种人Ig AD相关风险基因,疾病相关的风险基因的低表达可能是中国汉族人群Ig AD发病率低的原因。 | 陆萍 凌冰 王宁 Lennart Hammarstrm | 2016 | 中国实验血液学杂志2016，24，4： | 4 |
| 2 | Recurrent aphthous ulcer stomatitis and treatment pain management with Low Level Laser Therapy-a randomized controlled trial.显示文摘 | Margit Albrektson Lennart Hedstr?m H?kan Bergh | 2014 | Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology2014，，： | 2 |
| 3 | Interferon-γ inhibits ghrelin expression and secretion via a somatostatin-mediated mechanism显示文摘AIM:To investigate if and how the proinflammatory cytokine interferon γ(IFNγ) affects ghrelin expression in mice.METHODS:The plasma concentration of ghrelin,andgastric ghrelin and somatostatin expression,were examined in wild-type mice and mice infected with Helicobacter pylori(H.pylori).Furthermore,ghrelin expression was examined in two achlorhydric mouse models with varying degrees of gastritis due to bacterial overgrowth.To study the effect of IFNγ alone,mice were given a subcutaneous infusion of IFNγ for 7 d.Finally,the influence of IFNγ and somatostatin on the ghrelin promoter was characterized.RESULTS:H.pylori infection was associated with a 50% reduction in ghrelin expression and plasma concentration.Suppression of ghrelin expression was inversely correlated with gastric inflammation in achlorhdyric mouse models.Subcutaneous infusion of IFNγ suppressed fundic ghrelin mRNA expression and plasma ghrelin concentrations.Finally,we showed that the ghrelin promoter operates under the control of somatostatin but not under that of IFNγ.CONCLUSION:Gastric infection and inflammation is associated with increased IFNγ expression and reduced ghrelin expression.IFNγ does not directly control ghrelin expression but inhibits it indirectly via somatostatin. | Jesper AB Strickertsson Kristina BV DΦssing Anna JM Aabakke Hans-Olof Nilsson Thomas VO Hansen Ulrich Knigge Andreas Kjr Torkel Wadstrm Lennart Friis-Hansen | 2011 | World Journal of Gastroenterology2011，17，26： | 2 |
| 4 | Functional studies of mesenchymal stem cells derived from adult human adipose tissue显示文摘 | Andrea Dicker Katarina Le Blanc Gaby ?str?m Vanessa van Harmelen Cecilia G?therstr?m Lennart Blomqvist Peter Arner Mikael Rydén | 2005 | Experimental Cell Research2005，，2： | 2 |
| 5 | Enteral donor pre-treatment with ursodeoxycholic acid protects the liver against ischaemia-reperfusion injury in rats显示文摘 | Grzegorz Nowak Ulf G. Norén Annika Wernerson Hanns-Ulrich Marschall Lennart M?ller Bo-G?ran Ericzon | 2005 | Transplant International2005，，12： | 1 |
| 6 | Minimization of imbalance cost trading wind power on the short-term power market显示文摘 | Julija M Lennart S | 2006 | IEEE Transactions on Energy Conversion2006，21，3： | 1 |
| 7 | 2型糖尿病管理策略对于肾脏危险因素的多向性效应显示文摘糖尿病肾病被定义为糖尿病合并蛋白尿(尿白蛋白〉30mg/24h)或肾功能损害(eGFR〈6ml/min/1.73m^2)或二者兼有。其金标准为肾脏活检。但应注意,诊断需除外其他可能导致肾损害的病因,例如在无糖尿病视网膜病变时eGFR快速下降,或蛋白尿快速增多需考虑有无其他导致肾脏损害的原因。糖尿病肾病现已成为终末期肾脏病的首要原因。 | 李嘉佩 王相清 Marcel H A Muskiet Lennart Tonneijck Mark M Smits | 2015 | 糖尿病天地(临床)2015，9，6： | 1 |
| 8 | Impacts of rotations and crop residue treatments on soil organic matter content in two Swedish long-term experiments显示文摘 | Lennart M Jan P | 2006 | Archives of Agronomy and Soil Science2006，52，5： | 1 |
| 9 | Alzheimer mechanisms andtherapeutic strategies 显示文摘 | HUANG Y D LENNART M | 2012 | Cell2012，148，6： | 1 |
| 10 | Steroid hormone determination in water using an environmentally friendly membrane based extraction technique显示文摘 | SAIOA Z PAR H LENNART M | 2008 | Journal of Chromatography A2008，1192，： | 1 |
| 11 | Experimental studies of the fluid dynamics in the separation zone in dissolved air flotation显示文摘 | Lundh M Lennart J | | 0，，01： | 1 |
| 12 | Relating the molecular structure of comb-type superplasticizers to the compression rheology of MgO suspensions显示文摘 | Ane M. Kjeldsen Robert J. Flatt Lennart Bergstr?m | 2006 | Cement and Concrete Research2006，，7： | 1 |
| 13 | Minimization of imbalance cost trading wind power on the short-term power market显示文摘 | Julija M Lennart S | 2006 | IEEE Trans on Power Systems2006，21，3： | 1 |
| 14 | Determination of vitamins A and E in milk powder using supercritical fuild extraction for sample clean-up 显示文摘 | Lennart M | 2000 | Journal of Chromatography A2000，874，： | 1 |
| 15 | Harmful azo colorants inleather-Determination based on their cleavage and extraction of corresponding carcinogenic aromatic amines using modern extrac- tion techniques显示文摘 | Cecilia S E Richard D Lennart M | 2002 | Journal of Chromatography A2002，955，2： | 1 |
| 16 | Supercritical fluid extraction (SFE) in food analysis: a review显示文摘 | ELKE A HANS B LENNART M | 1998 | Food Additives and Contaminants1998，15，6： | 1 |
| 17 | Fetal and maternal lactate increase during active second stage of labour显示文摘 | Lennart Nordstr?m Siva Achanna Keiichi Naka Sabaratnam Arulkumaran | 2001 | British Journal of Obstetrics and Gynaecology2001，，3： | 1 |
| 18 | Experimental studies of the fluid dynamics in the separation zone in dissolved air flotation显示文摘 | LUNDH M LENNART J | 2000 | Water Research2000，34，1： | 1 |
| 19 | Membrane-based tech- niques for sample enrichment 显示文摘 | JAN A J LENNART M | 2000 | Journal of Chromatography A2000，902，1： | 1 |
| 20 | Fast protection of strong power systems with fault current limiters and PLL-aided fault detection显示文摘 | Ohrstrom M Lennart S | 2011 | IEEE Transactions on Power Delivery2011，26，3： | 1 |
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