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| 1 | Aplastic anemia and severe pancytopenia during treatment with peg-interferon,ribavirin and telaprevir for chronic hepatitis C显示文摘Telaprevir and Boceprevir are the first direct acting antivirals approved for chronic hepatitis C in combination with peg-interferon alfa and ribavirin.Pancytopenia due to myelotoxicity caused by these drugs may occur,but severe hematological abnormalities or aplastic anemia(AA) have not been described.We collected all cases of severe pancytopenia observed during triple therapy with telaprevir in four Spanish centers since approval of the drug in 2011.Among 142 cirrhotic patients receiving treatment,7 cases of severe pancytopenia(5%) were identified and three were consistent with the diagnosis of AA.Mean age was 59 years,five patients had compensated cirrhosis and two patients had severe hepatitis C recurrence after liver transplantation.Severe pancytopenia was diagnosed a median of 10 wk after the initiation of therapy.Three patients had pre-treatment hematological abnormalities related to splenomegaly.In six patients,antiviral treatment was interrupted at the onset of hematological abnormalities.Two patients died due to septic complications and one patient due to acute alveolar hemorrhage.The remaining patients recovered.Severe pancytopenia and especially AA,are not rare during triple therapy with telaprevir in patients with advanced liver disease.Close monitoring is imperative in this setting to promptly detect serious hematological disorders and to prevent further complications. | Sabela Lens Jose L Calleja Ana Campillo Jose A Carrion Teresa Broquetas Christie Perello Juan de la Revilla Zoe Marino Maria-Carlota Londono Jose M Sanchez-Tapias Alvaro Urbano-Ispizua Xavier Forns | 2015 | World Journal of Gastroenterology2015，21，17： | 4 |
| 2 | Cardiovascular impact of COVID-19 with a focus on children: A systematic review显示文摘BACKGROUND Since the beginning of the pandemic,coronavirus disease-2019(COVID-19)in children has shown milder cases and a better prognosis than adults.Although the respiratory tract is the primary target for severe acute respiratory syndrome coronavirus 2(SARS-CoV-2),cardiovascular involvement is emerging as one of the most significant and life-threatening complications of SARS-CoV-2 infection in adults.AIM To summarize the current knowledge about the potential cardiovascular involvement in pediatric COVID-19 in order to give a perspective on how to take care of them during the current pandemic emergency.METHODS Multiple searches in MEDLINE,PubMed were performed using the search terms“COVID-19”or“SARS-CoV-2'were used in combination with“myocardial injury”or'arrhythmia'or“cardiovascular involvement”or'heart disease'or'congenital heart disease'or“pulmonary hypertension”or'long QT'or“cardiomyopathies”or“channelopathies”or'Multisystem inflammatory system'or'PMIS'or“MIS-C”or”Pediatric multisystem inflammatory syndrome'or'myocarditis'or'thromboembolism to identify articles published in English language from January 1st,2020 until July 31st,2020.The websites of World Health Organization,Centers for Disease control and Prevention,and the Johns Hopkins Coronavirus Resource Center were reviewed to provide up to date numbers and infection control recommendations.Reference lists from the articles were reviewed to identify additional pertinent articles.Retrieved manuscripts concerning the subject were reviewed by the authors,and the data were extracted using a standardized collection tool.Data were subsequently analyzed with descriptive statistics.For Pediatric multisystemic inflammatory syndrome temporally associated with COVID-19(PMIS),multiple meta-analyses were conducted to summarize the pooled mean proportion of different cardiovascular variables in this population in pseudo-cohorts of observed patients.RESULTS A total of 193 articles were included.Most publications used in this review were single case reports,small case series,and observational small-sized studies or literature reviews.The meta-analysis of 16 studies with size>10 patients and with complete data about cardiovascular involvement in children with PMIS showed that PMIS affects mostly previously healthy school-aged children and adolescents presenting with Kawasaki disease-like features and multiple organ failure with a focus on the heart,accounting for most cases of pediatric COVID-19 mortality.They frequently presented cardiogenic shock(53%),ECG alterations(27%),myocardial dysfunction(52%),and coronary artery dilation(15%).Most cases required PICU admission(75%)and inotropic support(57%),with the rare need for extracorporeal membrane oxygenation(4%).Almost all of these children wholly recovered in a few days,although rare deaths have been reported(2%).Out of PMIS cases we identified 10 articles reporting sporadic cases of myocarditis,pulmonary hypertension and cardiac arrythmias in previously healthy children.We also found another 10 studies reporting patients with preexisting heart diseases.Most cases consisted in children with severe COVID-19 infection with full recovery after intensive care support,but cases of death were also identified.The management of different cardiac conditions are provided based on current guidelines and expert panel recommendations.CONCLUSION There is still scarce data about the role of cardiovascular involvement in COVID-19 in children.Based on our review,children(previously healthy or with preexisting heart disease)with acute COVID-19 requiring hospital admission should undergo a cardiac workup and close cardiovascular monitoring to identify and treat timely life-threatening cardiac complications. | Moises Rodriguez-Gonzalez Ana Castellano-Martinez Helena Maria Cascales-Poyatos Alvaro Antonio Perez-Reviriego | 2020 | World Journal of Clinical Cases2020，8，21： | 3 |
| 3 | Managing product/process knowledge in the concurrent/ simultaneous enterprise environment 显示文摘 | Mikel Sorlia Dragen Stokicb Alvaro Gorostizaa Ana Campos | 2006 | Robotics and Computer - Integrated Manufacturing2006，22，56： | 1 |
| 4 | Intramolecular excited state quenching 5--1,10-phenanthroline,a new donor ligand显示文摘 | Alvaro D Ana M L Bárbara L | 2005 | Polyhedron2005，24，： | 1 |
| 5 | Effect of chronic ethanol consumption on endothelin-1 generation and conversion of exogenous big-endothelin-1 by the rat carotid artery显示文摘 | Carlos R. Tirapelli Débora A. Casolari Alvaro Yogi Rita C. Tostes Eurode Legros Vera L. Lanchote Sérgio A. Uyemura Ana M. de Oliveira | 2007 | Alcohol2007，，2： | 1 |
| 6 | Galileo Constellation Design显示文摘 | Alvaro M G Esperanza H M Ana B M P | 2001 | GPS Solutions2001，4，4： | 1 |
| 7 | Mapping Fe - bearing hydrated sulphate minerals with short wave infrared (SWIR) spectral analysis at San Miguel mine environment, Iberian Pyrite Belt (SW Spain) 显示文摘 | Francisco Velasco Ana Alvaro Saioa Suarez | 2005 | Journal of Geochemical Exploration2005，87，： | 1 |
| 8 | Loss of Dickkopf-1 Restores Neurogenesis in Old Age and Counteracts Cognitive Decline显示文摘 | Désirée R.M. Seib Nina S. Corsini Kristina Ellwanger Christian Plaas Alvaro Mateos Claudia Pitzer Christof Niehrs Tansu Celikel Ana Martin-Villalba | 2013 | Cell Stem Cell2013，，2： | 1 |
| 9 | Bimodal effect of nitric oxide in the enzymatic activity of indoleamine 2,3-dioxygenase in human monocytic cells显示文摘 | Ana S. López Estíbaliz Alegre Angel Díaz Carmen Mugueta Alvaro González | 2006 | Immunology Letters2006，，2： | 1 |
| 10 | Synthesis and antifungal activities of natural and synthetic biflavonoids 显示文摘 | GABRIEL S ANA B ALVARO V | 2011 | Bioorg & Med Chem2011，19，： | 1 |
| 11 | First characterization of fluoroquinolone resistance in streptococcus suis 显示文摘 | JOSE A E ALVARO S M ANA C | 2007 | Antimicrobial Agents and Chemotherapy2007，51，77： | 1 |
| 12 | First characterization of fluoroquinolone resistance in Streptococcus suis 显示文摘 | Jose Antonio Escudero Alvaro San Millan Ana Catalan | 2007 | Antimicrobial Agents and Chemotherapy2007，51，2： | 1 |
| 13 | Impact of Social Responsibility Programmes in Stakeholder Satisfaction: An Empirical Study of Portuguese Managers' Perceptions显示文摘 | Fonseca Luis Ramos Amilcar Rosa Alvaro Braga Ana Cristina Sampaio Paulo | 2012 | Journal of US-China Public Administration2012，9，5： | 0 |
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