|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Feasibility of cold snare polypectomy in Japan: A pilot study显示文摘AIM: To investigate the feasibility of cold snare polypectomy(CSP) in Japan.METHODS: The outcomes of 234 non-pedunculated polyps smaller than 10 mm in 61 patients who underwent CSP in a Japanese referral center were retrospectively analyzed. The cold snare polypectomies were performed by nine endoscopists with no prior experience in CSP using an electrosurgical snare without electrocautery.RESULTS: CSPs were completed for 232 of the 234 polyps. Two(0.9%) polyps could not be removed without electrocautery. Immediate postpolypectomy bleeding requiring endoscopic hemostasis occurred in eight lesions(3.4%; 95%CI: 1.1%-5.8%), but all were easily managed. The incidence of immediate bleeding after CSP for small polyps(6-9 mm) was significantly higher than that of diminutive polyps(≤ 5 mm; 15% vs 1%, respectively). Three(5%) patients complained of minor bleeding after the procedure but required no intervention. The incidence of delayed bleeding requiringendoscopic intervention was 0.0%(95%CI: 0.0%-1.7%). In total, 12% of the resected lesions could not be retrieved for pathological examination. Tumor involvement in the lateral margin could not be histologically assessed in 70(40%) lesions.CONCLUSION: CSP is feasible in Japan. However, immediate bleeding, retrieval failure and uncertain assessment of the lateral tumor margin should not be underestimated. Careful endoscopic diagnosis before and evaluation of the tumor residue after CSP are recommended when implementing CSP in Japan. | Yoji Takeuchi Takeshi Yamashina Noriko Matsuura Takashi Ito Mototsugu Fujii Kengo Nagai Fumi Matsui Tomofumi Akasaka Noboru Hanaoka Koji Higashino Hiroyasu Iishi Ryu Ishihara Henrik Thorlacius Noriya Uedo | 2015 | World Journal of Gastrointestinal Endoscopy2015，7，17： | 14 |
| 2 | Pink-color sign in esophageal squamous neoplasia, and speculation regarding the underlying mechanism显示文摘AIM:To investigate the reasons for the occurrence of the pink-color sign of iodine-unstained lesions. METHODS:In chromoendoscopy, the pink-color sign of iodine-unstained lesions is recognized as useful for the diagnosis of esophageal squamous cell carcinoma. Patients with superficial esophageal neoplasms treated by endoscopic resection were included in the study. Areas of mucosa with and without the pink-color sign were evaluated histologically. The following histologic features that were possibly associated with the pinkcolor sign were evaluated. The keratinous layer and basal cell layer were classified as present or absent. Cellular atypia was classified as high grade, moderate grade or low grade, based on nuclear irregularity, mitotic figures, loss of polarity, chromatin pattern and nuclear/cytoplasmic ratio. Vascular change was assessed based on dilatation, tortuosity, caliber change and variability in shape. Vessels with these four findings were classified as positive for vascular change. Endoscopic images of the lesions were captured immediately after iodine staining, 2-3 min after iodine staining and after complete fading of iodine staining. Quantitative analysis of color changes after iodine staining was also performed. RESULTS:A total of 61 superficial esophageal neoplasms in 54 patients were included in the study. The lesions were located in the cervical esophagus in one case, the upper thoracic esophagus in 10 cases, the mid-thoracic esophagus in 33 cases, and the lower thoracic esophagus in 17 cases. The median diameter of the lesions was 20 mm (range:2-74 mm). Of the 61 lesions, 28 were classified as pink-color sign positive and 33 as pink-color sign negative. The histologic diagnosis was high-grade intraepithelial neoplasia (HGIN) or cancer invading into the lamina propria in 26 of the 28 pink-color sign positive lesions. There was a significant association between pink-color sign positive epithelium and HGIN or invasive cancer (P = 0.0001). Univariate analyses found that absence of the keratinous layer and cellular atypia were significantly associated with the pink-color sign. After Bonferroni correction, there were no significant associations between the pink-color sign and presence of the basal membrane or vascular change. Multivariate analyses found that only absence of the keratinous layer was independently associated with the pink-color sign (OR = 58.8, 95%CI:5.5-632).Quantitative analysis was performed on 10 superficial esophageal neoplasms with both pink-color sign positive and negative areas in 10 patients. Pink-color sign positive mucosa had a lower mean color value in the late phase (pinkish color) than in the early phase (yellowish color), and had similar mean color values in the late and final phases. These findings suggest that pinkcolor positive mucosa underwent color fading from the color of the iodine (yellow) to the color of the mucosa (pink) within 2-3 min after iodine staining. Pink-color sign negative mucosa had similar mean color values in the late and early phases (yellowish color), and had a lower mean color value in the final phase (pinkish color) than in the late phase. These findings suggest that pink-color sign negative mucosa did not undergo color fading during the 2-3 min after iodine staining, and underwent color fading only after spraying of sodium thiosulfate. CONCLUSION:The pink-color sign was associated with absence of the keratinous layer. This sign may be caused by early fading of iodine staining. | Ryu Ishihara Hiromitsu Kanzaki Hiroyasu Iishi Kengo Nagai Fumi Matsui Takeshi Yamashina Noriko Matsuura Takashi Ito Mototsugu Fujii Sachiko Yamamoto Noboru Hanaoka Yoji Takeuchi Koji Higashino Noriya Uedo Masaharu Tatsuta Yasuhiko Tomita Shingo Ishiguro | 2013 | World Journal of Gastroenterology2013，19，27： | 10 |
| 3 | Laparoscopic hemicolectomy in a patient with situs inversustotalis显示文摘As among persons with normal anatomy, occasional patients with situs inversus develop malignant tumors. Recently, several laparoscopic operations have been reported in patients with situs inversus. We describe laparoscopic hemicolectomy with radical lymphadenectomy in such a patient. Careful consideration of the mirror-image anatomy permitted safe operation using techniques not otherwise differing from those in ordinary cases. Thus, curative laparoscopic surgery for colon cancer in the presence of situs inversus is feasible and safe. | Yushi Fujiwara Yosuke Fukunaga Masayuki Higashino Shinya Tanimura Masashi Takemura Yoshinori Tanaka Harushi Osugi | 2007 | World Journal of Gastroenterology2007，13，37： | 6 |
| 4 | Comprehensive monitoring of chlorinated aromatic and heteroaromatic pollutants at sites contaminated by chlorine production processes to inform policy making显示文摘The production of chlorine by the chlor-alkali process using graphite electrodes was one of the largest sources of polychlorinated dibenzo-p-dioxins and dibenzofurans(PCDD/PCDFs)in history with estimates in the kg TEQ range for individual factories.In addition,the chlorine production predecessor processes in the former Leblanc soda factories generated large amounts of PCDD/PCDFs,also in kg TEQ range for individual sites.In both processes coal tar,used as pitch binder for electrodes in the chlor-alkali process or tars for sealing chlorine chambers,was the major source for PCDD/PCDFs formation.The complex PAH mixture in the tars which were chlorinated in the processes contained approx.1%dibenzofuran.Therefore in this study we screened the full range of chlorinated aromatic and heteroaromatic compounds in contaminated soils from former chlor-alkali plants in Germany and Japan as well as from a German Leblanc factory,using high resolution time-of-flight mass spectrometry GC-HR-TOF-MS.At all three sites the full range of unintentionally produced persistent organic pollutants(POPs)listed in the Stockholm Convention(PCDFs,PCDDs,PCBs,PCNs,HCB,HCBD and PeCBz)were present at high ppb levels and TEQ was up to several 100,000 ng/kg soil in hot spot areas.Additionally,a wide range of other polychlorinated(PC-)PAHs(PC-phenanthrene/anthracene,PC-pyrene/fluoranthene,PC-benzo(a)anthracene/chrysene)were detected.Some of these compound classes were present in one to two order of magnitude higher concentrations compared to PCDFs.Furthermore,polychlorinated methyldibenzofurans,polychlorinated dimethyl-/ethyl-dibenzofurans,and polychlorinated carbazoles e the N-analogue of dibenzofuran-were detected at levels comparable to PCDFs at all three sites.Polychlorinated benzonitriles were detected in addition to chlorobenzenes as monoaromatic pollutant.Since all three factories have stopped production 50e120 years ago,all detected chlorinated aromatics can be regarded as very persistent.The technologies have been used in several hundred locations globally.These(former)chlorine production sites should be assessed for contamination and their contemporary threat to humans and the environment should be evaluated.The toxicity of most of these polychlorinated PAHs and hetero-PAHs is unknown but due to their related structures,similar toxicity profiles can be expected and need to be investigated.Furthermore,all processes where chlorine and complex organic material are present should be screened for the entire resulting chlorinated pollutant mixture,the detailed fingerprints should be documented,and the overall toxicological risk assessed for individual processes to inform policy making. | Takumi Takasuga Hiroaki Takemori Teru Yamamoto Kazuo Higashino Yuko Sasaki Roland Weber | 2020 | Emerging Contaminants2020，6，1： | 4 |
| 5 | Clinical features and outcomes of delayed perforation after endoscopic submucosal dissection for early gastric cancer显示文摘 | N. Hanaoka N. Uedo R. Ishihara K. Higashino Y. Takeuchi T. Inoue R. Chatani M. Hanafusa Y. Tsujii H. Kanzaki N. Kawada H. Iishi M. Tatsuta Y. Tomita I. Miyashiro M. Yano | 2010 | Endoscopy2010，，12： | 3 |
| 6 | Delayed perforation: A hazardous complication of endoscopic resection for non‐ampullary duodenal neoplasm显示文摘 | Takuya Inoue Noriya Uedo Takeshi Yamashina Sachiko Yamamoto Noboru Hanaoka Yoji Takeuchi Koji Higashino Ryu Ishihara Hiroyasu Iishi Masaharu Tatsuta Hidenori Takahashi Hidetoshi Eguchi Hiroaki Ohigashi | 2014 | Digestive Endoscopy2014，，2： | 3 |
| 7 | A novel videoendoscopy system by using autofluorescence and reflectance imaging for diagnosis of esophagogastric cancers <ce:link locator='fx1'/>显示文摘 | Noriya Uedo Hiroyasu Iishi Masaharu Tatsuta Takuya Yamada Hideharu Ogiyama Kazuho Imanaka Naotoshi Sugimoto Koji Higashino Ryu Ishihara Hiroyuki Narahara Shingo Ishiguro | 2005 | Gastrointestinal Endoscopy2005，，4： | 2 |
| 8 | Longterm outcomes after endoscopic mucosal resection for early gastric cancer显示文摘 | Noriya Uedo Hiroyasu Iishi Masaharu Tatsuta Ryu Ishihara Koji Higashino Yoji Takeuchi Kazuho Imanaka Takuya Yamada Sachiko Yamamoto Shunsuke Yamamoto Hideaki Tsukuma Shingo Ishiguro | 2006 | Gastric Cancer2006，，2： | 2 |
| 9 | Utility of endoscopic ultrasonography in assessing the indications for endoscopic surgery of submucosal esophageal tumors 显示文摘 | Takada N Higashino M Osugi H | 1999 | Surg Endosc1999，13，3： | 2 |
| 10 | Intralesional steroid injection to prevent stricture after endoscopic submucosal dissection for esophageal cancer: a controlled prospective study显示文摘 | N. Hanaoka R. Ishihara Y. Takeuchi N. Uedo K. Higashino T. Ohta H. Kanzaki M. Hanafusa K. Nagai F. Matsui H. Iishi M. Tatsuta Y. Ito | 2012 | Endoscopy2012，，11： | 2 |
| 11 | Laparoscopic distal gastrectomy with regional lymph node dissection for gastric cancer显示文摘 | Tanimura S Higashino M Fukunaga Y | | 0，，09： | 2 |
| 12 | Longterm outcomes after endoscopic mucosal resection for early gastric cancer显示文摘 | Noriya Uedo Hiroyasu Iishi Masaharu Tatsuta Ryu Ishihara Koji Higashino Yoji Takeuchi Kazuho Imanaka Takuya Yamada Sachiko Yamamoto Shunsuke Yamamoto Hideaki Tsukuma Shingo Ishiguro | 2006 | Gastric Cancer2006，，2： | 2 |
| 13 | History of cardiac computed tomography: single to 320-detector row multislice computed tomography显示文摘 | Gregory S. Hurlock Hiroshi Higashino Teruhito Mochizuki | 2009 | The International Journal of Cardiovascular Imaging2009，，1： | 2 |
| 14 | Comparison of EMR and endoscopic submucosal dissection for en bloc resection of early esophageal cancers in Japan显示文摘 | Ryu Ishihara Hiroyasu Iishi Noriya Uedo Yoji Takeuchi Sachiko Yamamoto Takuya Yamada Eriko Masuda Koji Higashino Motohiko Kato Hiroyuki Narahara Masaharu Tatsuta | 2008 | Gastrointestinal Endoscopy2008，，6： | 2 |
| 15 | Intravenous nicorandil can preserve microvascular integrity and myocardial viability in patients with reperfused anterior wall myocardial infarction显示文摘 | Hiroshi Ito Yoshiaki Taniyama Katsuomi Iwakura Nagahiro Nishikawa Tohru Masuyama Tsunehiko Kuzuya Masatsugu Hori Yorihiko Higashino Kenshi Fujii Takazo Minamino | 1999 | Journal of the American College of Cardiology1999，，3： | 2 |
| 16 | Low-intensity walking as mild medication for pressure control in prehypertensive and hypertensive subjects:how far shall we wander?显示文摘Successful prevention and treatment of hypertension depend on the appropriate combination of antihypertensive drug therapy and nondrug lifestyle modi?cation. While most hypertension guidelines recommend moderate- to high-intensity exercise, we decided to explore a mild yet effective type of exercise to add to hypertension management, especially in populations with complications or frailty. After comparing the short-term cardiovascular effects of low-speed walking versus high-speed walking for 3 kilometers (km)(3 km/h versus 6 km/h) in young, healthy volunteers, we delivered low-speed walking (low-intensity walking, 2.5 metabolic equivalents of task, METs) as exercise therapy in 42 prehypertensive and 43 hypertensive subjects. We found that one session of 3 km low-intensity walking exerted a transient pressure-lowering effect as well as a mild negative chronotropic effect on heart rate in both the prehypertensive and hypertensive subjects;these short-term bene?ts on blood pressure and heart rate were accompanied by a brief increase in urine β-endorphin output. Then we prescribed regular low-intensity walking with a target exercise dose (exercise volume) of 500–1000 METs·min/week (50–60 min/day and 5–7 times/week) in hypertensive subjects in addition to their daily activities. Regular low-intensity walking also showed mild but signi?cant blood pressure-lowering and heart rate-reducing effects in 7 hypertensive subjects within two months. It is hypothesized that regular low-intensity exercise of the necessary dose could be taken as a pragmatic and supplementary medication for hypertension management. | Qin Lu Sheng-ming Wang Yi-xiao Liu Hong Chen Rui Zhang Wen-hui Zhang Yuan-yuan Zou Jia-wei Zhou Xin-yi Guo Ying Zhang Teng-Li Huang Yu-hang Liu Si-qi Zhang Kyosuke Yamanishi Hiromichi Yamanishi Hideaki Higashino Haruki Okamura | 2019 | Acta Pharmacologica Sinica2019，40，8： | 2 |
| 17 | Bioavailabilily of calcium from calcium carbonate,DL-calcium lactate and powdered oystershell calcium in vit D-Deficient or replete rats显示文摘 | TSUGAWA N OKANO T HIGASHINO R | 1995 | Biol Pharm Bull1995，18，5： | 1 |
| 18 | A novel videoendoscopy system by using autofluorescence and reflectance imaging for diagnosis of esophagogastric cancers <ce:link locator='fx1'/>显示文摘 | Noriya Uedo Hiroyasu Iishi Masaharu Tatsuta Takuya Yamada Hideharu Ogiyama Kazuho Imanaka Naotoshi Sugimoto Koji Higashino Ryu Ishihara Hiroyuki Narahara Shingo Ishiguro | 2005 | Gastrointestinal Endoscopy2005，，4： | 1 |
| 19 | Intracorporeal Billroth 1 reconstruction by triangulating stapling technique after laparoscopic distal gastrectomy for gastric cancer显示文摘 | Tanimura S Higashino M Fukunaga Y | 2008 | Surg Laparosc Endosc Percutan Tech2008，18，1： | 1 |
| 20 | Laparoscopic gastrectomy for gastric cancer: experience with more than 600 cases显示文摘 | S. Tanimura M. Higashino Y. Fukunaga M. Takemura Y. Tanaka Y. Fujiwara H. Osugi | 2008 | Surgical Endoscopy2008，，5： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员