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| 1 | 乙型肝炎病毒基本核心启动子及前C区突变与基因型的关系显示文摘目的 探讨乙型肝炎病毒 (HBV)基本核心启动子 (BCP)及前C区突变与基因型之间的关系。方法 随机选取 113例慢性HBV感染者外周血 ,采用INNO LiPA法测定BCPT176 2 A176 4双突变及前C区A1896突变 ,测定HBVS基因序列明确基因型。结果 在C基因型感染者中BCPT176 2 A176 4双突变率明显高于B基因型感染者 ,差异有显著性 (34.2 %∶10 % ,χ2 =6 .74 ,P <0 .0 1) ,而前C区A1896突变率在B基因型和C基因型感染者中差异无显著性 (2 .5 %∶4 .1% ,χ2 =0 .0 0 ,P >0 .0 5 )。结论 与B基因型相比 ,C基因型感染者更易发生BCPT176 2 A176 4双突变。 | 房继莲 魏来 李若冰 丛旭 许军 Erwin Sablon 孙焱 王豪 王宇 | 2004 | 中华微生物学和免疫学杂志2004，24，6： | 11 |
| 2 | 乙型肝炎病毒基本核心启动子及前C区突变对疾病进展的影响显示文摘目的 研究乙型肝炎病毒 (HBV)基本核心启动子 (BCP)T176 2 /A176 4双突变及前C区A1896突变与肝脏损伤程度的相关性。方法 2 0 0 0~ 2 0 0 2年哈尔滨医科大学附属第二医院及广东省廉江市医院随机选取 113例慢性HBV感染者 ,采用INNO -LiPA法测定HBVBCPT176 2 /A176 4双突变及前C区A1896突变 ,同时测定HBVS基因序列明确基因型。结果 CHB组、LC组、HCC组BCPT176 2 /A176 4双突变率明显高于AsC组 (分别为 2 4 . 1%比 2. 8% ,χ2 =5 .93,P <0 . 0 5 ;71. 4 %比 2 .8% ,χ2 =2 3 .83,P <0 .0 1和 5 5 . 6 %比 2 .8% ,χ2 =13. 0 9,P <0 . 0 1) ,LC组BCPT176 2 /A176 4双突变率显著高于CHB组 (71 .4 %比 2 4 . 1% ,χ2 =9 .12 ,P <0 .0 1) ;单一C基因型感染者CHB、LC和HCC组BCPT176 2 /A176 4双突变率明显高于AsC组 (分别为 33 .3%比 5 . 3% ,χ2 =3 .89,P <0 .0 5 ;6 9 .2 %比5 . 3% ,P <0 . 0 1和 5 0 .0 %比 5. 3% ,P <0 . 0 5 )。各组前C区A1896突变率均较低 ,在CHB组和LC组无一例发生 ;HCC组前C区A1896突变率与AsC组比较差异无显著性 (11 .1%比 8. 3% ,χ2 =0 . 0 0 ,P >0 . 0 5 )。结论 在慢性HBV感染者中 ,BCPT176 2 /A176 4双突变与慢性肝病进展有关。 | 房继莲 丛旭 李若冰 许军 Erwin Sablon 孙焱 王豪 王宇 魏来 | 2005 | 中国实用内科杂志2005，25，3： | 6 |
| 3 | Molecular analysis of hepatitis B virus isolates in Mexico:Predominant circulation of hepatitis B virus genotype H显示文摘AIM: To determine the genotypes in Mexican hepatitis Bvirus (HBV) isolates and characterize their precore andcore promoter mutations.METHODS: Forty-nine HBV isolates of Mexico obtainedfrom sera of 15 hepatitis patients, 6 hemodialysis pa-tients, 20 men seeking HIV testing, and 8 AIDS patientswere analyzed. HBV isolates were amplified by PCR,and genotyped by line probe assay (INNO-LiPA HBVGenotyping; INNOGENETICS N V, Ghent, Belgium).HBV genotype confirmation was performed by DNAsequencing part of the sAg region. Precore and core pro-moter mutation characterization was performed by lineprobe assay (INNO-LiPA HBV PreCore; INNOGENETICS NV, Ghent, Belgium).RESULTS: Overall, HBV genotype H was found in 37(75.5%) out of the 49 isolates studied. HBV genotypesG, A, and D were found in 5 (10.2%), 4 (8.2%), and 3(6.1%) isolates, respectively. HBV genotype H was pre-dominant in isolates from hemodialysis patients (100%),hepatitis patients (80%), and men seeking HIV test-ing (75%), and accounted for half of infections in AIDSpatients (50%). Six (12.2%) out of the 49 HBV isolatesshowed both wild type and mutant populations at pre-core codon 28. These mixed wild type and precore mu-tant populations were observed in one HBV genotype Aisolate and in all HBV genotype G isolates. A dual variantcore promoter mutation was observed in 1 (2%) of theisolates, which was genotype H.CONCLUSION: HBV genotype H is highly predominantin HBV isolates of Mexico followed by genotypes G, Aand D. A low frequency of precore and core promotermutations is observed in HBV Mexican isolates. | Cosme Alvarado-Esquivel Erwin Sablon Carlos Jesús Conde-GonzálezNational Institute of Public Health Cuernavaca Morelos Mexico Luis Juárez-Figueroa Lilia Ruiz-Maya Sergio-Aguilar Benavides | 2006 | World Journal of Gastroenterology2006，12，40： | 6 |
| 4 | INNO-LiPA乙型肝炎病毒基因分型方法的评价显示文摘目的 评价INNO LiPA乙型肝炎病毒基因分型的方法 ,并探讨了基因型与临床疾病的关系。方法 随机选取 113例慢性HBV感染者外周血采用INNO LiPA和S基因序列分析两种方法测定HBV基因型。结果 1 INNO LiPA基因分型法与S基因序列分析法测定的基因型结果比较 ,符合率 82 3% (93/ 113) ,误判率 3 5 % (4/ 113) ,B/C型混合感染检出率 5 3% (6 / 113)。 2 LC组和HCC组C基因型比率高于AsC组 ,差异有显著性 (分别为 92 9%比 5 2 8% ,X2 =7 0 3,P <0 0 1和 88 9%比 5 2 8% ,X2 =3 91,P <0 0 5 ) ;LC组C基因型比率高于CHB组 ,差异有显著性 (92 9%比 6 1 1% ,X2 =5 12 ,P <0 0 5 )。结论 1 INNO LiPA法是一种较灵敏的快速检测HBV基因型的实验方法 ,尤其检测混合基因型感染灵敏度高。 2 C基因型HBV感染与较重肝病有关。 | 房继莲 魏来 李若冰 丛旭 许军 Erwin Sablon 王宇 | 2004 | 中华检验医学杂志2004，27，12： | 4 |
| 5 | Epidemiological study of hepatitis B virus genotypes, core promoter and precore mutations of chronic hepatitis B infection in Hong Kong显示文摘 | Man-Fung Yuen Erwin Sablon Yasuhito Tanaka Takanobu Kato Masashi Mizokami Joke Doutreloigne He-Jun Yuan Danny Ka-Ho Wong Siu-Man Sum Ching-Lung Lai | 2004 | Journal of Hepatology2004，，1： | 2 |
| 6 | Long-Term suppression of hepatitis B e antigen-negative chronic hepatitis B by 24-month interferon therapy显示文摘 | Pietro Lampertico Ersilio Del Ninno Mauro Viganò Raffaella Romeo Maria Francesca Donato Erwin Sablon Alberto Morabito Massimo Colombo | 2003 | Hepatology2003，，4： | 1 |
| 7 | Factors associated with hepatitis B virus DNA breakthrough in patients receiving prolonged lamivudine therapy显示文摘 | Yuen MF Sablon E Hui CK | 2001 | Hepatology2001，34，8： | 1 |
| 8 | Genetic organization and heterogeneity of the iceA locus of Helicobacter pylori显示文摘 | Céu Figueiredo Wim G.V Quint Ricardo Sanna Erwin Sablon John P Donahue Qing Xu Geraldine G Miller Richard M Peek Martin J Blaser Leen-Jan van Doorn | 2000 | Gene2000，，1： | 1 |
| 9 | Long-term follow-up study of Chinese patients with YMDD mutations: significance of hepatitis B virus genotypes and characteristics of blochemical flares显示文摘 | Yuen M F Yuan H J Sablon E | 2004 | J Clin Microbiol2004，42，： | 1 |
| 10 | Significance of hepatitis B genotype in acute exacerbation,HBeAgseroconversion,cirrhosis-related complications,and hepatocellular carcinoma显示文摘 | Yuen MF Sablon E Yuan H J | 2003 | Hepatology2003，37，3： | 1 |
| 11 | Factors associated with hepatitis B virus DNA breakthrough in patients receiving prolonged lamivudine therapy显示文摘 | YUEN MF SABLON E HUI CK | 2001 | Hepatology2001，34，4： | 1 |
| 12 | Hepatitis B virus genotypes B and C do not affect the antiviral response to lamivudine显示文摘 | YuenMF WongDK SablonE etal | 2003 | Antivir Ther2003，8，： | 1 |
| 13 | Prognostic factors in severe exacerbation of chronic hepatitis B 显示文摘 | Yuen MF Sablon E Hui CK | 2003 | Clin Infect Dis2003，36，8： | 1 |
| 14 | Advances in Molecular Diagnosis of HBV Infection and Drug Resistance显示文摘 | Sablon E Shapiro F | 2005 | Int J Med Sci2005，2，1： | 1 |
| 15 | Hepatitis B and C do not affect the antiviral response to lamivudine 显示文摘 | Yuen MF Wong DK Sablon E | 2003 | Antivir Ther2003，81，： | 1 |
| 16 | Epidemiological study of hepatitis B virus genotypes,core promoter and precore mutations of chronic hepatitis B infection in Hong Kong显示文摘 | Yuen MF Sablon E Tanaka Y | 2004 | J Hepatol2004，41，： | 1 |
| 17 | HBsAg seroclearance in chronic hepatitis B in the Chinese:virological,histological,and clinical aspects显示文摘 | Yuen M F Wong D E Sablon E | 2004 | Hepatology2004，39，6： | 1 |
| 18 | Long-term follow-up study of Chinese patients with YMDD mutations: significance of hepatitis B virus genotypes and characteristics of biochemical flares显示文摘 | Yuen MF Yuan HI Sablon E | 2004 | J Clin Microbiol2004，42，9： | 1 |
| 19 | Prognoslic factors in severe exacerbation of chronic hepatitis B显示文摘 | Yuen M F Sablon E Hui CK | 2003 | Clin Infect Dis2003，36，8： | 1 |
| 20 | Prognostic factors in severe exacerbation of chronic hepatitis B显示文摘 | Yuen MF Sablon E Hui CK | 2003 | Clin Infect Dis2003，36，8： | 1 |
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