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| 1 | Abnormal ground reaction forces lead to a general decline in gait speed in knee osteoarthritis patients显示文摘AIM To analyse ground reaction forces at higher speeds using another method to be more sensitive in assessing significant gait abnormalities. METHODS A total of 44 subjects, consisting of 24 knee osteoarthritis(OA) patients and 20 healthy controls were analysed. The knee OA patients were recruited from an orthopaedic clinic that were awaiting knee replacement. All subjects had their gait patterns during stance phase at top walking speed assessed on a validated treadmill instrumented with tandem force plates. Temporal measurements and ground reaction forces(GRFs) along with a novel impulse technique were collected for both limbs and a symmetry ratio was applied to all variables to assess inter-limb asymmetry. All continuous variables for each group were compared using a student t-test and χ2 analysis for categorical variables with significance set at α = 0.05. Receiver operator characteristics curves were utilised to determine best discriminating ability.RESULTS The knee OA patients were older(66 ± 7 years vs 53 ± 9 years, P = 0.01) and heavier(body mass index: 31 ± 6 vs 23 ± 7, P < 0.001) but had a similar gender ratio when compared to the control group. Knee OA patients were predictably slower at top walking speed(1.37 ± 0.23 m/s vs 2.00 ± 0.20 m/s, P < 0.0001) with shorter mean step length(79 ± 12 cm vs 99 ± 8 cm, P < 0.0001) and broader gait width(14 ± 5 cm vs 11 ± 3 cm, P = 0.015) than controls without any known lower-limb joint disease. At a matched mean speed(1.37 ± 0.23 vs 1.34 ± 0.07), ground reaction results revealed that pushoff forces and impulse were significantly(P < 0.0001) worse(18% and 12% respectively) for the knee OA patients when compared to the controls. Receiver operating characteristic curves analysis demonstrated total impulse to be the best discriminator of asymmetry, with an area under the curve of 0.902, with a cut-off of-3% and a specificity of 95% and sensitivity of 88%.CONCLUSION Abnormal GRFs in knee osteoarthritis are clearly evident at higher speeds. Analysing GRFs with another method may explain the general decline in knee OA patient's gait. | Anatole Vilhelm Wiik Adeel Aqil Mads Brevadt Gareth Jones Justin Cobb | 2017 | World Journal of Orthopedics2017，8，4： | 7 |
| 2 | Current concepts in the management of bisphosphonate associated atypical femoral fractures显示文摘Bisphosphonates are a class of drugs used as the mainstay of treatment for osteoporosis.Bisphosphonates function by binding to hydroxyapatite,and subsequently targeting osteoclasts by altering their ability to resorb and remodel bone.Whilst aiming to reduce the risk of fragility fractures,bisphosphonates have been associated with atypical insufficiency fractures,specifically in the femur.Atypical femoral fractures occur distal to the lesser trochanter,until the supracondylar flare.There are a number of the differing clinical and radiological features between atypical femoral fractures and osteoporotic femoral fractures,indicating that there is a distinct difference in the respective underlying pathophysiology.At the point of presentation of an atypical femoral fracture,bisphosphonate should be discontinued.This is due to the proposed inhibition of osteoclasts and apoptosis,resulting in impaired callus healing.Conservative management consists primarily of cessation of bisphosphonate therapy and partial weightbearing activity.Nutritional deficiencies should be investigated and appro-priately corrected,most notably dietary calcium and vitamin D.Currently there is no established treatment guidelines for either complete or incomplete fractures.There is agreement in the literature that nonoperative management of bisphosphonate-associated femoral fractures conveys poor outcomes.Currently,the favoured methods of surgical fixation are cephalomedullary nailing and plate fixation.Newer techniques advocate the use of both modalities as it gives the plate advantage of best reducing the fracture and compressing the lateral cortex,with the support of the intramedullary nail to stabilise an atypical fracture with increased ability to load-share,and a reduced bending moment across the fracture site.The evidence suggests that cephalomedullary nailing of the fracture has lower revision rates.However,it is important to appreciate that the anatomical location and patient factors may not always allow for this.Although causation between bisphosphonates and atypical fractures is yet to be demonstrated,there is a growing evidence base to suggest a higher incidence to atypical femoral fractures in patients who take bisphosphonates.As we encounter a growing comorbid elderly population,the prevalence of this fracture-type will likely increase.Therefore,it is imperative clinicians continue to be attentive of atypical femoral fractures and treat them effectively. | Branavan Rudran Jonathan Super Rajan Jandoo Victor Babu Soosai Nathan Edward Ibrahim Anatole Vilhelm Wiik | 2021 | World Journal of Orthopedics2021，12，9： | 2 |
| 3 | HIF-1α and VEGF are Associated with Disease Progression in Esophageal Carcinoma显示文摘 | Heikki Takala Juha Saarnio Heikki Wiik Pasi Ohtonen Ylermi Soini | 2011 | Journal of Surgical Research2011，，1： | 2 |
| 4 | Use of ketamine sedation for the management of displaced paediatric forearm fractures显示文摘AIM To determine if ketamine sedation is a safe and cost effective way of treating displaced paediatric radial and ulna fractures in the emergency department. METHODS Following an agreed interdepartmental protocol, fractures of the radius and ulna(moderately to severely displaced) in children between the age of 2 and 16 years old, presenting within a specified 4 mo period, were manipulated in our paediatric emergency department. Verbal and written consent was obtained prior to procedural sedation to ensure parents were informed and satisfied to have ketamine. A single attempt at manipulation was performed. Pre and postmanipulation radiographs were requested and assessed to ensure adequacy of reduction. Parental satisfaction surveys were collected after the procedure to assess the perceived quality of treatment. After closed reduction and cast immobilisation, patients were then followed-up in the paediatric outpatient fracture clinic and functional outcomes measured prospectively. A cost analysis compared to more formal manipulation under a general anaesthetic was also undertaken.RESULTS During the 4 mo period of study, 10 closed, moderate to severely displaced fractures were identified and treated in the paediatric emergency department using our ketamine sedation protocol. These included fractures of the growth plate(3), fractures of both radius and ulna(6) and a single isolated proximal radius fracture. The mean time from administration of ketamine until completion of the moulded plaster was 20 min. The mean time interval from sedation to full recovery was 74 min. We had no cases of unacceptable fracture reduction and no patients required any further manipulation, either in fracture clinic or under a more formal general anaesthetic. There were no serious adverse events in relation to the use of ketamine. Parents, patients and clinicians reported extremely favourable outcomes using this technique. Furthermore, compared to using a manipulation under general anaesthesia, each case performed under ketamine sedation was associated with a saving of ￡1470, the overall study saving being ￡14700. CONCLUSION Ketamine procedural sedation in the paediatric population is a safe and cost effective method for the treatment of displaced fractures of the radius and ulna, with high parent satisfaction rates. | Anatole Vilhelm Wiik Poonam Patel Joanna Bovis Adele Cowper Philip Socrates Pastides Alison Hulme Stuart Evans Charles Stewart | 2018 | World Journal of Orthopedics2018，9，3： | 2 |
| 5 | Surface Roughening Mechanisms for Printing Paper Containing Mechanical Pulp 显示文摘 | FORSETH T WIIK K HELLE T | 1997 | Nordic Pulp & Paper Research Journal1997，12，1： | 1 |
| 6 | Claudins-1,3,4,5 and 7in esophageal cancer:loss of claudin-3 and 4 expression is associatedwith metastatic behavior AP显示文摘 | Takala H Saarnio J Wiik H | 2007 | MIS2007，115，7： | 1 |
| 7 | Molecular and structural composition of phospholipid membranes in livers of marine and freshwater fish in relation to temperature显示文摘 | Indranil Dey Csaba Buda Tarja Wiik | 1993 | Biochemistry1993，90，： | 1 |
| 8 | The use of citrullinated pep tides and proteins for the diagnosis of rheumatoid arthritis显示文摘 | Pruijn GJ Wiik A van Venrooij WJ | 2010 | Ar- thritis Res Ther2010，12，1： | 1 |
| 9 | A common genetic polymorphism associated with lower coagulation factor Ⅶ levels in healthy individuals显示文摘 | Green F Kelleher C Wiikes H | 1991 | Arteriosclerosis Thromb1991，11，3： | 1 |
| 10 | Serum uric acid is associated with new-onset diabetes in hypertensive patients with left ventricular hypertrophy:the life Study显示文摘 | Wiik B P Larstorp A C Hoieggen A | 2010 | Am J Hypenens2010，23，8： | 1 |
| 11 | The use of citrulli hated peptides and proteins for the diagnosis of rheuma toid arthritis 显示文摘 | Pruijn GJ Wiik A van Venrooij WJ | 2010 | Arthritis Res Ther2010，12，1： | 1 |
| 12 | Rational use of ANCA in the diagnosis of vasculitis显示文摘 | Wiik A | | 0，，： | 1 |
| 13 | Delineation of a standard procedure for indirect immunofluorescence detection of ANCA 显示文摘 | Wiik A | 1989 | APMIS1989，97，6： | 1 |
| 14 | Anti-CCP and RF IgM:predictors of impaired endothelial function in rheumatoid arthritis patients显示文摘 | Hjeltnes G Hollan I Forre O Wiik A | 2011 | Scand J Rheumatol2011，40，： | 1 |
| 15 | Neutrophil-specific autoantibodies in chronic inflamatory bowel diseases显示文摘 | Wiik A | | 0，，1： | 1 |
| 16 | Steady state power system issues when planning large wind farms 显示文摘 | WIIK J GJERDE J O GIENGEDAL T | 2002 | IEEE Power Engineering Society Winter Meeting2002，，1： | 1 |
| 17 | Diminished immunoreaetivity of γ- glutamylcysteine synthetase in the airways of smokers lung 显示文摘 | Harju T Wiik RK Kinnula V | 2002 | Am J Respir Crit Care Med2002，166，5： | 1 |
| 18 | Cytokines,autoantibod ies and viral antibodies in premorbid and postdiagnostie sera from patients with rheumatoid arthritis: case-control study nested in a cohort of Norwegian blood donor显示文摘 | Jorgensen KT Wiik A Pedersen M | 2008 | Ann Rheum Dis2008，67，86： | 1 |
| 19 | Prevalence and clinical significance of antikeratin antibodies and other serological markers in Lithuanian patients with rheumatoid arthritis显示文摘 | Vasiliauskiene L Wiik A Hoier-Madsen M | 2001 | Ann Rheum Dis2001，60，5： | 1 |
| 20 | Total mesorectal excision for rectal cancer: diference in outcome for low and hish reetal cancer显示文摘 | Faerden AE Naimy N Wiik P | 1995 | Dis Colon Rectum1995，48，： | 1 |
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