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| 1 | Crucial role of the sarcoplasmic reticulum in the developmental regulation of Ca2+ transients and contraction in cardiomyocytes derived from embryonic stem cells显示文摘 | Fu JD Li J Tweedie D Yu HM Chen L Wang R Riordon DR Brugh SA Wang SQ Boheler KR Yang HT | 2006 | 中国生物学文摘2006，20，7： | 9 |
| 2 | Combined carriership of TLR9 -1237C and CD14 -260T alleles enhances the risk of developing chronic relapsing pouchitis显示文摘AIM: To investigate the single nucleotide polymorphisms (SNPs) in genes involved in bacterial recognition and the susceptibility to pouchitis or pouchitis severity.METHODS: Analyses of CD14 -260C>T, CARD15/NOD2 3020insC, Toll-like receptor (TLR)4 +896A>G,TLR9 -1237T>C, TLR9+ 2848G>A, and IRAKM +22148G>A SNPs were performed in 157 ileal-pouch anal anastomosis (IPAA) patients (79 patients who did not develop pouchitis, 43 infrequent pouchitis patients,35 chronic relapsing pouchitis patients) and 224 Italian Caucasian healthy controls.RESULTS: No significant differences were found in SNP frequencies between controls and IPAA patients.However, a significant difference in carriership frequency of the TLR9-1237C allele was found between the infrequent pouchitis and chronic relapsing pouchitis groups [P = 0.028, odd's ratio (OR) = 3.2, 95%CI = 1.2-8.6].This allele uniquely represented a 4-locus TLR9 haplotype comprising both studied TLR9 SNPs in Caucasians.Carrier trait analysis revealed an enhanced combined carriership of the alleles TLR9 -1237C and CD14 -260T in the chronic relapsing pouchitis and infrequent pouchitis group (P = 0.018, OR = 4.1, 95%CI = 1.4 -12.3).CONCLUSION: There is no evidence that the SNPs predispose to the need for IPAA surgery. The significant increase of the combined carriership of the CD14 -260T and TLR9 -1237C alleles in the chronic relapsing pouchitis group suggests that these markers identify a subgroup of IPAA patients with a risk of developing chronic or refractory pouchitis. | KM Lammers S Ouburg SA Morré JBA Crusius P Gionchetti F Rizzello C Morselli E Caramelli R Conte G Poggioli M Campieri AS Pea | 2005 | World Journal of Gastroenterology2005，11，46： | 7 |
| 3 | Updated worldwide survey on the methods,efficacy,and safety of catheter ablation for human atrial fibrillation显示文摘 | Cappato R Calkins H Chen SA | | Circ Arrhythm Electrophysiol0，，： | 2 |
| 4 | 卒中介入治疗培训指南:国际多学会共识文件显示文摘1背景
缺血性卒中是全球人口死亡和残疾的首要原因。很多急性大血管闭塞(emergent large vesselocclusion,ELVO)患者都会遗留长期残疾。事实上,这些颅内大动脉闭塞经常会导致大面积脑损伤,进而造成患者死亡或严重致残。 | Lavine SD Cockroft K Hoh B Bambakidis N Khalessi AA Woo H Riina H Siddiqui A Hirsch JA Chong W Rice H Wenderoth J Mitchell P Coulthard A Signh TJ Phatorous C Khangure M Klurfan P ter Brugge K Iancu D Gunnarsson T Pongpech S Rodesch G Soderman M Taylor A Krings T Orbach D Picard L Suh DC Zheng HQ Jansen O Muto M Szikora I Pierot L Brouwer P Gralla J Renowden S Andersson T Fiehler J Turjman F White P Januel AC Spelle L Kulcsar Z Chapot R Biondi A Dima S Taschner C Szajner M Krajina A Sakai N Matsumaru Y Yoshknura S Ezura M Fujinaka T Iihara K Ishii A Higashi T Hirohata M Hyodo A Ito Y Kawanishi M Kiyosue H Kobayashi E Kobayashi S Kuwayama N Matsumoto Y Miyachi S Murayama Y Nagata I Nakahara I Nemoto S Niimi Y Oishi H Satomi J Satow T Sugiu K Tanaka M Terada T Yamagami H Diaz O Lylyk P Jayaraman MV Patsalides A Gandhi CD Lee SK Abruzzo T Albani B Ansari SA Arthur AS Baxter BW Bulsara KR Chen M Almandoz JE Fraser JF Heck DV Hetts SW Hussain MS Klucznik RP Leslie-Mawzi TM Mack WJ McTaggart RA Meyers PM Mocco J Prestigiacomo CA Pride GL Rasmussen PA Starke RM Sunenshine PJ Tarr RW Frei DF Pabo M Nogueira RG Zaidat OO Jovin T Linfante I Yavagal D Liebeskind D Novakovic R Pongpech S 许岩 孙瑞 郭芮兵 | 2017 | 国际脑血管病杂志2017，25，5： | 2 |
| 5 | Pancreatic fistula after a pancreaticoduodenectomy for ductal adenocarcinoma and its association with morbidity: a multicentre study of the F rench S urgical A ssociation显示文摘 | Pietro Addeo Jean Robert Delpero Francois Paye Elie Oussoultzoglou Pascal R Fuchshuber Alain Sauvanet Antonio Sa Cunha Yves Patrice Le Treut Mustapha Adham Jean‐Yves Mabrut Laurence Chiche Philippe Bachellier | 2014 | HPB2014，，1： | 2 |
| 6 | Manipulation of human embryonal carcinoma stem cells and the development of neural subtypes显示文摘 | Stewart R Christie VB Przyborski SA | 2003 | Stem Cells2003，21，： | 2 |
| 7 | 血管生成素样蛋白2水平与肾移植术后主动脉僵硬度和死亡率呈正相关显示文摘血管生成素样蛋白2(angiopoietin-like-2,ANGPTL2)是一种分泌性糖蛋白,可诱发血管内皮功能障碍、动脉粥样硬化和心血管病。循环ANGPTL2在慢性肾脏病(chronic kidney disease,CKD)患者中增加,加重患心血管病的风险。 | Desjardins MP Thorin-Trescases N Sidibé A Fortier C DeSerres SA Larivière R Thorin E Agharazii M 陈云 叶鹏 | 2017 | 中华高血压杂志2017，25，12： | 2 |
| 8 | Tissue-specific transcriptional imprinting and heterogeneity in human innate lymphoid cells revealed by full-length single-cell RNA-sequencing显示文摘The impact of the microenvironment on innate lymphoid cell(ILC)-mediated immunity in humans remains largely unknown.Here we used full-length Smart-seq2 single-cell RNA-sequencing to unravel tissue-specific transcriptional profiles and heterogeneity of CD127+ILCs across four human tissues.Correlation analysis identified gene modules characterizing the migratory properties of tonsil and blood ILCs,and signatures of tissue-residency,activation and modified metabolism in colon and lung ILCs.Trajectory analysis revealed potential differentiation pathways from circulating and tissue-resident naïve ILCs to a spectrum of mature ILC subsets.In the lung we identified both CRTH2+and CRTH2−ILC2 with lung-specific signatures,which could be recapitulated by alarmin-exposure of circulating ILC2.Finally,we describe unique TCR-V(D)J-rearrangement patterns of blood ILC1-like cells,revealing a subset of potentially immature ILCs with TCR-δ rearrangement.Our study provides a useful resource for in-depth understanding of ILC-mediated immunity in humans,with implications for disease. | Luca Mazzurana Paulo Czarnewski Viktor Jonsson Leif Wigge Markus Ringnér Teresa CWilliams Avinash Ravindran Åsa KBjörklund Jesper Säfholm Gunnar Nilsson Sven-Erik Dahlén Ann-Charlotte Orre Mamdoh Al-Ameri Charlotte Höög Charlotte Hedin Sylwester Szczegielniak Sven Almer Jenny Mjösberg | 2021 | Cell Research2021，31，5： | 2 |
| 9 | Spontaneous intracranial hypotension显示文摘 | Renowden SA Gregory R Hyman N | 1995 | J Neurol Neurosurg Psychiatry1995，59，5： | 2 |
| 10 | Expression of a truncated Pasteurella multocida toxin antigen in Bordetella bronchiseptica显示文摘 | Rajeev S Nair R V Kania SA Bemis D A | 2003 | Vet Microbiol2003，94，4： | 1 |
| 11 | Evaluation of the effects of total sleep deprivation on cerebral blood flow using single photo emission computerized tomography 显示文摘 | Volk SA Kaendler SH Weber R | 1992 | Acta Psychiatr Scand1992，86，3： | 1 |
| 12 | The value of procalcitonin at predicting the severity of acute pancreatitis and devel- opment of infected pancreatic necrosis: systematic review 显示文摘 | Mofidi R Suttie SA Patil PV | 2009 | Surgery2009，146，1： | 1 |
| 13 | An essential role for Scurfin in CD4- CD25+T regulatory celia显示文摘 | Khattri R Cox T Yasayko SA | 2003 | J Nature Immunol2003，4，4： | 1 |
| 14 | One hundred and seventeen clades of euagarics显示文摘 | MONCALVO J VILGALYS R REDHEAD SA | 2002 | Mol Phylogenet Evol2002，23，： | 1 |
| 15 | Comparison of thyroid hormone and cortisolts with APACHE II and TISS scoring systems as predictors of mortality in the medical intensive care unit显示文摘 | Arem R Thornby JI Deppe SA | 1997 | J Intensive Care Med1997，12，： | 1 |
| 16 | Analytical modelling of normal and oblique ballistic impact on ceramic/metal lightweight armours显示文摘 | Zaera R Sa'nchez-Ga'lvez V | 1998 | International Journal of Impact Engineering1998，21，1： | 1 |
| 17 | Bioinformatics of granzymes: sequence comparison and structural studies on granzyme family by homology modeling 显示文摘 | Sattar R Ali SA Abbasi A | 2003 | Biochem Biophys Res Commun2003，308，4： | 1 |
| 18 | High incidence of esophageal and gastric cancer in Kashmir in a population with special personal and dietary habits显示文摘 | Khuroo MS Zargar SA Mahajan R | 1992 | Gut1992，33，1： | 1 |
| 19 | Safety and drug utilization pro-file of varenicline as used in general practice in England: interimresults from a prescription-event monitoring study 显示文摘 | Kasliwal R Wilton LV Shakir SA | 2009 | Drug Saf2009，32，6： | 1 |
| 20 | Nutrition support in acute panereatitis:a systematic review of the literature显示文摘 | McClave SA Chang WK Dhaliwal R etal | 2006 | JPEN2006，30，2： | 1 |
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