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| 1 | Erianin,a novel dibenzyl compound in Dendrobium extract,inhibits lung cancer cell growth and migration via calcium/calmodulin-dependent ferroptosis显示文摘Ferroptosis,a novel form of programmed cell death,is characterized by iron-dependent lipid peroxidation and has been shown to be involved in multiple diseases,including cancer.Stimulating ferroptosis in cancer cells may be a potential strategy for cancer therapy.Therefore,ferroptosis-inducing drugs are attracting more attention for cancer treatment.Here,we showed that erianin,a natural product isolated from Dendrobium chrysotoxum Lindl,exerted its anticancer activity by inducing cell death and inhibiting cell migration in lung cancer cells.Subsequently,we demonstrated for the first time that erianin induced ferroptotic cell death in lung cancer cells,which was accompanied by ROS accumulation,lipid peroxidation,and GSH depletion.The ferroptosis inhibitors Fer-1 and Lip-1 but not Z-VAD-FMK,CQ,or necrostatin-1 rescued erianin-induced cell death,indicating that ferroptosis contributed to erianin-induced cell death.Furthermore,we demonstrated that Ca^(2+)/CaM signaling was a critical mediator of erianin-induced ferroptosis and that blockade of this signaling significantly rescued cell death induced by erianin treatment by suppressing ferroptosis.Taken together,our data suggest that the natural product erianin exerts its anticancer effects by inducing Ca^(2+)/CaMdependent ferroptosis and inhibiting cell migration,and erianin will hopefully serve as a prospective compound for lung cancer treatment. | Peng Chen Qibiao Wu Jiao Feng Lili Yan Yitian Sun Shuiping Liu Yu Xiang Mingming Zhang Ting Pan Xiaying Chen Ting Duan Lijuan Zhai Bingtao Zhai Wengang Wang Ruonan Zhang Bi Chen Xuemeng Han Yicong Li Liuxi Chen Ying Liu Xingxing Huang Ting Jin Wenzheng Zhang Hong Luo Xiaohui Chen Yongqiang Li Qiujie Li Guohua Li Qin Zhang Lvjia Zhuo Zuyi Yang Huifen Tang Tian Xie Xiaoping Ouyang Xinbing Sui | 2020 | Signal Transduction and Targeted Therapy2020，5，1： | 42 |
| 2 | Nitrate Leaching from Maize Intercropping Systems with N Fertilizer Over-Dose显示文摘A 2-yr field experiment was conducted on a calcareous alluvial soil with four summer maize intercropping systems at Shangzhuang Experiment Station (116.3°E, 39.9°N) in the North China Plain. The objective was to determine nitrate leaching from intercropping systems involving maize (Zea mays L.): sole maize (CK), maize + soybean (CST), maize + groundnut (CGT), maize + ryegrass (CHM), and maize+ alfalfa (CMX). Intercropping greatly reduced nitrate accumulation in the 100-200 cm soil layers compared with maize monoculture. Nitrate accumulation under intercropping systems decreased significantly at the 140-200 cm soil depth; the accumulation varied in the order CK>CST>CMX>CHM>CGT. However, compared to the CK treatment, nitrate leaching losses during the maize growing period were reduced by 20.9- 174.8 (CGT), 35.2-130.8 (CHM), 60.4-122.0 (CMX), and 30.6-82.4 kg ha-1 (CST). The results also suggested that intercropping is an effective way to reduce nitrogen leaching in fields with N fertilizer over-dose. | NIE Sheng-wei AEgfinya Eneji CHEN Yuan-quan SUI Peng HUANG Jian-xiong HUANGShao-min | 2012 | Journal of Integrative Agriculture2012，11，9： | 24 |
| 3 | Review of Current Status and Research Approaches to Nitrogen Pollution in Farmlands显示文摘In this paper, the history, current status, and research approaches to nitrogen pollution were reviewed using systems analysis and deductions. The seriousness of N pollution world-wide was highlighted and recommendations were made to address the situation. A new hypothesis based on phytoremediation, which means the use of plants to directly or indirectly degrade or remove contaminats from soil and water, was proposed. | NIE Sheng-wei GAO Wang-sheng CHEN Yuan-quan SUI Peng A Egrinya Eneji | 2009 | Agricultural Sciences in China2009，8，7： | 23 |
| 4 | Baicalin induces ferroptosis in bladder cancer cells by downregulating FTH1显示文摘Ferroptosis is a non-apoptotic regulated cell death caused by iron accumulation and subsequent lipid peroxidation.Currently,the therapeutic role of ferroptosis on cancer is gaining increasing interest.Baicalin an active component in Scutellaria baicalensis Georgi with anticancer potential various cancer types;however,the effects of baicalein on bladder cancer and the underlying molecular mechanisms remain largely unknown.In the study,we investigated the effect of baicalin on bladder cancer cells5637 and KU-19-19.As a result,we show baicalin exerted its anticancer activity by inducing apoptosis and cell death in bladder cancer cells.Subsequently,we for the first time demonstrate baicalin-induced ferroptotic cell death in vitro and in vivo,accompanied by reactive oxygen species(ROS) accumulation and intracellular chelate iron enrichment.The ferroptosis inhibitor deferoxamine but not necrostatin-1,chloroquine(CQ),N-acetyl-L-cysteine,L-glutathione reduced,or carbobenzoxy-valyl-alanyl-aspartyl-[O-methyl]-fluoromethylketone(Z-VAD-FMK) rescued baicalin-induced cell death,indicating ferroptosis contributed to baicalin-induced cell death.Mechanistically,we show that ferritin heavy chain1(FTH1) was a key determinant for baicalin-induced ferroptosis.Overexpression of FTH1 abrogated the anticancer effects of baicalin in both 5637 and KU19-19 cells.Taken together,our data for the first time suggest that the natural product baicalin exerts its anticancer activity by inducing FTH1-dependent ferroptosis,which will hopefully provide a prospective compound for bladder cancer treatment. | Na Kong Xiaying Chen Jiao Feng Ting Duan Shuiping Liu Xueni Sun Peng Chen Ting Pan Lili Yan Ting Jin Yu Xiang Quan Gao Chengyong Wen Weirui Ma Wencheng Liu Mingming Zhang Zuyi Yang Wengang Wang Ruonan Zhang Bi Chen Tian Xie Xinbing Sui Wei Tao | 2021 | Acta Pharmaceutica Sinica B2021，11，12： | 23 |
| 5 | Gut microbial diversity analysis using Illumina sequencing for functional dyspepsia with liver depression-spleen deficiency syndrome and the interventional Xiaoyaosan in a rat model显示文摘AIM To investigate gut microbial diversity and the interventional effect of Xiaoyaosan(XYS) in a rat model of functional dyspepsia(FD) with liver depression-spleen deficiency syndrome. METHODS The FD with liver depression-spleen deficiency syndrome rat model was established through classic chronic mild unpredictable stimulation every day. XYS group rats received XYS 1 h before the stimulation. The models were assessed by parameters including state ofthe rat, weight, sucrose test result and open-field test result. After 3 wk, the stools of rats were collected and genomic DNA was extracted. PCR products of the V4 region of 16 S rD NA were sequenced using a barcoded Illumina paired-end sequencing technique. The primary composition of the microbiome in the stool samples was determined and analyzed by cluster analysis.RESULTS Rat models were successfully established, per data from rat state, weight and open-field test. The microbiomes contained 20 phyla from all samples. Firmicutes, Bacteroidetes, Proteobacteria, Cyanobacteria and Tenericutes were the most abundant taxonomic groups. The relative abundance of Firmicutes, Proteobacteria and Cyanobacteria in the model group was higher than that in the normal group. On the contrary, the relative abundance of Bacteroidetes in the model group was lower than that in the normal group. Upon XYS treatment, the relative abundance of all dysregulated phyla was restored to levels similar to those observed in the normal group. Abundance clustering heat map of phyla corroborated the taxonomic distribution. CONCLUSION The microbiome relative abundance of FD rats with liver depression-spleen deficiency syndrome was significantly different from the normal cohort. XYS intervention may effectively adjust the gut dysbacteriosis in FD. | Juan-Juan Qiu Zhe Liu Peng Zhao Xue-Jun Wang Yu-Chun Li Hua Sui Lawrence Owusu Hui-Shu Guo Zheng-Xu Cai | 2017 | World Journal of Gastroenterology2017，23，5： | 23 |
| 6 | Subsoiling and Ridge Tillage Alleviate the High Temperature Stress in Spring Maize in the North China Plain显示文摘High temperature stress(HTS)on spring maize(Zea mays L.)during the filling stage is the key factor that limits the yield increase in the North China Plain(NCP).Subsoiling(SS)and ridge tillage(R)were introduced to enhance the ability of spring maize to resist HTS during the filling stage.The field experiments were conducted during the 2011 and 2012 maize growing seasons at Wuqiao County,Hebei Province,China.Compared with rotary tillage(RT),the net photosynthetic rate,stomatal conductance,transpiration rate,and chlorophyll relative content(SPAD)of maize leaves was increased by 40.0,42.6,12.8,and 29.7%under SS,and increased by 20.4,20.0,5.4,and 14.2%under R,repectively.However,the treatments reduce the intercellular CO2concentration under HTS.The SS and R treatments increased the relative water content(RWC)by 11.9 and6.2%,and the water use efficiency(WUE)by 24.3 and 14.3%,respectively,compared with RT.The SS treatment increased the root length density and soil moisture in the 0-80 cm soil profile,whereas the R treatment increased the root length density and soil moisture in the 0-40 cm soil profile compared with the RT treatment.Compared with 2011,the number of days with temperatures 33°C was more 2 d and the mean day temperature was higher 0.9°C than that in 2012,whereas the plant yield decreased by 2.5,8.5 and 10.9%,the net photosynthetic rate reduced by 7.5,10.5 and 18.0%,the RWC reduced by 3.9,5.6 and6.2%,and the WUE at leaf level reduced by 1.8,5.2 and 13.1%in the SS,R and RT treatments,respectively.Both the root length density and the soil moisture also decreased at different levels.The yield,photosynthetic rate,plant water status,root length density,and soil moisture under the SS and R treatments declined less than that under the RT treatment.The results indicated that SS and R can enhance the HTS resistance of spring maize during the filling stage,and led to higher yield by directly improving soil moisture and root growth and indirectly improving plant water status,photosynthesis and grain filling.The study can provide a theoretical basis for improving yield of maize by adjusting soil tillage in the NCP. | TAO Zhi-qiang SUI Peng CHEN Yuan-quan LI Chao NIE Zi-jin YUAN Shu-fen SHI Jiang-tao GAO Wang-sheng | 2013 | Journal of Integrative Agriculture2013，12，12： | 20 |
| 7 | The ICM method with objective function transformed by variable discrete condition for continuum structure显示文摘ICM (独立连续印射) 方法能与是的最小化的重量解决拓扑的优化问题对排水量限制客观、使 \O 遭到。为了得到一种更清楚的拓扑的配置,由介绍拓扑的变量的分离条件并且与原来的目的集成,有多目的一个最佳的模型被提出让拓扑的变量尽可能近接近 0 或 1,并且模型减少在结果上删除率的效果。过滤图象的方法被采用消除发生在连续统结构的拓扑学优化的棋盘模式和网孔依赖。计算效率通过选择伪活跃的排水量限制和一个设计区域被提高。数字例子显示这个算法柔韧、适用,尽管重复的数字稍微关于原来的算法被增加。 | Yunkang Sui Xirong Peng | 2006 | Acta Mechanica Sinica2006，22，1： | 19 |
| 8 | The causes and impacts for heat stress in spring maize during grain filling in the North China Plain--A review显示文摘High-temperature stress(HTS) at the grain-filling stage in spring maize(Zea mays L.) is the main obstacle to increasing productivity in the North China Plain(NCP). To solve this problem, the physiological mechanisms of HTS, and its causes and impacts, must be understood. The HTS threshold of the duration and rate in grain filling, photosynthetic characteristics(e.g., the thermal stability of thylakoid membrane, chlorophyll and electron transfer, photosynthetic carbon assimilation), water status(e.g., leaf water potential, turgor and leaf relative water content) and signal transduction in maize are reviewed. The HTS threshold for spring maize is highly desirable to be appraised to prevent damages by unfavorable temperatures during grain filling in this region. HTS has negative impacts on maize photosynthesis by damaging the stability of the thylakoid membrane structure and degrading chlorophyll, which reduces light energy absorption, transfer and photosynthetic carbon assimilation. In addition, photosynthesis can be deleteriously affected due to inhibited root growth under HTS in which plants decrease their water-absorbing capacity, leaf water potential, turgor, leaf relative water content, and stomatal conductance. Inhibited photosynthesis decrease the supply of photosynthates to the grain, leading to falling of kernel weight and even grain yield. However, maize does not respond passively to HTS. The plant transduces the abscisic acid(ABA) signal to express heat shock proteins(HSPs), which are molecular chaperones that participate in protein refolding and degradation caused by HTS. HSPs stabilize target protein configurations and indirectly improve thylakoid membrane structure stability, light energy absorption and passing, electron transport, and fixed carbon assimilation, leading to improved photosynthesis. ABA also induces stomatal closure to maintain a good water status for photosynthesis. Based on understanding of such mechanisms, strategies for alleviating HTS at the grain-filling stage in spring maize are summarized. Eight strategies have the potential to improve the ability of spring maize to avoid or tolerate HTS in this study, e.g., adjusting sowing date to avoidHTS, breeding heat-tolerance varieties, and tillage methods, optimizing irrigation, heat acclimation, regulating chemicals, nutritional management, and planting geometric design to tolerate HTS. Based on the single technology breakthrough, a comprehensive integrated technical system is needed to improve heat tolerance and increase the spring maize yield in the NCP. | TAO Zhi-qiang CHEN Yuan-quan LI Chao ZOU Juan-xiu YAN Peng YUAN Shu-fen WU Xia SUI Peng | 2016 | Journal of Integrative Agriculture2016，15，12： | 15 |
| 9 | Soil Nitrous Oxide Emissions Under Maize-Legume Intercropping System in the North China Plain显示文摘Many studies have focused on various agricultural management measures to reduce agricultural nitrous oxide(N2O) emission. Howev er, few studies have investigated soil N2O emissions in intercropping systems in the North China Plain. Thus, we conducted a field experiment to compare N2O emissions under monoculture and maize-legume intercropping systems. In 2010, five treatments, including monocultured maize(M), maize-peanut(MP), maize-alfalfa(MA), maize-soybean(MS), and maize-sweet clover(MSC) intercropping were designed to investigate this issue using the static chamber technique. In 2011, M, MP, and MS remained, and monocultured peanuts(P) and soybean(S) were added to the trial. The results showed that total production of N2O from different treatments ranged from(0.87±0.12) to(1.17±0.11) kg ha-1 in 2010, while those ranged from(3.35±0.30) to(9.10±2.09) kg ha-1 in 2011. MA and MSC had no significant effect on soil N2O production compared to that of M(P<0.05). Cumulative N2O emissions from MP in 2010 were significantly lower than those from M, but the result was the opposite in 2011(P<0.05). MS significantly reduced soil N2O emissions by 25.55 and 48.84% in 2010 and 2011, respectively(P<0.05). Soil N2O emissions were significantly correlated with soil water content, soil temperature, nitrification potential, soil NH4+, and soil NO3- content(R2=0.160-0.764, P<0. 01). A stepwise linear regression analysis indicated that soil N2O release was mainly controlled by the interaction between soil moisture and soil NO3- content(R2=0.828, P<0.001). These results indicate that MS had a coincident effect on soil N2O flux and significantly reduced soil N2O production compared to that of M over two growing seasons. | HUANG Jian-xiong CHEN Yuan-quan SUI Peng NIE Sheng-wei GAO Wang-sheng | 2014 | Journal of Integrative Agriculture2014，13，6： | 14 |
| 10 | Impacts of ice cover on local scour around semi-circular bridge abutment显示文摘The presence of ice cover in winter can significantly change the flow field around bridge abutments,which can also cause a different local scour pattern.To investigate the impacts of ice cover,results from a recent flume experiments were presented.Smooth and rough ice covers were created to investigate the impacts of ice cover roughness on the scour geometry around the semi-circular abutment.Three bed materials were used,with50D s of 0.58 mm,0.50 mm,0.47 mm respectively.Scour volume and scour area were calculated.It was found that the maximum scour depth was located 75o inclined to the flume wall.Under rough ice cover,the scour area and scour depth were the largest.An empirical equation on the maximum scour depth was also developed. | WU Peng HIRSHFIELD Faye SUI Jueyi 王军 陈胖胖 | 2014 | Journal of Hydrodynamics2014，26，1： | 13 |
| 11 | Rapid and sensitive detection of pesticides by surface-enhanced Raman spectroscopy technique based on glycidyl methacrylate-ethylene dimethacrylate(GMA-EDMA) porous material显示文摘A novel method of fast and sensitive SERS detection using GMA-EDMA porous material combined with a miniature device was reported in this study.A100μL solution containing sample,silver colloid and NaCl was evenly mixed to ensure the sample molecules would adsorb onto silver nanoparticles.Then the mixture was added onto the porous material surface slowly,so that the aggregation of silver colloid would stay on the surface while the liquid components would flow away.This technology can improve the sensitivity of SERS detection.By this method,two pesticides tricyclazole and paraquat were successfully detected at concentrations of 5×10^(-3) mg/L and 1×10^(-3) mg/L,respectively. | Qing-Qing Li Yi-Ping Du Ying Xu Xuan Wang Shi-Qian Ma Jin-Pei Geng Peng Cao Tao Sui | 2013 | Chinese Chemical Letters2013，24，4： | 10 |
| 12 | An Observational Analysis of the Oceanic and Atmospheric Structure of Global-Scale Multi-decadal Variability显示文摘The aim of the present study was to identify multi-decadal variability(MDV) relative to the current centennial global warming trend in available observation data. The centennial global warming trend was first identified in the global mean surface temperature(STgm) data. The MDV was identified based on three sets of climate variables, including sea surface temperature(SST), ocean temperature from the surface to 700 m, and the NCEP and ERA40 reanalysis datasets, respectively.All variables were detrended and low-pass filtered. Through three independent EOF analyses of the filtered variables, all results consistently showed two dominant modes, with their respective temporal variability resembling the Pacific Decadal Oscillation/Inter-decadal Pacific Oscillation(PDO/IPO) and the Atlantic Multi-decadal Oscillation(AMO). The spatial structure of the PDO-like oscillation is characterized by an ENSO-like structure and hemispheric symmetric features. The structure associated with the AMO-like oscillation exhibits hemispheric asymmetric features with anomalous warm air over Eurasia and warm SST in the Atlantic and Pacific basin north of 10°S, and cold SST over the southern oceans. The Pacific and Atlantic MDV in upper-ocean temperature suggest that they are mutually linked.We also found that the PDO-like and AMO-like oscillations are almost equally important in global-scale MDV by EOF analyses. In the period 1975–2005, the evolution of the two oscillations has given rise to strong temperature trends and has contributed almost half of the STgm warming. Hereon, in the next decade, the two oscillations are expected to slow down the global warming trends. | Peng LIU Chung-Hsiung SUI | 2014 | Advances in Atmospheric Sciences2014，31，2： | 9 |
| 13 | Effects of Repetitive Transcranial Magnetic Stimulation on Astrocytes Proliferation and nNOS Expression in Neuropathic Pain Rats显示文摘 | Lu YANG Sai-hua WANG Yan HU Yan-fang SUI Tao PENG Tie-cheng GUO | 2018 | Current Medical Science2018，38，3： | 8 |
| 14 | Structures and catalytic performances of Me/SAPO-34(Me=Mn,Ni,Co)catalysts for low-tem perature SCR of NO_x by ammonia显示文摘Me/SAPO-34(Me=Mn,Ni,Co)series of catalysts were prepared by a wetness impregnation method and investigated for the selective catalytic reduction of nitrogen oxides with ammonia(NH 3-SCR).Among them,Mn/SAPO-34 catalyst was found as the most promising candidate based on its superior low-temperature activity.The catalysts were characterized by X-ray diffraction(XRD),transmission electron microscopy images(TEM),nuclear magnetic resonance(NMR),X-ray photoelectron spectroscopy(XPS),temperature programmed reduction and desorption(TPR and TPD),and diffuse reflectance infrared Fourier transformed spectroscopy(DRIFTS)of NH_(3)/NO_(x)adsorption.Mn/SAPO-34 is obviously different from Ni/SAPO-34 and Co/SAPO-34 in the active species state and distribution.Surface MnO_(x)species which play an essential role in NO oxidation and NO_(2)adsorption,act as better active sites than nickel and cobalt mostly in the form of the aluminates and silicates. | Xuesong Liu Zhiming Sui Hongfeng Chen Yong Chen Haigang Liu Peng Jiang Zhongyun Shen Wensheng Linghu Xiaodong Wu | 2021 | Journal of Environmental Sciences2021，33，6： | 8 |
| 15 | Surface enhanced Raman spectroscopy signals of mixed pesticides and their identification显示文摘A rapid and sensitive method to identify and analyze mixed pesticides of tricyclazole,paraquat and flusilazole by surface-enhanced Raman scattering has been reported.Aqueous samples can be detected by SERS in low concentrations of 0.01 mg/L, 0.1 mg/L and 2.85 mg/L for individual tricyclazole,paraquat and flusilazole respectively.When mixing the three pesticides in the low concentrations,their characteristic peaks can still be identified from the SERS spectrum of the mixture. | Hui Rong Tang Qing Qing Li Yu Lan Ren Jin Pei Geng Peng Cao Tao Sui Xuan Wang Yi Ping Du | 2011 | Chinese Chemical Letters2011，22，12： | 7 |
| 16 | Effects of flooding stress on the photosynthetic apparatus of leaves of two Physocarpus cultivars显示文摘We applied under pot-culture conditions and the double-casing pot method to study the characteristics of photosynthetic gas exchange and chlorophyll fluorescence in the leaves of Physocarpus amurensis Maxim(PA) and Physocarpus opulifolius under flooding stress.Our results indicate a significantly higher flooding tolerance of P.opulifolius compared to P.amurensis.Especially in P.amurensis, the limitation of non-stomatal factors played a major role in the advanced stages of flooding stress,observed as a rapid increase of the intercellular CO_2 concentration(C_i) and a decrease of the stomatal limitation value(L_s).The maximal PSII photochemical efficiencies(F_v/F_m) and actual photochemical efficiency(?_(PSII)) in the leaves of P.opulifolius were significantly higher, and the extent of decrease during the flooding process was smaller than in P.amurensis.In addition, the non-chemical quenching(NPQ) in the leaves of P.opulifolius significantly increased from the 10 th day under flooding stress,while the variation of NPQ in the leaves of P.amurensis was much smaller.This indicates that the leaves of P.opulifolius had not only higher PSII photochemical activity, but also improved tolerance to flooding stress, which may be caused by its ability to dissipate excess excitation energy by starting NPQ.At the 16 th day under flooding stress, the PIABSsignificantly decreased with greater extent of decrease than F_v/F_m in the leaves of both Physocarpus,but the decreasing extent of PIABSin P.opulifolius was significantly smaller than in P.amurensis.In the 16 th day under flooding stress, the fluorescence at J and I point(V_J and V_I) in P.amurensis were significantly higher, and the extent of increase in V_J was greater than V_I.However, the variations of V_Jand V_I in the leaves of P.opulifolius were smaller, suggesting that the damage sites of flooding stress to PSII in the leaves of P.amurensis were mainly located in the electron transport process from Q_A at the PSII receptor side to Q_B.Flooding stress reduced the proportion(φ Eo) of luminous energy absorbed by the PSII reaction center for the electron transport following Q_A^-, while the maximum quantum yield(φ Do) of non-photochemical quenching increased.However, the TR_o/RC and ETo/RC in the leaves of P.amurensis decreased accompanied by a dramatic increase of energy(DI_o/RC) from the dissipation in the reaction center.This further indicated that the function of the PSII reaction center in the leaves of P.amurensis was significantly lower than in P.opulifolius. | Huihui Zhang Peng Feng Wei Yang Xin Sui Xin Li Wei Li Rongtao Zhang Siyu Gu Nan Xu | 2018 | Journal of Forestry Research2018，29，4： | 6 |
| 17 | Preparation, characterization, pharmacokinetics and anticancer effects of PEGylated β-elemene liposomes显示文摘Objective:This study aimed to develop a new polyethylene glycol(PEG)ylatedβ-elemene liposome(PEG-Lipo-β-E)and evaluate its characterization,pharmacokinetics,antitumor effects and safety in vitro and in vivo.Methods:The liposomes were prepared by ethanol injection and high-pressure micro-jet homogenization.Characterization of the liposomes was conducted,and drug content,entrapment efficiency(EE),in vitro release and stability were studied by ultra-fast liquid chromatography(UFLC)and a liquid surface method.Blood was drawn from rats to establish the pharmacokinetic parameters.The anticancer effect was evaluated in a KU-19-19 bladder cancer xenograft model.Histological analyses were performed to evaluate safety.Results:The PEG-Lipo-β-E showed good stability and was characterized as 83.31±0.181 nm in size,0.279±0.004 in polydispersity index(PDI),-21.4±1.06 mV in zeta potential,6.65±0.02 in pH,5.024±0.107 mg/mL inβ-elemene(β-E)content,and 95.53±1.712%in average EE.The Fourier transform infrared spectroscopy(FTIR)and differential scanning calorimetry(DSC)indicated the formation of PEG-Lipo-β-E.Compared to elemene injection,PEG-Lipo-β-E demonstrated a 1.75-fold decrease in clearance,a 1.62-fold increase in half-life,and a 1.76-fold increase in area under the concentration-time curves(AUCs)from 0 hour to 1.5 hours(P<0.05).PEG-Lipo-β-E also showed an enhanced anticancer effect in vivo.Histological analyses showed that there was no evidence of toxicity to the heart,kidney,liver,lung or spleen.Conclusions:The present study demonstrates PEG-Lipo-β-E as a new formulation with ease of preparation,high EE,good stability,improved bioavailability and antitumor effects. | Bingtao Zhai Qibiao Wu Wengang Wang Mingming Zhang Xuemeng Han Qiujie Li Peng Chen Xiaying Chen Xingxing Huang Guohua Li Qin Zhang Ruonan Zhang Yu Xiang Shuiping Liu Ting Duan Jianshu Lou Tian Xie Xinbing Sui | 2020 | Cancer Biology & Medicine2020，17，1： | 6 |
| 18 | Aggregate stability and associated C and N in a silty loam soil as affected by organic material inputs显示文摘To make recycling utilization of organic materials produced in various agricultural systems, five kinds of organic materials were applied in a field test, including crop straw(CS), biogas residue(BR), mushroom residue(MR), wine residue(WR), pig manure(PM), with a mineral fertilizer(CF) and a no-fertilizer(CK) treatment as a control. Our objectives were: i) to quantify the effects of organic materials on soil C and N accumulation; ii) to evaluate the effects of organic materials on soil aggregate stability, along with the total organic carbon(TOC), and N in different aggregate fractions; and iii) to assess the relationships among the organic material components, soil C and N, and C, N in aggregate fractions. The trial was conducted in Wuqiao County, Hebei Province, China. The organic materials were incorporated at an equal rate of C, and combined with a mineral fertilizer in amounts of 150 kg N ha-1, 26 kg P ha-1 and 124 kg K ha-1 respectively during each crop season of a wheat-maize rotation system. The inputted C quantity of each organic material treatment was equivalent to the total amount of C contained in the crop straw harvested in CS treatement in the previous season. TOC, N, water-stable aggregates, and aggregate-associated TOC and N were investigated. The results showed that organic material incorporation increased soil aggregation and stabilization. On average, the soil macroaggregate proportion increased by 14%, the microaggregate proportion increased by 3%, and mean-weight diameter(MWD) increased by 20%. TOC content followed the order of PM>WR>MR>BR>CS>CK>CF; N content followed the order WR>PM>MR>BR>CS>CF>CK. No significant correlation was found between TOC, N, and the quality of organic material. Soil silt and clay particles contained the largest part of TOC, whereas the small macroaggregate fraction was the most sensitive to organic materials. Our results indicate that PM and WR exerted better effects on soil C and N accumulation, followed by MR and BR, suggesting that organic materials from ex situ farmland could promote soil quality more as compared to straw returned in situ. | LONG Pan SUI Peng GAO Wang-sheng WANG Bin-bin HUANG Jian-xiong YAN Peng ZOU Juan-xiu YAN Ling-ling CHEN Yuan-quan | 2015 | Journal of Integrative Agriculture2015，14，4： | 6 |
| 19 | An ATF24 peptide-functionalized β-elemene-nanostructured lipid carrier combined with cisplatin for bladder cancer treatment显示文摘Objective:In this study,we aimed to develop an amino-terminal fragment(ATF)peptide-targeted liposome carryingβ-elemene(ATF24-PEG-Lipo-β-E)for targeted delivery into urokinase plasminogen activator receptor-overexpressing bladder cancer cells combined with cisplatin(DDP)for bladder cancer treatment.Methods:The liposomes were prepared by ethanol injection and high-pressure microjet homogenization.The liposomes were characterized,and the drug content,entrapment efficiency,andin vitro release were studied.The targeting efficiency was investigated using confocal microscopy,ultra-fast liquid chromatography,and an orthotopic bladder cancer model.The effects of ATF24-PEG-Lipo-β-E combined with DDP on cell viability and proliferation were evaluated by a Cell Counting Kit-8(CCK-8)assay,a colony formation assay,and cell apoptosis and cell cycle analyses.The anticancer effects were evaluated in a KU-19-19 bladder cancer xenograft model.Results:ATF24-PEG-Lipo-β-E had small and uniform sizes(~79 nm),high drug loading capacity(~5.24 mg/mL),high entrapment efficiency(98.37±0.95%),and exhibited sustained drug release behavior.ATF24-PEG-Lipo-β-E had better targeting efficiency and higher cytotoxicity than polyethylene glycol(PEG)ylatedβ-elemene liposomes(PEG-Lipo-β-E).DDP,combined with ATF24-PEG-Lipo-β-E,exerted a synergistic effect on cellular apoptosis and cell arrest at the G2/M phase,and these effects were dependent on the caspase-dependent pathway and Cdc25C/Cdc2/cyclin B1 pathways.Furthermore,thein vivo antitumor activity showed that the targeted liposomes effectively inhibited the growth of tumors,using the combined strategy.Conclusions:The present study provided an effective strategy for the targeted delivery ofβ-elemene(β-E)to bladder cancer,and a combined strategy for bladder cancer treatment. | Bingtao Zhai Peng Chen Wengang Wang Shuiping Liu Jiao Feng Ting Duan Yu Xiang Ruonan Zhang Mingming Zhang Xuemeng Han Xiaying Chen Qiujie Li Guohua Li Ying Liu Xingxing Huang Wenzheng Zhang Ting Pan Lili Yan Ting Jin Tian Xie Xinbing Sui | 2020 | Cancer Biology & Medicine2020，17，3： | 5 |
| 20 | Local scour around bridge abutments under ice covered condition-an experimental study显示文摘本地人在桥牌附近搜索桥墩是一个活跃研究话题许多十年了。但是很少的研究在本地人上关于冰盖子的影响被进行了在桥桥墩附近搜索现象。盖住的斜槽试验的一系列冰在这研究被进行。在本地人的类型搜索的不同桥墩的形状因素被比较。在冰盖子下面,为半圆形的桥墩的形状因素从 0.66 ∼0.71 。三不同不一致的沉积与 D 50 0.58 公里, 0.50 公里,和 0.47 公里的 s 分别地。冰的二种类型盖住,也就是光滑、不平的盖子,被创造在桥墩附近模仿冰盖子的影响。最大搜索深度在不同条件下面被分析。scour 洞的轮廓被阴谋在桥桥墩附近显示出床形态学和沉积免职。在最大值之间的一种实验关系搜索深度, densimetric 弗鲁德数字和沉积尺寸被开发。 | Peng WU Faye HIRSHFIELD Jue-yi SUI | 2015 | International Journal of Sediment Research2015，30，1： | 5 |
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