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| 1 | role of the normal gut microbiota显示文摘Relation between the gut microbiota and human health is being increasingly recognised. It is now well established that a healthy gut flora is largely responsible for overall health of the host. The normal human gut microbiota comprises of two major phyla, namely Bacteroidetes and Firmicutes. Though the gut microbiota in an infant appears haphazard, it starts resembling the adult flora by the age of 3 years. Nevertheless, there exist temporal and spatial variations in the microbial distribution from esophagus to the rectum all along the individual's life span. Developments in genome sequencing technologies and bioinformatics have now enabled scientists to study these microorganisms and their function and microbehost interactions in an elaborate manner both in health and disease. The normal gut microbiota imparts specific function in host nutrient metabolism, xenobiotic and drug metabolism, maintenance of structural integrity of the gut mucosal barrier, immunomodulation, and protection against pathogens. Several factors play a role in shaping the normal gut microbiota. They include(1) the mode of delivery(vaginal or caesarean);(2) diet during infancy(breast milk or formula feeds) and adulthood(vegan based or meat based); and(3) use of antibiotics or antibiotic like molecules that are derived from the environment or the gut commensal community. A major concern of antibiotic use is the long-term alteration of the normal healthy gut microbiota and horizontal transfer of resistance genes that could result in reservoir of organisms with a multidrug resistant gene pool. | Sai Manasa Jandhyala Rupjyoti Talukdar Chivkula Subramanyam Harish Vuyyuru Mitnala Sasikala D Nageshwar Reddy | 2015 | World Journal of Gastroenterology2015，21，29： | 187 |
| 2 | Pancreatic stellate cell: Pandora's box for pancreatic disease biology显示文摘Pancreatic stellate cells(PSCs) were identified in the early 1980 s, but received much attention after 1998 when the methods to isolate and culture them from murine and human sources were developed. PSCs contribute to a small proportion of all pancreatic cells under physiological condition, but are essential for maintaining the normal pancreatic architecture. Quiescent PSCs are characterized by the presence of vitamin A laden lipid droplets. Upon PSC activation, these perinuclear lipid droplets disappear from the cytosol, attain a myofibroblast like phenotype and expresses the activation marker, alpha smooth muscle actin. PSCs maintain their activated phenotype via an autocrine loop involving different cytokines and contribute to progressive fibrosis in chronic pancreatitis(CP) and pancreatic ductal adenocarcinoma(PDAC). Several pathways(e.g., JAK-STAT, Smad, Wnt signaling, Hedgehog etc.), transcription factors and mi RNAs have been implicated in the inflammatory and profibrogenic function of PSCs. The role of PSCs goes much beyond fibrosis/desmoplasia in PDAC. It is now shown that PSCs are involved in significant crosstalk between the pancreatic cancer cells and the cancer stroma. These interactions result in tumour progression, metastasis, tumour hypoxia, immune evasion and drug resistance. This is the rationale for therapeutic preclinical and clinical trials that have targeted PSCs and the cancer stroma. | Ratnakar R Bynigeri Aparna Jakkampudi Ramaiah Jangala Chivukula Subramanyam Mitnala Sasikala G Venkat Rao D Nageshwar Reddy Rupjyoti Talukdar | 2017 | World Journal of Gastroenterology2017，23，3： | 25 |
| 3 | Biomonitoring for traditional herbal medicinal products using DNA metabarcoding and single molecule, real-time sequencing显示文摘Global concerns have been paid to the potential hazard of traditional herbal medicinal products(THMPs). Substandard and counterfeit THMPs, including traditional Chinese patent medicine, health foods, dietary supplements, etc. are potential threats to public health. Recent marketplace studies using DNA barcoding have determined that the current quality control methods are not sufficient for ensuring the presence of authentic herbal ingredients and detection of contaminants/adulterants. An efficient biomonitoring method for THMPs is of great needed. Herein, metabarcoding and single-molecule, realtime(SMRT) sequencing were used to detect the multiple ingredients in Jiuwei Qianghuo Wan(JWQHW), a classical herbal prescription widely used in China for the last 800 years. Reference experimental mixtures and commercial JWQHW products from the marketplace were used to confirm the method. Successful SMRT sequencing results recovered 5416 and 4342 circular-consensus sequencing(CCS) reads belonging to the ITS2 and psb A-trn H regions. The results suggest that with the combination of metabarcoding and SMRT sequencing, it is repeatable, reliable, and sensitive enough to detect species in the THMPs, and the error in SMRT sequencing did not affect the ability to identify multiple prescribed species and several adulterants/contaminants. It has the potential for becoming a valuable tool for the biomonitoring of multi-ingredient THMPs. | Tianyi Xin Zhichao Xu Jing Jia Christine Leon Songnian Hu Yulin Lin Subramanyam Ragupathy Jingyuan Song Steven G.Newmaster | 2018 | Acta Pharmaceutica Sinica B2018，8，3： | 22 |
| 4 | Outcome of complex tibial plateau fractures with Ilizarov external fixation with or without minimal internal fixation显示文摘Purpose: To evaluate the clinico-radiological outcome of complex tibial plateau fractures treated with Ilizarov external fixation with or without minimal internal fixation. Methods: This retrospective review was conducted on all the cases of Schatzker types V and VI tibial plateau fractures treated by Ilizarov external fixation between July 2006 and December 2015 with the minimum follow-up duration of one year. There were 30 patients: 24 males and 6 females, mean age 43.33 years, and mean follow-up 3.6 years. Three of them were open fractures;15 cases were Schatzkertype V fractures and the other 15 type VI. According to AO/OTA classification, there were 11 type C1, 12 C2 and 7 type C3 fractures. Outcome assessment was made with American Knee Society Score (AKSS) and Rasmussen's Radiological Score (RRS) at final follow-up. Results: Out of the 30 cases, mini-open reduction was performed in 7, bone graft in 4, minimal internal fixation in 10 and knee temporary immobilisation in 11 patients. Mean duration of external fixation was 11.8 weeks. All fractures united. Pin tract infections in 7 and common peroneal neuropathy in 2 patients were self-limiting. Two patients had axial misalignment of less than 10°. At final follow-up, the mean knee range of motion was 114.7, mean AKSS 81.5 and mean RRS 16.7. On statistical analysis, Schatzker type of fractures, use of minimal internal fixation and knee-spanning did not influence the final outcome. Conclusion: Ilizarov external fixator with or without minimal internal fixation provides acceptable outcome for complex tibial plateau fractures. Care must be taken to look for minor loss of alignment, especially in Type VI Schatzker fractures after removal of the fixator. However small sample size precludes firm conclusions. | Koushik Narayan Subramanyam Madhusudhan Tammanaiah Abhishek Vasant Mundargi Ritesh Nilakanthrao Bhoskar Patllola Siddharth Reddy | 2019 | Chinese Journal of Traumatology2019，22，3： | 10 |
| 5 | Effectiveness of spinosad against seven major storedgrain insects on corn显示文摘在 2005 年 1 月,是的美国环境保护机构 registeredspinosad 存储谷物杀虫撒布剂。在压制主要店谷物昆虫的玉米上的 spinosad 的功效上的引用数据都没被出版。在这篇论文,我们在实验室在轰炸玉米上把 spinosad 的功效与七只主要店谷物昆虫作比较。测试的 Insectspecies 是红黑粉虫, Tribolium castaneum (Jacquelin duVal ) ;生锈的谷物甲壳虫, Cryptolestes ferrugineus (Stephens ) ;更小的谷物 borer, Rhyzopertha 西班牙托钵僧一(F.) ;sawtoothed 谷物甲壳虫, Oryzaephilus surinamensis (L.) ;米象, Sitophilus oryzae (L.) ;玉米象鼻虫, Sitophilus zeamais (Motschulsky ) ;并且印度饭蛾, Plodia interpunctella (Hiibner ) 。Cornkernels 在 0, 0.1, 0.5, 1,和 2 活跃成分(a.i ) 与 spinosad 被对待为控制七种的 mg/kg。甲壳虫成年人或 P。interpunctella 鸡蛋被介绍进保持未经治疗或对待杀虫药剂的玉米的 100 g 的每只集装箱。七昆虫种在控制处理上幸存很好,生产了 28 ~ 336 子孙,并且引起了在 49 天以后的重要的核损坏。在对待 spinosad 的玉米上, C 的成年死亡。ferrugineus, R。西班牙托钵僧一, O.surinamensis, S。oryzae,和 S。zeamais 是 >
98% 在在 12 天以后的 1 和 2 mg/kg。在≥ 0.5mg/kg 的 Spinosad 完全在 49 天以后在 21 天和 P.interpunctella 的 egg-to-adult 出现以后压制了 egg-to-larval 幸存,而 16% T。在 1 或 2 mg/kg 在 12 days.Spinosad 以后在 1 mg/kg 熬过的 castaneum 成年人在 49 天以后提供了子孙生产的完全或近的完全的抑制和所有种类的核损坏。我们的结果显示以 1 mg/kg 的当前的标记的率的 spinosad 对玉米上的七个店谷物害虫是有效的。 | FANGNENG HUANG BHADRIRAJU SUBRAMANYAM | 2007 | Insect Science2007，14，3： | 6 |
| 6 | Luciferase reporter phage phAE85 for rapid detection of rifampicin resistance in clinical isolates of Mycobacterium tuberculosis显示文摘Objective:To evaluate luciferase reporter phage(LRP)phAE85 in rapid detection of rifampicin resistance in a region where TB is endemic.Methods:One hundred and ninety primary isolates on Lowenstein-Jensen medium were tested.Middlebrook 7H9 complete medium with and without rifampicin at 2μg/mL was inoculated with standard inoculum from suspensions of the clinical isolate.After incubation for 72 h,LRP was added.Following 4 h of further incubation,light output from both control and test was measured as relative light units.Strains exhibiting a reduction of less than 50%relative light units in the drug containing vial compared to control were classified as resistant.Results were compared with the conventional minimum inhibitory concentration method(MIC)of drug susceptibility testing.Results:The two methods showed high level of agreement of 97%(CI 0.94,0.99)and P value was 0.000 1.The sensitivity and specificity of LRP assay for detection of rifampicin resistance were 91%h(CI 0.75,0.98)and 99ct(CI0.95,1.00)respectively.Time to detection of resistance by LRP assay was 3 d in comparison with 28 d by the minimum inhibitory concentration method.Conclusions:LRP assay with phAE85 is 99%specific,91%sensitive and is highly reproducible.Thus the assay offers a simple procedure for drug sensitivity testing,within die scope of semi-automation. | Gomathi Sivaramakrishnan Balaji Subramanyam Ponnuraja C Vanaja Kumar | 2013 | Asian Pacific Journal of Tropical Medicine2013，6，9： | 4 |
| 7 | WONCA研究论文摘要汇编(一百二十八)——经济增长与儿童早期营养不良的相关性:源于36个低及中收入国家的121个人口学和健康调查证据显示文摘背景人们普遍认为经济增长是改善人们健康状况的必要条件(通常也是充分条件)。此研究针对低收入和中等收入国家的宏观经济增长与早期儿童营养不良的减少的相关性进行评估。方法对1990年1月1日-2011年12月31日的36个国家的121项人口学和健康调查的数据进行分析。样本包含了具有国家代表性的0-35个月儿童的横断面调查数据,结果变量为发育迟滞、低体质量及消瘦。主要自变量为不变价的人均生产总值和校正后的购买力平价。研究采用逻辑回归模式评价人均生产总值的变化与营养不良儿童变化的关联。根据国家固定效应,调查年-固定效应,群组,儿童、母亲和家庭的地区及社会经济复合变量进行模式校正。结果研究样本含发育迟滞儿童462854例; | Sebastian Vollmer Kenneth Harttgen Malavika A Subramanyam 周淑新 | 2014 | 中国全科医学2014，17，19： | 4 |
| 8 | The pricing of discretionary accruals显示文摘 | K.R. Subramanyam | 1996 | Journal of Accounting and Economics1996，，1： | 3 |
| 9 | Dexamethasone Added to Mepivacaine Prolongs the Duration of Analgesia After Supraclavicular Brachial Plexus Blockade显示文摘 | Simon J. Parrington Dermot O’Donnell Vincent W.S. Chan Danielle Brown-Shreves Rajeev Subramanyam Melody Qu Richard Brull | 2010 | Regional Anesthesia and Pain Medicine2010，，5： | 2 |
| 10 | Financial statement effects of adopting international accounting standards: the case of Germany显示文摘 | Mingyi Hung K. R. Subramanyam | 2007 | Review of Accounting Studies2007，，4： | 2 |
| 11 | Using dynamic dewpoint isotherms to determine the optimal storage conditions of inert dust-treated hard red winter wheat显示文摘Water-solid interactions play a key role in determining the efficacy of inert dusts. The critical water activity(Awc) for phase transition in amorphous materials is an important characteristic of amorphous inert dusts used as grain protectants. As water activity(Aw) rises above Awc, amorphous dusts undergo a transition from glassy or vitreous state to rubbery state. Such a transition induces dramatic changes in material properties, texture and structure, and hence impact their performance as grain protectants. Full Dynamic Dewpoint Isotherms(DDI) of a synthetic amorphous zeolite intended for grain protection were generated using the Vapor Sorption Analyzer(VSA) to determine Awcby investigating the relationship between moisture content and Awat constant temperatures. Sorption experimental data was fitted using three sorption isotherm models: Guggenheim-Anderson-de Boer(GAB), Double Log Polynomial(DLP),and Brunauer-Emmet-Teller(BET). DLP model was the best model to estimate zeolite and wheat sorption isotherms. Full sorption isotherms of zeolite and wheat obtained at 25, 35, and 45 °C clearly showed the hysteresis phenomenon. The hysteresis loops were of type H3 for wheat, and of type H4 for zeolite powder. The intensity of hysteresis remained unchanged for wheat. However, the intensity of hysteresis decreased with increasing temperatures during water adsorption by porous zeolite powder. Monolayer moisture content values for each sorption direction were provided only by GAB and BET models and indicated a decrease in monolayer moisture content with an increase in temperature. The net isosteric heats of sorption and the differential enthalpy of zeolite estimated by the Clausius–Clapeyron equation and determined graphically decreased with increasing moisture content. Conversely, differential entropy of zeolite decreased with increasing zeolite moisture content. The optimal moisture content of inert dust for grain treatment was dependent on wheat moisture content and wheat storage temperature. This is the first time that a synthetic amorphous dust is being investigated for grain protection.Our results recommend the application of inert dusts at the optimal moisture content to mitigate moisture migration within the system 'wheat-dust', thus ensuring dust maximal efficacy. | Kouame Yao Jennifer Anthony Ronaldo Maghirang David Hagstrum Kunyan Zhu Subramanyam Bhadriraju | 2020 | Grain & Oil Science and Technology2020，3，4： | 2 |
| 12 | Functional Accumulation of Antenna Proteins in Chlorophyll b-Less Mutants of Chlamydomonas reinhardtii显示文摘绿水藻 Chlamydomonas reinhardtii 包含几轻收获的叶绿素 a/b 建筑群(LHC ) :四主要 LHCII,二次要的 LHCII,和九 LHCI。我们描绘了三叶绿素祝福异种在这些叶绿素 a/b 绑定蛋白质的函数,汇编,和稳定性上估计叶绿素 b 缺乏的效果。我们在使为叶绿素 a 负责的 CAO 基因失去活性到叶绿素 b 变换的二异种识别了点变化。所有 LHCII 在 CAO 异种积累了到野类型的层次,但是他们为 photosystem II 的轻收获的功能被损害。相反,大多数 LHCI 为我仍然是的 photosystem 在异种和他们的轻收获的能力积累了到野类型的层次未改变。出人意料地, LHCI 累积和 photosystem 我在异种增加与相比的功能的天线尺寸在野类型当在暗淡的光成长时。当 CAO 变化被放在一个 yellow-in-the-dark 背景(yid-BF3 ) 时,在哪个叶绿素合成在暗淡的光仍然保持有限,主要 LHCII 并且大多数 LHCI 的累积显著地被减少,显示叶绿素的那持续合成一是要求了保存天线蛋白质的解朊的抵抗。在为 thylakoid FtsH 朊酶活动与一个变异的有缺陷者一起穿过 yid-BF3 以后,确实, yid-BF3-ftsh1 恢复了 LHCI 的野类型的层次,它为 FtsH 朊酶把 LHCI 定义为新底层。 | Sandrine Bujaldon Natsumi Kodama Fabrice Rappaport Rajagopal Subramanyam Catherine de Vitry Yuichiro Takahashi FrancisAndre Wollman | 2017 | Molecular Plant2017，10，1： | 2 |
| 13 | Optimal DG unit placement for loss reduction in radial distribution system-a case study显示文摘 | Devi1A L Subramanyam B | 2007 | ARPN Journal of Engineering and Applied Sciences2007，2，6： | 1 |
| 14 | Bibliometric studies of research collaboration显示文摘 | Subramanyam K | 1983 | Journal of Information Science1983，，6： | 1 |
| 15 | Occurrence of recurrent aphthous stomatitisonly on lining mucosa and its relationship to smoking-a possible hy-pothesis显示文摘 | Subramanyam R V | 2011 | Med Hypotheses2011，77，2： | 1 |
| 16 | A K-band tunable microstrip bandpass filter using a thin-film conductor/ferroelectric/dielectric multilayer configuration 显示文摘 | Subramanyam G Van Keuls F Miranda F A | 1998 | Microwave and Guided Wave Letters IEEE1998，8，2： | 1 |
| 17 | Contribution of contact toxicity and wheat condition to mortality of stored product insects exposed to spinosad显示文摘 | Toews M D Subramanyam B | 2003 | Pest Management Science2003，59，5： | 1 |
| 18 | The effect of audit quality on earnings management 显示文摘 | Becker C M DeFond J Jiambalvo Subramanyam K R | 1998 | Contemporary Accounting Research1998，，15： | 1 |
| 19 | Positive correlations between serum calcineurin activity and left ventricular hypertrophy显示文摘 | Choudhary R Sastry BK Subramanyam C | 2005 | Int J Cardiol2005，105，3： | 1 |
| 20 | Physical properties of Zinc Oxide films prepared by dc reactive magnetron sputtering at different sputtering pressures显示文摘 | Subramanyam T K Naidu B S | 2000 | Cryst Res Technao2000，35，10： | 1 |
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