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| 1 | Luciferase reporter phage phAE85 for rapid detection of rifampicin resistance in clinical isolates of Mycobacterium tuberculosis显示文摘Objective:To evaluate luciferase reporter phage(LRP)phAE85 in rapid detection of rifampicin resistance in a region where TB is endemic.Methods:One hundred and ninety primary isolates on Lowenstein-Jensen medium were tested.Middlebrook 7H9 complete medium with and without rifampicin at 2μg/mL was inoculated with standard inoculum from suspensions of the clinical isolate.After incubation for 72 h,LRP was added.Following 4 h of further incubation,light output from both control and test was measured as relative light units.Strains exhibiting a reduction of less than 50%relative light units in the drug containing vial compared to control were classified as resistant.Results were compared with the conventional minimum inhibitory concentration method(MIC)of drug susceptibility testing.Results:The two methods showed high level of agreement of 97%(CI 0.94,0.99)and P value was 0.000 1.The sensitivity and specificity of LRP assay for detection of rifampicin resistance were 91%h(CI 0.75,0.98)and 99ct(CI0.95,1.00)respectively.Time to detection of resistance by LRP assay was 3 d in comparison with 28 d by the minimum inhibitory concentration method.Conclusions:LRP assay with phAE85 is 99%specific,91%sensitive and is highly reproducible.Thus the assay offers a simple procedure for drug sensitivity testing,within die scope of semi-automation. | Gomathi Sivaramakrishnan Balaji Subramanyam Ponnuraja C Vanaja Kumar | 2013 | Asian Pacific Journal of Tropical Medicine2013，6，9： | 4 |
| 2 | The effect of audit quality on earnings management 显示文摘 | Becker C M DeFond J Jiambalvo Subramanyam K R | 1998 | Contemporary Accounting Research1998，，15： | 1 |
| 3 | Positive correlations between serum calcineurin activity and left ventricular hypertrophy显示文摘 | Choudhary R Sastry BK Subramanyam C | 2005 | Int J Cardiol2005，105，3： | 1 |
| 4 | The Effect of Aluminum on the Work Hardening and Wear Resistance of Hadfield Manganese Steel显示文摘 | Zuidema B K Subramanyam D K Leslie W C | 1987 | Metallurgical Transactions A1987，18，： | 1 |
| 5 | Positive correlations between serum calcineurin activity and left ventricular hypertrophy显示文摘 | Choudhary R Sastry BK Subramanyam C | 2005 | Int J Cardiol2005，105，3： | 1 |
| 6 | Attached versus suspended biomass activity in upflow anaerobic filters显示文摘 | SUBRAMANYAM Y V SASTRY C A | 1989 | Journal of the Institution of Engineers (India)1989，70，22： | 1 |
| 7 | The Effect of Audit Quality on Earnings Management显示文摘 | Becker C Defond M Jiambalvo J Subramanyam K | 1998 | Con- temporary Accounting Research1998，，： | 1 |
| 8 | The effect of audit quality on earnings management 显示文摘 | Becker C L M L DeFond J Jiambalvo K R Subramanyam | 1998 | Contemporary Accounting Research1998，15，1： | 1 |
| 9 | The effect of audit quality on earnings management 显示文摘 | Becker C L Defond M L Jiambalvo J Subramanyam K R | 1998 | Contemporary Accounting Research1998，，： | 1 |
| 10 | The Effect of Audit Quality on Earnings Management 显示文摘 | Becker C L DeFond M L Jiambalvo J Subramanyam K R | 1998 | Contemporary Accounting Research1998，，： | 1 |
| 11 | The Effect of Audit Quality on Earmings Management 显示文摘 | Becker C DeFond M Jiambalvo J and Subramanyam K R | 1998 | Contemporary Accounting Research1998，15，： | 1 |
| 12 | Colossal magnetoresistance in epitaxial La((1-x-y))NayMnO3 thin films显示文摘 | Sahana M Singh R N Shivakumara C Vasanthacharya N Y Hedge M S Subramanian S Prasad V Subramanyam S V | 1997 | Applied Physics Letters1997，70，： | 1 |
| 13 | Design, synthesis, and pharmacological evaluation of a novel series of pyridopyrazine-I ,6- dione gamma-secretase modulators显示文摘 | Pettersson M Johnson D S Subramanyam C | 2014 | J Med Chem2014，57，3： | 1 |
| 14 | Antibacterial and antifungal activity of ten essential oils in vitro 显示文摘 | Pattnaik S Subramanyam VR Kole C | 1996 | Microbios1996，86，349： | 1 |
| 15 | Gra- phene:The new two dimensional nanomaterial 显示文摘 | Rao C N R Sood A K Subramanyam K S | 2009 | Angew Chem Int Ed2009，48，： | 1 |
| 16 | The effect of audit auality on earnings management 显示文摘 | C L BECKER M L DEFOND J J IAMBALVO K R SUBRAMANYAM | 1998 | Contemporary Accounting Research1998，15，1： | 1 |
| 17 | The effect of audit quality on earnings management显示文摘 | Becker C M Defond J Jiambalvo K R Subramanyam | 1998 | Contemporary Accounting Research1998，15，： | 1 |
| 18 | Long-lived private in formation and imperfect competition 显示文摘 | Subramanyam A | 1992 | Journal of Finance1992，47，： | 1 |
| 19 | Positive correlations be- tween serum calcineurin activity and left ventricular hypertrophy 显示文摘 | Choudhary R Sastry BK Subramanyam C | 2003 | Int J Cardiol2003，105，3： | 1 |
| 20 | Antibacterial and antifungal activity of ten essential oils in vitro显示文摘 | Pattnaik S Subramanyam VR Kole C | 1996 | Microbios1996，86，349： | 1 |
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