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| 1 | 美国临床肿瘤学会IV期非小细胞肺癌化疗的临床实践指南更新显示文摘本文旨在为IV期非小细胞肺癌患者的治疗提供更新版推荐。本文资料检索源自2002年以来公布的相关随机试验文献。此指南范围限于化疗与生物治疗。更新委员会对这些文献进行了总结并提供了推荐更新。162篇文献符合标准被纳入参考。本推荐基于可改善总生存期的治疗方法。仅改善无进展生存期的治疗方法推动了对毒性及生存质量的监测。对于体力状态评分为0分或1分患者的一线治疗,可推荐以铂类为基础的细胞毒性药物的两药联用。对铂类治疗有禁忌的患者,可采用非铂类细胞毒性两药联合。对于体力状态评分为2分的患者,单一细胞毒性药物即可。对于疾病进展或经过4个周期的治疗仍对治疗无反应的患者,应停止一线细胞毒性化疗。即使在6个周期后患者对治疗仍有反应,亦应停止两药细胞毒性化疗。对于伴有明确的表皮生长因子受体(epidermal growth factor receptor,EGFR)突变的患者,可推荐一线采用吉非替尼治疗;对于EGFR突变为阴性或不明确的患者,细胞毒性化疗更佳。除具有特定临床特征的患者外,可推荐贝伐单抗与卡铂-紫杉醇联用。对于通过免疫组化证实EGFR阳性的肿瘤患者,可推荐西妥昔单抗与顺铂-长春瑞滨联用。多西紫杉醇、厄洛替尼、吉非替尼或培美曲塞被推荐作为二线治疗。对于未曾接受过厄洛替尼或吉非替尼治疗的患者,可推荐厄洛替尼作为三线治疗。现有数据不足以推荐常规三线采用细胞毒性药物。已有的证据也不足以推荐常规应用分子标记物选择化疗。 | Christopher G. AZZOLI Sherman Baker JR Sarah TEMIN William PAO Timothy ALIFF Julie BRAHMER David H. JOHNSON Janessa L. LASKIN Gregory MASTERS Daniel MILTON Luke NORDQUIST David G. PFISTER Steven PIANTADOSI Joan H. SCHILLER Reily SMITH Thomas J. SMITH John R. STRAWN David TRENT Giuseppe GIACCONE 丁燕(翻译) 南娟(翻译) 刘谦(翻译) 周清华(校对) 陈军(校对) | 2010 | 中国肺癌杂志2010，13，3： | 43 |
| 2 | FAIR Principles:Interpretations and Implementation Considerations显示文摘The FAIR principles have been widely cited,endorsed and adopted by a broad range of stakeholders since their publication in 2016.By intention,the 15 FAIR guiding principles do not dictate specific technological implementations,but provide guidance for improving Findability,Accessibility,Interoperability and Reusability of digital resources.This has likely contributed to the broad adoption of the FAIR principles,because individual stakeholder communities can implement their own FAIR solutions.However,it has also resulted in inconsistent interpretations that carry the risk of leading to incompatible implementations.Thus,while the FAIR principles are formulated on a high level and may be interpreted and implemented in different ways,for true interoperability we need to support convergence in implementation choices that are widely accessible and(re)-usable.We introduce the concept of FAIR implementation considerations to assist accelerated global participation and convergence towards accessible,robust,widespread and consistent FAIR implementations.Any self-identified stakeholder community may either choose to reuse solutions from existing implementations,or when they spot a gap,accept the challenge to create the needed solution,which,ideally,can be used again by other communities in the future.Here,we provide interpretations and implementation considerations(choices and challenges)for each FAIR principle. | Annika Jacobsen Ricardo de Miranda Azevedo Nick Juty Dominique Batista Simon Coles Ronald Cornet Melanie Courtot Merce Crosas Michel Dumontier Chris T.Evelo Carole Goble Giancarlo Guizzardi Karsten Kryger Hansen Ali Hasnain Kristina Hettne Jaap Heringa Rob W.W.Hooft Melanie Imming Keith G.Jeffery Rajaram Kaliyaperumal Martijn GKersloot Christine R.Kirkpatrick Tobias Kuhn Ignasi Labastida Barbara Magagna PeterMcQuilton Natalie Meyers Annalisa Montesanti Mirjam van Reisen Philippe Rocca-Serra Robert Pergl Susanna-Assunta Sansone Luiz Olavo Bonino da Silva Santos Juliane Schneider George Strawn Mark Thompson Andra Waagmeester Tobias Weigel Mark D.Wilkinson Egon L.Willighagen Peter Wittenburg Marco Roos Barend Mons Erik Schultes | 2020 | Data Intelligence2020，2，1： | 26 |
| 3 | Not Ready for Convergence in Data Infrastructures显示文摘Much research is dependent on Information and Communication Technologies(ICT).Researchers in different research domains have set up their own ICT systems(data labs)to support their research,from data collection(observation,experiment,simulation)through analysis(analytics,visualisation)to publication.However,too frequently the Digital Objects(DOs)upon which the research results are based are not curated and thus neither available for reproduction of the research nor utilization for other(e.g.,multidisciplinary)research purposes.The key to curation is rich metadata recording not only a description of the DO and the conditions of its use but also the provenance-the trail of actions performed on the DO along the research workflow.There are increasing real-world requirements for multidisciplinary research.With DOs in domain-specific ICT systems(silos),commonly with inadequate metadata,such research is hindered.Despite wide agreement on principles for achieving FAIR(findable,accessible,interoperable,and reusable)utilization of research data,current practices fall short.FAIR DOs offer a way forward.The paradoxes,barriers and possible solutions are examined.The key is persuading the researcher to adopt best practices which implies decreasing the cost(easy to use autonomic tools)and increasing the benefit(incentives such as acknowledgement and citation)while maintaining researcher independence and flexibility. | Keith Jeffery Peter Wittenburg Larry Lannom George Strawn Claudia Biniossek Dirk Betz Christophe Blanchi | 2021 | Data Intelligence2021，3，1： | 7 |
| 4 | The Culture and Storage of Tropical Dayblooming Waterlily Tuber In College Station显示文摘 | Kirk | 1986 | Water Garden Journal1986，2，4： | 1 |
| 5 | Culture of black drum(Pogonias cromis)in cages receiving effluent from a power plant effluent characterized by wide salinity fluctuations显示文摘 | Holt R S Strawn K | 1976 | Proc World Mar Soc1976，8，： | 1 |
| 6 | Promoter hypermethylation of progesterone receptor isoform B ( PR - B ) in endometriosis显示文摘 | Wu Y Strawn E Basir Z | 2006 | Epigenetics2006，1，2： | 1 |
| 7 | Promoter hypermethylation of progesterone receptor isoform BPRB in endometriosis 显示文摘 | Wu Y Strawn E Basir Z | 2006 | Epigenetics2006，1，2： | 1 |
| 8 | Inhibition oherogenesis by losartan in monkeys with diet-induced hypercholesterolemia显示文摘 | Chappell MC Dean RH | 2000 | Circulation2000，101，： | 1 |
| 9 | The Kinetics of Mixed Ni-Al Hydroxide Formation on Clay and Aluminum Oxide Minerals:A TimeResolved XAFS Study显示文摘 | Scheidegger A M Strawn D G Lamble G M | | 0，，13： | 1 |
| 10 | Progesterone receptor mesengerribonucleic acid and protein are overexpressed in human uterineleiomyomas显示文摘 | Bmdon DD Bethea CL Strawn EY | 2003 | Am J Obs Gyn2003，169，： | 1 |
| 11 | Angiotensin- (1 - 7) reduces smooth muscle growth after vascular injury显示文摘 | STRAWN W B FERRARIO C M TALLANT E A | 1999 | Hypertension1999，33，1： | 1 |
| 12 | Growth and digestibility by three sizes of Penaeus vannamei Boone: effects of dietary protein level and protein source显示文摘 | Smith L L Lawrence A Strawn K | 1985 | Aquaculture1985，46，： | 1 |
| 13 | Role of the renin-angiotensin-aldosterone system and proinflammatory mediators in cardiovascular disease显示文摘 | Ferrario CM Strawn WB | | 0，，： | 1 |
| 14 | Aberrant expression of deoxyribonucleic acid methyltransferases DNMT1,DNMT3A,and DNMT3B in women with endometriosis显示文摘 | WU Y STRAWN E BASIR Z | | 0，，01： | 1 |
| 15 | Pathophysiology of the ovarian hyperstimulation syndrome显示文摘 | Haning JRV Strawn EY Nolten WE | 1985 | Obstet Gynecol1985，66，： | 1 |
| 16 | New paradigms for the treatment of cancer: the role of anti - angiogenesis agents 显示文摘 | Cherrington JM Strawn LM Shawver LK | 2000 | Adv Cancer Res2000，79，： | 1 |
| 17 | Progesterone receptor messenger ribonucleic acid and protein are overexpressed in human uterine leiomyomas显示文摘 | Bradon DD Bethea CL Strawn EY | 1993 | AM J Obstet Gynecol1993，169，： | 1 |
| 18 | Aberrant expression of deoxyribonucleic acid methyhransferases DNMT1, DNMT3A and DNMT3B in women with endometriosis显示文摘 | Wu Y Strawn E Basir Z | 2007 | Fertil Steril2007，87，1： | 1 |
| 19 | Neuroleptic malignant syndrome显示文摘 | Strawn JR Keck PE Jr Caroff SN | | 0，，06： | 1 |
| 20 | The Use of XAFS to Distinguish between Inner- and Outer-Sphere Lead Adsorption Complexes on MontmoriUonite显示文摘 | Daniel G Strawn and Donald L | 1999 | J Colloid Interface Sci1999，216，2： | 1 |
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