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| 1 | 最新AD研究用诊断标准:IWG-2标准显示文摘在过去的8年中,国际工作组织(IWG)和美国国立老化研究院-阿尔茨海默协会(NIA-AA)建立了阿尔茨海默病(AD)诊断标准,它能更好地定义AD的临床表型,整合了生物标记物于诊断流程中,并覆盖了疾病的全程。本意见书充分地权衡了IWG标准的优缺点,建议改进诊断框架。依据这些改进,AD的诊断变得简单,只要有恰当的AD临床表型(典型或不典型)和与AD的病理相一致的病理生理学生物标志物出现。我们认为疾病的下游的定位性生物标志,如容积性磁共振成像(MRI)和氟脱氧葡萄糖-正电子发射型计算机断层成像(FDG-PET)等,适合更好地测量和监测疾病过程。本文还详述了非典型性AD、混合性AD和AD临床前期的特异诊断标准。 | 陈刚 曹雯炜 俞羚 糜建华 Dubois B Feldman HH Jacova C Hampel H Molinuevo JL Blennow K DeK osky ST Gauthier S Selkoe D Bateman R Cappa S Crutch S Engelborghs S Frisoni GB Fox NC Galasko D Habert MO Jicha GA Nordberg A Pasquier F Rabinovici G Robert P Rowe C Salloway S Sarazin M Epelbaum S de Souza LC Vellas B Visser PJ Schneider L Stern Y Scheltens P Cummings JL | 2014 | 神经病学与神经康复学杂志2014，11，3： | 31 |
| 2 | SFBs of Japanese plum(Prunussalicina):Cloning seven alleles and determining their linkage to the S-RNase gene显示文摘 | SAPIR G STERN R A GOLDWAY M | 2007 | Hortscience2007，42，7： | 1 |
| 3 | Mushrooms,Tumors, and Irnmunily 显示文摘 | Borchers A T Stern J S Hanckman R M | 1999 | Proceedings of the Society for Experimental Biology and Medicine1999，221，： | 1 |
| 4 | Mapping Gossans inArid Regions with Landsat TM and SIR-C Images:the BeddahoAlteration Zone in Northern Eritrea显示文摘 | Abdelsalam M G Stern R J Berhane W G | 2000 | Journal of African EarthSciences2000，30，4： | 1 |
| 5 | Reduction of irreducible Hawkins Ⅲ talar neck fracture by means of a medial malleolar osteotomy: a report of three cases with a 4-year mean follow-up 显示文摘 | GONZALEZ A STERN R ASSAL M | 2011 | J Orthop Trauma2011，25，5： | 1 |
| 6 | Dosage effects of a Drosophila sodium channel gene on i)ehavior and axonal ex- citability显示文摘 | STERN M KREBER R GANETZK'Y B | 1990 | Genetics1990，124，1： | 1 |
| 7 | Preshaping Photoresist for Refractive Microlens Fabrication显示文摘 | Jay T R Stern M B | 1994 | Opt Eng1994，33，11： | 1 |
| 8 | On the drag and virtual mass coefficients in Biot's equations显示文摘 | Bedford A Costley R D Stern M | 1984 | J Acoust Soc Am1984，76，6： | 1 |
| 9 | XPD codon 751 polymorphism,metabolism genes,smoking,and bladder cancer risk显示文摘 | STERN M C JOHNSON L R BELL D A | 2002 | Cancer Epidemiol Biomarkers Prev2002，11，101： | 1 |
| 10 | The extensile approach for the operative treatment of high-energy pilon fractures:surgical technique and softtissue healing显示文摘 | Assal M Ray A Stern R | 2007 | J Orthop Trauma2007，21，3： | 1 |
| 11 | An un- steady single-phase level set method for viscous free sur- face flows 显示文摘 | CARRICA P M WILSON R V STERN F | 2007 | International Journal for Numerical Methods in Fluids2007，53，2： | 1 |
| 12 | Happiness and time perspective as potential mediators of quality of life and depression in adolescent cancer显示文摘 | BITSKO M J STERN M DILLON R | 2008 | Pediatr Blood Cancer2008，50，3： | 1 |
| 13 | Reduction of irreducible Hawkins Ⅲ talar neck fracture by means of a medial malleolar osteotomy:a report of three cases with a 4-year mean follow-up显示文摘 | Gonzalez A Stern R Assal M | | 0，，05： | 1 |
| 14 | Quality of life and surgi cal sat is faction after vaginal reconstructvies oblateratite surgery for the treatment of advanced pelvic organ prolapsed 显示文摘 | Murphy M Stern schuss G Huff R | 2008 | Am Job stet Gynecology2008，198，： | 1 |
| 15 | The pathology of dry eye:the interaction between the ocular surface and lacrimal glands显示文摘 | Stern M E Beuerman R W Fox R I | 1998 | Cornea1998，17，6： | 1 |
| 16 | The prevalence of psoria- sis in African Americans:results from a population-based study 显示文摘 | Gelfand J M Stern R S Nijsten T | 2005 | J Am Acad Dermato12005，52，1： | 1 |
| 17 | Hyaluronidases: their genomies, structures, and mechanisms of action显示文摘 | Stern R Jedrzejas M J | 2006 | Chem Rev2006，106，3： | 1 |
| 18 | Effects of soybean hulls and lignosulfonate- treated soybean meal on ruminal fermentation in lactating dairy cows 显示文摘 | Mansfield H R Stern M D | 1994 | J Dairy Sci1994，77，： | 1 |
| 19 | Endometrial carcinoma staging byMR imaging显示文摘 | Hricak H Stern J L Fisher M R | 1987 | Radiology1987，162，2： | 1 |
| 20 | Genetics and genomics of chloroplast biogenesis: maize as a model system 显示文摘 | Stern D B Hanson M R Barkan A | 2004 | Trends in plant science2004，9，6： | 1 |
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