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| 1 | 最新AD研究用诊断标准:IWG-2标准显示文摘在过去的8年中,国际工作组织(IWG)和美国国立老化研究院-阿尔茨海默协会(NIA-AA)建立了阿尔茨海默病(AD)诊断标准,它能更好地定义AD的临床表型,整合了生物标记物于诊断流程中,并覆盖了疾病的全程。本意见书充分地权衡了IWG标准的优缺点,建议改进诊断框架。依据这些改进,AD的诊断变得简单,只要有恰当的AD临床表型(典型或不典型)和与AD的病理相一致的病理生理学生物标志物出现。我们认为疾病的下游的定位性生物标志,如容积性磁共振成像(MRI)和氟脱氧葡萄糖-正电子发射型计算机断层成像(FDG-PET)等,适合更好地测量和监测疾病过程。本文还详述了非典型性AD、混合性AD和AD临床前期的特异诊断标准。 | 陈刚 曹雯炜 俞羚 糜建华 Dubois B Feldman HH Jacova C Hampel H Molinuevo JL Blennow K DeK osky ST Gauthier S Selkoe D Bateman R Cappa S Crutch S Engelborghs S Frisoni GB Fox NC Galasko D Habert MO Jicha GA Nordberg A Pasquier F Rabinovici G Robert P Rowe C Salloway S Sarazin M Epelbaum S de Souza LC Vellas B Visser PJ Schneider L Stern Y Scheltens P Cummings JL | 2014 | 神经病学与神经康复学杂志2014，11，3： | 31 |
| 2 | Corticotropin-releasing factor and urocortin 1 activate CREB through functionally selective G/ signalling in hippocampal pyramidal neurons显示文摘 | Stern C M Meitzen J Mermelstein P G | 2011 | Eur J Neurosci2011，34，5： | 1 |
| 3 | Boundary element solution of 3-D wave scatter problems in a poroelastic medium显示文摘 | Zimmerman C Stern M | 1993 | Eng Anal Bound Elem1993，12，： | 1 |
| 4 | Meat consumption,cooking practices,meat mutagens,and risk of prostate cancer显示文摘 | JOHN E M STERN M C RASHMI S | 2011 | Nutrition and Cancer2011，63，4： | 1 |
| 5 | Prognosis of HIV-l-infected patients up to 5 years after initiation of HAART: collaborative a- nalysis of prospective studies显示文摘 | May M Sterne JA Sabin C | 2007 | AIDS2007，21，9： | 1 |
| 6 | XPD codon 751 polymorphism,metabolism genes,smoking,and bladder cancer risk显示文摘 | STERN M C JOHNSON L R BELL D A | 2002 | Cancer Epidemiol Biomarkers Prev2002，11，101： | 1 |
| 7 | Evaluation of a mathematical model of rnmen digestion and an in vitro simulation of rumen proteolysis to estimate the rumen- undegraded nitrogen content of feedstuffs显示文摘 | Krishnamoorthy U Sniffen C J Stern M D | 1983 | Brit J Nutr1983，50，3： | 1 |
| 8 | Role of the JAK/STAT signaling pathway in diabetic nephropathy显示文摘 | Marrero M B Banes-Berceli A K Stern D M Eaton D C | 2006 | Am J Physiol2006，290，4： | 1 |
| 9 | Pulmonary function in patients with diabetes mellitus显示文摘 | Benbassat C A Stern E Kramer M | 2001 | Am J Med Sci2001，322，3： | 1 |
| 10 | Boundary element solution of 3-D wave scatter problems in a poroelastic medium显示文摘 | ZIMMERMAN C STERN M | 1993 | Engineering Analysis with Boundary Elements1993，12，4： | 1 |
| 11 | Evaluation of mathraatical of digestion and in vitro simulation of rumen proteolysis to estimate the rumen undegxaded nitrogen content of feedstuffs显示文摘 | Krishnamoorthy U C Siffen C J Stern M D | 1983 | British Journal of Nutrition1983，50，55： | 1 |
| 12 | Novel technique for management of distal ureter and en block resection of bladder cuff during hand-assisted laparoscopic nephroureterectomy显示文摘 | Vardi l Y Stern J A Gonzalez C M | 2006 | Urology2006，67，： | 1 |
| 13 | Boundary element solution of 3-D wave scatter problems in a poroelastic medium显示文摘 | ZIMMERMAN C STERN M | 1993 | Engineering Analysis with Boundary Elements1993，12，： | 1 |
| 14 | Evaluation of mathematical model of digesta and in vitro simulation of rumen proteolysis to estimate the rumen undegraded nitrogen content of feedstuffs 显示文摘 | Krishnamoorthy U C Sniffen C J Stern M D | 1983 | British Journal of Nutrition1983，50，： | 1 |
| 15 | Isolation and identification of 'diazepam-like' compounds from bovine urine显示文摘 | Luk K C Stern L Welgele M | 1983 | Journal of Natural Products1983，46，6： | 1 |
| 16 | Procedural and strain-related variables significantly affect outcome in a murine model of focal cerebral ischemia显示文摘 | CONNOLLY E S J R WINFREE C J STERN D M | 1996 | Neurosurgery1996，38，3： | 1 |
| 17 | The structure-directing properties of ^2-显示文摘 | WELK M E NORQUIST A J STERN C L | 2000 | Inorg Chem2000，39，18： | 1 |
| 18 | Mercury and methylmercury exposure in the New Jersey pregnant population显示文摘 | Stern All Gochfeld M Weisel C | 2001 | Arch Environ Health2001，56，1： | 1 |
| 19 | A molecular pathway determining left-right asymmetry in chick embryogenesis显示文摘 | JOHNSON R L STERN C D | 1995 | Cell1995，82，： | 1 |
| 20 | Evaluation of mathmatical model of digesta and in vitro simulation of rumen proteolysis to estimate the rumen undegraded nitrogen content of feedstuffs显示文摘 | Krishnamoorthy U C Sniffen C J Stern M D | 1983 | Br J Nutr1983，50，： | 1 |
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