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| 1 | Neoadjuvant treatment for resectable pancreatic adenocarcinoma显示文摘Pancreatic adenocarcinoma is the fourth leading cause of cancer mortality in the United States in both men and women, with a 5-year survival rate of less than 5%. Surgical resection remains the only curative treatment, but most patients develop systemic recurrence within 2 years of surgery. Adjuvant treatment with chemotherapy or chemoradiotherapy has been shown to improve overall survival, but the delivery of treatment remains problematic with up to 50% of patients not receiving postoperative treatment. Neoadjuvant therapy can provide benefits of eradication of micrometastasis and improved delivery of intended treatment. We have reviewed the findings from completed neoadjuvant clinical trials, and discussed the ongoing studies. Combinational cytotoxic chemotherapy such as fluorouracil, leucovorin, irinotecan, and oxaliplatin and gemcitabine plus nanoparticle albumin-bound(nab)-paclitaxel, active in the metastatic setting, are being studied in the neoadjuvant setting. In addition, novel targeted agents such as inhibitor of immune checkpoint are incorporated with cytotoxic chemotherapy in early-phase clinical trial. Furthermore we have explored the utility of biomarkers which can personalize treatment and select patients for target-driven therapy to improve treatment outcome. The treatment of resectable pancreatic adenocarcinoma requires multidisciplinary approach and novel strategies including innovative trials to make progress. | John Wong Naveenraj L Solomon Chung-Tsen Hsueh | 2016 | World Journal of Clinical Oncology2016，7，1： | 3 |
| 2 | Association between thrombotic risk factors and extent of fibrosis in patients with non-alcoholic fatty liver diseases显示文摘AIM: To evaluate the prevalence of genetic and acquired prothrombotic risk factors and their association with the extent of fibrosis and fatty infiltration in patients with non-alcoholic fatty liver disease (NAFLD).METHODS: Forty-four patients with chronic hepatitis (28 men and 16 women, with mean age of 45±11 and 49±12 years, respectively) constituted the patient population of this study. The groups were divided as follows: 15 patients with fatty liver (FL); 15 with non-alcoholic steatohepatitis (NASH); 14 with chronic viral hepatitis (CH) diagnosed by histology and liver technetium scan or ultrasound; and 10 healthy individuals. Thrombophilic, coagulation factors and genetic mutations were diagnosed by standard hemostatic and molecular coagulation assays.RESULTS: Activated protein C (APC) resistance and protein S were the most prevalent thrombotic risk factors (6% and 10% in NAFLD vs 21% and 14% in CH; P<0.01 and P<0.05, respectively). One thrombotic risk factor was identified in 41% of patients (23% mild fibrosis, 18% severe fibrosis) and two thrombotic risk factors in 6% of patients with NAFLD and severe fibrosis. While no differences in APC ratio, lupus anticoagulant, fibrinogen, factor V Leiden,prothrombin, and MTHFR mutation were found. Protein S levels were significantly lower in NASH patients than in patients with FL alone (92±19 vs106±2, P<0.01). Protein C levels were markedly higher in patients with NAFLD and mild or severe fibrosis as compared to the patients with CH, respectively (128±40 vs96±14, P<0.001 or 129±36 vs 88±13, P<0.01).CONCLUSION: Up to 46% of patients with NAFLD may have thrombotic risk factors, and the presence of thrombotic risk factors is correlated with the extent of hepatic fibrosis,suggesting a crucial role of the coagulation system in the pathogenesis of hepatic fibrosis. | N Assy I Bekirov Y Mejritsky L Solomon S Szvalb O Hussein | 2005 | World Journal of Gastroenterology2005，11，37： | 3 |
| 3 | Causes of encephalitis and differences in their clinical presentations in England: a multicentre, population-based prospective study显示文摘 | Julia Granerod Helen E Ambrose Nicholas WS Davies Jonathan P Clewley Amanda L Walsh Dilys Morgan Richard Cunningham Mark Zuckerman Ken J Mutton Tom Solomon Katherine N Ward Michael PT Lunn Sarosh R Irani Angela Vincent David WG Brown Natasha S Crowcroft | 2010 | The Lancet Infectious Diseases2010，，12： | 2 |
| 4 | The anaphase-promoting complex:It's not just for mitosis any more显示文摘 | Harper J W Burton J L Solomon M J | 2002 | Genes Dev2002，16，： | 2 |
| 5 | Mycophenolate mofetil or intravenous cyclophosphamide for lupus nephritis with poor kidney function:a subgroup analysis of the Aspreva Lupus Management Study显示文摘 | Walsh M Solomons N Lisk L | | 0，，05： | 1 |
| 6 | Refractive surgery survey 2001 显示文摘 | Solomon KD Holzer MP Sandoval HP Vargas LG Werner L Vroman DT et ol | 2002 | J Cataract Refract Surg2002，28，2： | 1 |
| 7 | Social Percolation Models 显示文摘 | Solomon S Weisbuch G De Arcangelis L Jan N Stauffer D | 2000 | Physica A2000，277，12： | 1 |
| 8 | Drug-induced arthropathy and necrosis of the femoral head显示文摘 | Solomon L | | 0，，02： | 1 |
| 9 | Early detection of avascular necro-sis of the femoral head by MRI 显示文摘 | Fordyce MJF Solomon L | 1993 | J Bone Joint Surg Br1993，75，： | 1 |
| 10 | Activity and safety of crizotinib in patients with ALK -positive non-small-cell lung cancer: updated results from a phase 1 study显示文摘 | D Ross Camidge Yung-Jue Bang Eunice L Kwak A John Iafrate Marileila Varella-Garcia Stephen B Fox Gregory J Riely Benjamin Solomon Sai-Hong I Ou Dong-Wan Kim Ravi Salgia Panagiotis Fidias Jeffrey A Engelman Leena Gandhi Pasi A J?nne Daniel B Costa Geoffrey | 2012 | Lancet Oncology2012，，10： | 1 |
| 11 | Trends in Small Business and Entrepreneurship Education in the United States 显示文摘 | Solomon G T Fernald L W | 1991 | Entrepreneurship: Theory & Practice1991，15，3： | 1 |
| 12 | Comparative genomesequencing for discovery of novel polymorphisms in Bacillus anthracis 显示文摘 | Read TD Salzberg SL Pop M Shumway M Umayam L Jiang L Holtzapple E Busch JD Smith KL Schupp JM Solomon D Keim P Fraser CM | 2002 | Science2002，296，5575： | 1 |
| 13 | Trends In Small Bussiness and Entrepreneurship Education in The Uunited States显示文摘 | SOLOMON G T FERNALD L W | 1991 | Entrepreneurship Theory & Po- raetice1991，15，3： | 1 |
| 14 | Black carbon affects the cycling of non-blackcarbon in soil显示文摘 | Liang BQ Lehmann J Sohi SP Thies JE Neill BO Trujillo L Gaunt J Solomon D Groossman J Neves EG Luizao FJ | 2010 | Organic Geochemistry2010，41，2： | 1 |
| 15 | Early detection of avascular necrosis of the femoral head by MRI显示文摘 | Fordyce MJ Solomon L | 1993 | J Bone Joint Surg(Br)1993，75，3： | 1 |
| 16 | Earth mover’s distances on discrete surfaces显示文摘 | Solomon J Rustamov R Guibas L | 2014 | ACM Transactions on Graphics2014，33，67： | 1 |
| 17 | Hierarchical requirement of SWI/SNF in RB-mediated repression of Plk1显示文摘 | Gunawardena RW Siddiqui H Solomon DA e t a l | 2004 | J Biol Chem2004，279，29： | 1 |
| 18 | Evaluation of candidate vaccine approaches for mers-cov显示文摘 | Wang L Shi W Joyce M G Modjarrad K Zhang Y Leung K Lees C R Zhou T Yassine H M KanekiyoM Yang Z Y Chen X Becker M M Freeman M Vogel L Johnson J C Olinger G Todd J P Bagci U Solomon J Mollura D J Hensley L Jahrling P Deni- son M R Rao S S Subbarao K Kwong P D Mascola J R Kong W P Graham B S | 2015 | Nat Commun2015，6，： | 1 |
| 19 | Erythrocyte O2 transport and metabolism and effects of vitamin B6 therapy in type II diabetes mellitus显示文摘 | SOLOMON L R COHEN K | 1989 | Diabetes1989，38，7： | 1 |
| 20 | Origin and evolution of Japanese encephalitis virus in southeast asia显示文摘 | Solomon T Ni H L David W C Beasley | 2003 | J Virol2003，77，5： | 1 |
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