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| 1 | GRADE指南:Ⅷ.证据质量评价--间接性显示文摘直接证据来自直接比较我们关注的干预措施用于我们关注的患者人群,并测量患者重要结局的研究。间接证据可由以下4种方式之一产生。第一,患者可能与我们关注的患者不同(适用性一词常用于这类间接性)。第二,所检验的干预措施可能与我们关注的干预措施不同。有关患者和干预措施间接性的决策取决于对生物或社会因素差异是否大到可能使效应尺度出现预期的较大差异的考虑。第三,结果可能有别于最初设定的结局指标——如替代结果本身不重要,但测量之是基于替代结果的变化反映患者重要结局变化这一假设。第四类间接性在概念上与前三类不同,发生于临床医生必须在未经直接比较的两种干预措施间做出选择时。这种情况下比较治疗方案需要特定的统计方法,并根据患者人群、联合干预措施、结局测量指标及备选干预措施试验方法的差异程度,将证据级别降低1或2级。 | Gordon Guyatt Andrew D.Oxman Regina Kunz James Woodcock Jan Brozek Mark Helfand Pablo Alonso-Coello Yngve Falck-Ytter Roman Jaeschke Gunn Vist Elie A.Akl Piet N Post Susan Norris Joerg Meerpohl Mona Nasser 代表GRADE工作组 李幼平 杨晓妍 李鸿浩 | 2011 | 中国循证医学杂志2011，11，12： | 30 |
| 2 | 2018加拿大心境障碍与焦虑障碍治疗协作组/国际双相障碍学会指南:双相障碍的管理显示文摘加拿大心境障碍与焦虑障碍治疗协作组(Canadian Network for Mood and Anxiety Treatments,CANMAT)曾于2005年发布了第1版双相障碍管理指南,并分别于2007、2009和2013年对该指南进行了更新,其中最近的2次更新是与国际双相障碍学会(International Society for Bipolar Disorders,ISBD)合作完成。2018版CANMAT/ISBD双相障碍治疗指南(以下简称指南)反映了自2005年首版指南发表以来本领域取得的重大进展,包括疾病诊断与疾病管理的更新以及药物治疗与心理治疗的近期研究进展。这些前沿进展中综合考虑了循证证据的级别,并基于治疗疗效、临床实践经验、安全性、耐受性和药物导致的转相风险等,对一线、二线及三线治疗方案进行了简明而清晰的推荐。本指南中新增内容涵盖了双相Ⅰ型障碍(BD-Ⅰ)的躁狂发作急性期、抑郁发作急性期和双相障碍维持期的一线及二线治疗推荐等级划分。这种对治疗推荐等级的划分综合考虑了治疗方法对双相障碍不同时相的影响,将进一步帮助临床医生做出基于循证证据的治疗决策。锂盐、喹硫平、双丙戊酸盐、阿塞那平、阿立哌唑、帕利哌酮、利培酮和卡利拉嗪单药或联合使用被推荐为躁狂发作急性期的一线治疗选择。BD-Ⅰ抑郁期的一线治疗选择包括喹硫平、鲁拉西酮、锂盐、拉莫三嗪单药,鲁拉西酮联合锂盐或双丙戊酸盐或拉莫三嗪辅助治疗。尽管急性期治疗有效的药物通常应继续用于BD-Ⅰ的维持期治疗,但也存在一些特殊情况(例如抗抑郁药)。现有数据表明,锂盐、喹硫平、双丙戊酸盐、拉莫三嗪、阿塞那平和阿立哌唑单药或联合治疗应被视为维持治疗的初始或更换治疗方案时的一线选择。除了探讨BD-Ⅰ的相关问题外,本指南中还对双相Ⅱ型障碍(BD-Ⅱ)的临床管理进行了系统回顾并给予治疗推荐,同时针对特殊人群也有相关推荐,如处于各个生殖周期的女性、儿童、青少年和老年人。此外,本指南中还讨论了特定精神疾病及共病(如物质滥用、焦虑障碍和代谢性疾病)的影响。最后,本指南中概述了安全性和药物监测的相关问题。CANMAT/ISBD工作组希望本指南能够成为全球临床医生的实用工具。 | Lakshmi N Yatham Sidney H Kennedy Sagar V Parikh Ayal Sehaffer David J Bond Benicio N Frey Verinder Sharma Benjamin I Goldstein Soham Rej Serge Beaulieu Martin Alda Glenda MaeQueen Roumen V Milev Arun Ravindran Claire O'Donovan Diane Mclntosh Raymond W Lam Gustavo Vazquez Flavio Kapczinski Roger S Melntyre Jan Kozicky Shigenobu Kanba Beny Lafer Trisha Suppes Joseph R Calabrese Eduard Vieta Gin Malhi Robert M Post Michael Berk 胡晨(译) 王刚(译) | 2019 | 中华精神科杂志2019，52，1： | 25 |
| 3 | Cyclooxygenase-2 polymorphisms and the risk of esophageal adeno-or squamous cell carcinoma显示文摘AIM:To determine whether-1195 A→G and/or-765 G→C polymorphisms in Cyclooxygenase-2(COX-2 ) may have a risk modifying effect on the development of esophageal carcinoma in a Dutch Caucasian population.METHODS:Two study groups were recruited, 252 patients with esophageal carcinoma and 240 healthy controls, matched for race, age, gender and recruiting area.DNA was isolated from whole blood and used for genotyping.PCR products were digested with restriction enzymes and products were analyzed by agarose gel electrophoresis.Odds ratios(OR) and 95% confldence intervals(CI) were estimated.RESULTS:The distribution of the-1195 A→G polymorphism was signif icantly different in esophageal cancer patients compared to controls.The-1195 GG genotype resulted in a higher risk of developing esophageal adenocarcinoma(OR = 3.85, 95% CI:1.45-10.3) compared with the-1195 AA genotype as a reference.The-765 G→C genotype distribution was not different between the two groups.The GG/ GG haplotype was present more often in esophageal adenocarcinoma patients than in controls(OR = 3.45, 95% CI:1.24-9.58;with AG/AG as a reference).The same trends were observed in patients with squamous cell carcinomas, however, the results did not reach statistical signif icance.CONCLUSION:Presence of the COX-2-1195 GG genotype and of the GG/GG haplotype may result in a higher risk of developing esophageal carcinoma. | Jón O Kristinsson Paul van Westerveld Rene HM te Morsche Hennie MJ Roelofs T Wobbes Ben JM Witteman Adriaan CITL Tan Martijn GH van Oijen Jan BMJ Jansen Wilbert HM Peters | 2009 | World Journal of Gastroenterology2009，15，28： | 11 |
| 4 | 固定低剂量三联抗高血压药物与常规治疗对斯里兰卡轻度至中度高血压患者血压控制的疗效差异:一项随机临床试验显示文摘控制不良的高血压是全球领先的公共卫生问题,需要新的治疗策略。该研究评估低剂量三联抗高血压药物治疗是否能达到比常规治疗更好的血压控制。研究者纳入2016年2月至2017年5月在斯里兰卡11所城市医院诊所就诊的需要开始抗高血压治疗(未治疗的患者)或接受单药治疗的患者,进行低剂量三联降压与常规治疗比较的随机、开放性试验,随访至2017年10月。 | Web-ster R Salam A de Silva HA Selak V Stepien S Rajapakse S Amarasekara S Amarasena N Billot L de Silva AP Fernando M Guggilla R Jan S Jayawardena J Maulik PK Mendis S Munasinghe J Naik N Prabhakaran D Ranasinghe G Thom S Tisserra N Senaratne V Wijekoon S Wijeyasingam S Rodgers A Patel A 刘莉 叶鹏 | 2018 | 中华高血压杂志2018，26，12： | 7 |
| 5 | Hot deformation of Mg-Y-Zn alloy with a low content of the LPSO phase studied by in-situ synchrotron radiation diffraction显示文摘The compressive deformation behavior of the extruded WZ42(Mg98.5Y1Zn0.5 in at.%)magnesium alloy containing a low amount of long-period stacking ordered(LPSO)phase was studied by in-situ synchrotron radiation diffraction technique.Tests were conducted at temperatures between room temperature and 350℃.Detailed microstructure investigation was provided by scanning electron microscopy,particularly the backscattered electron imaging and electron backscatter diffraction technique.The results show that twinning lost its dominance and kinking of the LPSO phase became more pronounced with increasing deformation temperature.No cracks of the LPSO phase and no debonding r at the interface between the LPSO phase and the Mg matrix were observed at temperatures above 200℃.At 350℃,the LPSO phase lost its strengthening effect and the deformation of the alloy was mainly realized by the dynamic recrystallization of the Mg matrix. | Klaudia Horváth Fekete Daria Drozdenko Jan Capek Kristián Máthis Domonkos Tolnai Andreas Stark Gerardo Garcés Patrik Dobron | 2020 | Journal of Magnesium and Alloys2020，8，1： | 5 |
| 6 | Subcycle control of terahertz waveform polarization using all-optically induced transient metamaterials显示文摘Coherent radiation with frequencies ranging from 0.3 to 30 THz has recently become accessible using femtosecond laser technology.These terahertz(THz)waves have already been applied in spectroscopy and imaging and can be manipulated using static optical elements such as lenses,polarizers and filters.However,ultrafast modulation of THz radiation is required as well,for instance,in short-range wireless communication or for preparing shaped THz transients for the coherent control of numerous material excitations.Here,we demonstrate an all-optically created transient metamaterial that allows us to manipulate the polarization of THz waveforms with subcycle switch-on times.The polarization-modulated pulses are potentially interesting for controlling elementary motions such as the vibration of crystal lattices,the rotation of molecules and the precession of spins. | N Kamaraju Andrea Rubano Linke Jian Surajit Saha T Venkatesan Jan Notzold R Kramer Campen Martin Wolf Tobias Kampfrath | 2014 | Light(Science & Applications)2014，3，1： | 5 |
| 7 | Adult-to-adult living-donor liver transplantation: The experience of the Université catholique de Louvain显示文摘Background: Liver transplantation is the treatment for end-stage liver diseases and well-selected malignancies. The allograft shortage may be alleviated with living donation. The initial UCLouvain experience of adult living-donor liver transplantation(LDLT) is presented. Methods: A retrospective analysis of 64 adult-to-adult LDLTs performed at our institution between 1998 and 2016 was conducted. The median age of 29(45.3%) females and 35(54.7%) males was 50.2 years(interquartile range, IQR 32.9–57.5). Twenty-two(34.4%) recipients had no portal hypertension. Three(4.7%) patients had a benign and 33(51.6%) a malignant tumor [19(29.7%) hepatocellular cancer, 11(17.2%) secondary cancer and one(1.6%) each hemangioendothelioma, hepatoblastoma and embryonal liver sarcoma]. Median donor and recipient follow-ups were 93 months(IQR 41–159) and 39 months(22–91), respectively. Results: Right and left hemi-livers were implanted in 39(60.9%) and 25(39.1%) cases, respectively. Median weights of right-and left-liver were 810 g(IQR 730–940) and 454 g(IQR 394–534), respectively. Graft-to-recipient weight ratios(GRWRs) were 1.17%(right, IQR 0.98%-1.4%) and 0.77%(left, 0.59%-0.95%). One-and five-year patient survivals were 85% and 71%(right) vs. 84% and 58%(left), respectively. Oneand five-year graft survivals were 74% and 61%(right) vs. 76% and 53%(left), respectively. The patient and graft survival of right and left grafts and of very small( < 0.6%), small(0.6%–0.79%) and large( ≥0.8%) GRWR were similar. Survival of very small grafts was 86% and 86% at 3-and 12-month. No donor died while five(7.8%) developed a Clavien–Dindo complication IIIa, IIIb or IV. Recipient morbidity consisted mainly of biliary and vascular complications; three(4.7%) recipients developed a small-for-size syndrome according to the Kyushu criteria. Conclusions: Adult-to-adult LDLT is a demanding procedure that widens therapeutic possibilities of many hepatobiliary diseases. The donor procedure can be done safely with low morbidity. The recipient operation carries a major morbidity indicating an important learning curve. Shifting the risk from the donor to the recipient, by moving from the larger right-liver to the smaller left-liver grafts, should be further explored as this policy makes donor hepatectomy safer and may stimulate the development of transplant oncology. | Samuele Iesari Milton Eduardo Inostroza Nú?ez Juan Manuel Rico Juri Olga Ciccarelli Eliano Bonaccorsi-Riani Laurent Coubeau Pierre-Fran?ois Laterre Pierre Goffette Chantal De Reyck Beno?t Lengelé Pierre Gianello Jan Lerut | 2019 | Hepatobiliary & Pancreatic Diseases International2019，18，2： | 5 |
| 8 | IBS and the role of otilonium bromide显示文摘 | Guy Boeckxstaens Enrico S. Corazziari Fermín Mearin Jan Tack | 2013 | International Journal of Colorectal Disease2013，，3： | 4 |
| 9 | Response of soil mite abundance and diversity to a monospecific timber Tectona grandis plantation in Ivory Coast显示文摘 | Julien Kouadio N'DRI Henri Marc ANDRE Jan LAGERLOEF Jerome Ebagnerin TONDOH Thierry HANCE | 2013 | Current Zoology2013，59，5： | 3 |
| 10 | Pyramidal ownership and the creation of new firms显示文摘 | Jan Bena Hernán Ortiz-Molina | 2013 | Journal of Financial Economics2013，，3： | 2 |
| 11 | A study of projections for key point based registration of panoramic terrestrial 3D laser scan显示文摘This paper surveys state-of-the-art image features and descriptors for the task of 3D scan registration based on panoramic reflectance images.As modern terrestrial laser scanners digitize their environment in a spherical way,the sphere has to be projected to a two-dimensional image.To this end,we evaluate the equirectangular,the cylindrical,the Mercator,the rectilinear,the Pannini,the stereographic,and the z-axis projection.We show that the Mercator and the Pannini projection outperform the other projection methods. | Hamidreza HOUSHIAR Jan ELSEBERG Dorit BORRMANN Andreas NÜCHTER | 2015 | Geo-Spatial Information Science2015，18，1： | 2 |
| 12 | Harnessing the power of immersive virtual reality-visualization and analysis of 3D earth science data sets显示文摘The availability and quantity of remotely sensed and terrestrial geospatial data sets are on the rise.Historically,these data sets have been analyzed and quarried on 2D desktop computers;however,immersive technologies and specifically immersive virtual reality(iVR)allow for the integration,visualization,analysis,and exploration of these 3D geospatial data sets.iVR can deliver remote and large-scale geospatial data sets to the laboratory,providing embodied experiences of field sites across the earth and beyond.We describe a workflow for the ingestion of geospatial data sets and the development of an iVR workbench,and present the application of these for an experience of Iceland’s Thrihnukar volcano where we:(1)combined satellite imagery with terrain elevation data to create a basic reconstruction of the physical site;(2)used terrestrial LiDAR data to provide a geo-referenced point cloud model of the magmatic-volcanic system,as well as the LiDAR intensity values for the identification of rock types;and(3)used Structure-from-Motion(SfM)to construct a photorealistic point cloud of the inside volcano.The workbench provides tools for the direct manipulation of the georeferenced data sets,including scaling,rotation,and translation,and a suite of geometric measurement tools,including length,area,and volume.Future developments will be inspired by an ongoing user study that formally evaluates the workbench’s mature components in the context of fieldwork and analyses activities. | Jiayan Zhao Jan Oliver Wallgrün Peter C.LaFemina Jim Normandeau Alexander Klippel | 2019 | Geo-Spatial Information Science2019，22，4： | 2 |
| 13 | Carpal Tunnel Syndrome: Hand Surgeons, Hand Therapists, and Physical Medicine and Rehabilitation Physicians Agree on a Multidisciplinary Treatment Guideline—Results From the European HANDGUIDE Study显示文摘 | Bionka M. Huisstede Jan Fridén J. Henk Coert Peter Hoogvliet | 2014 | Archives of Physical Medicine and Rehabilitation2014，，12： | 2 |
| 14 | Genetic Variation in IL28B Is Associated With Chronic Hepatitis C and Treatment Failure: A Genome-Wide Association Study显示文摘 | Andri Rauch Zoltán Kutalik Patrick Descombes Tao Cai Julia Di Iulio Tobias Mueller Murielle Bochud Manuel Battegay Enos Bernasconi Jan Borovicka Sara Colombo Andreas Cerny Jean–Fran?ois Dufour Hansjakob Furrer Huldrych F. Günthard Markus Heim Bernard Hirs | 2010 | Gastroenterology2010，，4： | 2 |
| 15 | Where are we now?Re-visiting the Digital Earth through human-centered virtual and augmented reality geovisualization environments显示文摘The original Digital Earth concept,formulated by Al Gore(1998),is essentially a virtual reality system.In this(imagined)system,users are able to freely explore all possible recorded knowledge or information about the Earth though an interactive interface.While we imagine such an interface primarily as visual for now,it can be expected that in the future other senses will be engaged,allowing for even more realistic virtual experiences.Even though‘realism’in the experience is desirable(i.e.,it feels real),immersive experiences provided by visualization environments can go beyond reality,as they can be enhanced with queryable information.Of course one can also create fictitious experiences and simulations in such environments;including information about possible pasts(e.g.,ancient Rome)and futures(e.g.,a planned neighborhood);or spaces that we cannot(easily)directly experience(e.g.,the Moon,Mars,other far-away spaces,under the oceans,core of the earth,etc.). | Arzu Çöltekin Danielle Oprean Jan Oliver Wallgrün Alexander Klippel | 2019 | International Journal of Digital Earth2019，12，2： | 2 |
| 16 | PNPLA3 I148M (rs738409) genetic variant is associated with hepatocellular carcinoma in obese individuals显示文摘 | Maria Antonella Burza Carlo Pirazzi Cristina Maglio Kajsa Sj?holm Rosellina Margherita Mancina Per-Arne Svensson Peter Jacobson Martin Adiels Marco Giorgio Baroni Jan Borén Stefano Ginanni Corradini Tiziana Montalcini Lars Sj?str?m Lena Mariana Susann Car | 2012 | Digestive and Liver Disease2012，，12： | 2 |
| 17 | Pressurised liquid extraction of flavonoids in onions 显示文摘 | Malene S Jan H C John N | 2009 | Method Development and Validation Talanta2009，80，： | 1 |
| 18 | Variations on the Notch pathway in neu- ral development显示文摘 | Justice N J Jan YN | 2002 | Curr Opin Neurobiol2002，12，： | 1 |
| 19 | CloudSim:a toolkit for modeling and simulation of cloud computing environments and evaluation of resource provi- sioning algorithms 显示文摘 | CALHEIROS R N RAN JAN R BELOGLAZOY A | | Practice and Experience0，41，1： | 1 |
| 20 | Social Percolation Models 显示文摘 | Solomon S Weisbuch G De Arcangelis L Jan N Stauffer D | 2000 | Physica A2000，277，12： | 1 |
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