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| 1 | Adenosine A 2A R modulates cardiovascular function by activating ERK1/2 signal in the rostral ventrolateral medulla of acute myocardial ischemic rats显示文摘 | Meiyan Jiang Chengrong Zhang Jin Wang Jun Chen Chunmei Xia Dongshu Du Na Zhao Yinxiang Cao Linlin Shen Danian Zhu | 2011 | Life Sciences2011，，5： | 4 |
| 2 | An efficient and recyclable iron(III)-containing imidazolium salt catalyst for cross-coupling of aryl Grignard reagents with alkyl halides显示文摘1,3-Bis(2,6-diisopropylphenyl)imidazolium chloride, [DIPrim]Cl, was used to produce a novel iron(III)-containing imidazolium salt [DIPrim][FeCl 4 ], which included a N,N-diarylimidazolium cation (R = 2,6-diisopropylphenyl), [DIPrim] + , and tetrachloroferrate(III) anion, [FeCl 4 ]. This compound was an effective and easy-to-use catalyst for the cross-coupling of aryl Grignard reagents with primary and secondary alkyl halides bearing -hydrogens. After simply decanting the cross-coupling product in the ether layer, [DIPrim][FeCl 4 ] could be reused in at least four successive runs without significant loss of catalytic activity. | YAN ChunHui WANG LinLin GAO HuanHuan SUN HongMei SHEN Qi | 2012 | Chinese Science Bulletin2012，57，16： | 4 |
| 3 | Drilling Force and Temperature of Bone under Dry and Physiological Drilling Conditions显示文摘Many researches on drilling force and temperature have been done with the aim to reduce the labour intensiveness of surgery, avoid unnecessary damage and improve drilling quality. However, there has not been a systematic study of mid- and high-speed drilling under dry and physiological conditions(injection of saline). Furthermore, there is no consensus on optimal drilling parameters. To study these parameters under dry and physiological drilling conditions, pig humerus bones are drilled with medical twist drills operated using a wide range of drilling speeds and feed rates. Drilling force and temperature are measured using a YDZ-II01 W dynamometer and a NEC TVS-500 EX thermal infrared imager, respectively, to evaluate internal bone damage. To evaluate drilling quality, bone debris and hole morphology are observed by SEM(scanning electron microscopy). Changes in drilling force and temperature give similar results during drilling such that the value of each parameter peaks just before the drill penetrates through the osteon of the compact bone into the trabeculae of the spongy bone. Drilling temperatures under physiological conditions are much lower than those observed under dry conditions, while a larger drilling force occurs under physiological conditions than dry conditions. Drilling speed and feed rate have a significant influence on drilling force, temperature, bone debris and hole morphology. The investigation of the effect of drilling force and temperature on internal bone damage reveals that a drilling speed of 4500 r/min and a feed rate of 50 mm/min are recommended for bone drilling under physiological conditions. Drilling quality peaks under these optimal parameter conditions. This paper proposes the optimal drilling parameters under mid- and high-speed surgical drilling, considering internal bone damage and drilling quality, which can be looked as a reference for surgeons performing orthopedic operations. | XU Linlin WANG Chengyong JIANG Min HE Huiyu SONG Yuexian CHEN Hanyuan SHEN Jingnan ZHANG Jiayong | 2014 | Chinese Journal of Mechanical Engineering2014，27，6： | 3 |
| 4 | Overexpression of miR-101 suppresses collagen synthesis by targeting EZH2 in hypertrophic scar fibroblasts显示文摘Background:MicroRNA-101(miR-101)is a tumor suppressor microRNA(miRNA)and its loss is associated with the occurrence and progression of various diseases.However,the biological function and target of miR-101 in the pathogenesis of hypertrophic scars(HS)remains unknown.Methods:We harvested HS and paired normal skin(NS)tissue samples from patients and cultured their fibroblasts(HSF and NSF,respectively).We used quantitative reverse transcriptase polymerase chain reaction(qRT-PCR),fluorescence in situ hybridization(FISH),enzyme-linked immunosorbent assays(ELISA)and Western blot analyses to measure mRNA levels and protein expression of miR-101,enhancer of zeste homolog 2(EZH2),collagen 1 and 3(Col1 and Col3)andα-smooth muscle actin(α-SMA)in different in vitro conditions.We also used RNA sequencing to evaluate the relevant signaling pathways and bioinformatics analysis and dual-luciferase reporter assays to predict miR-101 targets.We utilized a bleomycin-induced fibrosis mouse model in which we injected miR-101 mimics to evaluate collagen deposition in vivo.Results:We found low expression of miR-101 in HS and HSF compared to NS and NSF.Overexpressing miR-101 decreased Col1,Col3 andα-SMA expression in HSF.We detected high expression of EZH2 in HS and HSF.Knockdown of EZH2 decreased Col1,Col3 andα-SMA in HSF.Mechanistically,miR-101 targeted the 3-untranslated region(3UTR)of EZH2,as indicated by the decreased expression of EZH2.Overexpressing EZH2 rescued miR-101-induced collagen repression.MiR-101 mimics effectively suppressed collagen deposition in the bleomycin-induced fibrosis mouse model.Conclusions:Our data reveal that miR-101 targets EZH2 in HS collagen production,providing new insight into the pathological mechanisms underlying HS formation. | Jie Li Yan Li Yunchuan Wang Xiang He Jing Wang Weixia Cai Yanhui Jia Dan Xiao Jian Zhang Ming Zhao Kuo Shen Zichao Li Wenbin Jia Kejia Wang Yue Zhang Linlin Su Huayu Zhu Dahai Hu | 2021 | Burns & Trauma2021，9，1： | 3 |
| 5 | Surface Oxygen Injection in Tin Disulfide Nanosheets for Efficient CO_(2) Electroreduction to Formate and Syngas显示文摘Surface chemistry modification represents a promising strategy to tailor the adsorption and activation of reaction intermediates for enhancing activity.Herein,we designed a surface oxygen-injection strategy to tune the electronic structure of SnS_(2) nanosheets,which showed effectively enhanced electrocatalytic activity and selectivity of CO_(2) reduction to formate and syngas(CO and H_(2)).The oxygen-injection SnS_(2) nanosheets exhibit a remarkable Faradaic efficiency of 91.6%for carbonaceous products with a current density of 24.1 mA cm^(−2) at−0.9 V vs RHE,including 83.2%for formate production and 16.5%for syngas with the CO/H_(2) ratio of 1:1.By operando X-ray absorption spectroscopy,we unravel the in situ surface oxygen doping into the matrix during reaction,thereby optimizing the Sn local electronic states.Operando synchrotron radiation infrared spectroscopy along with theoretical calculations further reveals that the surface oxygen doping facilitated the CO_(2) activation and enhanced the affinity for HCOO*species.This result demonstrates the potential strategy of surface oxygen injection for the rational design of advanced catalysts for CO_(2) electroreduction. | Tao Chen Tong Liu Tao Ding Beibei Pang Lan Wang Xiaokang Liu Xinyi Shen Sicong Wang Dan Wu Dong Liu Linlin Cao Qiquan Luo Wei Zhang Wenkun Zhu Tao Yao | 2021 | Nano-Micro Letters2021，13，11： | 3 |
| 6 | Modify Cd3As2 nanowires with sulfur to fabricate self-powered NIR photodetectors with enhanced performance显示文摘Cd_(3)As_(2)nanowires(NWs)have great potential in the near-infrared(NIR)photodetection field due to their excellent optoelectronic properties as a typical Dirac semimetal.However,the existence of surface oxidization limits their photoresponse performance for practical applications.Here,we modified the surface of Cd_(3)As_(2)NWs with sulfur to prevent surface oxidizing and optimize the bandgap structure to improve the photoresponse performance.The S-modified Cd_(3)As_(2)samples existed as core/shell Cd_(3)As_(2)/CdS NWs and the corresponding single NW device showed a responsivity of 0.95 A/W in the NIR band at a 0 V bias,which is three orders of magnitude higher than that of an unmodified NW.This study provides an efficient and universally applicable way to prevent semimetals nanostructures from oxidizing and promote their optoelectronic properties. | Yongxu Yan Wenhao Ran Zhexin Li Linlin Li Zheng Lou Guozhen Shen | 2021 | Nano Research2021，14，10： | 2 |
| 7 | Recent advanced applications of ion-gel in ionic-gated transistor显示文摘Diversified regulation of electrons have received much attention to realize a multi-functional transistor,and it is crucial to have a considerable control over the charge carriers in transistors.Ionic gel,as the dielectric material in transistors,facilitates a large capacitance,and high induced-carrier concentrations.This review presents the recent progress in ionic-gated transistors(IGTs)that have good mechanical stability as well as high physical and chemical stability.We first briefly introduce the various applications of IGTs in sensors,neuromorphic transistors,organic transistor circuits,and health detection.Finally,the future perspectives of IGTs are discussed and some possible solutions to the challenges are also proposed. | Depeng Wang Shufang Zhao Ruiyang Yin Linlin Li Zheng Lou Guozhen Shen | 2021 | npj Flexible Electronics2021，5，1： | 2 |
| 8 | HEp-2 image classification using intensity order pooling based features and bag of words显示文摘 | SHEN Linlin LIN Jiaming WU Shengyin | 2013 | Pattern Recognition2013，47，7： | 1 |
| 9 | Gabor wavelets and general discriminant analysis for face identification and verification显示文摘 | Shen Linlin Li Bai Fairhurst M | 2007 | Image and Vision Computing2007，25，5： | 1 |
| 10 | Gabor Wavelets and General Discriminant Analysis for Face Identification and Verification显示文摘 | Shen Linlin Li Bai Fairhurst M | 2007 | Image Vision Computing2007，25，5： | 1 |
| 11 | Neuromorphic-computing-based adaptive learning using ion dynamics in flexible energy storage devices显示文摘High-accuracy neuromorphic devices with adaptive weight adjustment are crucial for high-performance computing.However,limited studies have been conducted on achieving selective and linear synaptic weight updates without changing electrical pulses.Herein,we propose high-accuracy and self-adaptive artificial synapses based on tunable and flexible MXene energy storage devices.These synapses can be adjusted adaptively depending on the stored weight value to mitigate time and energy loss resulting from recalculation.The resistance can be used to effectively regulate the accumulation and dissipation of ions in single devices,without changing the external pulse stimulation or preprogramming,to ensure selective and linear synaptic weight updates.The feasibility of the proposed neural network based on the synapses of flexible energy devices was investigated through training and machine learning.The results indicated that the device achieved a recognition accuracy of~95%for various neural network calculation tasks such as numeric classification. | Shufang Zhao Wenhao Ran Zheng Lou Linlin Li Swapnadeep Poddar Lili Wang Zhiyong Fan Guozhen Shen | 2022 | National Science Review2022，9，11： | 1 |
| 12 | Analysis for load limitation of square-shaped silicon diaphragms 显示文摘 | Linlin Z Chen X Shen G | 2006 | Solid-State Elec- tronics2006，50，910： | 1 |
| 13 | A rexiew on Gabor wavelets for face recognition 显示文摘 | Shen Linlin Bai I i | 2006 | Pattern Analysis and Applications2006，，9： | 1 |
| 14 | miR-3677-3p promotes hepatocellular carcinoma progression via inhibiting GSK3β显示文摘MicroRNAs play im portant roles in regulating hepatocellular carcinoma(HCC)form ation,progression and metastasis.However,their functions and the underlying m olecular mechanisms are still unclear.Here,we found that miR-3677-3p was highly expressed in prim ary tumor tissues of HCC patients.And its inhibition by using sponge in HCC cells could suppress cell proliferation sig nificantly,but it has no effect on cell apoptosis.Through directly targeting to the 37 untranslated region of glycogen synthase kinase 3-β(GSK3β),miR-3677-3p could inhibit GSK3β expression.Our study revealed that the miR-3677-3p/GSK3β axis may play a crucial role in HCC and miR-3677-3p may serve as a potential diagnostic biom arker or a therapeutic target for HCC. | Yanfei Li Yajie Zhou Linlin Ma Dingsheng Liu Zhensheng Dai Junwei Shen | 2020 | Acta Biochimica et Biophysica Sinica2020，52，12： | 1 |
| 15 | Gabor wavelets and general discriminant analysis for face identification and verification显示文摘 | SHEN Linlin BAI Li FAIRHURST M | 2007 | Image and Vision Computing2007，25，5： | 1 |
| 16 | Expression of β-1,4-Galactosyltransferase-I in Rat during Inflammation显示文摘 | Ji Qian Chun Cheng Haiou Liu Jianping Chen Meijuan Yan Shuqiong Niu Jing Qin Linlin Sun Lei Liu Jianxin Gu Aiguo Shen | 2007 | Inflammation (-)2007，，1： | 1 |
| 17 | Analysis for load limitation of square-shaped silicon diaphragms显示文摘 | Xu Chen Shen Guangdi | 2006 | Solid-State Eletronics2006，50，： | 1 |
| 18 | A review on Gabor wavelets for face recognition显示文摘 | Linlin Shen Li Bai | 2006 | Pattern Analysis and Applications (-)2006，，2： | 1 |
| 19 | Mutual Boost learning for selecting Gabor features for face recognition 显示文摘 | Linlin Shen | 2006 | Pattern Rocognition Letters (S0167-8655)2006，27，15： | 1 |
| 20 | Mutualboostlearning for selecting gaborfeatures for face recognition显示文摘 | Shen Linlin Bai Li | 2006 | Pattern Recognition Letters2006，27，15： | 1 |
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