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| 1 | The relation between HLA-DQA1 genes and genetic susceptibility to duodenal ulcer in Wuhan Hans显示文摘AIM To study the genetic susceptibility of HLA-DQA1 alleles to duodenal ulcer in Wuhan Hans.METHODS Seventy patients with duodenalulcer and fifty healthy controls were examinedfor HLA-DQA1 genotypes.HLA-DQA1 typing wascarried out by digesting the locus specificpolymerase chain reaction amplified productswith alleles specific restriction enzymes(PCR-RFLP),i.e.,Apal Ⅰ,Bsaj Ⅰ,Hph Ⅰ,Fok Ⅰ,Mbo Ⅱ and Mnl Ⅰ.RESULTS The allele frequencies of DQA1 * 0301and DQA1 * 0102 in patients with duodenal ulcerwere significantly higher and lower respectivelythan those in healthy controls(0.40 vs 0.20,P = 0.003,mcorret = 0.024)and(0.05 vs 0.14,P = 0.012,but Pcorret>0.05),respectively.CONCLUSION DQA1 * 0301 is a susceptiblegene for duodenal ulcer in Wuhan Hans,andthere are immunogenetic differences in HLA-DQA1 locus between duodenal ulcer patients andhealthy controls. | Du YP Deng CS Lu DY Huang MF Guo SF Hou W | 2000 | World Journal of Gastroenterology2000，6，1： | 37 |
| 2 | 肺炎链球菌耐药性和血清型分布及隐匿性耐药克隆株的研究显示文摘目的 了解儿童肺炎链球菌携带者耐药菌株的流行情况 ,比较携带者菌株血清型与肺炎链球菌结合疫苗血清型的符合率 ,寻找单个患儿同时携带敏感和耐药菌株的可能性。方法 (1)对1997年 11月~ 12月在北京儿童医院普通门诊登记的 3个月~ 5岁儿童进行问卷调查 ;(2 )采集鼻咽拭子和尿标本 ,培养、分离和鉴定肺炎链球菌 ,并测定尿标本中的抗生素活性 ;(3)根据NCCLS方法使用微量稀释法测定肺炎链球菌对青霉素、头孢呋新、头孢噻肟、复方新诺明、红霉素和氯霉素的敏感性 ;(4 )从最初发现的青霉素、红霉素敏感株中寻找“隐匿性耐药克隆株”。结果 (1) 5 0 2例受试儿童中 ,分离出 190株肺炎链球菌 ,携带率为 37.8% (190 / 5 0 2 ) ,对青霉素的敏感率为 91.1% ;(2 )只有33 .9%的菌株血清型与建议使用的肺炎链球菌结合疫苗血清型相符 ;(3) 4 2例含青霉素和红霉素敏感菌株鼻咽拭子中发现 6株 (14% )“隐匿性耐药克隆株”。结论 在携带者中 ,肺炎链球菌对 β 内酰胺类耐药还不常见 ,但对红霉素和复方新诺明耐药却非常严重 ;建议使用的结合疫苗血清型不能覆盖大部分携带菌株 ;耐药菌株的小部分隐匿在敏感菌株中 。 | 俞桑洁 王槿芳 李洁 李艳 王雪莲 Whitney CG Levine OS Dowell SF 杨永弘 | 2000 | 中华儿科杂志2000，38，7： | 40 |
| 3 | A study of preoperative methionine-depleting parenteral nutrition plus chemotherapy in gastric cancer patients显示文摘AIM To investigate the interference ofmethionine.free parenteral nutrition plus 5-Fu(-MetTPN+5-Fu)in gastric cancer cell kineticsand the side effects of the regimen.METHODS Fifteen patients with advancedgastric cancer were randomly divided into twogroups,7 patients were given preoperatively aseven-day course of standard parenteralnutrition in combination with a five-day courseof chemotherapy(sTPN+5-Fu),while the other8 patients were given methionine-deprivedparenteral nutrition and 5-Fu(-MetTPN+5-Fu).Cell cycles of gastric cancer and normal mucosawere studied by flow cytometry(FCM).Bloodsamples were taken to measure the serumprotein,methionine(Met)and cysteine(Cys)levels,and liver and kidney functions.RESULTS As compared with the resultsobtained before the treatment,the percentage ofG0/G1 tumor cells increased and that of S phasedecreased in the-MetTPN+5-Fu group,while thecontrary was observed in the sTPN+5-Fu group.Except that the ALT,AST and AKP levels wereslightly increased in a few cases receiving-MetTPN+5-Fu,all the other biochemicalparameters were within normal limits.Serum Cys level decreased slightly after the treatmentin both groups.Serum Met level of patientsreceiving sTPN+5-Fu was somewhat higher aftertreatment than that before treatment;however,no significant change occurred in the -MetTPN+5-Fu group,nor operative complications in bothgroups.CONCLUSION -MetTPN+5-Fu exerted asuppressive effect on cancer cell proliferation,probably through a double mechanism ofcreating a state of'Met starvation'adverse tothe tumor cell cycle,and by allowing 5-Fu to killspecifically cells in S phase.Preoperative short-term administration of -MetTPN+5-Fu had littleundesirable effect on host metabolism. | Cao WX Cheng QM Fei XF Li SF Yin HR Lin YZ | 2000 | World Journal of Gastroenterology2000，6，2： | 22 |
| 4 | 煤矸石—水相互作用溶解动力学:Ⅱ.煤矸石微量金属元素的…显示文摘通过对自然风化前后煤矸石微量重金属元素含量与赋存状态的分析和研究发现:煤矸石的自然风化过程是一个微量重金属的富集过程,在这个过程中,以硫化物矿物存在的微量重金属随着硫的氧化而分解,但是,由于已风化煤矸石表面有机质和铁的胶体的存在,这些重金属元素没能迁移到周围环境中去,而是保留在煤矸石的残余构架中,这样,就微量重金属的污染而言,煤矸石对周围环境的影响是有限的。 | 党志 Watts,SF | 1996 | 中国科学(D辑)1996，26，1： | 20 |
| 5 | 乙型肝炎病毒耐药性临床需知显示文摘应本刊的邀请,由美国密歇根大学国际知名肝病学家骆淑芳教授(Anna SF LOK)提供本文,她是AASLD乙型肝炎指南的主要执笔者。原文为英文,由本人根据本刊篇幅适当精炼。并补充恩替卡韦、替比夫定和替诺福韦的最新资料,请参阅:Hepatology,2006,44(2):309-313;44(2):318-325;44(6):1404-1407;44(6):1656-1665;Gastroenterology,2006,131(6) | Anna SF LOK | 2007 | 肝脏2007，12，1： | 15 |
| 6 | 新型人工肝——分子吸附再循环系统及其临床应用显示文摘到目前为止,急慢性重型肝炎的治疗仍强调基础护理和一般的支持对症处理,缺乏清除肝脏毒素和促进肝细胞再生的有效手段。虽然血液透析、灌流和血浆置换已被用于重型肝炎的治疗,但其临床疗效尚未被公认。与上述血液净化方法不同的是,新型人工肝——分子吸附再循环系统在有效清除水溶性中小毒素分子的同时,还可以选择性清除亲脂性及与血浆白蛋白相结合的毒素分子,并保留血液中有用的重要营养物质和蛋白质。本文对这一新型人工肝支持系统的基本原理、使用方法、不良反应及临床应用研究进展作了综述。 | 李勇年 Aldinger SF 高建兴 | 2002 | 国外医学(流行病学.传染病学分册)2002，29，6： | 14 |
| 7 | Review on Partial Discharge Detection Techniques Related to High Voltage Power Equipment Using Different Sensors显示文摘当在高电压操作一台设备或一个功率系统时,与部分分泌物(PD ) 联系的问题能被追踪到象臭氧和氧化氩氮气体的形成那样的电磁的排放,声学的排放或化学反应。高电压设备和高电压安装主人与对在象力量变压器,煤气的绝缘的变电所(GIS ) ,和电报安装那样的设备监视 PD 的过程的条件的需要达成协议。这份报纸考察象电的察觉,化学察觉,声学的察觉,和光察觉那样的可得到的 PD 察觉方法(包含的高电压设备) 。每个方法的优点和劣势被探索了并且比较。评论建议光察觉技术为应用在精确性和适用性的考虑提供许多优点什么时候与另外的技术相比。 | MM YAACOB MA ALSAEDI JR RASHED AM DAKHIL SF ATYAH | 2014 | Photonic Sensors2014，4，4： | 14 |
| 8 | Symptom clusters and quality of life among patients with advanced heart failure显示文摘ObjectivesTo 与先进的心失败(HF ) 和与他们 .MethodsThis 是的生活(QoL ) 的质量的独立关系在病人之中识别症状簇会见了 119 个病人与的代表性的研究的第二等的数据分析在香港在一所地区性的医院的衰老老人单位推进了 HF。症状侧面和 QoL 被使用埃德蒙顿症状评价规模(ESAS ) 和 McGill QoL 问询表估计。探索因素分析被用来识别症状簇。层次回归分析被用来与他们的 QoL 检验独立关系,在调整病人们在先进年龄的年龄,性,和 comorbidities.ResultsThe 的效果以后(82.9 ±6.5 年) 。三不同症状簇被识别:他们是悲痛簇(呼吸,焦虑,和消沉的包括的短小) , decondition 簇(疲劳,睡意,恶心,和减少的胃口) ,和不快聚类(概括不快的疼痛,和感觉) 。这三症状簇说明了病人症状经验的 63.25% 变化。对在这些症状簇之间的中等关联小显示他们是独立人士互相。在调整年龄,性和 comorbidities 以后,悲痛(β=− 0.635, P <0.001 ) , decondition (β=− 0.148, P = 0.01 ) ,并且不快(β=− 0.258, P <0.001 ) 症状簇独立地预言他们的 QoL.ConclusionsThis 学习与先进 HF 在病人之中识别了特殊症状簇。结果使需要清楚些为为这限制生活的疾病优化症状控制开发辩解的照顾干预。 | Doris SF Yu Helen YL Chan Doris YP Leung Elsie Hui Janet WH Sit | 2016 | Journal of Geriatric Cardiology2016，13，5： | 12 |
| 9 | Near-infrared fluorescence sentinel lymph node detection in gastric cancer: A pilot study显示文摘AIM: To investigate feasibility and accuracy of nearinfrared fluorescence imaging using indocyanine green: nanocolloid for sentinel lymph node(SLN) detection in gastric cancer.METHODS: A prospective, single-institution, phaseI feasibility trial was conducted. Patients suffering from gastric cancer and planned for gastrectomy were included. During surgery, a subserosal injection of 1.6 m L ICG:Nanocoll was administered around the tumor. NIR fluorescence imaging of the abdominal cavity was performed using the Mini-FLARE? NIR fluorescence imaging system. Lymphatic pathways and SLNs were visualized. Of every detected SLN, the corresponding lymph node station, signal-to-background ratio and histopathological diagnosis was determined. Patients underwent standard-of-care gastrectomy. Detected SLNs outside the standard dissection planes were also resected and evaluated.RESULTS: Twenty-six patients were enrolled. Four patients were excluded because distant metastases were found during surgery or due to technical failure of the injection. In 21 of the remaining 22 patients, at least 1 SLN was detected by NIR Fluorescence imaging(mean 3.1 SLNs; range 1-6). In 8 of the 21 patients, tumor-positive LNs were found. Overall accuracy of the technique was 90%(70%-99%; 95%CI), which decreased by higher p T-stage(100%, 100%, 100%, 90%, 0% for respectively Tx, T1, T2, T3, T4 tumors). All NIR-negative SLNs were completely effaced by tumor. Mean fluorescence signal-to-background ratio of SLNs was 4.4(range 1.4-19.8). In 8 of the 21 patients, SLNs outside the standard resection plane were identified, that contained malignant cells in 2 patients.CONCLUSION: This study shows successful use of ICG:Nanocoll as lymphatic tracer for SLN detection in gastric cancer. Moreover, tumor-containing LNs outside the standard dissection planes were identified. | Quirijn RJG Tummers Leonora SF Boogerd Wobbe O de Steur Floris PR Verbeek Martin C Boonstra Henricus JM Handgraaf John V Frangioni Cornelis JH van de Velde Henk H Hartgrink Alexander L Vahrmeijer | 2016 | World Journal of Gastroenterology2016，22，13： | 9 |
| 10 | 接受激素替代疗法的绝经后亚洲妇女的干眼症(英文)显示文摘目的:比较接受和不接受激素替代疗法的绝经后妇女干眼症的发生情况。方法:采用横断面研究方法比较对照组和接受激素替代疗法的绝经后妇女干眼症的发生。对所有的受试者行泪液分泌实验,泪膜破裂时间和玫瑰红孟加拉染色检查。结果:总共54例妇女被纳入研究,其中接受激素替代疗法(第2组)30例(55.6%),对照组24例(44.4%)没有进行任何激素治疗(第1组)。在第2组中,11例服用雌激素(2A组),其余19例同时服用雌激素和孕酮(2B组)。在第1组组中有29.2%发生了干眼症,第2组为70.0%(P=0.003),进一步分析发现2B组(84.2%)较2A组(45.5%)更多发生了干眼症(P=0.042)。结论:本研究发现在绝经后服用激素的妇女中干眼症比较常见,它否定了先前激素替代疗法具有防止干眼症发生的假设。 | B Shaharuddin SF Ismail-Mokhtar E Hussein | 2007 | 国际眼科杂志2007，7，5： | 9 |
| 11 | Quality of life and palliative care needs of elderly patients with advanced heart failure显示文摘 | Helen YL Chan Doris SF Yu Doris YP Leung Aileen WK Chan Elsie Hui | 2016 | Journal of Geriatric Cardiology2016，13，5： | 7 |
| 12 | Pulmonary infection control window in treatment of severe respiratory failure of chronic obstructive pulmonary diseases: a prospective, randomized controlled, multi-centred study显示文摘Background Early withdraw from invasive mechanical ventilation (MV) followed by noninvasive MV is a new strategy for changing modes of treatment. This study was conducted to estimate the feasibility and the efficacy of early extubation and sequential noninvasive MV commenced at beginning of pulmonary infection control window in patients with exacerbated hypercapnic respiratory failure caused by chronic obstructive pulmonary diseases (COPD). Methods A prospective, randomized controlled study was conducted in eleven teaching hospitals' respiratory or medical intensive care units in China. Ninety intubated COPD patients with severe hypercapnic respiratory failure triggered by pulmonary infection (pneumonia or purulent bronchitis) were involved in the study. When the pulmonary infection had been controlled by antibiotics and comprehensive therapy, the 'pulmonary infection control window (PIC window)' has been reached. Each case was randomly assigned to study group (extubation and noninvasive MV via facial mask immediately) or control group (invasive MV was received continuously after PIC window by using conventional weaning technique).Results Study group (n=47) and control group (n=43) had similar clinical characteristics initially and at the time of PIC window. Compared with control group, study group had shorter duration of invasive MV [(6.4±4.4) days vs (11.3±6.2) days, P=0.000], lower rate of ventilator associated pneumonia (VAP) (3/47 vs 12/43, P=0.014), fewer days in ICU [(12±8) days vs (16±11) days, P=0.047] and lower hospital mortality (1/47 vs 7/43, P=0.025).Conclusions In COPD patients requiring intubation and invasive MV for hypercapnic respiratory failure, which is exacerbated by pulmonary infection, early extubation followed by noninvasive MV initiated at the start of PIC window may decrease significantly the duration of invasive MV, the risk of VAP and hospital mortality. | Wang, C Zhan, QY Cao, ZX Wei, LQ Cheng, ZZ Liu, S Zhang, JL Chen, RC Luo, Q Niu, SF Zhu, L Wu, DW Fang, BM Wu, TH Wang, CZ Liu, YN | 2005 | Chinese Medical Journal2005，，19： | 6 |
| 13 | Geological thermal events in Tarim Basin显示文摘TARIM Basin is the biggest sedimentary basin in China, and it is also an important area of | Chen, HL Yang, SF Dong, CW Zhu, GQ Jia, CA Wei, GQ Wang, ZG | 1997 | Chinese Science Bulletin1997，42，7： | 5 |
| 14 | Comparisons of grain size characteristics of red earth from southern China with that of loess and dune sand from Beijing region显示文摘The comparisons of grain size distributions among eolian deposits along the monsoon wind trajectory are a fundamental task for the reconstruction of the past wind regimes. Here the authors sampled the dune sands in Hunsandak desert, loess deposits in Beijing region and red earth in southern China. Grain size analyses show that the distribution models of the loess | Xiong, SF Ding, ZL Liu, DS | 1999 | Chinese Science Bulletin1999，44，18： | 3 |
| 15 | 药物开发中与草药相互作用药物的鉴定显示文摘迄今为止,几种临床上重要的药物已被鉴定与常用的草药相互作用。这些药物包括华法林、咪达唑仑、地高辛、阿米替林、茚地那韦、环孢素A、他克莫司、伊立替康。重要的是这些药物大多治疗指数极窄,大部分是细胞色素P450(CYP)和(或)P糖-蛋白(P-gp)的底物。由于药物-草药相互作用能显著地影响药物的循环浓度,改变临床结果,因此与常用的草药相互作用的药物的鉴定在药物开发中具重要的意义。计算机模拟、体外、动物和人体研究经常用于鉴定药物和草药的相互作用。建议将药物-草药和草药-CYP相互作用研究纳入药物开发中。 | Zhou SF Zhou ZW Li CG 贾秀虹 | 2008 | 国际药学研究杂志2008，35，3： | 2 |
| 16 | Technical report: fallopian tube recanalization: a simplified technique 显示文摘 | Millward SF Claman P Leader A | 1994 | Clin Radiol1994，49，： | 2 |
| 17 | 微合金化钢奥氏体静态再结晶临界温度的确定显示文摘本文建立了一种能准确确定微合金化钢奥氏体静态再结晶临界温度(SRCT)(也就是说再结晶开始被抑制的温度)的一种方法。采用扭转试验并应用反椎法)back extrapolation)确定了分别含有Nb,V、Ti的三种钢在两种应变(0。20和0.35)和若干温度下奥氏体再结晶分数。激活能与温度的倒数的图示表示法使我们能够把每种钢的SRCT确立为应变和奥氏昌粒尺寸的函数。 | Medi.,SF 郑之旺 | 1995 | 国外钢铁钒钛1995，8，2： | 2 |
| 18 | Comparative analysis of laparoscopic versus open partial nephrectomy for renal tumors in 200 patients显示文摘 | Gill IS Matin SF Desai MM | 2003 | The Journal of Urology2003，，01： | 2 |
| 19 | Physical activity in adolescence and young adulthood and breast cancer risk:a quantitative review显示文摘 | Lagerros YT Hsieh SF Hsieh CC | 2004 | Eur J Cancer Prev2004，13，1： | 2 |
| 20 | Activated protein kinase C isoforms target to cardiomyocyte caveolae: stimulation of local protein phosphorylation显示文摘 | Rybin VO Xu X Steinberg SF | 1999 | Circ Res1999，84，9： | 2 |
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