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	题名	作者	年代	出处	被引量
1	Association of N-terminal pro-brain natriuretic peptide with the severity of coronary artery disease in patients with normal left ventricular ejection fraction显示文摘	Wu NQ Guo YL Li XL Liu J Qing P Xu RX Zhu CG Jia Y J Liu G Dong Q Jiang LX Li J J Ma FL	2014	Chinese Medical Journal2014，，4：	23
2	Chemoprotective effects of curcumin in esophageal epithelial cells exposed to bile acids显示文摘AIM:To investigate the ability of curcumin to counteract the impact of bile acids on gene expression of esophageal epithelial cells.METHODS:An esophageal epithelial cell line(HET1A)was treated with curcumin in the presence of deoxycholic acid.Cell proliferation and viability assays were used to establish an appropriate dose range for curcumin.The combined and individual effects of curcumin and bile acid on cyclooxygenase-2(COX-2)and superoxide dismutase(SOD-1 and SOD-2)gene expression were also assessed.RESULTS:Curcumin in a dose range of 10-100μmol/L displayed minimal inhibition of HET-1A cell viability.Deoxycholic acid at a concentration of 200μmol/L caused a 2.4-fold increase in COX-2 gene expression compared to vehicle control.The increased expression of COX-2 induced by deoxycholic acid was partially reversed by the addition of curcumin,and curcumin reduced COX-2 expression 3.3-to 1.3-fold.HET-1A cells exposed to bile acid yielded reduced expression of SOD-1 and SOD-2 genes with the exception that high dose deoxycholic acid at 200μmol/L led to a 3-fold increase in SOD-2 expression.The addition of curcumin treatment partially reversed the bile acid-induced reduction in SOD-1 expression at all concentrations of curcumin tested.CONCLUSION:Curcumin reverses bile acid suppression of gene expression of SOD-1.Curcumin is also able to inhibit bile acid induction of COX-2 gene expression.	Matthew R Bower Harini S Aiyer Robert CG Martin Yan Li	2010	World Journal of Gastroenterology2010，16，33：	10
3	脂蛋白a水平与冠状动脉粥样硬化性心脏病患者复发事件的关系显示文摘脂蛋白a是否是冠状动脉粥样硬化性心脏病(冠心病)患者复发性心血管事件(recurrent cardiovascular events,RCVEs)的预测因子尚未确定。本研究旨在探讨脂蛋白a对一个真实世界、大规模首诊心血管事件(cardiovascular event,CVE)患者队列中RCVEs的潜在影响。方法:本实验为多中心的前瞻性研究,纳入经血管造影诊断的冠心病并经历首次CVE的患者7562例。入院时测量所有患者的脂蛋白a浓度.	周卫(译) 叶鹏(校) Liu HH Cao YX Jin JL Zhang HW Hua Q Li YF Guo YL Zhu CG Wu NQ Gao Y Xu RX Hong LF	2020	中华高血压杂志2020，28，5：	5
4	药物开发中与草药相互作用药物的鉴定显示文摘迄今为止,几种临床上重要的药物已被鉴定与常用的草药相互作用。这些药物包括华法林、咪达唑仑、地高辛、阿米替林、茚地那韦、环孢素A、他克莫司、伊立替康。重要的是这些药物大多治疗指数极窄,大部分是细胞色素P450(CYP)和(或)P糖-蛋白(P-gp)的底物。由于药物-草药相互作用能显著地影响药物的循环浓度,改变临床结果,因此与常用的草药相互作用的药物的鉴定在药物开发中具重要的意义。计算机模拟、体外、动物和人体研究经常用于鉴定药物和草药的相互作用。建议将药物-草药和草药-CYP相互作用研究纳入药物开发中。	Zhou SF Zhou ZW Li CG 贾秀虹	2008	国际药学研究杂志2008，35，3：	2
5	Transfusion in coronary ar-tery bypass grafting is associated with reduced long-term sur-vival显示文摘	Koch CG Li L Duncan AI	2006	Ann Thorac Surg2006，81，5：	1
6	Association analysis of single nucleo- tide polymorphisms of proinflammatory cytokine and their receptors genes with rheumatoid arthritis in northwest Chinese ttan population 显示文摘	You CG Li XJ Li YM	2013	Cytokine2013，61，1：	1
7	PAX Genes in Cancer;Friends or Foes显示文摘	Li CG Eccles MR	2012	Front Genet2012，，3：	1
8	Effective Application of Knowledge Management in Evidence-based Chinese Medicine:A Case Study显示文摘	Yang AW Allan G Li CG	2009	Evid Based Complement Alternat Med2009，6，3：	1
9	Stem cell factor/c-Kit interactions regulate human islet-epithelial cluster proliferation and differentialion显示文摘	Li J Goodyer CG Fellows F	2006	Int J Biochem Cell Biol2006，38，56：	1
10	Photocrosslinkable polysaccharides based on chondroitin sulfate显示文摘	Li Q Williams CG Sun DD	2004	J Biomed Mater Res A2004，68，1：	1
11	Percutaneous vertebroplasty for eosinophlic granuloma of the cervical spine in a child显示文摘	Tan HQ Li MH Wu CG	2007	Pediatr Radiol2007，37，10：	1
12	Structure-based design of novel guanidine/benzamidine mimics: potent and orally bioavailable factor Xa inhibitors as novel anticoagulants 显示文摘	Lam PY Clark CG Li R	2003	J Med Chem2003，46，21：	1
13	Deployment of endograft in the ascending aorta to reverse type A aortic dissection 显示文摘	Wang ZG Massimo CG Li M	2003	Asian J Surg2003，26，：	1
14	Transition-metal-based Lewis acid catalysis of aza-type Michael additions of amines to a,p-unsaturated electrophiles in water显示文摘	Xu LW Li L Xia CG	2004	Helv Chim Acta2004，87，6：	1
15	Effective surgical adjuvant therapy for high-risk rectal carcinoma显示文摘	Krook JE Moertel CG Gunderson LI	1991	N Engl J Med1991，324，11：	1
16	Duration of red-cell storage and complications after cardiac surgery显示文摘	Koch CG Li L Sessler DI	2008	N Engl J Med2008，358，12：	1
17	Identification of key tissue type for antler regeneration through pedicle periosteum deletion显示文摘	Li C Mackintosh CG Martin SK Clark DE	2007	Cell Tissue Res2007，328，1：	1
18	Functional role of a conserved motif in TM6 of the rat μ opioid receptor: constitutively active and inactive receptors result from substitutions of Thr6显示文摘	Huang P Jin Li Chen CG	2001	Biochemistry2001，40，13：	1
19	Association analysis of single nucleotide polymorphisms of proinflammatory cytokine and their receptors genes with rheumatoid arthritis in northwest Chinese Han population 显示文摘	You CG Li XJ Li YM	2013	Cytokine2013，61，1：	1
20	Persistent effect of red cell transfusion on health-related quality of life after cardiac surgery显示文摘	Koch CG Khandwala F Li L	2006	Ann Thorac Surg2006，82，1：	1

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