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| 1 | Elevated pro-inflammatory and lipotoxic mucosal lipids characterise irritable bowel syndrome显示文摘AIM:To investigate the pathophysiology of irritable bowel syndrome(IBS)by comparing the global mucosal metabolic profiles of IBS patients with those of healthy controls.METHODS:Fifteen IBS patients fulfilling the Rome Ⅱcriteria,and nine healthy volunteers were included in the study.A combined lipidomics(UPLC/MS)and metabolomics(GC×GC-TOF)approach was used to achieve global metabolic profiles of mucosal biopsies from the ascending colon.RESULTS:Overall,lipid levels were elevated in patients with IBS.The most significant upregulation was seen for pro-inflammatory lysophosphatidylcholines.Other lipid groups that were significantly upregulated in IBS patients were lipotoxic ceramides,glycosphingolipids,and di-and triacylglycerols.Among the metabolites,the cyclic ester 2(3H)-furanone was almost 14-fold upregulated in IBS patients compared to healthy subjects(P=0.03).CONCLUSION:IBS mucosa is characterised by a distinct pro-inflammatory and lipotoxic metabolic profile.Especially,there was an increase in several lipid species such as lysophospholipids and ceramides. | Kajsa Kajander Eveliina Myllyluoma Sinikka Kyrnpalo Martin Rasmussen Pentti Sipponen Ismo Mattila Tuulikki Seppnen-Laakso Heikki Vapaatalo Matej Orei Riitta Korpela | 2009 | World Journal of Gastroenterology2009，15，48： | 5 |
| 2 | The chemokines CXCL8 and CXCL12:molecular and functional properties,role in disease and efforts towards pharmacological intervention显示文摘Chemokines are an indispensable component of our immune system through the regulation of directional migration and activation of leukocytes.CxCL8 is the most potent human neutrophil-attracting chemokine and plays crucial roles in the response to infection and tissue injury.CXCL8 activity inherently depends on interaction with the human CXC chemokine receptors CXCR1 and CXCR2,the atypical chemokine receptor ACKR1,and glycosaminoglycans.Furthermore,(hetero)dimerization and tight regulation of transcription and translation,as well as post-translational modifications further fine-tune the spatial and temporal activity of CXCL8 in the context of inflammatory diseases and cancer.The CxCL8 interaction with receptors and glycosaminoglycans is therefore a promising target for therapy,as illustrated by multiple ongoing clinical trials.CXCL8-mediated neutrophil mobilization to blood is directly opposed by CXCL12,which retains leukocytes in bone marrow.CXCL12 is primarily a homeostatic chemokine that induces migration and activation of hematopoietic progenitor cells,endothelial cells,and several leukocytes through interaction with CXCR4,ACKR1,and ACKR3.Thereby,it is an essential player in the regulation of embryogenesis,hematopoiesis,and angiogenesis.However,CXCL12 can also exert inflammatory functions,as illustrated by its pivotal role in a growing list of pathologies and its synergy with CXCL8 and other chemokines to induce leukocyte chemotaxis.Here,we review the plethora of information on the CXCL8 structure,interaction with receptors and glycosaminoglycans,different levels of activity regulation,role in homeostasis and disease,and therapeutic prospects.Finally,we discuss recent research on CXCL12 biochemistry and biology and its role in pathology and pharmacology. | Seppe Cambier Mieke Gouwy Paul Proost | 2023 | Cellular & Molecular Immunology2023，20，3： | 4 |
| 3 | Fecal Transplantation, Through Colonoscopy, Is Effective Therapy for Recurrent Clostridium difficile Infection显示文摘 | Eero Mattila Raija Uusitalo–Sepp?l? Maarit Wuorela Laura Lehtola Heimo Nurmi Matti Ristikankare Veikko Moilanen Kimmo Salminen Maaria Sepp?l? Petri S. Mattila Veli–Jukka Anttila Perttu Arkkila | 2012 | Gastroenterology2012，，3： | 3 |
| 4 | Association of Helicobacter pylori IgA antibodies with the risk of peptic ulcer disease and gastric cancer显示文摘AIM: To compare the prevalence of Helicobacter pylori (Hpylori) IgG and IgA antibodies between adult subjects,with defined gastric diseases, nondefined gastric disorders and those representing the population.METHODS: Data on H pylori IgG and IgA antibodies,determined by enzyme immunoassay, were analyzed in 3 252 subjects with DGD including 482 patients with gastric ulcer, 882 patients with duodenal ulcer, 1 525patients with chronic gastritis only and 363 subjects with subsequent gastric cancer, 19 145 patients with NoDg and4 854 POPUL subjects. The age-adjusted prevalences were calculated for 1- and 20-year age cohorts.RESULTS: The prevalences of IgG antibodies were equally high (89-96%) in all 20-year age cohorts of the DGD groups, whereas the prevalences of IgG antibodies were lower and increased by age in the POPUL and NoDg groups. The prevalences of IgA antibodies were also higher in the DGD groups; among them CA (84-89%) and GU groups (78-91%) showed significantly higher prevalences than DU (68-77%) and CG patients (59-74%) (OR 2.49, 95%CI 1.86-3.34 between the GU and DU groups). In the CA, GU, and DU groups, the IgA prevalences showed only minor variation according to age, while they increased by age in the CG, POPUL, and NoDg groups (P≤0.0001). The IgA response, but not the IgG response, was associated with an increased risk of CA (OR 2.41, 95%CI 1.79-3.53) and GU (OR 2.57,95%CI 1.95-3.39) in comparison with CG patients.CONCLUSION: An IgA antibody response during H pylori infection is significantly more common in CA and GU patients as compared with CG patients. | Timo U Kosunen Kari Seppl Seppo Sarna Arpo Aromaa Paul Knekt Jarmo Virtamo Anniina Salomaa-Rsnen Hilpi Rautelin | 2005 | World Journal of Gastroenterology2005，11，43： | 3 |
| 5 | 地理空间约束的业务流程建模方法显示文摘明晰了受地理空间约束的业务流程的两个基本概念:地理位置与地理空间信息.首先,提出了地理空间约束思想,分析了地理空间约束的内涵,并在工作流元模型的知识基础上构建了地理空间约束的UML语义框架;其次,以形式化的方式提出了地理空间约束的业务流程建模方法(LAWF-net),并描述了LAWF-net模型转化为CPN可执行模型的规则,探讨了地理空间约束对流程建模的影响;最后,通过案例结合GIS系统来扩展CPN Tools,不仅验证了LAWF-net建模方法的可行性,而且实现了地理空间约束的业务流程的可视化. | 朱鑫伟 朱国宾 Seppe VANDEN BROUCKE | 2015 | 软件学报2015，26，3： | 3 |
| 6 | Vasohibin-1 and vasohibin-2 expression in gastric cancer cells and TAMs显示文摘 | Zhanlong Shen Tuuli Kauttu Hanna Sepp?nen Sanna Vainionp?? Yingjiang Ye Shan Wang Harri Mustonen Pauli Puolakkainen | 2012 | Medical Oncology2012，，4： | 2 |
| 7 | 血清补体C3/C4比值是再发心血管事件的新指标 | Palikhe A. Sinisalo J. Seppnen M. M.-L. Lokki 罗亮 | 2007 | 世界核心医学期刊文摘(心脏病学分册)2007，0，8： | 2 |
| 8 | Fluoride varnishes in caries prevention显示文摘 | | 2004 | Med Princ Pract2004，13，6： | 1 |
| 9 | Intestinal microbiota and immunoglobulin E responses in 5-year-old Estonian children 显示文摘 | Sepp E Julge K Mikelsaar M | 2005 | Clin Exp Allergy2005，35，： | 1 |
| 10 | Basic fibroblast growth factor increases expression of the alpha v beta 3 integrin complex on human microvascular endothelial cells显示文摘 | SEPP NT LI J LEE KH | 1994 | J Invest Dermatol1994，103，： | 1 |
| 11 | Influence of Department Volume on Survival for Ovarian Cancer: Results From a Prospective Quality Assurance Program of the Austrian Association for Gynecologic Oncology显示文摘 | Christian Marth Sonja Hiebl Willi Oberaigner Raimund Winter Sepp Leodolter Paul Sevelda | 2009 | International Journal of Gynecological Cancer2009，，1： | 1 |
| 12 | Effect of catalyst and polymerization conditions on the preparation of low molecular weight lactic acid polymers显示文摘 | Hiltunen K Seppǎlǎ J V Hǎrkǎnen M | 1997 | Macromolecules1997，30，： | 1 |
| 13 | The neuronal guidance cue Slit2 induces targeted migration and may play a role in brain metastasis of breast cancer cells显示文摘 | Bernd C. Schmid Günther A. Rezniczek Gerhild Fabjani Toshiyuki Yoneda Sepp Leodolter Robert Zeillinger | 2007 | Breast Cancer Research and Treatment2007，，3： | 1 |
| 14 | Metabolomic changes in fatty liver can be modified by dietary protein and calcium during energy restriction显示文摘AIM: To characterise the effect of energy restriction (ER) on liver lipid and primary metabolite profile by using metabolomic approach. We also investigated whether the effect of energy restriction can be further enhanced by modif ication of dietary protein source and calcium. METHODS: Liver metabolomic profile of lean and obese C57Bl/6J mice (n = 10/group) were compared with two groups of weight-reduced mice. ER was performed on control diet and whey protein-based high-calcium diet (whey + Ca). The metabolomicanalyses were performed using the UPLC/MS based lipidomic platform and the HPLC/MS/MS based primary metabolite platform. RESULTS: ER on both diets significantly reduced hepatic lipid accumulation and lipid droplet size, while only whey + Ca diet significantly decreased blood glucose (P < 0.001) and serum insulin (P < 0.01). In hepatic lipid species the biggest reduction was in the level of triacylglycerols and ceramides while the level of cholesterol esters was significantly increased during ER. Interestingly, diacylglycerol to phospholipid ratio, an indicator of relative amount of diabetogenic diglyceride species, was increased in the control ER group, but decreased in the whey + Ca ER group (P < 0.001, vs obese). ER on whey + Ca diet also totally reversed the obesity induced increase in the relative level of lipotoxic ceramides (P < 0.001, vs obese; P > 0.05, vs lean). These changes were accompanied with up-regulated TCA cycle and pentose phosphate pathway metabolites. CONCLUSION: ER-induced changes on hepatic metabolomic profile can be significantly affected by dietary protein source. The therapeutic potential of whey protein and calcium should be further studied. | Taru K Pilvi Tuulikki Seppnen-Laakso Helena Simolin Piet Finckenberg Anne Huotari Karl-Heinz Herzig Riitta Korpela Matej Orei Eero M Mervaala | 2008 | World Journal of Gastroenterology2008，14，28： | 1 |
| 15 | Successful treatment of recalcitrant relapsing polychondritis with monoclonal antibodies显示文摘 | Ratzinger G Kuen-Spiegl M Sepp N | 2009 | J Eur Acad Dermatol Venereol2009，23，4： | 1 |
| 16 | Basic fibroblast growth factor increases expression of the alpha v beta 3 integrin complex on human microvascular endothelial cells 显示文摘 | Sepp NT Li LJ Lee KH | 1994 | J Invest Dermatol1994，103，3： | 1 |
| 17 | Patent foramen ovale is not associated with an increased risk of stroke recurrence显示文摘 | Feurer R Sadikovic S Sepp D | 2010 | Eur J Neurol2010，17，11： | 1 |
| 18 | Markers of Insulin Sensitivity in 12-Year-Old Children Born from Preeclamptic Pregnancies显示文摘 | Sepp?S Voutilainen R Tenhola S | 2015 | J Pediatr2015，167，1： | 1 |
| 19 | Oral health-related knowledge, attitudes, behavior and family characteristics amo- ng Finnish schoolchildren with and without active initial caries lesions 显示文摘 | Poutanen R Lahti S Sepp L | 2007 | Acta Odontol Scand2007，65，2： | 1 |
| 20 | Complement C3 variant and the risk of age-related macular degeneration 显示文摘 | Yates JR Sepp T Matham BK | 2009 | N Engl J Med2009，357，6： | 1 |
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