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| 1 | New aspects in the pathomechanism and diagnosis of the laryngopharyngeal reflux-clinical impact of laryngeal proton pumps and pharyngeal p H metry in extraesophageal gastroesophageal reflux disease显示文摘AIM:To determine the laryngeal H+K+-ATPase and pharyngeal p H in patients with laryngopharyngeal reflux(LPR)-symptoms as well as to assess the symptom scores during PPI therapy.METHODS:Endoscopy was performed to exclude neoplasia and to collect biopsies from the posterior cricoid area(immunohistochemistry and PCR analysis).Immunohistochemical staining was performed with monoclonal mouse antibodies against human H+K+-ATPase.Quantitative real-time RT-PCR for each of the H+K+-ATPase subunits was performed.The p H values were assessed in the aerosolized environment of the oropharynx(Dxp H Catheter) and compared to a subsequently applied combined p H/MII measurement.RESULTS:Twenty patients with LPR symptoms were included.In only one patient,the laryngeal H+K+-ATPase was verified by immunohistochemical staining.In another patient,real-time RT-PCR for each H+K+-ATPase subunit was positive.Fourteen out of twenty patients had pathological results in Dxp H,and 6/20 patients had pathological results in p H/MII.Four patients had pathological results in both functional tests.Nine out of twenty patients responded to PPIs.CONCLUSION:The laryngeal H+K+-ATPase can only be sporadically detected in patients with LPR symptoms and is unlikely to cause the LPR symptoms.Alternative hypotheses for the pathomechanism are needed.The role of pharyngeal p H-metry remains unclearand its use can only be recommended for patients in a research study setting. | Valentin Becker Romina Drabner Simone Graf Christoph Schlag Simon Nennstiel Anna Maria Buchberger Roland M Schmid Dieter Saur Monther Bajbouj | 2015 | World Journal of Gastroenterology2015，21，3： | 14 |
| 2 | 粲物理中的CP破坏:发现和展望显示文摘In physics, the symmetries and their violation always provide deep insights into the Nature. The parity (P) symmetry represents the system is unchanged under the space reflection. The violation of parity, firstly proposed by Lee and Yang and subsequently discovered in 1956, plays the key role in the understanding of the weak interaction which is one of the four basic forces of nature. | Miroslav Saur 于福升 | 2020 | Science Bulletin2020，65，17： | 3 |
| 3 | Nociceptin effect on intestinal motility depends on opioidreceptor like-1 receptors and nitric oxide synthase colocalization显示文摘AIM: To study the effect of the opioid-receptor like-1(ORL1) agonist nociceptin on gastrointestinal(GI)myenteric neurotransmission and motility. METHODS: Reverse transcriptase- polymerase chain reaction and immunohistochemistry were used to localize nociceptin and ORL1 in mouse tissues. Intracellular electrophysiological recordings of excitatory and inhibitory junction potentials(EJP, IJP) were made in a chambered organ bath. Intestinal motility was measured in vivo. RESULTS: Nociceptin accelerated whole and upper GI transit, but slowed colonic expulsion in vivo in an ORL1-dependent manner, as shown using [Nphe1]NOC and AS ODN pretreatment. ORL1 and nociceptin immunoreactivity were found on enteric neurons. Nociceptin reduced the EJP and the nitric oxide-sensitive slow IJP in an ORL1-dependent manner, whereas the fast IJP was unchanged. Nociceptin further reduced the spatial spreading of the EJP up to 2 cm. CONCLUSION: Compounds acting at ORL1 are good candidates for the future treatment of disorders associated with increased colonic transit, such as diarrhea or diarrhea-predominant irritable bowel syndrome. | Andrei Sibaev Jakub Fichna Dieter Saur Birol Yuece Jean-Pierre Timmermans Martin Storr | 2015 | World Journal of Gastrointestinal Pharmacology and Therapeutics2015，6，3： | 2 |
| 4 | IL-6 trans-signaling promotes pancreatitis-associated lung injury and lethality显示文摘 | Zhang Hong Neuh?fer Patrick Song Liang Rabe Bj?rn Lesina Marina Kurkowski Magdalena U Treiber Matthias Wartmann Thomas Regnér Sara Thorlacius Henrik Saur Dieter Weirich Gregor Yoshimura Akihiko Halangk Walter Mizgerd Joseph P Schmid Roland | 2013 | Journal of Clinical Investigation2013，，3： | 2 |
| 5 | External control of anthocyanin formation in apple显示文摘 | Saure M C | 1990 | Scientia Horticulturae1990，42，： | 1 |
| 6 | Influence of platinum on ceria sulfation 显示文摘 | BAZIN P SAUR O LAVALLEY J C BLANCHARD G VISCIGLIO V TOURET O | 1997 | Applied Catalysis B: Environmental1997，11，34： | 1 |
| 7 | Physical problems with the vitrification of large biological systems显示文摘 | Fahy G M Saur J Williams R J | 1990 | Cryobiology1990，27，： | 1 |
| 8 | Acetylation as a Transcriptional Control Mechanism—HDACs and HATs in Pancreatic Ductal Adenocarcinoma显示文摘 | Günter Schneider Oliver H. Kr?mer Roland M. Schmid Dieter Saur | 2011 | Journal of Gastrointestinal Cancer2011，，： | 1 |
| 9 | Reassessment of the role of calcium in development of bitter pit in apple 显示文摘 | Saure MC | 1996 | Australian Journal of Plant Physiology1996，23，： | 1 |
| 10 | Melatonin reduces non-adrenergic, non-cholinergic relaxant neurotransmission by inhibition of nitric oxide synthase activity in the gastrointestinal tract of rodents in vitro 显示文摘 | Storr M Koppitz P Sibaev A Saur D Kurjak M Franck H | 2002 | J Pineal Res2002，33，2： | 1 |
| 11 | Dynamics of language reorganization after stroke显示文摘 | Saur D Lange R Baumgaertner A | 2006 | Brain2006，，129： | 1 |
| 12 | Choosing the optimal wall shear parameter for the prediction of plaque location—A patient-specific computational study in human left coronary arteries显示文摘 | Farhad Rikhtegar Joseph A. Knight Ufuk Olgac Stefan C. Saur Dimos Poulikakos William Marshall Philippe C. Cattin Hatem Alkadhi Vartan Kurtcuoglu | 2012 | Atherosclerosis2012，，2： | 1 |
| 13 | External control of anthocyan in information in apple显示文摘 | Saure M C | 1990 | Scienti a Horticulture1990，42，： | 1 |
| 14 | External control of anthocyanin formation in apple: a review显示文摘 | SAURE M | 1990 | Scientia Horticulturae1990，42，3： | 1 |
| 15 | External control of anthocyanin formation in apple显示文摘 | SAURE M C | 1990 | Sci Hort1990，42，： | 1 |
| 16 | New views of the prerequisites for an occurrence of bitter pit in apple and its control by calcium sprays 显示文摘 | Saure MC | 2002 | Acta Hort (ISHS)2002，594，： | 1 |
| 17 | Dynamics of lan- guage reorganization after stroke显示文摘 | Saur D Lange R Baumgaertner A | 2006 | Brain2006，129，6： | 1 |
| 18 | External control of anthocyanin formation in apple显示文摘 | Saure M C | 1990 | Scientia Horticulturae1990，42，3： | 1 |
| 19 | External control of anthocyanin formation in apple显示文摘 | Saure MC | 1990 | Sci Hort1990，42，： | 1 |
| 20 | Calcium translocation to fleshy fruit: its mechan- wasmand endogenous control 显示文摘 | Saure M C | 2005 | Scientia Horticulturae2005，105，： | 1 |
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