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145篇 您的检索式:作者名="SAURE M"
    题名 作者 年代 出处 被引量
1New aspects in the pathomechanism and diagnosis of the laryngopharyngeal reflux-clinical impact of laryngeal proton pumps and pharyngeal p H metry in extraesophageal gastroesophageal reflux disease显示文摘AIM:To determine the laryngeal H+K+-ATPase and pharyngeal p H in patients with laryngopharyngeal reflux(LPR)-symptoms as well as to assess the symptom scores during PPI therapy.METHODS:Endoscopy was performed to exclude neoplasia and to collect biopsies from the posterior cricoid area(immunohistochemistry and PCR analysis).Immunohistochemical staining was performed with monoclonal mouse antibodies against human H+K+-ATPase.Quantitative real-time RT-PCR for each of the H+K+-ATPase subunits was performed.The p H values were assessed in the aerosolized environment of the oropharynx(Dxp H Catheter) and compared to a subsequently applied combined p H/MII measurement.RESULTS:Twenty patients with LPR symptoms were included.In only one patient,the laryngeal H+K+-ATPase was verified by immunohistochemical staining.In another patient,real-time RT-PCR for each H+K+-ATPase subunit was positive.Fourteen out of twenty patients had pathological results in Dxp H,and 6/20 patients had pathological results in p H/MII.Four patients had pathological results in both functional tests.Nine out of twenty patients responded to PPIs.CONCLUSION:The laryngeal H+K+-ATPase can only be sporadically detected in patients with LPR symptoms and is unlikely to cause the LPR symptoms.Alternative hypotheses for the pathomechanism are needed.The role of pharyngeal p H-metry remains unclearand its use can only be recommended for patients in a research study setting.Valentin Becker Romina Drabner Simone Graf Christoph Schlag Simon Nennstiel Anna Maria Buchberger Roland M Schmid Dieter Saur Monther Bajbouj 2015World Journal of Gastroenterology2015,21,3:14
2External control of anthocyanin formation in apple显示文摘Saure M C 1990Scientia Horticulturae1990,42,:1
3Physical problems with the vitrification of large biological systems显示文摘Fahy G M Saur J Williams R J 1990Cryobiology1990,27,:1
4Melatonin reduces non-adrenergic, non-cholinergic relaxant neurotransmission by inhibition of nitric oxide synthase activity in the gastrointestinal tract of rodents in vitro 显示文摘Storr M Koppitz P Sibaev A Saur D Kurjak M Franck H 2002J Pineal Res2002,33,2:1
5External control of anthocyan in information in apple显示文摘Saure M C 1990Scienti a Horticulture1990,42,:1
6External control of anthocyanin formation in apple: a review显示文摘SAURE M 1990Scientia Horticulturae1990,42,3:1
7External control of anthocyanin formation in apple显示文摘SAURE M C 1990Sci Hort1990,42,:1
8External control of anthocyanin formation in apple显示文摘Saure M C 1990Scientia Horticulturae1990,42,3:1
9Calcium translocation to fleshy fruit: its mechan- wasmand endogenous control 显示文摘Saure M C 2005Scientia Horticulturae2005,105,:1
10External control of anthocyanin formation in apple显示文摘Saure M C 1990Sci Hort1990,42,3:1
11External control of anthocyanin formation in apple显示文摘 1990Sci Hort1990,42,:1
12Inter-observer agreement of ultrasonographic measurement of alpha and beta angles and the final type classification based on the Graf method显示文摘Simon EA Saur F Buerge M 2004Swiss Med2004,134,5:1
13Calcium transloeation to fleshy fruit: its mechanism and endogenous control 显示文摘Saure M C 2005Sci Hortic2005,105,1:1
14Nature and mechanism of formation of sulfate species on copper/alumina sorbentcatalysts for SO2显示文摘Waqif M Saur O Lavlley J C 1991Removal J Phys Chem1991,95,10:1
15External control of anthocyanin formation in apple显示文摘Saure M C 1990Sci Hort1990,30,:1
16External control of anthocyanin formation in apple显示文摘Saure M C 1990Sci Hort1990,30,:1
17Phosphoinositide-3-kinase signaling controls S-phase kinase-associated protein 2 transcription via E2F1 in pancreatic ductal adenocarcinoma cells 显示文摘Reichert M Saur D Hamacher R 2007Cancer Res2007,67,9:1
18Inter observer agreement of ltrasonographic measurement of alpha and beta angles and the final type classification based on the Graf method显示文摘Simon EA Saur F Buerge M 2004Swiss Med Wkly2004,134,4546:1
19University - Industry Networks for Innovation 显示文摘Marques M J Alves J Saur I 2005Regional Growth Agendas Conference Aalborg Denmark2005,2005,:1
20External control of anthocyanin formation in apple 显示文摘Saur M C 1990Scientia Horticulture1990,42,3:1
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