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| 1 | A Neuro-genetic Based Short-term Forecasting Framework for Network Intrusion Prediction System显示文摘Information systems are one of the most rapidly changing and vulnerable systems, where security is a major issue. The number of security-breaking attempts originating inside organizations is increasing steadily. Attacks made in this way, usually done by 'authorized' users of the system, cannot be immediately traced. Because the idea of filtering the traffic at the entrance door, by using firewalls and the like, is not completely successful, the use of intrusion detection systems should be considered to increase the defense capacity of an information system. An intrusion detection system (IDS) is usually working in a dynamically changing environment, which forces continuous tuning of the intrusion detection model, in order to maintain sufficient performance. The manual tuning process required by current IDS depends on the system operators in working out the tuning solution and in integrating it into the detection model. Furthermore, an extensive effort is required to tackle the newly evolving attacks and a deep study is necessary to categorize it into the respective classes. To reduce this dependence, an automatically evolving anomaly IDS using neuro-genetic algorithm is presented. The proposed system automatically tunes the detection model on the fly according to the feedback provided by the system operator when false predictions are encountered. The system has been evaluated using the Knowledge Discovery in Databases Conference (KDD 2009) intrusion detection dataset. Genetic paradigm is employed to choose the predominant features, which reveal the occurrence of intrusions. The neuro-genetic IDS (NGIDS) involves calculation of weightage value for each of the categorical attributes so that data of uniform representation can be processed by the neuro-genetic algorithm. In this system unauthorized invasion of a user are identified and newer types of attacks are sensed and classified respectively by the neuro-genetic algorithm. The experimental results obtained in this work show that the system achieves improvement in terms of misclassification cost when compared with conventional IDS. The results of the experiments show that this system can be deployed based on a real network or database environment for effective prediction of both normal attacks and new attacks. | Siva S. Sivatha Sindhu S. Geetha M. Marikannan A. Kannan | 2009 | International Journal of Automation and computing2009，6，4： | 7 |
| 2 | Antineoplastic effects of deoxyelephantopin,a sesquiterpene lactone from Elephantopusscaber, on lung adenocarcinoma (A549) cells显示文摘OBJECTIVE: Deoxyelephantopin, a sesquiterpene lactone from Elephantopus scaber, showed inhibition of the growth of various tumor cells in vitro. In the present study, we investigated the cytotoxicity and apoptosis-inducing capacity of deoxyelephantopin on lung adenocarcinoma (A549) cells. METHODS: The cytotoxic effect of deoxyelephantopin on A549 cells and normal lymphocytes was evaluated using 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay and 50% inhibitory concentration (IC50) value was determined. The self-renewal and proliferating potential of A549 cells after treatment with deoxyelephantopin were examined by colony formation assay. Cellular morphology of deoxyelephantopin-treated cells was observed using phasecontrast microscopy. The induction of apoptosis was evaluated using acridine orange and ethidium bromide staining, Hoechst 33342 staining, terminal deoxynucleotidyl transferase-mediated dUTP biotin nick end-labeling (TUNEL) assay, DNA fragmentation analysis and Annexin V-fluorescein isothiocyanate staining by flow cytometry. Activation of caspases was detected using fluorogenic substrate specific to caspases 2, 3, 8 and 9 and flow cytometric analysis. The total cellular DNA content and expression of cleaved poly (ADP-ribose) polymerase was also analyzed. RESULTS: Deoxyelephantopin exhibited cytotoxicity to A549 cells (IC50=12.287 μg/mL), however, there was no toxicity towards normal human lymphocytes. Deoxyelephantopin suppressed the colony-forming ability of A549 cells in a dose-dependent manner. Acridine orange, ethidium bromide and Hoechst 33342 staining showed cell shrinkage, chromosomal condensation and nuclear fragmentation, indicating induction of apoptosis. Deoxyelephantopin increased apoptosis of A549 cells, as evidenced by more TUNEL-positive cells. DNA fragmentation and Annexin V staining revealed late-stage apoptotic cell population. Deoxyelephantopin inhibited A549 cell growth by cell cycle arrest at G2/M phase and induced apoptosis through both extrinsic and intrinsic pathways. CONCLUSION: These results suggest that deoxyelephantopin has great potential as a new chemotherapeutic agent to be developed further for the treatment of lung cancer. | Farha A. Kabeer Geetha B. Sreedevi Mangalam S. Nair Dhanya S. Rajalekshmi LathaP. Gopalakrishnan Sujathan Kunjuraman Remani Prathapan | 2013 | Journal of Integrative Medicine2013，11，4： | 4 |
| 3 | Safety evaluation of superabsorbent baby diapers显示文摘 | Kirstin Kosemund Harald Schlatter Jennifer L. Ochsenhirt Edburga L. Krause Daniel S. Marsman Geetha N. Erasala | 2008 | Regulatory Toxicology and Pharmacology2008，，2： | 1 |
| 4 | Tribological and electrical properties of nanocrystalline Cu films deposited by DC magnetron sputtering with varying temperature显示文摘 | M. Geetha N. Kumar K. Panda S. Dhara S. Dash B.K. Panigrahi A.K. Tyagi R. Jayavel V. Kamaraj | 2013 | Tribology International2013，，： | 1 |
| 5 | Effect of Feronia limonia on mosquito larvae显示文摘 | A.Abdul Rahuman Geetha Gopalakrishnan B.Saleem Ghouse S. Arumugam B. Himalayan | 2000 | Fitoterapia2000，，5： | 1 |
| 6 | Sol–gel derived silver doped nanocrystalline titania catalysed photodegradation of methylene blue from aqueous solution显示文摘 | Senthilkumaar S. Porkodi K. Gomathi R. Geetha Maheswari A. Manonmani N | 2005 | Dyes and Pigments2005，，1： | 1 |
| 7 | Incidence and Management of Gastrointestinal Bleeding With Continuous Flow Assist Devices显示文摘 | Ashim Aggarwal Rojina Pant Shivani Kumar Priya Sharma Colleen Gallagher Antone J. Tatooles Pat S. Pappas Geetha Bhat | 2012 | The Annals of Thoracic Surgery2012，，： | 1 |
| 8 | CHEBYSHEV CENTERS PROXIMINALITY AND FARTHEST POINTS IN STRONG NORMED ALMOST LINEAR SPACES显示文摘Some results from the theory of best (or best simultaneous) approximation in a narmed linear space have been extended to a normed almost linear space [strong normed almost linear space]. | Geetha S. Rao T. L. Bhaskaramurthi | 1997 | Analysis in Theory and Applications1997，13，4： | 0 |
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