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| 1 | Comparison of TiAlN, AlCrN, and AlCrN/TiAlN coatings for cutting-tool applications显示文摘Monolayer and bilayer coatings of TiAlN, AlCrN, and AlCrN/TiAlN were deposited onto tungsten carbide inserts using the plasma enhanced physical vapor deposition process. The microstructures of the coatings were characterized using scanning electron microscopy(SEM) and atomic force microscopy(AFM). The SEM micrographs revealed that the AlCrN and AlCrN/TiAlN coatings were uniform and highly dense and contained only a limited number of microvoids. The TiAlN coating was non-uniform and highly porous and contained more micro droplets. The hardness and scratch resistance of the specimens were measured using a nanoindentation tester and scratch tester, respectively. Different phases formed in the coatings were analyzed by X-ray diffraction(XRD). The AlCrN/TiAlN coating exhibited a higher hardness(32.75 GPa), a higher Young's modulus(561.97 GPa), and superior scratch resistance(LCN = 46 N) compared to conventional coatings such as TiAlN, AlCrN, and TiN. | T.Sampath Kumar S.Balasivanandha Prabu Geetha Manivasagam K.A.Padmanabhan | 2014 | International Journal of Minerals,Metallurgy and Materials2014，21，8： | 8 |
| 2 | Lessons learned from an audit of 1250 anal fistula patients operated at a single center:A retrospective review显示文摘BACKGROUND A complex anal fistula is a challenging disease to manage.AIM To review the experience and insights gained in treating a large cohort of patients at an exclusive fistula center.METHODS Anal fistulas operated on by a single surgeon over 14 years were analyzed.Preoperative magnetic resonance imaging was done in all patients.Four procedures were performed:fistulotomy;two novel sphincter-saving procedures,proximal superficial cauterization of the internal opening and regular emptying and curettage of fistula tracts(PERFACT)and transanal opening of intersphincteric space(TROPIS),and anal fistula plug.PERFACT was initiated before TROPIS.As per the institutional GFRI algorithm,fistulotomy was done in simple fistulas,and TROPIS was done in complex fistulas.Fistulas with associated abscesses were treated by definitive surgery.Incontinence was evaluated objectively by Vaizey incontinence scores.RESULTS A total of 1351 anal fistula operations were performed in 1250 patients.The overall fistula healing rate was 19.4%in anal fistula plug(n=56),50.3%in PERFACT(n=175),86%in TROPIS(n=408),and 98.6%in fistulotomy(n=611)patients.Continence did not change significantly after surgery in any group.As per the new algorithm,1019 patients were operated with either the fistulotomy or TROPIS procedure.The overall success rate was 93.5%in those patients.In a subgroup analysis,the overall healing rate in supralevator,horseshoe,and fistulas with an associated abscess was 82%,85.8%,and 90.6%,respectively.The 90.6%healing rate in fistulas with an associated abscess was comparable to that of fistulas with no abscess(94.5%,P=0.057,not significant).CONCLUSION Fistulotomy had a high 98.6%healing rate in simple fistulas without deterioration of continence if the patient selection was done judiciously.The sphincter-sparing procedure,TROPIS,was safe,with a satisfactory 86%healing rate for complex fistulas.This is the largest anal fistula series to date. | Pankaj Garg Baljit Kaur Ankita Goyal Vipul D Yagnik Sushil Dawka Geetha R Menon | 2021 | World Journal of Gastrointestinal Surgery2021，13，4： | 8 |
| 3 | A Neuro-genetic Based Short-term Forecasting Framework for Network Intrusion Prediction System显示文摘Information systems are one of the most rapidly changing and vulnerable systems, where security is a major issue. The number of security-breaking attempts originating inside organizations is increasing steadily. Attacks made in this way, usually done by 'authorized' users of the system, cannot be immediately traced. Because the idea of filtering the traffic at the entrance door, by using firewalls and the like, is not completely successful, the use of intrusion detection systems should be considered to increase the defense capacity of an information system. An intrusion detection system (IDS) is usually working in a dynamically changing environment, which forces continuous tuning of the intrusion detection model, in order to maintain sufficient performance. The manual tuning process required by current IDS depends on the system operators in working out the tuning solution and in integrating it into the detection model. Furthermore, an extensive effort is required to tackle the newly evolving attacks and a deep study is necessary to categorize it into the respective classes. To reduce this dependence, an automatically evolving anomaly IDS using neuro-genetic algorithm is presented. The proposed system automatically tunes the detection model on the fly according to the feedback provided by the system operator when false predictions are encountered. The system has been evaluated using the Knowledge Discovery in Databases Conference (KDD 2009) intrusion detection dataset. Genetic paradigm is employed to choose the predominant features, which reveal the occurrence of intrusions. The neuro-genetic IDS (NGIDS) involves calculation of weightage value for each of the categorical attributes so that data of uniform representation can be processed by the neuro-genetic algorithm. In this system unauthorized invasion of a user are identified and newer types of attacks are sensed and classified respectively by the neuro-genetic algorithm. The experimental results obtained in this work show that the system achieves improvement in terms of misclassification cost when compared with conventional IDS. The results of the experiments show that this system can be deployed based on a real network or database environment for effective prediction of both normal attacks and new attacks. | Siva S. Sivatha Sindhu S. Geetha M. Marikannan A. Kannan | 2009 | International Journal of Automation and computing2009，6，4： | 7 |
| 4 | Ti based biomaterials, the ultimate choice for orthopaedic implants – A review显示文摘 | M. Geetha A.K. Singh R. Asokamani A.K. Gogia | 2008 | Progress in Materials Science2008，，3： | 6 |
| 5 | Guidelines on postoperative magnetic resonance imaging in patients operated for cryptoglandular anal fistula:Experience from 2404 scans显示文摘Magnetic resonance imaging(MRI)is considered the gold standard for the evaluation of anal fistulas.There is sufficient literature available outlining the interpretation of fistula MRI before performing surgery.However,the interpretation of MRI becomes quite challenging in the postoperative period after the surgery of fistula has been undertaken.Incidentally,there are scarce data and no set guidelines regarding analysis of fistula MRI in the postoperative period.In this article,we discuss the challenges faced while interpreting the postoperative MRI,the timing of the postoperative MRI,the utility of MRI in the postoperative period for the management of anal fistulas,the importance of the active involvement and experience of the treating clinician in interpreting MRI scans,and the latest advancements in the field. | Pankaj Garg Baljit Kaur Vipul D Yagnik Sushil Dawka Geetha R Menon | 2021 | World Journal of Gastroenterology2021，27，33： | 6 |
| 6 | Antineoplastic effects of deoxyelephantopin,a sesquiterpene lactone from Elephantopusscaber, on lung adenocarcinoma (A549) cells显示文摘OBJECTIVE: Deoxyelephantopin, a sesquiterpene lactone from Elephantopus scaber, showed inhibition of the growth of various tumor cells in vitro. In the present study, we investigated the cytotoxicity and apoptosis-inducing capacity of deoxyelephantopin on lung adenocarcinoma (A549) cells. METHODS: The cytotoxic effect of deoxyelephantopin on A549 cells and normal lymphocytes was evaluated using 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay and 50% inhibitory concentration (IC50) value was determined. The self-renewal and proliferating potential of A549 cells after treatment with deoxyelephantopin were examined by colony formation assay. Cellular morphology of deoxyelephantopin-treated cells was observed using phasecontrast microscopy. The induction of apoptosis was evaluated using acridine orange and ethidium bromide staining, Hoechst 33342 staining, terminal deoxynucleotidyl transferase-mediated dUTP biotin nick end-labeling (TUNEL) assay, DNA fragmentation analysis and Annexin V-fluorescein isothiocyanate staining by flow cytometry. Activation of caspases was detected using fluorogenic substrate specific to caspases 2, 3, 8 and 9 and flow cytometric analysis. The total cellular DNA content and expression of cleaved poly (ADP-ribose) polymerase was also analyzed. RESULTS: Deoxyelephantopin exhibited cytotoxicity to A549 cells (IC50=12.287 μg/mL), however, there was no toxicity towards normal human lymphocytes. Deoxyelephantopin suppressed the colony-forming ability of A549 cells in a dose-dependent manner. Acridine orange, ethidium bromide and Hoechst 33342 staining showed cell shrinkage, chromosomal condensation and nuclear fragmentation, indicating induction of apoptosis. Deoxyelephantopin increased apoptosis of A549 cells, as evidenced by more TUNEL-positive cells. DNA fragmentation and Annexin V staining revealed late-stage apoptotic cell population. Deoxyelephantopin inhibited A549 cell growth by cell cycle arrest at G2/M phase and induced apoptosis through both extrinsic and intrinsic pathways. CONCLUSION: These results suggest that deoxyelephantopin has great potential as a new chemotherapeutic agent to be developed further for the treatment of lung cancer. | Farha A. Kabeer Geetha B. Sreedevi Mangalam S. Nair Dhanya S. Rajalekshmi LathaP. Gopalakrishnan Sujathan Kunjuraman Remani Prathapan | 2013 | Journal of Integrative Medicine2013，11，4： | 4 |
| 7 | Prevalences of oligozoospermia and azoospermia in male partners of infertile couples from different parts of India显示文摘瞄准:为了决定是否在精子缺乏, oligozoospermia 和平均数的流行有任何地区性的变化,精子从印度的不同部分在不肥沃的夫妇的男搭挡数。方法:从位于印度的五个城市的六个不同实验室在过去的五年分析的 16,714 件精液样品上的数据被对照并且评估。结果:在精子缺乏的流行有一个地区性的变化。精子缺乏的流行在 Kurnool 和 Jodhpur 极其高(38.3% 和 37.4% ,分别地) 。也在 Kurnool 在 oligozoospermia (51%) 的流行有一个地区性的变化。在精子在 normospermic 人数的平均数没有有效差量。结论:在精子缺乏的流行有一个地区性的变化,在男性的 oligozoospermia 从印度的不同区域不肥沃的夫妇合伙。在 Kurnool 和 Jodhpur 的精子缺乏的流行比任何另外的全球报导的文学高。进一步的研究需要被执行决定这的原因。 | Rajvi H.Mehta Sanjay Makwana Geetha M. Ranga R.J.Srinivasan S.S.Virk | 2006 | Asian Journal of Andrology2006，8，1： | 3 |
| 8 | Diagnosis of anorectal tuberculosis by polymerase chain reaction,GeneXpert and histopathology in 1336 samples in 776 anal fistula patients显示文摘BACKGROUND The association of tuberculosis(TB)with anal fistulas can make its treatment quite difficult.The main challenge is timely detection of TB in anal fistulas and its proper management.There is little data available on diagnosis and management of TB in anal fistulas.AIM To detect TB in fistula-in-ano patients were analyzed in different methods utilized.METHODS A retrospective analysis of different methods,polymerase chain-reaction(PCR),GeneXpert and histopathology(HPE),utilized to detect tuberculosis in fistula-inano patients,treated between 2014-2020,was performed.The sampling was done for tissue(fistula tract lining)and pus(when available).The detection rate of various tests to detect TB and prevalence rate of TB in simple vs complex fistulae were studied.RESULTS In 1336 samples(776 patients)tested,TB was detected in 133 samples(122 patients).TB was detected in 52/703(7.4%)samples tested by PCR-tissue,in 77/331(23.2%)samples tested by PCR-pus,3/197(1.5%)samples tested with HPE-tissue and 1/105(0.9%)samples tested by GeneXpert.To detect TB,PCRtissue was significantly better than HPE-tissue(52/703 vs 3/197 respectively)(P=0.0012,significant,Fisher’s exact test)and PCR-pus was significantly better than PCR-tissue(77/331 vs 52/703 respectively)(P<0.00001,significant,Fisher’s exact test).TB fistulas were more complex than non-tuberculous fistulas[78/113(69%)vs 278/727(44.3%)respectively](P<0.00001,significant,Fisher’s exact test)but the overall healing rate was similar in tuberculous and non-tuberculous fistula groups[90/102(88.2%)vs 518/556(93.2%)respectively](P=0.10,not significant,Fisher’s exact test).CONCLUSION This is the largest study of anorectal TB to be published.The detection of TB by polymerase chain-reaction was significantly higher than by histopathology and GeneXpert.Amongst polymerase chain-reaction,pus had a higher detection rate than tissue.TB fistulas were more complex than non-tuberculous fistulas but aggressive diagnosis and meticulous treatment led to comparable overall success rates in both groups. | Pankaj Garg Ankita Goyal Vipul D Yagnik Sushil Dawka Geetha R Menon | 2021 | World Journal of Gastrointestinal Surgery2021，13，4： | 3 |
| 9 | Ti based biomaterials, the ultimate choice for orthopaedic implants – A review显示文摘 | M. Geetha A.K. Singh R. Asokamani A.K. Gogia | 2008 | Progress in Materials Science2008，，3： | 3 |
| 10 | Isolation and identification of mosquito larvicidal compound from Abutilon indicum (Linn.) Sweet显示文摘 | A. Abdul Rahuman Geetha Gopalakrishnan P. Venkatesan Kannappan Geetha | 2008 | Parasitology Research2008，，5： | 3 |
| 11 | The cellular and molecular basis of hyperthermia显示文摘 | Bert Hildebrandt Peter Wust Olaf Ahlers Annette Dieing Geetha Sreenivasa Thoralf Kerner Roland Felix Hanno Riess | 2002 | Critical Reviews in Oncology and Hematology2002，，： | 3 |
| 12 | Pyoderma Gangrenosum with Oral Involvement–Case Report and Review of the Literature显示文摘Pyoderma gangrenosum (PG) is a rare, noninfectious neutrophilic dermatosis. Clinically, it begins with sterile pustules that rapidly progress into painful ulcers of variable depth and size with undermined violaceous borders. The diagnosis of PG is based on the history of an underlying disease, a typical clinical presentation, histopathology, and exclusion of other diseases. The peak incidence occurs between the ages of 20 to 50 years with women being more often affected than men. There have been very few reports of pyoderma gangrenosum with oral mucosal involvement. Oral lesions in previously reported cases have included ulcers of varying sizes from a few mm to several cm and have been reported to have been found on the tongue, soft and hard palate, buccal mucosa, and gingiva. Some of these oral lesions have been associated with ulcerative colitis, inflammatory bowel disease, and polycythemia rubra vera. A few cases were reported with biopsy findings, the histological picture being nonspecific, showing ulceration, and necrosis with inflam- matory cell infiltrate. A peculiar case of pyoderma gan- grenosum with an oral lesion is presented here, and the differential diagnosis is discussed. | Geetha Paramkusam Venkateswarlu Meduri Naresh Gangeshetty | 2010 | International Journal of Oral Science2010，2，2： | 2 |
| 13 | 材料模型对高温Ti-6Al-4V合金理论成形极限图预测的影响(英文)显示文摘成形极限图是一种用来描述使板材不发生局部颈缩所需最大主应变的重要图形。它是一种预测板材变形过程中变形极限的方便、有效的工具。本研究中,在400°C和不同样品宽度的条件,通过Nakazima实验得到了Ti-6Al-4V合金的成形极限图。此外,为了使用成形极限图对材料参数进行理论预测,提出了不同的各向异性屈服准则(Barlat 1989,Barlat 1996,Hill 1993)和不同的硬化模型(Hollomon幂定律、Johnson-Cook(JC)模型、改进的Zerilli-Armstrong(m-ZA)和Arrhenius(m-Arr)模型)。结合所提出的屈服准则和本构模型,通过Marciniak和Kuczynski(M-K)理论确定了Ti-6Al-4V合金的成形极限图。结果表明:屈服模型对材料成形极限图的影响大于本构模型的影响。然而,材料的厚度缺陷系数(f_0)与其硬化模型密切相关。Hill(1993)屈服准则最适合于成形极限图右边区域的预测,而Barlat(1989)屈服准最适合于成形极限图左边区域的预测。由于所得到的混合理论成形极限图兼具Barlat(1989)和Hill(1993)屈服模型和m-Arr硬化模型的优点,因此,它与实验得到的成形极限图吻合很好。 | Nitin KOTKUNDE Sashank SRINIVASAN Geetha KRISHNA Amit Kumar GUPTA Swadesh Kumar SINGH | 2016 | Transactions of Nonferrous Metals Society of China2016，26，3： | 2 |
| 14 | Guidelines to diagnose and treat peri-levator high-5 anal fistulas: Supralevator, suprasphincteric, extrasphincteric, high outersphincteric, and high intrarectal fistulas显示文摘Supralevator,suprasphincteric,extrasphincteric,and high intrarectal fistulas(high fistulas in muscle layers of the rectal wall)are well-known high anal fistulas which are considered the most complex and extremely challenging fistulas to manage.Magnetic resonance imaging has brought more clarity to the pathophysiology of these fistulas.Along with these fistulas,a new type of complex fistula in high outersphincteric space,a fistula at the roof of ischiorectal fossa inside the levator ani muscle(RIFIL),has been described.The diagnosis,management,and prognosis of RIFIL fistulas is reported to be even worse than supralevator and suprasphincteric fistulas.There is a lot of confusion regarding the anatomy,diagnosis,and management of these five types of fistulas.The main reason for this is the paucity of literature about these fistulas.The common feature of all these fistulas is their complete involvement of the external anal sphincter.Therefore,fistulotomy,the simplest and most commonly performed procedure,is practically ruled out in these fistulas and a sphincter-saving procedure needs to be performed.Recent advances have provided new insights into the anatomy,radiological modalities,diagnosis,and management of these five types of high fistulas.These have been discussed and guidelines formulated for the diagnosis and treatment of these fistulas for the first time in this paper. | Pankaj Garg Vipul D Yagnik Sushil Dawka Baljit Kaur Geetha R Menon | 2022 | World Journal of Gastroenterology2022，28，16： | 2 |
| 15 | Molecular characterization of DnaJ 5 homologs in silkworm Bombyx mori and its expression during egg diapause显示文摘有 B 的 Bombyx mori DnaJ 5 相当或相同的事物的 cDNA 序列(1 056 bp ) 的比较。mori 染色体揭示了那在另外的 Hsps 不同,它有 234 bp 的 intron。DnaJ 5 相当或相同的事物包含 351 氨基酸, 70 在 N 终端结束包含保存 DnaJ 领域。B 的这个相当或相同的事物。mori 有类似于另外的昆虫,和在 B 识别的 13 个不同 DnaJ 相当或相同的事物的所有理想的功能的领域。mori 染色体在不同染色体上被散布。Hsp40 基因表示的表示顺序标签数据库分析表明在翅膀圆盘的更高的表示由导致 diapause 的鸡蛋列在后面。Microarray 分析在导致 diapause 的鸡蛋在 oviposition 以后在 18thh 揭示了 DnaJ 5 相当或相同的事物的更高的表示。通过 qPCR 在的 DnaJ 5 表示的进一步的确认导致 diapause 并且在不同时间间隔的 nondiapause 鸡蛋在 diapause 揭示了更高的表示在 18 点的鸡蛋和在 oviposition 以后的 24h,它因为 Hsp 40 是它的合作女伴,与 Hsp70 的表示与一致。这研究因此在在 B 感应的鸡蛋 diapause 提供 Hsp40 基因,和它的角色的染色体组织的一个轮廓。mori。 | Sasibhushan Sirigineedi Esvaran Vijayagowri Geetha N. Murthy Guruprasada Rao Kangayam M. Ponnuvel | 2014 | Insect Science2014，21，6： | 2 |
| 16 | Chemical profiling of Elaeocarpus serratus L.by GC-MS显示文摘Objective:To determine the possible bioactive components of the ethanolic extract of leaves of Elaeocarpus serratus(E.serratus).Methods:The present research was carried out by using GC-MS analysis,while mass spectra of the compounds found in the extract was matched with the National Institute of Standards and Technology and Wiley library.Results:Thirty components from leaves of the above said plant were identified.The active principles with their retention time,molecular formula,molecular weight and concentration(%)in the ethanol extracts of leaf of E.serratus are obtained.Conclusions:This is the first report of documentation of active constituents from leaves of E.serratus.The research reveals the potential of E.serratus leaves as a good source of bioactive compounds such as fatty acid esters,alcohols,hydrocarbons,aldehydes,alkenes,fatty acids and amides that justify the use of this plant for its various ailments by traditional practitioners. | Geetha DH Rajeswari M Indhiramuthu Jayashree | 2013 | Asian Pacific Journal of Tropical Biomedicine2013，3，12： | 2 |
| 17 | Insulin dependent diabetes mellitus induced by chemotherapy and granuloeyte, maerophage colony factor 显示文摘 | GEETHA N LALI V S HUSSIAN B M | 1999 | I Assoc Physicians India1999，47，8： | 1 |
| 18 | Methy1 parathion induced sperm shape abnormalities in mouse显示文摘 | Geetha Mathew K K Vijayalaxmi A Abdal Rahiman | 1992 | Mutat Res1992，280，： | 1 |
| 19 | Ti based biomaterials,the ultimate choice for orthopaedic implants-A review 显示文摘 | Geetha M Singh A K Asokanmani R | 2009 | Progress inMaterials Science2009，29，39： | 1 |
| 20 | Alpha-tocopherol reduces doxorubicin-induced toxicity in rats--histological and bio- chemical evidences 显示文摘 | Geetha A Sankar R Marar T | 1990 | Indian J Physiol Pharmaeol1990，34，： | 1 |
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