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| 1 | High-resolution geochemistry records of climate changes since late-glacial from Dajiuhu peat in Shennongjia Mountains,Central China显示文摘A peat core with depths of 297 cm was obtained from the Dajiuhu Basin(31°29′27″N,109°59′45″E,1760 m)in Hubei Province,Central China.10 AMS ages provide a time control and reveal that this core spans the past about 16.0 kaBP(calibrated age)(1 4C age:13.3 kaBP).Multi-proxy indexes analysis of geochemistry shows the following character of climate and environmental changes since about 16 kaBP:(1) The climate during the late-glacial period was cold and wet as a whole,but fluctuated continually.11.4- 12.6 cal.kaBP,12.6-15.2 cal.kaBP and 15.2-16 kaBP were corresponding respectively to the Younger Drays,Bφlling-Allerφd Warm Period and the Oldest Drays.(2)Inheriting the some climate characteristics of the late-glacial,the climate during the early-Holocene was wet and temperature increased gradually,during which an obvious dry event around 10.6 cal.kaB appeared.(3)The climate during the mid-Holocene was genarally warm and wet.During 9.2-7.5 kaBP,temperature increased gradually, precipitation was less comparatively and the 8.2 kaBP cold event which might be representative in the globe was reflected markedly.Then,multi-proxy records were relatively stable during 6.7-4.2 kaBP, which shows the best water and thermal condition in the Holocene Optimum.(4)Around 4.2 kaBP,the climate and environment transform from warm and wet to cool and dry,which may result in the collapse of the Neolithic Culture and midwifery the civilization of Xia Dynasty in this region.After 0.9 kaBP,the climate turned cool and wet.Climate and environmental changes archived in Dajiuhu peat respond to the global changes since the late-glacial period and can be contrasted to the changes recorded in other high-resolution archives from the East Asia Monsoon region,which take on the variety model that the monsoon strengthened abruptly after the late-glacial,was strong during the early Holocene,subse- quently declined and became weak after the middle Holocene with dry climate.According to our analysis,the driving mechanism should be the response of solar radiation changes in the East Asia Monsoon region at middle latitudes. | MA ChunMei ZHU Cheng ZHENG ChaoGui WU ChunLin GUAN Yong ZHAO ZhiPing HUANG LinYan HUANG Run | 2008 | Chinese Science Bulletin2008，53，S1： | 19 |
| 2 | Impact of Holocene environmental change on temporal-spatial distribution of Neolithic sites in Huaihe River Basin, Anhui Province显示文摘The Huaihe River basin of Anhui is not only a transitional zone of physical geography, but also a convergent area of many cultures in China. It is one of the sensitive ecotones to global changes and the birthplace of Chinese civilization. Using the field archaeological data and the sporo-pollens and the age data of the drilling cores, we analysed Neolithic cultural development and environmental evolution in the Huaihe River basin of Anhui. According to the combination of some research results in archaeology with environmental evolution research, this paper discusses the relationship between culture and environment in the Huaihe River basin of Anhui. The Neolithic cultural development was strongly impacted by the environmental change. The primitive culture (Shishanzi) was developed in the beginning of the Holocene Megathermal Period with distinct regional feature of the culture. From 6.5 kaBP to 5.5 kaBP, the climate changed warmer and wetter. The frequent occurrence of flood and waterlog due to such a climate regime and high sea level caused the earth’s surface environment deteriorated in the Huaihe River basin of Anhui and the interruption of the Neolithic cultural development, hence a lack of archaeological sites. From 5.5 kaBP to 4.0 kaBP, the climate changed from wet to dry, the natural environment was propitious to human survival. Dawenkou Culture and Longshan Culture flourished in this period. The Neolithic cultural development, the number of the sites and their distribution characteristics of the sites in the study area differed apparently from those in Central China and Shandong Province. | HUANG Run ZHU Cheng GUAN Yong ZHENG Chaogui | 2006 | Journal of Geographical Sciences2006，16，2： | 5 |
| 3 | Rational development of a human antibody cocktail that deploys multiple functions to confer Pan-SARS-CoVs protection显示文摘Structural principles underlying the composition and synergistic mechanisms of protective monoclonal antibody cocktails are poorly defined.Here,we exploited antibody cooperativity to develop a therapeutic antibody cocktail against SARS-CoV-2.On the basis of our previously identified humanized cross-neutralizing antibody H014,we systematically an a lyzed a fully human n aive antibody library and rationally identified a potent neutralizing antibody partner,P17,which confers effective protection in animal model.Cryo-EM studies dissected the nature of the P17 epitope,which is SARS-CoV-2 specific and distinctly different from that of HOI4.High-resolution structure of the SARS-CoV-2 spike in complex with HOM and P17,together with functional investigations revealed that in a two-antibody cocktail,synergistic neutralization was achieved by S1 shielding and conformational locking,thereby blocking receptor attachment and viral membrane fusion,conferring high potency as well as robustness against viral mutation escape.Furthermore,cluster analysis identified a hypothetical 3rd antibody partner for further reinforcing the cocktail as pan-SARS-CoVs therapeutics. | Hangping Yao Yao Sun Yong-Qiang Deng Nan Wang Yongcong Tan Na-Na Zhang Xiao-Feng Li Chao Kong Yan-Peng Xuc Qi Chen Tian-Shu Cao Hui Zhao Xintian Yan Lei Cao Zhe Lv Dandan Zhu Rui Feng Nanping Wu Wenhai Zhang Yuhao Hu Keda Chen Rong-Rong Zhang Qingyu Lv Shihui Sun Yunhua Zhou Run Yan Guan Yang Xinglu Chanjuan Liu Xiangyun Lu Linfang Cheng Hongying Qiu Xing-Yao Huang Tianhao Weng Danrong Shi Weidong Jiang Junbin Shao Lei Wang Jie Zhang Tao Jiang Guojun Lang Cheng-Feng Qinc Lanjuan Li Xiangxi Wang | 2021 | Cell Research2021，31，1： | 5 |
| 4 | 1,5-dicaffeoylquinic acid protects primary neurons from amyloid β1-42-induced apoptosis via PI3K/Akt signaling pathway显示文摘背景最近, 1,5-dicaffeoylquinic 酸( 1,5-DQA ),从翠菊 scaber 孤立的 caffeoylquinic 酸衍生物,被发现有 neuroprotective effects.However , 1,5-DQA 的保护的机制还没清楚地是学习是在我们调查了的 neuronal culture.Methods 上探索 1,5-DQA 的保护的机制的这的 identified.The 目的对淀粉的 1-42 ( A42 )的 1,5-DQA 的 neuroprotective 效果在主要 neuronal culture.To 导致了 neurotoxicity 评估 neuroprotective | XIAO Hai-bing CAO Xu WANG Lei RUN Xiao-qin SU Ying TIAN Cheng SUN Sheng-gang LIANG Zhi-hou | 2011 | Chinese Medical Journal2011，，17： | 4 |
| 5 | Cloning the Structure Genes and Expression the N Gene of Porcine Epidemic Diarrhea Virus DX显示文摘The structure genes spike(S) ,nucleocapsid(N) ,membrane(M) ,small membrane(sM) of a porcine epidemic diarrhea virus(PEDV) strain DX isolated in Gansu province,North-west of China,were cloned,sequenced and compared with published sequences of PEDV strains. The nucleotide sequences encoding the entire S,sM,M and N genes open reading frame(ORF) of DX were 4 152,231,681 and 1 326 bases long respectively. There were transcription regulatory sequences(TRSs) upstream of the initiator ATG of the S,N and M genes. The amino acids sequences of S,M and N contained 30,3 and 7 potential asparagine(N) -linked glycosylation sites. Homologous analysis and phylogenetic trees showed that DX had the closest relationship with strains LJB/06,JS-2004-2Z and CH/HLJH/06 that were also isolated from China and indicated the prevalence of some PEDV isolates in China were widespread since the JS-2004-2Z strain originated from the south of the China,and LJB/06 and CH/HLJH/06 were isolated from northeast China. The N gene was cloned using two primers which contained Nco I and BamH I restriction enzyme sites and subcloned into expression vector pET30a. The recombinant plasmid was then transformed into E.coli Rossta. SDS-PAGE showed there was a protein of about 55kDa as expected and Western blot indicated the N protein had biological activity. | Jian-qiang LI Ji-xing LIU Xi LAN Jie CHENG Run WU Zhong-Zi LOU Xiang-ping YIN Xue-rui LI Bao-yu LI Bin YANG Zhi-yong LI | 2009 | Virologica Sinica2009，24，3： | 4 |
| 6 | PHYTOCHROME-INTERACTING FACTORS Interact with the ABA Receptors PYL8 and PYL9 to Orchestrate ABA Signaling in Darkness显示文摘PHYTOCHROME-INTERACTING FACTORS(PIFs)are a group of basic helix-loop-helix transcription factors that can physically interact with photoreceptors,including phytochromes and cryptochromes.It was previously demonstrated that PIFs accumulated in darkness and repressed seedling photomorphogenesis,and that PIFs linked different photosensory and hormonal pathways to control plant growth and development.In this study,we show that PIFs positively regulate the ABA signaling pathway during the seedling stage specifically in darkness.We found that PIFs positively regulate ABI5 transcript and protein levels in darkness in response to exogenous ABA treatment by binding directly to the G-box motifs in the ABI5 promoter.Consistently,PIFs and the G-box motifs in the ABI5 promoter determine ABI5 expression in darkness,and overexpression of ABI5 could rescue the ABA-insensitive phenotypes of pifq mutants in the dark.Moreover,we discovered that PIFs can physically interact with the ABA receptors PYL8 and PYL9,and that this interaction is not regulated by ABA.Further analyses showed that PYL8 and PYL9 promote PIF4 protein accumulation in the dark and enhance PIF4 binding to the ABI5 promoter,but negatively regulate PIF4-mediated ABI5 activation.Taken together,our data demonstrate that PIFs interact with ABA receptors to orchestrate ABA signaling in darkness by controlling ABI5 expression,providing new insights into the pivotal roles of PIFs as signal integrators in regulating plant growth and development. | Lijuan Qi Shan Liu Cong Li Jingying Fu Yanjun Jing Jinkui Cheng Hong Li Dun Zhang Xiaoji Wang Xiaojing Dong Run Han Bosheng Li Yu Zhang Zhen Li William Terzaghi Chun-Peng Song Rongcheng Lin Zhizhong Gong Jigang Li | 2020 | Molecular Plant2020，13，3： | 3 |
| 7 | Black phosphorus-based van der Waals heterostructures for mid-infrared light-emission applications显示文摘Mid-infrared(MIR)light-emitting devices play a key role in optical communications,thermal imaging,and material analysis applications.Two-dimensional(2D)materials offer a promising direction for next-generation MIR devices owing to their exotic optical properties,as well as the ultimate thickness limit.More importantly,van der Waals heterostructures-combining the best of various 2D materials at an artificial atomic level-provide many new possibilities for constructing MIR light-emitting devices of large tuneability and high integration.Here,we introduce a simple but novel van der Waals heterostructure for MIR light-emission applications built from thin-film BP and transition metal dichalcogenides(TMDCs),in which BP acts as an MIR light-emission layer.For BP–WSe_(2) heterostructures,an enhancement of~200% in the photoluminescence intensities in the MIR region is observed,demonstrating highly efficient energy transfer in this heterostructure with type-Ⅰ band alignment.For BP-MoS_(2) heterostructures,a room temperature MIR light-emitting diode(LED)is enabled through the formation of a vertical PN heterojunction at the interface.Our work reveals that the BP-TMDC heterostructure with efficient light emission in the MIR range,either optically or electrically activated,provides a promising platform for infrared light property studies and applications. | Xinrong Zong Huamin Hu Gang Ouyang Jingwei Wang Run Shi Le Zhang Qingsheng Zeng Chao Zhu Shouheng Chen Chun Cheng Bing Wang Han Zhang Zheng Liu Wei Huang Taihong Wang Lin Wang Xiaolong Chen | 2020 | Light(Science & Applications)2020，9，1： | 3 |
| 8 | The application of halide perovskites in memristors显示文摘New neuromorphic architectures and memory technologies with low power consumption,scalability and high-speed are in the spotlight due to the von Neumann bottleneck and limitations of Moore’s law.The memristor,a two-terminal synaptic device,shows powerful capabilities in neuromorphic computing and information storage applications.Active materials with high defect migration speed and low defect migration barrier are highly promising for high-performance memristors.Halide perovskite(HP)materials with point defects(such as gaps,vacancies,and inversions)have strong application potential in memristors.In this article,we review recent advances on HP memristors with exceptional performances.First,the working mechanisms of memristors are described.Then,the structures and properties of HPs are explained.Both electrical and photonic HP-based memristors are overviewed and discussed.Different fabrication methods of HP memristor devices and arrays are described and compared.Finally,the challenges in integrating HP memristors with complementary metal oxide semiconductors(CMOS)are briefly discussed.This review can assist in developing HP memristors for the next-generation information technology. | Gang Cao Chuantong Cheng Hengjie Zhang Huan Zhang Run Chen Beiju Huang Xiaobing Yan Weihua Pei Hongda Chen | 2020 | Journal of Semiconductors2020，41，5： | 2 |
| 9 | Photoinduced small electron polarons generation and recombination in hematite显示文摘Polarons generally affect adversely the photochemical and photophysical properties of transition metal oxides.However,the excited-state dynamics of polarons are not fully established to date and thus require an atomistic understanding.We focus onα-Fe_(2)O_(3)with photoexcitation,electron injection,and heterovalent doping as the small polaron models,and conduct simulations of ab initio adiabatic molecular dynamics(AIMD)and nonadiabatic molecular dynamics(NA-MD).The elaborately designed AIMD simulations show that localization of electron at a single Fe site is an adiabatic and ultrafast process within sub-15 fs.Fe_(2)O_(3)doping with an electron or a Si and Ti dopant forms a localized electron polaron while photoexcitation forms localized electron and hole polarons simultaneously,leading to diverse electron–hole recombination dynamics.NA-MD simulations demonstrate that recombination of an electron polaron created by doping with a delocalized hole at the valence band maximum ofα-Fe_(2)O_(3)takes place around 5 ps,while recombination between a pair of small electron and hole polarons in photoexcited Fe_(2)O_(3)delays to about 110 ps owing to weak NA coupling and fast decoherence process.The ultrafast formation of small electron polarons inα-Fe_(2)O_(3)impedes the accumulation of delocalized holes in the valence band that directly participate in water oxidation at photoanodes.The detrimental effect can be partially circumvented in photoexcited Fe_(2)O_(3)for slowing electron–hole recombination despite polarons may retain low charge mobility.These findings provide a fundamental understanding of the excited-state dynamics of small electron polaron inα-Fe_(2)O_(3)and may help design efficient transition metal oxides photoanodes. | Cheng Cheng Yonghao Zhu Zhaohui Zhou Run Long Wei-Hai Fang | 2022 | npj Computational Materials2022，，1： | 1 |
| 10 | Synthesis of lignin-base cationic flocculant and its application in removing anionic azo-dyes from simulated wastewater显示文摘 | Fang Run Cheng Xiansu Xu Xiaorong | | 0，，19： | 1 |
| 11 | Synthesis of lig- nin-base cationic flocculant and its application in removinganionic azo-dyes from simulated wastewater显示文摘 | Fang Run Cheng Xiansu Xu Xiaorong | 2010 | Biore- source Technology2010，101，： | 1 |
| 12 | Synthesis of lignin-base cationic flocculant and its application in removing anionic azo-dyes from simulated wastewater显示文摘 | Run Fang Xiansu Cheng Xiaorong Xu | 2010 | Bioresource Technology2010，，19： | 1 |
| 13 | Synthesis of lignin-base cationic flocculant and its application in removing anionic azo-dyes from simulated wastewater显示文摘 | Run Fang Xiansu Cheng Xiaorong Xu | 2010 | Bioresource Technology2010，101，： | 1 |
| 14 | Synthesis of lignin-base cationic flocculant and its application in removing anionic azo-dyes from simulated wastewater显示文摘 | FANG Run CHENG Xian-su XU Xiao-rong | 2010 | Bioresource Technology2010，101，19： | 1 |
| 15 | Occurrence of Streptococcus dysgalactiae subsp, equisimilis in Masked Palm Civet (Paguma larvata)显示文摘 | Run Cheng Li Chao Ting Xiao Xing Qian | 2012 | 11(12):2020-20232012，11，12： | 1 |
| 16 | Study on Reduction of β-Aromatic Amino Substituted Triazolyl Ketene Compounds显示文摘A series of b-aromatic amino substituted triazolyl ketenes were reduced at different conditions to enols and saturated alcohols, respectively. The preliminary biological tests showed that some of them exhibit good fungicidal activities. | Yang Zhou LI, Jun Ran CHENG*, Qing Min WANG, Xiang Yun GUO, Run Qiu HUANG Institute and State Key Laboratory of Elemento-organic Chemistry, Nankai University, Tianjin 300071 | 2003 | Chinese Chemical Letters2003，14，5： | 1 |
| 17 | Occurrence of Streptococcus dysgalactiae subsp, equisimilis in Masked Palm Civet (Paguma larvata)显示文摘 | Run Cheng Li Chao Ting Xiao Xing Qian | 2012 | Journal of Animal and Veteri- nary Advances2012，11，12： | 1 |
| 18 | Management experience of care workers during epidemic prevention and control of COVID-19显示文摘Since the rapid spread of COVID‑19,our hospital has actively implemented the idea of“preventing the coronavirus from entering.”We paid close attention to details,rapidly carried out personnel and material management at all levels,and strived to do a good job in the prevention and control of the epidemic,so as to achieve zero infection.Patients’carers are an important part of quality care.Lacking of protection knowledge of infectious diseases would increase the risk of nosocomial infection.Therefore,our nursing department set up a team of epidemic prevention and control management.The team made the revision on contingency plans and care management regulations during the outbreak of COVID‑19,strengthened epidemic prevention and control knowledge training,carried out the supervision inspection work,and paid attention to humanized management measures to provide an important guarantee for victory over the COVID‑19. | Na CHENG Run‑Xi TIAN Nan TONG Qing GONG Jia‑Yue LI Bao‑Jing WU De‑Yu KONG | 2020 | Journal of Integrative Nursing2020，2，2： | 1 |
| 19 | Synthesis of lignin-base cationic flocculant and its application in removing anionic azo-dyes from simulated wastewater显示文摘 | Run Fang Xiansu Cheng Xiaorong Xu | 2010 | Bioresource Technology2010，，19： | 1 |
| 20 | Synthesis of Asymmetric 4H-1, 3, 2-Benzodioxaphosphorin 2-Sulfides from Intramolecular Cyclization Reaction显示文摘Asymmetric 6-substituted-2-methoxy-4-(2,4-dichlorophenyl)-4H,3,2-benzodioxa-phosphorin 2-sulfides were prepared tyom intramolecular cyclization. The diastereomers wereseparated by column chromatography and fractional crystallization. Their structures werecharacterized on the basis of 1 H NMR. 31 P NMR and x-ray diffraction analysis. | Jun Ran CHENG Jia WEN Rut Lian SHAO Huan Yan CAO Run Qiu HUANG(Institute of Elemento-Organic Chemistry, Nankai University. Tianjin 300071) | 1999 | Chinese Chemical Letters1999，10，9： | 0 |
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