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| 1 | Outline of the Report on Cardiovascular Disease in China,2010显示文摘Major and profound changes have taken place in China over the past 30 years.Rapid socioeconomic progress has exerted a great impact on lifestyle,ranging from food,clothing,working and living conditions,and means of transportation to leisure activities and entertainment.At the same time,new health problems have emerged,and health services are facing new challenges.Presently,cardiovascular diseases (CVD) are among the top health problems of the Chinese people,and pose a serious challenge to all engaged in the prevention and control of these diseases.An epidemic of CVD in China is emerging as a result of lifestyle changes,urbanization and longevity.Both national policy decision-making and medical practice urgently need an authoritative report which comprehensively reflects the trends in the epidemic of CVD and current preventive measures.Since 2005,guided by the Bureau of Disease Prevention of the Ministry of Health of the People's Republic of China and the National Center for Cardiovascular Diseases of China,nationwide experts in the fields of epidemiology,clinical medicine and health economics in the realms of CVD,cerebrovascular disease,diabetes and chronic kidney disease,completed the Report on Cardiovascular Diseases in China every year.The report aims to provide a timely review of the trend of the epidemic and to assess the progress of prevention and control of CVD.In addition,as the report is authoritative,representative and readable,it will become an information platform in the CVD field and an important reference book for government,academic institutes,medical organizations and clinical physicians.This publication is expected to play a positive role in the prevention and control of CVD in China.We present an abstract from the Report on Cardiovascular Diseases in China (2010),including trends in CVD,morbidity and mortality of major CVDs,up-to-date assessment of risk factors,as well as health resources for CVD,and a profile of medical expenditure,with the aim of providing evidence for decision-making in CVD prevention and control programs in China,and of delivering the most authoritative information on CVD prevention and control for all citizens. | HUSheng Shou KONG Ling Zhi GAO Run Lin ZHU Man Lu WANG Wen WANG Yong Jun WU Zhao Su CHEN Wei Wei LIU Ming Bo For the editorial board | 2012 | Biomedical and Environmental Sciences2012，25，3： | 93 |
| 2 | Summary of Report on Cardiovascular Diseases in China,2012显示文摘The prevalence of cardiovascular diseases(CVDs)is associated with the socioeconomic prosperity,lifestyle changes,accelerated process of ageing and urbanization.The prevalence of CVDs is continuously increasing in China and will remain an upward trend in the next 10 years.CVDs are the leading cause of death for Chinese in both urban area and rural area. | WANG Wen HU Sheng Shou KONG Ling Zhi GAO Run Lin ZHU Man Lu WANG Yong Jun WU Zhao Su CHEN Wei Wei YANG Jin Gang MALi Yuan LIU Ming Bo For the editorial board | 2014 | Biomedical and Environmental Sciences2014，27，7： | 31 |
| 3 | Identifying paleoflood deposits archived in Zhongba Site,the Three Gorges reservoir region of the YangtzeRiver,China显示文摘Based on the principle that the present is the key to the past , detailed analyses, such as AMS 14C dating, grain size, component and morphology of heavy minerals, micro-morphology of zircon, Rb/Sr, magnetic susceptibility and total organic carbon (TOC), were conducted to identify paleoflood sediments archived in Zhongba Site. The results indicate that the plaeoflood sediments bear great similarities with modern flood sediments in the following aspects: (1) probability cumulative curves mainly show a pattern of 3―4 segments; (2) grain-size distribution of suspended matter ranges between 3 and 10Ф; (3) the sediments are well-sorted, most of which are suspended matter (>50%); (4) the same species, quantity and morphology of heavy minerals; (5) scanning electronic microscope images show that shapes of zircon are mainly oval and nearly spheral, rounded due to long-distance transport; (6) higher Rb/Sr values (0.55―0.66)than those of sediments from cultural layers (0.03―0.26); (7) magnetic susceptibility values (133.73―433.05 10-6m3/kg) are lower than those of sediments from cultural layers (959.25―2442.44 10?6 m3/kg); (8) TOC (0.14%―0.33%) are lower than those of sediments from cultural lay-ers (1.13%―2.95%). Our results demonstrate that, except for the 1981 flood, there are at least six paleoflood events that occurred during the Qing Dynasty, the middle of Song Dy-nasty, the early Warring States (400BC―350BC), the West Zhou Dynasty (920BC―900BC), the Xia Dynasty (2070BC―1600BC), and the late Neolithic Age (3000BC―2300BC), respectively . | ZHU Chen ZHENG Chaogui MA Chunmei SUN Zhibin ZHU Guangyao WANG Huilin GAO Huazhong WANG Pengling HUANG Run | 2005 | Chinese Science Bulletin2005，50，21： | 28 |
| 4 | Trends of Extreme Precipitation in Eastern China and Their Possible Causes显示文摘Significant increases of heavy precipitation and decreases of light precipitation have been reported over widespread regions of the globe. Global warming and effects of anthropogenic aerosols have both been proposed as possible causes of these changes. We examine data from urban and rural meteorological stations in eastern China(1955–2011) and compare them with Global Precipitation Climatology Project(GPCP) data(1979–2007) and reanalysis data in various latitude zones to study changes in precipitation extremes. Significant decreases in light precipitation and increases in heavy precipitation are found at both rural and urban stations, as well as low latitudes over the ocean, while total precipitation shows little change.Characteristics of these changes and changes in the equatorial zone and other latitudes suggest that global warming rather than aerosol effects is the primary cause of the changes. In eastern China, increases of annual total dry days(28 days) and 10 consecutive dry days(36%) are due to the decrease in light precipitation days, thereby establishing a causal link among global warming, changes in precipitation extremes, and higher meteorological risk of floods and droughts. Further, results derived from the GPCP data and reanalysis data suggest that the causal link exists over widespread regions of the globe. | LIU Run LIU Shaw Chen Ralph J.CICERONE SHIU Chein-Jung LI Jun WANG Jingli ZHANG Yuanhang | 2015 | Advances in Atmospheric Sciences2015，32，8： | 19 |
| 5 | Two gap-free reference genomes and a global view of the centromere architecture in rice显示文摘Rice(Oryza sativa),a major staple throughout the world and a model system for plant genomics and breeding,was the first crop genome sequenced almost two decades ago.However,reference genomes for all higher organisms to date contain gaps and missing sequences.Here,we report the assembly and analysis of gap-free reference genome sequences for two elite O.sativa xian/indica rice varieties,Zhenshan 97 and Minghui 63,which are being used as a model system for studying heterosis and yield.Gap-free reference genomes provide the opportunity for a global view of the structure and function of centromeres.We show that all rice centromeric regions share conserved centromere-specific satellite motifs with different copy numbers and structures.In addition,the similarity of CentO repeats in the same chromosome is higher than across chromosomes,supporting a model of local expansion and homogenization.Both genomes have over 395 non-TE genes located in centromere regions,of which∼41%are actively transcribed.Two large structural variants at the end of chromosome 11 affect the copy number of resistance genes between the two genomes.The availability of the two gap-free genomes lays a solid foundation for further understanding genome structure and function in plants and breeding climate-resilient varieties. | Jia-Ming Song Wen-Zhao Xie Shuo Wang Yi-Xiong Guo Dal-Hoe Koo Dave Kudrna Chenbo Gong Yicheng Huang Jia-Wu Feng Wenhui Zhang Yong Zhou Andrea Zuccolo Evan Long Seunghee Lee Jayson Talag Run Zhou Xi-Tong Zhu Daojun Yuan Joshua Udall Weibo Xie Rod AWing Qifa Zhang Jesse Poland Jianwei Zhang Ling-Ling Chen | 2021 | Molecular Plant2021，14，10： | 9 |
| 6 | Biochemical sensing in graphene-enhanced microfiber resonators with individual molecule sensitivity and selectivity显示文摘Photonic sensors that are able to detect and track biochemical molecules offer powerful tools for information acquisition in applications ranging from environmental analysis to medical diagnosis.The ultimate aim of biochemical sensing is to achieve both quantitative sensitivity and selectivity.As atomically thick films with remarkable optoelectronic tunability,graphene and its derived materials have shown unique potential as a chemically tunable platform for sensing,thus enabling significant performance enhancement,versatile functionalization and flexible device integration.Here,we demonstrate a partially reduced graphene oxide(prGO)inner-coated and fiber-calibrated Fabry-Perot dye resonator for biochemical detection.Versatile functionalization in the prGO film enables the intracavity fluorescent resonance energy transfer(FRET)to be chemically selective in the visible band.Moreover,by measuring the intermode interference via noise canceled beat notes and locked-in heterodyne detection with Hz-level precision,we achieved individual molecule sensitivity for dopamine,nicotine and single-strand DNA detection.This work combines atomic-layer nanoscience and high-resolution optoelectronics,providing a way toward high-performance biochemical sensors and systems. | Zhongxu Cao Baicheng Yao Chenye Qin Run Yang Yanhong Guo Yufeng Zhang Yu Wu Lei Bi Yuanfu Chen Zhenda Xie Gangding Peng Shu-Wei Huang Chee Wei Wong Yunjiang Rao | 2019 | Light(Science & Applications)2019，8，1： | 8 |
| 7 | H∞ Output Feedback Control of Constrained Systems via Moving Horizon Strategy显示文摘这份报纸与致动器浸透为分离时间的系统处理 H 产量反馈控制问题。开始,一条抑制 H 输出反馈控制途径在线性矩阵不平等(LMI ) 的框架被介绍优化。在骚乱精力界限上的某些假设下面,靠近环的 H 性能被完成。而且,动人的地平线策略被用于控制性能的一个联机管理以便靠近环的系统能在意外大骚乱的情况中满足控制限制。驱散限制被导出完成动人的地平线靠近环的系统消散。模拟结果证明抑制 H 控制器在骚乱假设下面有效地工作并且动人的地平线 H 控制器罐头交易自动地在令人满意的控制限制和提高的性能之间。 | WANG Juan LIU Zhi-Yuan CHEN Hong YU Shu-You PEI Run | 2007 | 自动化学报2007，33，11： | 7 |
| 8 | Formation Control and Obstacle Avoidance for Multiple Mobile Robots显示文摘这篇论文为一组 nonholonomic 考虑形成控制和障碍回避的问题活动机器人。根据非最优的模型预兆的控制,二个控制算法被建议。当解决费用在工作的最佳的控制问题被结合,两个算法被提出以便他们解决每个交往的机器人的动力学。潜在的功能被用来定义终端状态惩罚术语,和一个相应终端声明区域被加到优化限制。而且,包括稳定性和安全的主要问题也被讨论。模拟结果显示出建议控制策略的可行性。 | YANG Tian-Tian LIU Zhi-Yuan CHEN Hong PEI Run | 2008 | 自动化学报2008，34，5： | 7 |
| 9 | An observation-based perspective of winter haze days in four major polluted regions of China显示文摘An observation-based approach is used to examine key characteristics of winter haze days in four major polluted regions in China.Major findings in this study are:first,there was no significant trend in the number of winter haze days in most provinces and districts in eastern China from 1973 to 2012,contrary to the 2.5-fold increase in the emissions of particulate matter and its precursors(PM emissions)in the same period of time.Second,meteorological and climate conditions rather than PM emissions are in control of the interannual variabilities and trends of winter haze days.These interannual variabilities(ranging from 24 to 125%)pose a substantial masking effect that must be overcome by any control of PM emissions before its impact becomes statistically detectable.Finally,we find that global warming may have contributed significantly to the trend of winter haze days in eastern China. | Lu Mao Run Liu Wenhui Liao Xuemei Wang Min Shao Shaw Chen Liu Yuanhang Zhang | 2019 | National Science Review2019，6，3： | 7 |
| 10 | Construction of a BAC library from cucumber (Cucumis sativus L.) and identification of linkage group specific clones显示文摘A bacterial artificial chromosome (BAC) library consisting of 19,200 clones with an average insert size of 105 kb has been constructed from a cucumber (Cucumis sativus L.) inbred line S94,derived from a cultivar in North China. The entire library was equivalent to approximately 5 haploid cucumber genomes. To facilitate chromosome engineering and anchor the cucumber genetic linkage map to its chromosomes,15 sequence-characterized ampli?ed regions (SCAR) and seven simple sequence repeats (SSR) markers from each link-age group of cucumber were used to screen an ordered array of pooled BAC DNA with polymerase chain reaction (PCR). Fifteen mark-ers gave at least two positive clones. As a result,22 BAC clones representing 7 linkage groups of cucumber were identified,which further validated the genome coverage and utility of the library. This BAC library and linkage group specific clones provide essential resources for future research of the cucumber genome. | Yuan Guan Qi Chen Junsong Pan Zheng Li Huanle He Aizhong Wu Rentao Song Run Cai | 2008 | Progress in Natural Science:Materials International2008，18，2： | 7 |
| 11 | Review of CHINARE chemical oceanographic research in the Southern Ocean during 1984–2016显示文摘Between 1984 and 2016, China executed 33 Antarctic cruises with the icebreaker R/V Xuelong, which have provided opportunities for Chinese scientists to investigate the status and changes of the Southern Ocean. Research in chemical oceanography constitutes one of the primary missions of the Chinese National Antarctic Research Expedition(CHINARE). This paper reviews nearly 30 years of Chinese Antarctic expeditions, focusing on the major progress achieved in chemical oceanographic research. Specifically, the sea-surface distributions and air–sea fluxes of CO_2 and N_2O are considered, and the transport, flux, and budget of organic matter are investigated based on isotopes in the Southern Ocean, especially in Prydz Bay. In addition, the nutrient distribution and deep-water particle export in Prydz Bay and the study of aerosol heavy metal characteristics are considered. Finally, the prospects for future Chinese Antarctic chemical oceanographic research are outlined. | CHEN Liqi CHEN Min ZHAN Liyan QI Di GAO Zhongyong WANG Jianjun XU Suqing CHEN Kui ZENG Jian ZHANG Run | 2017 | Advances in Polar Science2017，28，2： | 6 |
| 12 | Factors of spatial distribution of recreation areas in peri-urban Beijing显示文摘在北京基于外部城市的区域的案例研究,这份报纸试图识别将影响仙子城市的娱乐区域的空间分发的因素,由分析从问询表,联机调查,文档和领域调查(2007 ) 收集了数据。为了完成健全信息,从不同管理部门的相关数据,主人和陆地使用类型,在案例研究区域包含了被收集。为在北京的仙子城市的娱乐区域的一个采样数据库被建立,并且象统计分析一样的 GIS 空间分析被使用。结果显示娱乐区域的空间分发被四个因素主要地影响,例如旅游吸引力和环境条件,政策和空间统治,消费需求和偏爱,陆地价格和可获得性。旅游吸引力和环境条件是为公共娱乐区域的主导的因素。商业娱乐区域高度与可接近性被联系。农业娱乐区域通常在 large-scaled 附近被纳入特殊农田舞台的区域。同时,娱乐企业簇在集体娱乐市场生长影响的郊区出现了。由陆地价格控制了,商业娱乐区域在他们的规模和发展中的紧张上被区分。政策和空间统治使娱乐区域的安排成为了平衡的更多和更多面向人。一个仙子城市的娱乐区域模型因此根据这分析被建立,它能指导城市的计划并且设计,陆地使用计划和娱乐资源开发。 | LIU Jiaming WANG Run CHEN Tian | 2010 | Journal of Geographical Sciences2010，20，5： | 6 |
| 13 | A review:Synthesis,modification and photocatalytic applications of ZnIn_(2)S_(4)显示文摘Solar energy is an ideal energy source for solving energy shortages and serious environmental problems.In the past few decades,photocatalytic technology which uses solar energy to deal with the above problems has caused great interest.ZnIn_(2)S_(4),as a layered ternary metal chalcogenide compound,has a series of advantages such as the wide light absorption range and adjustable bandgap.It has been applied in the different fields of photocatalysis in recent years.This review introduced the crystal structures and growth mechanism of ZnIn_(2)S_(4)and summarized the preparation methods of ZnIn_(2)S_(4).Also,the promoted strategies of ZnIn_(2)S_(4)based photocatalytic system and their applications in the pollutant removal,hydrogen evolution,reduction of CO_(2),nitrogen fixation,and chemical synthesis was summarized.Furthermore,the challenges and development directions of the current ZnIn_(2)S_(4)based photocatalytic system were proposed.It is hoped that this review will help researchers design a better ZnIn_(2)S_(4)based photocatalytic system. | Jie Wang Sijia Sun Run Zhou Yangzi Li Zetian He Hao Ding Daimei Chen Weihua Ao | 2021 | Journal of Materials Science & Technology2021，，19： | 6 |
| 14 | Prognostic Value of NT-proBNP in Stable Coronary Artery Disease in Chinese Patients after Percutaneous Coronary Intervention in the Drug-eluting Stent Era显示文摘Objective The predictive value of N-terminal pro-brain natriuretic peptide(NT-proBNP) in patients with stable coronary artery disease(SCAD) in the drug-eluting stent era is not yet clear. We aimed to evaluate the prognostic value of NT-proBNP in SCAD patients after percutaneous coronary intervention(PCI). Methods We examined 4,293 consecutive SCAD patients who underwent PCI between January 2013 and December 2013 in Fuwai Hospital, China. The primary endpoint was all-cause death. NT-proBNP levels were measured before PCI using Elisa kits(Biomedica, Austria). The indication for PCI was based on the degree of coronary stenosis and evidence of ischemia. Results Among 3,187 SCAD patients with NT-proBNP data, after a 2-year follow-up, NT-proBNP levels were predictive for all-cause death in the SCAD population [area under the receiver operating characteristic curve, 0.768; 95% confidence interval(CI), 0.687-0.849; P < 0.001]. At the optimum cutoff point of 732 pg/mL, the sensitivity and specificity of death was 75.0% and 72.3%, respectively. In a multivariable Cox regression model, the death hazard ratio was 6.43(95% CI, 2.99-13.82; P < 0.001) for patients with NT-proBNP levels ≥ 732 pg/mL, compared with < 732 pg/mL. Conclusion NT-proBNP is a strong predictor of 2-year death with SCAD after PCI in the drug-eluting stent era. | ZHAO Xue Yan LI Jian Xin TANG Xiao Fang XU Jing Jing SONG Ying JIANG Lin CHEN Jue SONG Lei GAO Li Jian GAO Zhan QIAO Shu Bin YANG Yue Jin GAO Run Lin XU Bo YUAN Jin Qing | 2018 | Biomedical and Environmental Sciences2018，31，12： | 5 |
| 15 | 内皮祖细胞的动员:糖尿病大鼠长期服用褪黑素预防勃起功能障碍的一个可能机制显示文摘糖尿病引起的氧化应激会对内皮祖细胞从骨髓中的动员产生重要影响。本文旨在探索长期给予褪黑素对提高I型糖尿病大鼠内皮祖细胞的动员作用,以及其对勃起功能障碍的预防功效。链脲佐菌素诱导的I型糖尿病大鼠被给予褪黑素。流式细胞术用于测定内皮祖细胞水平。骨髓组织中超氧化物歧化酶和丙二醛的水平用于反映骨髓组织中氧化应激水平。电刺激勃起神经记录海绵体内压力用于评价大鼠勃起功能。组织学评估阴茎海绵体组织中内皮密度及纤维化程度。结果显示长期给予褪黑素能够提高骨髓组织中超氧化物歧化酶的水平而降低丙二醛的水平,同时提高循环中内皮祖细胞的数量。治疗组大鼠海绵体内压和平均动脉压的比值较糖尿病对照组明显提高。组织学分析显示褪黑素治疗能够提高阴茎海绵体组织中内皮的密度。但是,褪黑素治疗并没有改善糖尿病大鼠阴茎海绵体组织中的纤维化状态。长期给予褪黑素对于保护I型糖尿病大鼠勃起功能具有一定的效果。改善内皮祖细胞的动员是可能的机制之一。 | Xue-Feng Qiu Xiao-Xin Li Yun Chen Hao-Cheng Lin Wen Yu Run Wang Yu-Tian Dai | 2012 | Asian Journal of Andrology2012，14，3： | 5 |
| 16 | Human rhinovirus C infection is associated with asthma in children determined by x TAG respiratory viral panel FAST显示文摘Dear Editor,Cumulative evidence supports the role of early-life viral infections,especially respiratory syncytial virus(RSV)and human rhinovirus(HRV),as major antecedents of childhood asthma(Lemanske,2002;Jackson et al.,2008).In this study,the x TAG respiratory viral panel FAST(RVP FAST)assay,a multiplex polymerase chain reaction(PCR)-based method(Arens et al.,2010;BaladaLlasat et al.,2011;Gharabaghi et al.,2011;Selvaraju,2012),was used to investigate the association of infec- | Dongmei Chen Qinwei Song Runan Zhu Yuan Qian Yu Sun Jie Deng Fang Wang Yaxin Ding Run Tian Chuanhe Liu Wenjing Zhu Linqing Zhao | 2017 | Virologica Sinica2017，32，2： | 5 |
| 17 | Human adenovirus(HAdV)infection in children with acute respiratory tract infections in Guangzhou,China,2010–2021:a molecular epidemiology study显示文摘Background Human adenovirus(HAdV)infection can cause a variety of diseases.It is a major pathogen of pediatric acute respiratory tract infections(ARIs)and can be life-threatening in younger children.We described the epidemiology and subtypes shifting of HAdV among children with ARI in Guangzhou,China.Methods We conducted a retrospective study of 161,079 children diagnosed with acute respiratory illness at the Guangzhou Women and Children’s Medical Center between 2010 and 2021.HAdV specimens were detected by real-time PCR and the hexon gene was used for phylogenetic analysis.Results Before the COVID-19 outbreak in Guangzhou,the annual frequency of adenovirus infection detected during this period ranged from 3.92%to 13.58%,with an epidemic peak every four to fve years.HAdV demonstrated a clear seasonal distribution,with the lowest positivity in March and peaking during summer(July or August)every year.A signifcant increase in HAdV cases was recorded for 2018 and 2019,which coincided with a shift in the dominant HAdV subtype from HAdV-3 to HAdV-7.The latter was associated with a more severe disease compared to HAdV-3.The average mortality proportion for children infected with HAdV from 2016 to 2019 was 0.38%but increased to 20%in severe cases.After COVID-19 emerged,HAdV cases dropped to 2.68%,suggesting that non-pharmaceutical interventions probably reduced the transmission of HAdV in the community.Conclusion Our study provides the foundation for the understanding of the epidemiology of HAdV and its associated risks in children in Southern China. | Yi Chen Tao Lin Chang‑Bing Wang Wan‑Li Liang Guang‑Wan Lian Mark Zanin Sook‑San Wong Xin‑Gui Tian Jia‑Yu Zhong Ying‑Ying Zhang Jia‑Hui Xie Ling‑Ling Zheng Fei‑Yan Chen Run Dang Ming‑Qi Zhao Yi‑Yu Yang Rong Zhou Bing Zhu | 2022 | World Journal of Pediatrics2022，18，8： | 5 |
| 18 | ^(226)Ra evidence for the ecosystem shift over the past 40 years in the North Pacific Subtropical Gyre显示文摘Surface seawater was collected for ^(226)Ra measurement in the North Pacific Subtropical Gyre from July to October, 1999 and October to December, 2003. Combined with the historical data reported for this sea area, a declined trend of surface ^(226)Ra concentrations was observed since 1960s, indicating the ecosystem shift in response to global warming. On one side, the enhanced stratification of the upper water column resulting from global warming reduced the ^(226)Ra input from the depth, on the other, the temporal increase of biological production resulting from the climate-related ecosystem structure change strengthened the ^(226)Ra removal from the surface ocean. Both the physical and biological processes resulted in the decrease of surface ^(226)Ra concentrations in the North Pacific Subtropical Gyre. The temporal trend of surface ^(226)Ra concentrations was consistent with the trends of chlorophyll a, silicate, phosphate and primary production previously reported. This study provided ^(226)Ra evidence for the ecosystem shift under global change. | YANG JunHong CHEN Min QIU YuSheng LI YanPing MA Qiang LUE E ZHANG Run HUANG YiPu | 2007 | Chinese Science Bulletin2007，52，6： | 5 |
| 19 | Rational development of a human antibody cocktail that deploys multiple functions to confer Pan-SARS-CoVs protection显示文摘Structural principles underlying the composition and synergistic mechanisms of protective monoclonal antibody cocktails are poorly defined.Here,we exploited antibody cooperativity to develop a therapeutic antibody cocktail against SARS-CoV-2.On the basis of our previously identified humanized cross-neutralizing antibody H014,we systematically an a lyzed a fully human n aive antibody library and rationally identified a potent neutralizing antibody partner,P17,which confers effective protection in animal model.Cryo-EM studies dissected the nature of the P17 epitope,which is SARS-CoV-2 specific and distinctly different from that of HOI4.High-resolution structure of the SARS-CoV-2 spike in complex with HOM and P17,together with functional investigations revealed that in a two-antibody cocktail,synergistic neutralization was achieved by S1 shielding and conformational locking,thereby blocking receptor attachment and viral membrane fusion,conferring high potency as well as robustness against viral mutation escape.Furthermore,cluster analysis identified a hypothetical 3rd antibody partner for further reinforcing the cocktail as pan-SARS-CoVs therapeutics. | Hangping Yao Yao Sun Yong-Qiang Deng Nan Wang Yongcong Tan Na-Na Zhang Xiao-Feng Li Chao Kong Yan-Peng Xuc Qi Chen Tian-Shu Cao Hui Zhao Xintian Yan Lei Cao Zhe Lv Dandan Zhu Rui Feng Nanping Wu Wenhai Zhang Yuhao Hu Keda Chen Rong-Rong Zhang Qingyu Lv Shihui Sun Yunhua Zhou Run Yan Guan Yang Xinglu Chanjuan Liu Xiangyun Lu Linfang Cheng Hongying Qiu Xing-Yao Huang Tianhao Weng Danrong Shi Weidong Jiang Junbin Shao Lei Wang Jie Zhang Tao Jiang Guojun Lang Cheng-Feng Qinc Lanjuan Li Xiangxi Wang | 2021 | Cell Research2021，31，1： | 5 |
| 20 | Molecular Epidemiological Study on Prevalence of Human Papillomaviruses in Patients with Common Warts in Beijing Area显示文摘Objective To study the circulation,distribution,and genomic diversity of HPVs in common warts in Beijing area of China.Methods Forty eight patients with pathologically diagnosed common warts were screened for the presence of HPV with HPV type-specific PCR and direct sequencing analysis.The genomic diversity of HPVs prevalent in Chinese patients was analyzed based on LCR.Results Forty one(85.5%)samples were positive for HPV DNA,13(31.7%)-HPV-57, 12(29.3%)-HPV-1a,7(17%)-HPV-27 and 5(12.2%)HPV-2a.Four cases were infected with two different HPV types,two(4.9%) with HPV-1a and HPV-27,one(2.4%)with HPV-1 and HPV-57 and one(2.4%)with HPV-27 and HPV-57.In contrast to the prevalence of single strain of novel HPV-57 variant and HPV-1 prototype.two HPV-2 and three HPV-27 novel variants were found to circulate in Beijing.Conclusion HPV-1.-2.-27 and-57 are predominantly prevalent in patients with common warts in Beijing. | YAN-JUN LEI CHEN GAO CHEN WANG JUN HAN JIAN-MING CHEN GUANG-CAI XIANG QI SHI HUI-YING JIANG WEI ZHOU RUN AN CHEN-FANG DONG YU-KANG YUAN XIAO-PING DONG | 2009 | Biomedical and Environmental Sciences2009，22，1： | 4 |
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