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| 1 | LncRNA-HOTAIR inhibition aggravates oxidative stress-induced H9c2 cells injury through suppression of MMP2 by miR-125显示文摘 | Linlin Li Mengna Zhang Weizhen Chen Ruirui Wang Zi Ye Yanyan Wang Xiao Li Cheguo Cai | 2018 | Acta Biochimica et Biophysica Sinica2018，50，10： | 20 |
| 2 | Dietary supplementation with Clostridium butyricum improves growth performance of broilers by regulating intestinal microbiota and mucosal epithelial cells显示文摘Clostridium butyricum has been widely considered an antibiotic substitute in recent years.It can promote growth performance,improve the immune response and enhance the intestinal barrier function of the host.In the present study,1-d-old Arbor Acres(AA)broilers were fed C.butyricum(1×109 cfu/kg)for 28 d.The transcriptomic characteristics of epithelial cells of the cecal mucosa were determined by RNA-sequence,and the cecal microbiota composition was explored by 16 S ribosomal RNA gene sequencing.The changes in the intestinal mucosa of broilers were then analyzed by tissue staining.Gene Ontology(GO)annotations identified substance transport and processes and pathways that might participate in intestinal development and cell viability.Kyoto Encyclopedia of Genes and Genomes(KEGG)pathway analysis revealed that the differentially expressed genes are involved in numerous pathways related to amino acid and vitamin metabolism and antioxidant and defensive functions,among others.The relative expression of some genes associated with intestinal barrier function(claudins 2,15,19,and 23,tight junction proteins 1,2,and 3 and mucin 1)was significantly increased in the treatment group(P<0.05 or P<0.01).Moreover,the proportion of Firmicutes was higher in the C.butyricum-treated group,whereas the proportion of Proteobacteria was higher in the control group.At the genus level,the relative abundances of Butyricicoccus and Lactobacillus,among other bacteria,were increased after C.butyricum supplementation.The tissue staining analysis showed that the cecal mucosa of broilers was significantly ameliorated after the addition of C.butyricum(P<0.05 or P<0.01).These results showed that dietary supplementation with C.butyricum can enhance the antioxidant capacity,mucosal barrier function,and stabilize the cecal microbiota,resulting in improving the growth performance. | Laipeng Xu Xiangli Sun Xianhua Wan Keke Li Fuchun Jian Wenting Li Ruirui Jiang Ruili Han Hong Li Xiangtao Kang Yanbin Wang | 2021 | Animal Nutrition2021，，4： | 12 |
| 3 | A survey on numerical simulations of drag and heat reduction mechanism in supersonic/hypersonic flows显示文摘Along with the survey on experimental investigations drawing attention to the drag and heat reduction mechanism, the authors simultaneously focus on the recent advances of numerical simulations on the schemes applied to supersonic/hypersonic vehicles. The CFD study has evolved as an irreplaceable method in scheme evaluation and aircraft optimization. Similar to our previous experimental survey, the advances in drag and heat reduction schemes are reviewed by similar kinds of mechanism in this article, namely the forward-facing cavity, the opposing jet, the aerospike, the energy deposition and their combinational configurations. This review article puts an emphatic eye on the flow conditions, numerical methods, novel schemes and analytical conclusions given in the simulations. Further, the multi-objective design optimization concept has also been illustrated due to the observable advantages of using CFD over experimental method, especially those performances conducted in drag reduction and thermal protection practice, and this would possess reference value in the design of aircraft system. | Xiwan SUN Wei HUANG Min OU Ruirui ZHANG Shibin LI | 2019 | Chinese Journal of Aeronautics2019，32，4： | 12 |
| 4 | Lingguizhugan Decoction, a Chinese herbal formula, improves insulin resistance in overweight/obese subjects with non-alcoholic fatty liver disease: a translational approach显示文摘Lingguizhugan Decoction(LGZG)has been investigated in basic studies,with satisfactory effects on insulin resistance in non-alcoholic fatty liver disease(NAFLD).This translational approach aimed to explore the effect and underlying mechanism of LGZG in clinical setting.A randomized,double-blinded,placebo-controlled trial was performed.A total of 243 eligible participants with NAFLD were equally allocated to receive LGZG(two groups:standard dose and low dose)or placebo for 12 weeks on the basis of lifestyle modifications.The primary efficacy variable was homeostasis model assessment of insulin resistance(HOMA-IR).Analyses were performed in two populations in accordance with body mass index(BMI;overweight/obese,BMI 24 kg/m^(2);lean,BMI<24 kg/m^(2)).For overweight/obese participants,low-dose LGZG significantly decreased their HOMA-IR level compared with placebo(0.19(1.47)versus 0.08(1.99),P=0.038).For lean subjects,neither dose of LGZG showed a superior effect compared with placebo.Methylated DNA immunoprecipitation sequencing and real-time qPCR found that the DNA N6-methyladenine modification levels of protein phosphatase 1 regulatory subunit 3A(PPP1R3A)and autophagy related 3(ATG3)significantly increased after LGZG intervention in overweight/obese population.Low-dose LGZG effectively improved insulin resistance in overweight/obese subjects with NAFLD.The underlying mechanism may be related to the regulation of DNA N6-methyladenine modification of PPP1R3A and ATG3.Lean subjects may not be a targeted population for LGZG. | Liang Dai Jingjuan Xu Baocheng Liu Yanqi Dang Ruirui Wang Lijie Zhuang Dong Li Lulu Jiao Jianying Wang Lei Zhang Linda LDZhong Wenjun Zhou Guang Ji | 2022 | Frontiers of Medicine2022，16，5： | 7 |
| 5 | The involvement of wheat U-box E3 ubiquitin ligase TaPUB1 in salt stress tolerance显示文摘U-box E3 ubiquitin ligases play important roles in the ubiquitin/26 S proteasome machinery and in abiotic stress responses. Ta PUB1-overexpressing wheat(Triticum aestivum L.) were generated to evaluate its function in salt tolerance. These plants had more salt stress tolerance during seedling and flowering stages, whereas the Ta PUB1-RNA interference(RNAi)-mediated knock-down transgenic wheat showed more salt stress sensitivity than the wild type(WT). Ta PUB1 overexpression upregulated the expression of genes related to ion channels and increased the net root Na+efflux, but decreased the net K+efflux and H+influx, thereby maintaining a low cytosolic Na+/K+ratio, compared with the WT. However,RNAi-mediated knock-down plants showed the opposite response to salt stress. Ta PUB1 could induce the expression of some genes that improved the antioxidant capacity of plants under salt stress. Ta PUB1 also interacted with Ta MP(Triticum aestivum α-mannosidase protein), a regulator playing an important role in salt response in yeast and in plants. Thus, low cytosolic Na+/K+ratios and better antioxidant enzyme activities could be maintained in wheat with overexpression of Ta PUB1 under salt stress. Therefore, we conclude that the U-box E3 ubiquitin ligase Ta PUB1 positively regulates salt stress tolerance in wheat. | Wenlong Wang Wenqiang Wang Yunzhen Wu Qinxue Li Guangqiang Zhang Ruirui Shi Junjiao Yang Yong Wang Wei Wang | 2020 | Journal of Integrative Plant Biology2020，62，5： | 6 |
| 6 | Direct imaging and determination of the crystal structure of six-layered graphdiyne显示文摘自从它的发现,因为它在由一根电子横梁的照耀下面是太精细的,很少层 graphdiyne 的水晶结构的直接成像和决心证明了困难。在这个工作,六分层的 graphdiyne nanosheet 的水晶结构被低电压的传播电子显微镜学(TEM ) 直接用低当前的密度观察。高分辨率的 TEM (HRTEM ) 模拟,电子精力损失光谱学,和电子衍射的联合使用表明同样综合的 nanosheet 是有 2.19 nm 的厚度的水晶的 graphdiyne (相应于六层的厚度) 并且叠的显示出的 ABC。因此,这个工作为存在和很少层 graphdiyne 的水晶结构提供直接证据,它是对 graphene 补足的二维的碳材料的一种新类型。 | Chao Li Xiuli Lu Yingying Han Shangfeng Tang Yi Ding Ruirui Liu Haihong Bao Yuliang Li Jun Luo Tongbu Lu | 2018 | Nano Research2018，11，3： | 5 |
| 7 | New deep eutectic solvents composed of crown ether, hydroxide and polyethylene glycol for extraction of non-basic N-compounds显示文摘Here we firstly report a series of new deep eutectic solvents(DESs) induced by small amounts of crown ether complex and mainly formed by polyethylene glycol. These DESs not only presented the ultra-deep extraction of non-basic N-compounds from fuel oils, but also opened up the possibility of other new applications in chemistry and materials science. | Mohammad Chand Ali Ruirui Liu Jia Chen Tianpei Cai Haijuan Zhang Zhan Li Honglin Zhai Hongdeng Qiu | 2019 | Chinese Chemical Letters2019，30，4： | 5 |
| 8 | Redox dual-stimuli responsive drug delivery systems for improving tumor-targeting ability and reducing adverse side effects显示文摘Cancer is a big challenge that has plagued the human beings for ages and one of the most effective treatments is chemotherapy. However, the low tumor-targeting ability limits the wide clinical application of chemotherapy. The microenvironment plays a critical role in many aspects of tumor genesis. It generates the tumor vasculature and it is highly implicated in the progression to metastasis. To maintain a suitable environment for tumor progression, there are special microenvironment in tumor cell, such as low pH, high level of glutathione(GSH) and reactive oxygen species(ROS), and more special enzymes, which is different to normal cell. Microenvironment-targeted therapy strategy could create new opportunities for therapeutic targeting. Compared to other targeting strategies, microenvironment-targeted therapy strategy will control the drug release into tumor cells more accurately. Redox responsive drug delivery systems(DDSs) are developed based on the high level of GSH in tumor cells. However, there are also GSH in normal cell though its level is lower. In order to control the release of drugs more accurately and reduce side effects, other drug release stimuli have been introduced to redox responsive DDSs. Under the synergistic reaction of two stimuli, redox dual-stimuli responsive DDSs will control the release of drugs more accurately and quickly and even increase the accumulation. This review summarizes strategies of redox dual-stimuli responsive DDSs such as pH, light, enzyme, ROS, and magnetic guide to delivery chemotherapeutic agents more accurately, aiming at providing new ideas for further promoting the drug release,enhancing tumor-targeting and improving anticancer effects. To better illustrate the redox dual-stimuli responsive DDS, preparations of carriers are also briefly described in the review. | Ruirui Li Feifei Peng Jia Cai Dandan Yang Peng Zhang | 2020 | Asian Journal of Pharmaceutical Sciences2020，15，3： | 5 |
| 9 | Application of red mud as a basic catalyst for biodiesel production显示文摘Red mud was investigated in triglyceride transesterification with a view to determine its viability as a basic catalyst for use in biodiesel synthesis.The effect of calcination temperature on the structure and activity of red mud catalysts was investigated.It was found that highly active catalyst was obtained by simply drying red mud at 200°C.Utilization of red mud as a catalyst for biodiesel production not only provides a cost-effective and environmentally friendly way of recycling this solid red mud waste,significantly reducing its environmental effects,but also reduces the price of biodiesel to make biodiesel competitive with petroleum diesel. | Qiang Liu Ruirui Xin Chengcheng Li Chunli Xu Jun Yang | 2013 | Journal of Environmental Sciences2013，25，4： | 5 |
| 10 | Cerebral fractional amplitude of low-frequency fluctuations may predict headache intensity improvement following acupuncture treatment in migraine patients显示文摘OBJECTIVE:To explore how baseline resting-state cerebral function predicts clinical outcomes of acupuncture treatment for migraine.METHODS:One hundred migraine patients and 46 healthy subjects were recruited.Patients were randomized into the acupuncture,sham acupuncture,and waiting list groups.Resting-state functional magnetic resonance imaging data were collected at baseline and after 1 month of longitudinal acupuncture treatments.Fractional amplitude of low-frequency fluctuations(f ALFF)calculations were applied to explore the associations between baseline f ALFF and changes in clinical variables in the acupuncture treatment group and the waiting list group.RESULTS:Compared with healthy subjects,migraine patients had lower f ALFF in the left rostral ventromedial medulla,right thalamus,left amygdala,and right angular gyrus.Regression analyses revealed that baseline f ALFF values in the left middle frontal gyrus,left superior temporal gyrus,and middle temporal gyrus were positively associated with headache intensity changes in the acupuncture treatment group,while baseline f ALFF values in the bilateral lingual gyrus and cuneus were negatively associated with headache intensity changes in this group.CONCLUSION:The baseline f ALFF values of brain regions associated with cognitive pain modulation,but not migraine severity,may predict future headache intensity improvement levels in migraine patients receiving acupuncture treatment. | Li Zhengjie Zhou Jun Cheng Shirui Lan Lei Sun Ruirui Liu Mailan Yang Jie Gao Yujie Guo Taipin Gong Qiyong Zeng Fang Liang Fanrong | 2020 | Journal of Traditional Chinese Medicine2020，40，6： | 5 |
| 11 | CitGVD:a comprehensive database of citrus genomic variations显示文摘Citrus is one of the most important commercial fruit crops worldwide.With the vast genomic data currently available for citrus fruit,genetic relationships,and molecular markers can be assessed for the development of molecular breeding and genomic selection strategies.In this study,to permit the ease of access to these data,a web-based database,the citrus genomic variation database(CitGVD,http://gffzz1758061741e3440chp66fopbukbwv6cnw.ffgz.tsg.suse.edu.cn/home)was developed as the first citrusspecific comprehensive database dedicated to genome-wide variations including single nucleotide polymorphisms(SNPs)and insertions/deletions(INDELs).The current version(V1.0.0)of CitGVD is an open-access resource centered on 1,493,258,964 high-quality genomic variations and 84 phenotypes of 346 organisms curated from in-house projects and public resources.CitGVD integrates closely related information on genomic variation annotations,related gene annotations,and details regarding the organisms,incorporating a variety of built-in tools for data accession and analysis.As an example,CitGWAS can be used for genome-wide association studies(GWASs)with SNPs and phenotypic data,while CitEVOL can be used for genetic structure analysis.These features make CitGVD a comprehensive web portal and bioinformatics platform for citrus-related studies.It also provides a model for analyzing genome-wide variations for a wide range of crop varieties. | Qiang Li Jingjing Qi Xiujuan Qin Wanfu Dou Tiangang Lei Anhua Hu Ruirui Jia Guojin Jiang Xiuping Zou Qin Long Lanzhen Xu Aihong Peng Lixiao Yao Shanchun Chen Yongrui He | 2020 | Horticulture Research2020，7，1： | 4 |
| 12 | Cloning and Expression Analysis of Citrus Genes Cs GH3.1 and Cs GH3.6Responding to Xanthomonas axonopodis pv. citri Infection显示文摘To study the functions of the early auxin-responsive genes Cs GH3.1 and Cs GH3.6 in citrus resistance against canker disease, we cloned Cs GH3.1and Cs GH3.6 in ‘Newhall' Navel Orange(Citrus sinensis Osbeck). They are 1 797 bp and 1 887 bp and encode 598 and 629 amino acids, respectively. In vitro mature leaves from susceptible ‘Newhall' and resistant Calamondin(C. madurensis) were inoculated by a Xanthomonas axonopodis pv. citri(Xac) bacterial suspension, and expression of Cs GH3.1 and Cs GH3.6 in the two varieties were analyzed using quantitative real-time PCR(q RT-PCR). ‘Newhall' leaves were treated with different hormones for 3 days, inoculated by Xac bacterial suspension, and then the symptoms in these leaves were investigated. We used q RT-PCR to analyze the effect of different hormones on Cs GH3.1 and Cs GH3.6 expression in ‘Newhall'leaves. The expression levels of both Cs GH3.1 and Cs GH3.6 were significantly induced by Xac in ‘Newhall' leaves, compared with levels in Calamondin leaves. 1-naphthy acetic acid(NAA) increased the hypertrophy of infection sites in ‘Newhall' leaves, while naphthyl-phthalamic acid(NPA)had no visible effect on lesion development. NAA hormone greatly improved expression of Cs GH3.1 in ‘Newhall', but not Cs GH3.6. These results indicate that the auxin primary-response gene Cs GH3.1 plays an important role in citrus susceptibility to Xac. | CHEN Min HE Yongrui XU Lanzhen PENG Aihong LEI Tiangang YAO Lixiao LI Qiang ZHOU Pengfei BAI Xiaojing DUAN Minjie JIANG Xueyou JIA Ruirui ZOU Xiuping CHEN Shanchun | 2016 | Horticultural Plant Journal2016，2，4： | 4 |
| 13 | Nest-like multilevel structured graphene oxide-on-polyacrylonitrile membranes for highly efficient filtration of ultrafine particles显示文摘Developing filtration media for particulate matter(PM)removal has been proven to be extremely challenging.Here,we report a facile and scalable strategy to fabricate a multi-level structured polyacrylonitrile/graphene oxide(PAN/GO)air filtration membrane to remove ultrafine particles in air by combining multi-jet electrospinning and physical bonding.Our approach allows the thin PAN nanofibers and two-dimensional GO nanosheets to form interpenetrating bonding structures on non-woven fabric and to assemble into stable filtration media.The resultant composite membranes can filtrate 300 nm particles with a high removal efficiency of 98.8%,a low pressure drop of 55 Pa,and a desirable quality factor of 0.34 Pa^(-1).This multi-level PAN/GO filter is expected to have wider applications not only for the ultrafine particle filtration and separation but also for the design of three-dimensional functional structures in the future. | Jing Li Danzhen Zhang Xin Jiang Xuanliang Zhao Ruirui Hu Yujia Zhong Hongwei Zhu | 2019 | Journal of Materiomics2019，5，3： | 4 |
| 14 | Atom table convolutional neural networks for an accurate prediction of compounds properties显示文摘Machine learning techniques are widely used in materials science.However,most of the machine learning models require a lot of prior knowledge to manually construct feature vectors.Here,we develop an atom table convolutional neural networks that only requires the component information to directly learn the experimental properties from the features constructed by itself.For band gap and formation energy prediction,the accuracy of our model exceeds the standard DFT calculations.Besides,through dataenhanced technology,our model not only accurately predicts superconducting transition temperatures,but also distinguishes superconductors and non-superconductors.Utilizing the trained model,we have screened 20 compounds that are potential superconductors with high superconducting transition temperature from the existing database.In addition,from the learned features,we extract the properties of the elements and reproduce the chemical trends.This framework is valuable for high throughput screening and helpful to understand the underlying physics. | Shuming Zeng Yinchang Zhao Geng Li Ruirui Wang Xinming Wang Jun Ni | 2019 | npj Computational Materials2019，，1： | 4 |
| 15 | TDP-43 regulates cancer-associated microRNAs显示文摘 | Xiaowei Chen Zhen Fan Warren McGee Mengmeng Chen Ruirui Kong Pushuai Wen Tengfei Xiao Xiaomin Chen Jianghong Liu Li Zhu Runsheng Chen Jane Y. Wu | 2018 | Protein & Cell2018，9，10： | 4 |
| 16 | Energy-level dependent H_2_O_2 production on metal-free,carbon-content tunable carbon nitride photocatalysts显示文摘Light-driven production of H_2O_2 from water and molecular oxygen could be a promising way for obtaining both solar fuels and fundamental chemicals. During that process, the H_2O_2 yield is strongly dependent on the reaction pathway associated with two-electron reduction of dioxygen by the photo-generated electrons. Herein, we synthesized a series of metal-free, carbon-content tunable carbon nitride photocatalysts(named C_3N_4-Carbon) by a facile hydrothermal reaction and subsequent thermal treatment at appropriate temperatures. The energy levels of the C_3N_4-Carbon catalysts vary with the carbon doping level, which is conveniently tuned by changing the initial glucose concentration during the hydrothermal reaction. The surface carbon species evolve with the carbon content and the nitrogen atoms in the structure of carbon nitride are partially substituted by foreign carbon atoms based on XPS measurements. The optimal catalyst leads to the highest H_2O_2 yield of 1271 μmol L^(-1) in an acidic aqueous solution(pH 3) after a reaction period of 4 h, twice higher than the pristine C_3N_4. In addition, the largest formation rate constant and the smallest decomposition rate constant of H_2O_2 are obtained on the optimal one according to the kinetics analyses. The decomposition tests of H_2O_2 indicate that the formation rate could be a dominant factor impacting the H_2O_2 yield. The conduction band position of the optimal catalyst is positively shifted to 0.06 V versus RHE, which is more favorable to the reduction of dioxygen to H_2O_2(O2/H_2O_2 at 0.69 V versus RHE). The positive shift of valence band also improves hole collection and leads to enhanced formation of H_2O_2. | Ruirui Wang Xin Zhang Fan Li Ding Cao Min Pu Dandan Han Junjiao Yang Xu Xiang | 2018 | Journal of Energy Chemistry2018，27，2： | 4 |
| 17 | Application of zeolite adsorption and biological anaerobic digestion technology on hydrothermal liquefaction wastewater显示文摘The post-hydrothermal liquefaction wastewater(PHWW)was obtained from a conversion process of Spirulina sp.to bio-crude oil via hydrothermal liquefaction(HTL)technology that was rich in organic matter and toxicant.In this study,zeolite was applied to overcome the inhibitions and improve anaerobic digestion(AD)efficiency.Three zeolite adding ways were evaluated:PHWW pretreated with zeolite for 5 h with/without solid-liquid separation before AD process and zeolite added to PHWW AD process directly,in order to find the most ideal way to add zeolite.Results indicated that zeolite had a positive effect on the AD process of the PHWW.The gas potential of PHWW after adding zeolite,as well as the chemical oxygen demand(COD)removal rate,was much higher than those of its initial state.Especially when the PHWW was pretreated by zeolite for 5 h without separation,the biogas yield increased by 73.96%(6170μmol/g CODremoved)compared with the initial PHWW(3546.7μmol/g CODremoved). | Li Ruirui Ran Xia Duan Na Yuanhui Zhang Liu Zhidan Lu Haifeng | 2017 | International Journal of Agricultural and Biological Engineering2017，10，1： | 3 |
| 18 | Copy number alteration profiling facilitates differential diagnosis between ossifying fibroma and fibrous dysplasia of the jaws显示文摘Ossifying fibroma(OF)and fibrous dysplasia(FD)are two fibro-osseous lesions with overlapping clinicopathological features,making diagnosis challenging.In this study,we applied a whole-genome shallow sequencing approach to facilitate differential diagnosis via precise profiling of copy number alterations(CNAs)using minute amounts of DNA extracted from morphologically correlated microdissected tissue samples.Freshly frozen tissue specimens from OF(n=29)and FD(n=28)patients were obtained for analysis.Lesion fibrous tissues and surrounding normal tissues were obtained by laser capture microdissection(LCM),with~30–50 cells(5000–10000µm2)per sample.We found that the rate of recurrent CNAs in OF cases was much higher(44.8%,13 of 29)than that in FD cases(3.6%,1 of 28).Sixty-nine percent(9 of 13)of the CNA-containing OF cases involved segmental amplifications and deletions on Chrs 7 and 12.We also identified eight CNA-associated genes(HILPDA,CALD1,C1GALT1,MICALL2,PHF14,AIMP2,MDM2,and CDK4)with amplified expression,which was consistent with the copy number changes.We further confirmed a jaw lesion with a previous uncertain diagnosis due to its ambiguous morphological features and the absence of GNAS mutation as OF based on the typical Chr 12 amplification pattern in its CNA profile.Moreover,analysis of a set of longitudinal samples collected from an individual with a cellular lesion in suspicion of OF at the first surgery,recurrence and the latest malignant transformation revealed identical CNA patterns at the three time points,suggesting that copy number profiling can be used as an important tool to identify borderline lesions or lesions with malignant potential.Overall,CNA profiling of fibro-osseous lesions can greatly improve differential diagnosis between OF and FD and help predict disease progression. | Ming Ma Lu Liu Ruirui Shi Jianyun Zhang Xiaotian Li Xuefen Li Jiaying Bai Jianbin Wang Yanyi Huang Tiejun Li | 2021 | International Journal of Oral Science2021，13，2： | 3 |
| 19 | Isoflavones’effects on pharmacokinetic profiles of main iridoids from Gardeniae Fructus in rats显示文摘Gardeniae Fructus(GF)and Semen Sojae Praeparatum(SSP)are both medicine food homologies and widely used in Chinese clinical prescriptions together.The research investigated the pharmacokinetics of four iridoids in normal rats and isolfavones-fed rats,which were administered with isolfavones from SSP for 7,14,21 and 28 consecutive days.A validated LC-MS/MS method was developed for determining shanzhiside,genipin-1-gentiobioside,geniposide and their metabolite genipin in rat plasma.Plasma samples were pretreated by solid-phase extraction using paeoniflorin as the internal standard.The chromatographic separation was performed on a Waters Atlantis T3(4.6 mm×150 mm,3 mm)column using a gradient mobile phase consisting of acetonitril and water(containing 0.06%acetic acid).The mass detection was under the multiple reaction monitoring(MRM)mode via polarity switching between negative and positive ionization modes.The calibration curves exhibited good linearity(r>0.997)for all components.The lower limit of quantitation was in the range of 1 e10 ng/m L.The intra-day and inter-day precisions(RSD)at three different levels were both less than 12.2%and the accuracies(RE)ranged fromà10.1%to 16.4%.The extraction recovery of them ranged from 53.8%to 99.7%.Pharmacokinetic results indicated the bioavailability of three iridoid glycosides and the metabolite,genipin in normal rats was higher than that in rats exposed to isoflavones.With the longer time of administration of isoflavones,plasma concentrations of iridoids decreased,while genipin sulfate,the phase II metabolite of genposide and genipin-1-gentiobioside,appeared the rising exposure.The pharmacokinetic profiles of main iridoids from GF were altered by isoflavones. | Ruirui Chang Jialin Liu Yusha Luo Taohong Huang Qiang Li Jun Wen Weidong Chen Tingting Zhou | 2020 | Journal of Pharmaceutical Analysis2020，10，6： | 2 |
| 20 | Import of Rift Valley fever to China:a potential new threat?显示文摘Several recent studies in Virologica Sinica and other journals have highlighted the enormous international challenge of emerging arboviral diseases,such as Zika virus disease,dengue,and chikungunya(Islam et al.,2015;Maurice et al.,2015;Dai et al.,2016;Deng et al.,2016;Song et al.,2016;Wang et al.,2016;Xu et al.,2016;Zhang et al.,2016;Zhou | Xinliang FU Lifang Wang Bo Fang Ruirui Ma Yun Zheng San Huang Pei Zhou Zongxi Cao Jin Tian Shoujun Li Guihong Zhang | 2016 | Virologica Sinica2016，31，5： | 2 |
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