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| 1 | CD146 acts as a novel receptor for netrin-1 in promoting angiogenesis and vascular development显示文摘Angiogenesis,最新形成的血容器从先存在发芽的一个过程,为脊椎动物开发和成年动态平衡是重要的。以前的研究证明了 neuronal 指导分子 netrin-1 参予脉管的系统的 angiogenesis 和形态发生。Netrin-1 在 angiogenesis 展出双活动:支持或禁止 angiogenesis。netrin-1 的 anti-angiogenic 活动被 UNC5B 受体调停。然而, netrin-1 怎么支持 angiogenesis,仍然保持不清楚。这里,我们报导那 CD146,免疫球蛋白总科的 endothelial transmembrane 蛋白质,是为 netrin-1 的受体。Netrin-1 与高亲密关系绑在 CD146,导致 endothelial 房间激活并且以一种 CD146 依赖的方式的下游的发信号。在由特定的 anti-CD146 抗体的 netrin-CD146 相互作用的鼠科的内皮细胞层或混乱的 cd146 基因的有条件的大美人堵住或减少 netrin-1-induced angiogenesis。在 zebrafish 胚胎, downregulating 任何一个 netrin-1a 或 CD146 与惹人注目的类似导致脉管的缺点。而且,将宫外的脉管的发芽由 netrin-1 overexpression 导致了的 CD146 块击倒。一起,我们的数据揭开 CD146 在 angiogenesis 为 CD146 作为为 netrin-1 并且也的以前未知的受体揭示功能的 ligand,表明在脊椎动物开发期间在 angiogenesis 发信号的 netrin-CD146 的参与。 | Tao Tu Chunxia Zhang Huiwen Yan Yongting Luo Ruirui Kong Pushuai Wen Zhongde Ye Jianan Chen Jing Feng Feng Liu Jane Y Wu Xiyun Yan | 2015 | Cell Research2015，25，3： | 23 |
| 2 | A two-step weighted least-squares method for joint estimation of source and sensor locations: A general framework显示文摘It is well known that the Two-step Weighted Least-Squares(TWLS) is a widely used method for source localization and sensor position refinement. For this reason, we propose a unified framework of the TWLS method for joint estimation of multiple disjoint sources and sensor locations in this paper. Unlike some existing works, the presented method is based on more general measurement model, and therefore it can be applied to many different localization scenarios.Besides, it does not have the initialization and local convergence problem. The closed-form expression for the covariance matrix of the proposed TWLS estimator is also derived by exploiting the first-order perturbation analysis. Moreover, the estimation accuracy of the TWLS method is shown analytically to achieve the Cramér-Rao Bound(CRB) before the threshold effect takes place. The theoretical analysis is also performed in a common mathematical framework, rather than aiming at some specific signal metrics. Finally, two numerical experiments are performed to support the theoretical development in this paper. | Ding WANG Jiexin YIN Tao TANG Ruirui LIU Zhidong WU | 2019 | Chinese Journal of Aeronautics2019，32，2： | 8 |
| 3 | The synthesis of 6-(tert-butyl)-8-fluoro-2,3-dimethylquinoline carbonate derivatives and their antifungal activity against Pyricularia oryzae显示文摘A series of novel 6-(/er/-butyl)-8-fluoro-2,3- dimethylquinoline carbonate derivatives were designed and synthesized. Bioassay results showed that some of them exhibited good activity against Pyricularia oryzae (P. oryzae). It was found that the compound 5q (benzyl (6-(tert-butyl)-8-fluoro-2,3-dimethylquinolin-4-yl) carbonate) possessed good activity against P. oryzae whatever protective activity (10 mg·L^-1) or curative activity (25 mg·L^-1), which was better than that of control tebufloquin. In addition, the frontier molecular orbit results revealed that the compound held higher activity against P. oryzae when the total energy was low and the ClogP was high, which may provide useful information for further design novel fungicides. | Long Cheng Ruirui Zhang Hongke Wu Xinghai Liu Tianming Xu | 2019 | Frontiers of Chemical Science and Engineering2019，13，2： | 8 |
| 4 | In situ decomposition of metal-organic frameworks into ultrathin nanosheets for the oxygen evolution reaction显示文摘氧进化反应(OER ) 是一个枢轴的过程为切开水并且包含氧电极的许多另外的精力技术。此处,新合成策略被建议准备 OER 催化剂基于一简单在共同基于的醋酸盐氢氧化物的 situ 分解还灵活金属器官的框架(MOF ) 。这个过程与优秀部件可控制性允许各种各样的 2D 氢氧化物 ultrathin nanosheets (UNS ) 的直接制造。同样获得的共同基于的氢氧化物 UNS 由于众多的活跃地点的暴露为 OER 表明优异催化活动。特别地, CoNi 氢氧化物 UNS 展出低过电位() 在 10 和 100 妈的当前的密度的 324 和 372 mV ? 沬? | Kai He Zhen Cao Ruirui Liu Ya Miao Yi Ding | 2016 | Nano Research2016，9，6： | 7 |
| 5 | Lingguizhugan Decoction, a Chinese herbal formula, improves insulin resistance in overweight/obese subjects with non-alcoholic fatty liver disease: a translational approach显示文摘Lingguizhugan Decoction(LGZG)has been investigated in basic studies,with satisfactory effects on insulin resistance in non-alcoholic fatty liver disease(NAFLD).This translational approach aimed to explore the effect and underlying mechanism of LGZG in clinical setting.A randomized,double-blinded,placebo-controlled trial was performed.A total of 243 eligible participants with NAFLD were equally allocated to receive LGZG(two groups:standard dose and low dose)or placebo for 12 weeks on the basis of lifestyle modifications.The primary efficacy variable was homeostasis model assessment of insulin resistance(HOMA-IR).Analyses were performed in two populations in accordance with body mass index(BMI;overweight/obese,BMI 24 kg/m^(2);lean,BMI<24 kg/m^(2)).For overweight/obese participants,low-dose LGZG significantly decreased their HOMA-IR level compared with placebo(0.19(1.47)versus 0.08(1.99),P=0.038).For lean subjects,neither dose of LGZG showed a superior effect compared with placebo.Methylated DNA immunoprecipitation sequencing and real-time qPCR found that the DNA N6-methyladenine modification levels of protein phosphatase 1 regulatory subunit 3A(PPP1R3A)and autophagy related 3(ATG3)significantly increased after LGZG intervention in overweight/obese population.Low-dose LGZG effectively improved insulin resistance in overweight/obese subjects with NAFLD.The underlying mechanism may be related to the regulation of DNA N6-methyladenine modification of PPP1R3A and ATG3.Lean subjects may not be a targeted population for LGZG. | Liang Dai Jingjuan Xu Baocheng Liu Yanqi Dang Ruirui Wang Lijie Zhuang Dong Li Lulu Jiao Jianying Wang Lei Zhang Linda LDZhong Wenjun Zhou Guang Ji | 2022 | Frontiers of Medicine2022，16，5： | 7 |
| 6 | Graphene oxide as an antimicrobial agent can extenCthe vase life of cut flowers显示文摘"PlantNanOmics" is an emerging topic in agricultural research that explores thepotential effect of application of nanomaterials on plant growth. Graphene oxide(GO) has excellent properties due to its basal carbon plane and oxygen-containingfunctional groups. In the present work, the antimicrobial activity of GO wasexploited to extend the vase life and improve the quality of cut roses (cv. Carola).The results revealed that the cut roses cultivated in low doses of GO (0.1 mg/L)had longer vase life, larger diameter, and better water relations. Microbialcontaminations at the basal stem end is the most common reason for stemblockage that causes water stress and early wilting of cut flowers. GO wasfound to act as a germicide, effectively inhibiting the microbial growth atthe cut stem end and improving water uptake and water balance of cut roses.Therefore, GO can serve as a promising preservative to increase the ornamentalvalue of cut flowers. | Yijia He Lichao Qian Xu Liu Ruirui Hu Meirong Huang Yule Liu Guoqiang Chen Dusan Losic Hongwei Zhu | 2018 | Nano Research2018，11，11： | 6 |
| 7 | Direct imaging and determination of the crystal structure of six-layered graphdiyne显示文摘自从它的发现,因为它在由一根电子横梁的照耀下面是太精细的,很少层 graphdiyne 的水晶结构的直接成像和决心证明了困难。在这个工作,六分层的 graphdiyne nanosheet 的水晶结构被低电压的传播电子显微镜学(TEM ) 直接用低当前的密度观察。高分辨率的 TEM (HRTEM ) 模拟,电子精力损失光谱学,和电子衍射的联合使用表明同样综合的 nanosheet 是有 2.19 nm 的厚度的水晶的 graphdiyne (相应于六层的厚度) 并且叠的显示出的 ABC。因此,这个工作为存在和很少层 graphdiyne 的水晶结构提供直接证据,它是对 graphene 补足的二维的碳材料的一种新类型。 | Chao Li Xiuli Lu Yingying Han Shangfeng Tang Yi Ding Ruirui Liu Haihong Bao Yuliang Li Jun Luo Tongbu Lu | 2018 | Nano Research2018，11，3： | 5 |
| 8 | New deep eutectic solvents composed of crown ether, hydroxide and polyethylene glycol for extraction of non-basic N-compounds显示文摘Here we firstly report a series of new deep eutectic solvents(DESs) induced by small amounts of crown ether complex and mainly formed by polyethylene glycol. These DESs not only presented the ultra-deep extraction of non-basic N-compounds from fuel oils, but also opened up the possibility of other new applications in chemistry and materials science. | Mohammad Chand Ali Ruirui Liu Jia Chen Tianpei Cai Haijuan Zhang Zhan Li Honglin Zhai Hongdeng Qiu | 2019 | Chinese Chemical Letters2019，30，4： | 5 |
| 9 | Application of red mud as a basic catalyst for biodiesel production显示文摘Red mud was investigated in triglyceride transesterification with a view to determine its viability as a basic catalyst for use in biodiesel synthesis.The effect of calcination temperature on the structure and activity of red mud catalysts was investigated.It was found that highly active catalyst was obtained by simply drying red mud at 200°C.Utilization of red mud as a catalyst for biodiesel production not only provides a cost-effective and environmentally friendly way of recycling this solid red mud waste,significantly reducing its environmental effects,but also reduces the price of biodiesel to make biodiesel competitive with petroleum diesel. | Qiang Liu Ruirui Xin Chengcheng Li Chunli Xu Jun Yang | 2013 | Journal of Environmental Sciences2013，25，4： | 5 |
| 10 | Cerebral fractional amplitude of low-frequency fluctuations may predict headache intensity improvement following acupuncture treatment in migraine patients显示文摘OBJECTIVE:To explore how baseline resting-state cerebral function predicts clinical outcomes of acupuncture treatment for migraine.METHODS:One hundred migraine patients and 46 healthy subjects were recruited.Patients were randomized into the acupuncture,sham acupuncture,and waiting list groups.Resting-state functional magnetic resonance imaging data were collected at baseline and after 1 month of longitudinal acupuncture treatments.Fractional amplitude of low-frequency fluctuations(f ALFF)calculations were applied to explore the associations between baseline f ALFF and changes in clinical variables in the acupuncture treatment group and the waiting list group.RESULTS:Compared with healthy subjects,migraine patients had lower f ALFF in the left rostral ventromedial medulla,right thalamus,left amygdala,and right angular gyrus.Regression analyses revealed that baseline f ALFF values in the left middle frontal gyrus,left superior temporal gyrus,and middle temporal gyrus were positively associated with headache intensity changes in the acupuncture treatment group,while baseline f ALFF values in the bilateral lingual gyrus and cuneus were negatively associated with headache intensity changes in this group.CONCLUSION:The baseline f ALFF values of brain regions associated with cognitive pain modulation,but not migraine severity,may predict future headache intensity improvement levels in migraine patients receiving acupuncture treatment. | Li Zhengjie Zhou Jun Cheng Shirui Lan Lei Sun Ruirui Liu Mailan Yang Jie Gao Yujie Guo Taipin Gong Qiyong Zeng Fang Liang Fanrong | 2020 | Journal of Traditional Chinese Medicine2020，40，6： | 5 |
| 11 | Mesocrystalline TiO2/sepiolite composites for the effective degradation of methyl orange and methylene blue显示文摘 | Ruirui LIU Zhijiang JI Jing WANG Jinjun ZHANG | 2018 | Frontiers of Materials Science2018，12，3： | 4 |
| 12 | MicroRNA Expression Signature and Antisense-Mediated Depletion Reveal an Essential Role of MicroRNA in Vascular Neointimal Lesion Formation显示文摘 | Ruirui Ji Yunhui Cheng Junming Yue Jian Yang Xiaojun Liu He Chen David B. Dean Chunxiang Zhang | 2007 | Circulation Research2007，，11： | 4 |
| 13 | TDP-43 regulates cancer-associated microRNAs显示文摘 | Xiaowei Chen Zhen Fan Warren McGee Mengmeng Chen Ruirui Kong Pushuai Wen Tengfei Xiao Xiaomin Chen Jianghong Liu Li Zhu Runsheng Chen Jane Y. Wu | 2018 | Protein & Cell2018，9，10： | 4 |
| 14 | TBM penetration rate prediction based on the long short-term memory neural network显示文摘Tunnel boring machines(TBMs)are widely used in tunnel engineering because of their safety and efficiency.The TBM penetration rate(PR)is crucial,as its real-time prediction can reflect the adaptation of a TBM under current geological conditions and assist the adjustment of operating parameters.In this study,deep learning technology is applied to TBM performance prediction,and a PR prediction model based on a long short-term memory(LSTM)neuron network is proposed.To verify the performance of the proposed model,the machine parameters,rock mass parameters,and geological survey data from the water conveyance tunnel of the Hangzhou Second Water Source project were collected to form a dataset.Furthermore,2313 excavation cycles were randomly composed of training datasets to train the LSTM-based model,and 257 excavation cycles were used as a testing dataset to test the performance.The root mean square error and the mean absolute error of the proposed model are 4.733 and 3.204,respectively.Compared with Recurrent neuron network(RNN)based model and traditional time-series prediction model autoregressive integrated moving average with explanation variables(ARIMAX),the overall performance on proposed model is better.Moreover,in the rapidly increasing period of the PR,the error of the LSTM-based model prediction curve is significantly smaller than those of the other two models.The prediction results indicate that the LSTM-based model proposed herein is relatively accurate,thereby providing guidance for the excavation process of TBMs and offering practical application value. | Boyang Gao RuiRui Wang Chunjin Lin Xu Guo Bin Liu Wengang Zhang | 2021 | Underground Space2021，6，6： | 4 |
| 15 | Application of zeolite adsorption and biological anaerobic digestion technology on hydrothermal liquefaction wastewater显示文摘The post-hydrothermal liquefaction wastewater(PHWW)was obtained from a conversion process of Spirulina sp.to bio-crude oil via hydrothermal liquefaction(HTL)technology that was rich in organic matter and toxicant.In this study,zeolite was applied to overcome the inhibitions and improve anaerobic digestion(AD)efficiency.Three zeolite adding ways were evaluated:PHWW pretreated with zeolite for 5 h with/without solid-liquid separation before AD process and zeolite added to PHWW AD process directly,in order to find the most ideal way to add zeolite.Results indicated that zeolite had a positive effect on the AD process of the PHWW.The gas potential of PHWW after adding zeolite,as well as the chemical oxygen demand(COD)removal rate,was much higher than those of its initial state.Especially when the PHWW was pretreated by zeolite for 5 h without separation,the biogas yield increased by 73.96%(6170μmol/g CODremoved)compared with the initial PHWW(3546.7μmol/g CODremoved). | Li Ruirui Ran Xia Duan Na Yuanhui Zhang Liu Zhidan Lu Haifeng | 2017 | International Journal of Agricultural and Biological Engineering2017，10，1： | 3 |
| 16 | Estimation of groundwater residence time and recession rate in watershed of the Loess Plateau显示文摘地下水住处时间为水资源开发和利用是水文学周期和必需品的重要指示物。在这份报纸,在非洪水季节,洪水季节和水年的地下水住处时间在位于黄河盆的中间的活动范围的 Wudinghe 河盆从十个水文学车站的每日的流速及流水量自记水位计被决定了。结果显示出那:在 Wudinghe 河盆经常的 baseflow 衰退在非洪水季节比那在洪水季节与更大的衰退率从 0.72 ~ 0.94 。空间地,在黄土区域的 baseflow 的衰退率最大,但是在沙的区域是最小的。当地下水的全面住处时间在在 Wudinghe 河盆的不同亚盆的 34 和 342 天之间时,地下水的一半住处时间从 1.8 ~ 45.5 天变化。地下水的年度平均全面住处时间在更低的活动范围在上面的活动范围从 117 天减少到 73 天。 | ZHU Ruirui ZHENG Hongxing LIU Changming | 2010 | Journal of Geographical Sciences2010，20，2： | 3 |
| 17 | Porous Carbon Architecture Assembled by Cross-Linked Carbon Leaves with Implanted Atomic Cobalt for High-Performance Li-S Batteries显示文摘The practical application of lithium-sulfur batteries is severely hampered by the poor conductivity,polysulfide shuttle effect and sluggish reaction kinetics of sulfur cathodes.Herein,a hierarchi-cally porous three-dimension(3D)carbon architecture assembled by cross-linked carbon leaves with implanted atomic Co-N4 has been deli-cately developed as an advanced sulfur host through a SiO_(2)-mediated zeolitic imidazolate framework-L(ZIF-L)strategy.The unique 3D architectures not only provide a highly conductive network for fast electron transfer and buffer the volume change upon lithiation-delithi-ation process but also endow rich interface with full exposure of Co-N4 active sites to boost the lithium polysulfides adsorption and conversion.Owing to the accelerated kinetics and suppressed shuttle effect,the as-prepared sulfur cathode exhibits a superior electrochemical perfor-mance with a high reversible specific capacity of 695 mAh g^(−1) at 5 C and a low capacity fading rate of 0.053%per cycle over 500 cycles at 1 C.This work may provide a promising solution for the design of an advanced sulfur-based cathode toward high-performance Li-S batteries. | Ruirui Wang Renbing Wu Chaofan Ding Ziliang Chen Hongbin Xu Yongfeng Liu Jichao Zhang Yuan Ha Ben Fei Hongge Pan | 2021 | Nano-Micro Letters2021，13，10： | 3 |
| 18 | Copy number alteration profiling facilitates differential diagnosis between ossifying fibroma and fibrous dysplasia of the jaws显示文摘Ossifying fibroma(OF)and fibrous dysplasia(FD)are two fibro-osseous lesions with overlapping clinicopathological features,making diagnosis challenging.In this study,we applied a whole-genome shallow sequencing approach to facilitate differential diagnosis via precise profiling of copy number alterations(CNAs)using minute amounts of DNA extracted from morphologically correlated microdissected tissue samples.Freshly frozen tissue specimens from OF(n=29)and FD(n=28)patients were obtained for analysis.Lesion fibrous tissues and surrounding normal tissues were obtained by laser capture microdissection(LCM),with~30–50 cells(5000–10000µm2)per sample.We found that the rate of recurrent CNAs in OF cases was much higher(44.8%,13 of 29)than that in FD cases(3.6%,1 of 28).Sixty-nine percent(9 of 13)of the CNA-containing OF cases involved segmental amplifications and deletions on Chrs 7 and 12.We also identified eight CNA-associated genes(HILPDA,CALD1,C1GALT1,MICALL2,PHF14,AIMP2,MDM2,and CDK4)with amplified expression,which was consistent with the copy number changes.We further confirmed a jaw lesion with a previous uncertain diagnosis due to its ambiguous morphological features and the absence of GNAS mutation as OF based on the typical Chr 12 amplification pattern in its CNA profile.Moreover,analysis of a set of longitudinal samples collected from an individual with a cellular lesion in suspicion of OF at the first surgery,recurrence and the latest malignant transformation revealed identical CNA patterns at the three time points,suggesting that copy number profiling can be used as an important tool to identify borderline lesions or lesions with malignant potential.Overall,CNA profiling of fibro-osseous lesions can greatly improve differential diagnosis between OF and FD and help predict disease progression. | Ming Ma Lu Liu Ruirui Shi Jianyun Zhang Xiaotian Li Xuefen Li Jiaying Bai Jianbin Wang Yanyi Huang Tiejun Li | 2021 | International Journal of Oral Science2021，13，2： | 3 |
| 19 | Isoflavones’effects on pharmacokinetic profiles of main iridoids from Gardeniae Fructus in rats显示文摘Gardeniae Fructus(GF)and Semen Sojae Praeparatum(SSP)are both medicine food homologies and widely used in Chinese clinical prescriptions together.The research investigated the pharmacokinetics of four iridoids in normal rats and isolfavones-fed rats,which were administered with isolfavones from SSP for 7,14,21 and 28 consecutive days.A validated LC-MS/MS method was developed for determining shanzhiside,genipin-1-gentiobioside,geniposide and their metabolite genipin in rat plasma.Plasma samples were pretreated by solid-phase extraction using paeoniflorin as the internal standard.The chromatographic separation was performed on a Waters Atlantis T3(4.6 mm×150 mm,3 mm)column using a gradient mobile phase consisting of acetonitril and water(containing 0.06%acetic acid).The mass detection was under the multiple reaction monitoring(MRM)mode via polarity switching between negative and positive ionization modes.The calibration curves exhibited good linearity(r>0.997)for all components.The lower limit of quantitation was in the range of 1 e10 ng/m L.The intra-day and inter-day precisions(RSD)at three different levels were both less than 12.2%and the accuracies(RE)ranged fromà10.1%to 16.4%.The extraction recovery of them ranged from 53.8%to 99.7%.Pharmacokinetic results indicated the bioavailability of three iridoid glycosides and the metabolite,genipin in normal rats was higher than that in rats exposed to isoflavones.With the longer time of administration of isoflavones,plasma concentrations of iridoids decreased,while genipin sulfate,the phase II metabolite of genposide and genipin-1-gentiobioside,appeared the rising exposure.The pharmacokinetic profiles of main iridoids from GF were altered by isoflavones. | Ruirui Chang Jialin Liu Yusha Luo Taohong Huang Qiang Li Jun Wen Weidong Chen Tingting Zhou | 2020 | Journal of Pharmaceutical Analysis2020，10，6： | 2 |
| 20 | Basic deep eutectic solvents as reactant, template and solvents for ultra-fast preparation of transition metal oxide nanomaterials显示文摘Developing a new type of deep eutectic solvents(DESs)is indispensable for expanding their application in various fields.Here,we report a series of new highly basic DESs.FT-IR,quantitative 1 H NMR,MD simulation and physical properties show that these basic liquids are made up of hydroxide acceptor of alkali metal hydroxides in which the hydrogen bonding interactions coordinate the donor.These DESs can be played three roles as new solvents,template and reactant for facile and ultra-fast preparation of transition metal oxide nanomaterials such as NiCo2 O4,MnCo2 O4,NiMn2 O4,CoCu2 O4 and Co3 O4 under mild condition.This work shows one of the low energy-intensive methods for nanomaterial preparation.These initial findings of basic deep eutectic solvents provide a potential applicability around the systematic development of transition metal oxide nanosheets. | Jia Chen Mohammad Chand Ali Ruirui Liu Jean Claude Munyemana Zhan Li Honglin Zhai Hongdeng Qiu | 2020 | Chinese Chemical Letters2020，31，6： | 2 |
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