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| 1 | Cerebral fractional amplitude of low-frequency fluctuations may predict headache intensity improvement following acupuncture treatment in migraine patients显示文摘OBJECTIVE:To explore how baseline resting-state cerebral function predicts clinical outcomes of acupuncture treatment for migraine.METHODS:One hundred migraine patients and 46 healthy subjects were recruited.Patients were randomized into the acupuncture,sham acupuncture,and waiting list groups.Resting-state functional magnetic resonance imaging data were collected at baseline and after 1 month of longitudinal acupuncture treatments.Fractional amplitude of low-frequency fluctuations(f ALFF)calculations were applied to explore the associations between baseline f ALFF and changes in clinical variables in the acupuncture treatment group and the waiting list group.RESULTS:Compared with healthy subjects,migraine patients had lower f ALFF in the left rostral ventromedial medulla,right thalamus,left amygdala,and right angular gyrus.Regression analyses revealed that baseline f ALFF values in the left middle frontal gyrus,left superior temporal gyrus,and middle temporal gyrus were positively associated with headache intensity changes in the acupuncture treatment group,while baseline f ALFF values in the bilateral lingual gyrus and cuneus were negatively associated with headache intensity changes in this group.CONCLUSION:The baseline f ALFF values of brain regions associated with cognitive pain modulation,but not migraine severity,may predict future headache intensity improvement levels in migraine patients receiving acupuncture treatment. | Li Zhengjie Zhou Jun Cheng Shirui Lan Lei Sun Ruirui Liu Mailan Yang Jie Gao Yujie Guo Taipin Gong Qiyong Zeng Fang Liang Fanrong | 2020 | Journal of Traditional Chinese Medicine2020，40，6： | 5 |
| 2 | Double emulsion-pretreated microwell culture for the in vitro production of multicellular spheroids and their in situ analysis显示文摘Multicellular spheroids have served as a promising preclinical model for drug efficacy testing and disease modeling.Many microfluidic tech no logies,in eluding those based on water-oil-water double emulsions,have been introduced for the production of spheroids.However,sustained culture and the in situ characterization of the gen erated spheroids are currently unavailable for the double emulsion-based spheroid model.This study presents a streamlined workflow,termed the double emulsion-pretreated microwell culture(DEPMiC),incorporating the features of(1)effective initiation of uniform-sized multicellular spheroids by the pretreatment of double emulsions produced by microfluidics without the requirement of biomaterial scaffolds;(2)sustained maintenance and culture of the produced spheroids with facile removal of the oil confinement;and(3)in situ characterization of individual spheroids localized in microwells by a built-in analytical station.Characterized by microscopic observations and Raman spectroscopy,the DEPMiC cultivated spheroids accumulated elevated lipid ordering on the apical membran巳similar to that observed in their Matrigel counterparts.Made possible by the proposed tech no logical advancement,this study subsequently examined the drug responses of these in vitro-generated multicellular spheroids.The developed DEPMiC platform is expected to gen erate health benefits in personalized cancer treatment by offering a pre-animal tool to dissect heterogeneity from individual tumor spheroids. | Fuyang Qu Shirui Zhao Guangyao Cheng Habibur Rahman Qinru Xiao Renee Wan Yi Chan Yi-Ping Ho | 2021 | Microsystems & Nanoengineering2021，7，3： | 0 |
| 3 | Amplification effect of near-field ground motion around deep tunnels based on finite fracturing seismic source model显示文摘Dynamic failure of rock masses around deep tunnels,such as fault-slip rockburst and seismic-induced collapse,can pose a significant threat to tunnel construction safety.One of the most significant factors that control the accuracy of its risk assessment is the estimation of the ground motion around a tunnel caused by seismicity events.In general,the characteristic parameters of ground motion are estimated in terms of empirical scaling laws.However,these scaling laws make it difficult to accurately estimate the near-field ground motion parameters because the roles of control factors,such as tunnel geometry,damage zone distribution,and seismic source parameters,are not considered.For this,the finite fracturing seismic source model(FFSSM)proposed in this study is used to simulate the near-field ground motion characteristics around deep tunnels.Then,the amplification effects of ground motion caused by the interaction between seismic waves and deep tunnels and corresponding control factors are studied.The control effects of four factors on the near-field ground motion amplification effect are analyzed,including the main seismic source wavelength,tunnel span,tunnel shape,and range of damage zones.An empirical formula for the maximum amplification factor(a_(m))of the near-field ground motion around deep tunnels is proposed,which consists of four control factors,i.e.the wavelength control factor(F_(λ)),tunnel span factor(F_(D)),tunnel shape factor(F_(s))and excavation damage factor(F_(d)).This empirical formula provides an easy approach for accurately estimating the ground motion parameters in seismicityprone regimes and the rock support design of deep tunnels under dynamic loads. | Qiankuan Wang Shili Qiu Yao Cheng Shaojun Li Ping Li Yong Huang Shirui Zhang | 2022 | Journal of Rock Mechanics and Geotechnical Engineering2022，14，6： | 0 |
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