|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Bone marrow-derived mesenchymal stem cells protect against experimental liver fibrosis in rats显示文摘AIM: Recent reports have shown the capacity of mesenchymal stem cells (MSCs) to differentiate into hepatocytes in vitro and in vivo. MSCs administration could repair injured liver, lung, or heart through reducing inflammation, collagen deposition, and remodeling. These results provide a clue to treatment of liver fibrosis. The aim of this study was to investigate the effect of infusion of bone marrow (BM)-derived MSCs on the experimental liver fibrosis in rats.METHODS: MSCs isolated from BM in male Fischer 344 rats were infused to female Wistar rats induced with carbon tetrachloride (CCl4) or dimethylnitrosamine (DMN).There were two random groups on the 42nd d of CCl4:CCl4/MSCs, to infuse a dose of MSCs alone; CCl4/saline,to infuse the same volume of saline as control. There were another three random groups after exposure to DMN: DMN10/MSCs, to infuse the same dose of MSCs on d 10; DMN10/saline, to infuse the same volume of saline on d 10; DMN20/MSCs, to infuse the same dose of MSCson d 20. The morphological and behavioral changes ofrats were monitored everyday. After 4-6 wk of MSCs administration, all rats were killed and fibrosis index were assessed by histopathology and radioimmunoassay. Smooth muscle alpha-actin (alpha-SMA) of liver were tested by immunohistochemistry and quantified by IBAS 2.5 software. Male rats sex determination region on the Y chromosome (sry) gene were explored by PCR.RESULTS: Compared to controls, infusion of MSCsreduced the mortality rates of incidence in CCl4-induced model (10% vs 20%) and in DMN-induced model (2040% vs 90%).The amount of collagen deposition and alpha-SMA staining was about 40-50% lower in liver of rats with MSCs than that of rats without MSCs. The similar results were observed in fibrosis index. And the effect of the inhibition of fibrogenesis was greater in DMN10/MSCs than in DMN20/MSCs. The sry gene was positive in the liver of rats with MSCs treatment by PCR.CONCLUSION: MSCs treatment can protect against experimental liver fibrosis in CCl4-induced or DMN-induced rats and the mechanisms of the anti-fibrosis by MSCs will be studied further. | Dong-ChangZhao Jun-XiaLei RuiChen Wei-HuaYu Xiu-MingZhang Shu-NongLi PengXiang | 2005 | World Journal of Gastroenterology2005，11，22： | 71 |
| 2 | Identification and characterization of neuroblasts in the subventricular zone and rostral migratory stream of the adult human brain显示文摘在成年人的前脑遗体在 subventricular 地区(SVZ ) 和象小径一样的喙的迁移的溪流(RMS ) 的存在在神经发生的成年人的大脑,而是坚持识别新神经原兴趣大高度争论。在现在的学习,我们在成年猴子,胎儿的人和成年人的大脑描述了 RMS 的一般配置。我们提供神经母细胞在成年人的大脑的前面的腹的 SVZ 和 RMS 连续地存在的证据。没有形成链,神经母细胞单身地或在对出现;他们展出迁移的形态学和合作快车不成熟的 neuronal 标记 doublecortin, polysialylated 神经房间粘附分子和 β III 导管素。很少这些神经母细胞看起来活跃地在前面的腹的 SVZ 正在增殖,显示沿着 RMS 散布的神经母细胞是最可能的但是任何一个都没在 RMS 源于腹的 SVZ。有趣地,没有神经母细胞在成年人的嗅觉的灯泡被发现。一起拿,我们的数据建议 SVZ 维持能力在成年人的大脑生产神经母细胞。 | CongminWang FangLiu Ying-YingLiu Cai-HongZhao YanYou LeiWang JingxiaoZhang BinWei TongMa QiangqiangZhang YueZhang RuiChen HongjunSong ZhengangYang | 2011 | Cell Research2011，21，11： | 13 |
| 3 | Numerical simulation of particle flow behavior in a screw conveyor using the discrete element method显示文摘Particle motion in a screw conveyor was simulated w让h the discrete element method. The particle flow behavior and transport processes at different screw rotating speeds and filling levels were investigated in this study. The spatial distributions of particle velocity were predicted. The predicted mass flow rate increased w让h increasing screw rotating speed and filling level. The contact forces and granular temperatures of particles were also calculated. The simulation results showed that the translational granular particle temperatures were higher than the rotational granular particle temperatures. In add让ion, the configurational temperatures of particles were calculated from simulated instantaneous particle overlaps, and results indicated that deformation of elastic particles contributed to the rate of energy dissipation. Good agreement between the numerical simulation and experimental results was achieved in this study. | Shuyan Wang Haolong Li Ruichao Tian Ruichen Wang Xu Wang Qiji Sun jiawei Fan | 2019 | Particuology2019，17，2： | 7 |
| 4 | Mechanisms and field test of solution mining by self-resonating cavitating water jets显示文摘Rapid solution mining is the key to cavern construction in salt formations. Rapid solution mining technology with self-resonating cavitating water jets is described in this paper. It can generate three main physical effects: helical flow dissolution, self-resonating cavitating jet erosion, and ultrasonic waves. A self-resonating cavitating nozzle was also designed with the principles based on theory of fluid transients and hydro-acoustics. Under ambient pressure, the experimental results show that the impulse amplitude of pressure reaches a peak at a standoff distance of 5-13 times the nozzle outlet diameter and the cutting ability of self-resonating cavitating jets is twice that of conventional jets under the same conditions. Compared with the conventional mining method, the field test indicates that rapid solution mining technology with self-resonating cavitating jets can speed the construction by more than 2 times at the pocket stage of cavern development. | Song Xianzhi Li Gensheng Yuan Jinping Tian Zhonglan Shen Ruichen Yuan Guangjie Huang Zhongwei | 2010 | Petroleum Science2010，7，3： | 5 |
| 5 | In Vitro Characterizations of PLLA/β-TCP Porous Matrix Materials and RMSC-PLLA-β-TCP Composite Scaffolds显示文摘To develop a novel degradable poly (L-lactic acid)/β-tricalcium phosphate (PLLA/β-TCP) bioactive materials for bone tissue engineering, β-TCP powder was produced by a new wet process. Porous scaffolds were prepared by three steps, I.e. Solvent casting, compression molding and leaching stage. Factors influencing the compressive strength and the degradation behavior of the porous scaffold, e.g. Weight fraction of pore forming agent-sodium chloride (NaCl), weight ratio of PLLA: β-TCP, the particle size ofβ-TCP and the porosity, were discussed in details. Rat marrow stromal cells (RMSC) were incorporated into the composite by tissue engineering approach. Biological and osteogenesis potential of the composite scaffold were determined with MTT assay, alkaline phosphatase (ALP) activity and bone osteocalcin (OCN) content evaluation. Results show that PLLA/β-TCP bioactive porous scaffold has good mechanical and pore structure with adjustable compressive strength needed for surgery. RMSCs seeding on porous PLLA/β-TCP composite behaves good seeding efficacy, biocompatibility and osteoinductive potential. Osteoprogenitor cells could well penetrate into the material matrix and begin cell proliferation and osteogenic differentiation. Osseous matrix could be formed on the surface of the composite after culturing in vitro. It is expected that the PLLA/β-TCP porous composites are promising scaffolds for bone tissue engineering in prosthesis surgery. | DaliZHOU WeizhongYANG GuangfuYIN ChangqiongZHENG YunZHANG HuaiqingCHEN RuiCHEN | 2004 | Journal of Materials Science & Technology2004，20，3： | 3 |
| 6 | Key technologies and practice for gas field storage facility construction of complex geological conditions in China显示文摘In view of complex geological characteristics and alternating loading conditions associated with cyclic large amount of gas injection and withdrawal in underground gas storage(UGS) of China, a series of key gas storage construction technologies were established, mainly including UGS site selection and evaluation, key index design, well drilling and completion, surface engineering and operational risk warning and assessment, etc. The effect of field application was discussed and summarized. Firstly, trap dynamic sealing capacity evaluation technology for conversion of UGS from the fault depleted or partially depleted gas reservoirs. A key index design method mainly based on the effective gas storage capacity design for water flooded heterogeneous gas reservoirs was proposed. To effectively guide the engineering construction of UGS, the safe well drilling, high quality cementing and high pressure and large flow surface injection and production engineering optimization suitable for long-term alternate loading condition and ultra-deep and ultra-low temperature formation were developed. The core surface equipment like high pressure gas injection compressor can be manufactured by our own. Last, the full-system operational risk warning and assessment technology for UGS was set up. The above 5 key technologies have been utilized in site selection, development scheme design, engineering construction and annual operations of 6 UGS groups, e.g. the Hutubi UGS in Xinjiang. To date, designed main indexes are highly consistent with actural performance, the 6 UGS groups have the load capacity of over 7.5 billion cubic meters of working gas volume and all the storage facilities have been running efficiently and safely. | MA Xinhua ZHENG Dewen SHEN Ruichen WANG Chunyan LUO Jinheng SUN Junchang | 2018 | Petroleum Exploration and Development2018，45，3： | 2 |
| 7 | Advances in oral peptide drug nanoparticles for diabetes mellitus treatment显示文摘Peptide drugs play an important role in diabetes mellitus treatment.Oral administration of peptide drugs is a promising strategy for diabetes mellitus because of its convenience and high patient compliance compared to parenteral administration routes.However,there are a series of formidable unfavorable conditions present in the gastrointestinal(GI)tract after oral administration,which result in the low oral bioavailability of these peptide drugs.To overcome these challenges,various nanoparticles(NPs)have been developed to improve the oral absorption of peptide drugs due to their unique in vivo properties and high design flexibility.This review discusses the unfavorable conditions present in the GI tract and provides the corresponding strategies to overcome these challenges.The review provides a comprehensive overview on the NPs that have been constructed for oral peptide drug delivery in diabetes mellitus treatment.Finally,we will discuss the rational application and give some suggestions that can be utilized for the development of oral peptide drug NPs.Our aim is to provide a systemic and comprehensive review of oral peptide drug NPs that can overcome the challenges in GI tract for efficient treatment of diabetes mellitus. | Yan Li Wen Zhang Ruichen Zhao Xin Zhang | 2022 | Bioactive Materials2022，7，9： | 2 |
| 8 | Comparative studies of metamodelling techniques under multiple modelling criteria 显示文摘 | Jin Ruichen Chert Wei Simpson T W | 2001 | Structural and Multidisciplinary Optimization2001，23，1： | 1 |
| 9 | Study on Biocompatibility of Complexes of Collagen–Chitosan–Sodium Hyaluronate and Cornea显示文摘 | JiansuChen QinhuaLi JintangXu YaoxiongHuang YongDing HongweiDeng SongbinZhao RuiChen | 2005 | Artificial Organs2005，，2： | 1 |
| 10 | An efficient algorithm for constructing optimal design of computer experiments显示文摘 | RUICHEN J WEI C AGUS SUDJIANTO | 2005 | Journal of Statistical Planning and Inference2005，，134： | 1 |
| 11 | Grey Incidence Analysis Applied to Civil Aircraft Customization Process显示文摘The airlines need to select the optional equipment according to their individual development demands and the manufacture′s standard specification manual when purchasing a new airplane.For this customization process,the selection theory is mainly based on qualitative analysis and quantitative analysis.The grey incidence analysis(GIA)is used for modeling,which evaluates the correlations between optional equipment and airlines′individual demands.Meanwhile,the customization demands are quantitatively processed as different weights in evaluation index system with analytical hierarchy process.Then,the value of grey incidence degree is obtained which shows whether the optional equipment is on the purchasing list or not.Finally,two airlines′customization demands are applied in the example of aircraft cabin′s seats,so two different purchasing priorities and equipment installation lists can be obtained.The results and comparisons verify the reasonable of modeling,which provides an objective scheme of aircraft equipment selection. | Ding Songbin Ge Ruichen Wang Xiaoli | 2016 | Transactions of Nanjing University of Aeronautics and Astronautics2016，33，2： | 1 |
| 12 | Comparative Studies of Metamodeling Techniques Under Multiple Modeling Criteria显示文摘 | Jin Ruichen Chen Wei Simpson T W | 2001 | Structural and Multidisciplinary Optimization2001，23，1： | 1 |
| 13 | An Efficient Algorithm for Constructing Optimal Design of Computer Experiments显示文摘 | Jin Ruichen Chen Wei Sudjianto Agus | 2005 | Journal of Statistical Planning and Inference2005，34，1： | 1 |
| 14 | Interconnect technology trend for microelectronics显示文摘 | Pai Chien-Shing Martinez Emilio | 1999 | Solid-State Electronics1999，43，6： | 1 |
| 15 | An efficient algorithm for constructing optimal design of computer experiments显示文摘 | Ruichen Jin Wei Chen Agus Sudjianto | 2004 | Journal of Statistical Planning and Influence2004，134，1： | 1 |
| 16 | CLINICAL RISK FACTORS IN REGIONAL BRAIN ISCHEMIA USING SINGLE PHOTON EMISSION COMPUTED TOMOGRAPHY显示文摘 | RuiChen FengxiaLiang Kei‐IchiroIshigami TsugiyasuKanda LiZeng AtsushiSaito MasayukiHasegawa NaohiroYamashita TomohikoItoh ToshikazuKigoshi YoichiIzumi NoboruTakekoshi ShigetoMorimoto | 2010 | Journal of the American Geriatrics Society2010，，： | 1 |
| 17 | Conceptual rotational mode design for optical conical scanning imaging small satellites显示文摘This paper focuses upon the novel optical conical scanning imaging working mode design for small satellites.This kind of satellite employs only one inclined optical camera achieving wide-swath imaging via a rotational motion about the nadir axis either by the camera or by the satellite.Three working modes are designed,i.e.,high-speed rotational mode,low-speed rotational mode,and variable-speed rotational mode.For the high-speed and low-speed working modes,the camera rotates at a constant speed and the corresponding angular velocity is derived under the consideration of guaranteed coverage and minimized overlap.To improve the system performance,an enhanced working mode taking advantages of both the high-speed rotational mode and lowspeed rotational mode is proposed.Working in this variable-speed rotational mode,the camera rotates slowly to get high-quality pictures when it works,while it rotates rapidly to reduce the energy consumption and save the storage during which period the camera is turned off to minimize the overlap.All these working modes are illustrated in detail,and numerical simulation tests are conducted to validate their effectiveness. | WANG Feng XI RuiChen YUE ChengFei LI HuaYi CAO XiBin | 2020 | Science China(Technological Sciences)2020，63，8： | 1 |
| 18 | Construction of Virtual Simulation Platform for Tourism显示文摘This paper introduced the application of the WebGIS and virtual reality technology in the tourism industry and analyzed the existing problems in the tourism information system.Taking Daqing Oil Field Scenic Sport as an example,it introduced a method of constructing the virtual simulation platform for tourism based on the combination of WebGIS and virtual reality technology.Through the virtual simulation platform of Daqing Tourism Scenic Spot,it verified the design idea,methods,and technical feasibility of the virtual tourism system,and built a specific,feasible,and practical virtual simulation platform for tourism.It showed the bright prospects of virtual tourism development based on WebGIS and virtual reality technology. | Shuang CHENG Qiuju XIE Jingfu ZHU Ya GAO Shuang WANG Ruichen CHI Ruijian LIU | 2017 | Asian Agricultural Research2017，9，2： | 1 |
| 19 | Evaluation of power regeneration in primary suspension for a railway vehicle显示文摘To improve the fuel economy of rail vehicles,this study presents the feasibility of using power regenerating dampers(PRDs)in the primary suspension systems of railway vehicles and evaluates the potential and recoverable power that can be obtained.PRDs are configured as hydraulic electromagnetic-based railway primary vertical dampers and evaluated in parallel and series modes(with and without a viscous damper).Hydraulic configuration converts the linear behavior of the track into a unidirectional rotation of the generator,and the electromagnetic configuration provides a controllable damping force to the primary suspension system.In several case studies,generic railway vehicle primary suspension systems that are configured to include a PRD in the two configuration modes are modeled using computer simulations.The simulations are performed on measured tracks with typical irregularities for a generic UK passenger route.The performance of the modified vehicle is evaluated with respect to key performance indicators,including regenerated power,ride comfort,and running safety.Results indicate that PRDs can simultaneously replace conventional primary vertical dampers,regenerate power,and exhibit desirable dynamic performance.A peak power efficiency of 79.87%is theoretically obtained in series mode on a top-quality German Intercity Express track(Track 270)at a vehicle speed of 160 mile/h(~257 km/h). | Ruichen WANG Zhiwei WANG | 2020 | Frontiers of Mechanical Engineering2020，15，2： | 1 |
| 20 | Pharmacokinetics after single and multiple intravaginal application of clindamycin phosphate vaginal gel in Chinese female volunteers显示文摘Objective:To investigate the pharmacokinetics of clindamycin phosphate vaginal gel in healthy Chinese female volunteers.Methods:Ten healthy Chinese female volun- teers were intravaginally given with 5.0g of clindamycin phosphate vaginal gel (equivalent to 100mg of clindamycin) once for single dose treatment,and 5.0g,once a day for 3 days,for mul- tiple dose treatment.The serum concentration of clindamycin were determined by HPLC-MS method and its pharmacokinetic parameters of clindamycin were calculated by DAS 1.0 soft- ware.Results:The main pharmacokinetic parameters of clindamycin for single dose and multiple doses were as follows:t_(1/2) were (15.30±2.62) hours and (14.78±2.49) hours,Tmax were (4.88±0.94) hours and (4.70±0.59) hours,Cmax were (38.30±22.77) ng/ml and (44.87±26.71) ng/ml,AUC0_(-∞) were (783.45±351.19) ng·ml^(-1)·h^(-1) and (1015.68±456.95) ng·ml^(-1)·h^(-1),respectively.Conclusion:The Cmax of clindamycin phosphate vaginal gel after a single dose and multiple doses are obviously lower and t_(1,2) are longer than that of clindamycin phosphate oral preparations,which suggests that clindamycin phosphate vaginal gel acts locally and can be slowly absorbed to circulation for systemic actions. | Wang Benjie Li Yunxia Yuan Guiyan Bu Fanlong Guo Ruichen | 2007 | 现代妇产科进展2007，16，2： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员