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| 1 | Nanozymes: an emerging field bridging nanotechnology and biology显示文摘Enzymes are biological catalysts that can convert substrates into products in biochemical reactions.In 1926,the first enzyme,urease,was determined to be a protein by James B.Sumner who won the Nobel Prize in 1946.Since then,enzymes have been considered to be proteins,which allows them to achieve their high catalytic activity with high specific activity under mild conditions.However,in general,the enzyme activity of proteins is lost after exposure to extremes of p H and high temperature,and proteins are also susceptible to digestion by proteases in the environment,which dramatically hinders their practical applications | Lizeng Gao Xiyun Yan | 2016 | Science China(Life Sciences)2016，59，4： | 17 |
| 2 | The Xiamaling oil shale generated through Rhodophyta over 800 Ma ago显示文摘A suit of oil shales, predominated by black argillaceous silicalite and finely laminated black-brown shale, has been discovered in a set of carbonaceous-siliceous mudstone formations (350 m in thickness) in the third member of Xiamaling Formation of the Upper Proterozoic Qingbaikou Series (900―873 MaBP), Xiahuayuan, Hebei Province, China. The oil shale, combustible with strong bitumen odour, has su- per-high TOC contents ranging from 21.4% to 22.9%, bitumen “A” contents from 0.58% to 0.88% and oil length from 5.29% to 10.57%. The ultrathin section observation of the shale and the identification of its kerogen demonstrate that its hydrocarbon-generative parent material is mainly benthonic Rhodophyta whose specific tetrasporangia are legible and abundant. It is rarely reported in the literature that such a hydrocarbon-generative parent material, composed mainly of Rhodophyta and with extraordinarily high contents of TOC and bitumen “A”, developed into a set of high-quality source rocks. The extracts of the oil shale are characteristic of richness in 17α(H)-diahopanes and n-alkyl tricyclic terpenoids but low in steranes. Such a biomarker feature is obviously different from that of the extracts from other Proterozoic marine carbonate source rocks of the studied area. Since the biological constitution of this oil shale is rather simple, it is clear that these biomarkers most likely represent to certain extent the specific mo- lecular constitutions of the benthonic Rhodophyta identified in the ultrathin sections of the samples. Studies on its lithologic association and depositional sequences suggest that this suit of the carbona- ceous-siliceous mudstone formation, which contains oil shales, was probably developed in an under- compensation deep-bay environment when a maximum transgression occurred during the formation of the third member of Xiamaling Formation. The high concentration of SiO2 in this organic-rich rock and the positive correlation between TOC and some trace elements such as P, Cu, Ni, W and Mo indicate that this suit of rocks was affected by activities of bottom thermal currents as deposited. | ZHANG ShuiChang ZHANG BaoMin BIAN LiZeng JIN ZhiJun WANG DaRui CHEN JianFa | 2007 | Science China Earth Sciences2007，50，4： | 12 |
| 3 | Vitamin B2 functionalized iron oxide nanozymes for mouth ulcer healing显示文摘Mouth ulcer is associated with inflammation and high risk of bacterial infection, which aggravates the patient's condition.Currently, there is no effective treatment for mouth ulcer. Herein, we report that vitamin-modified iron oxide nanoparticles improve the healing of mouth ulcer through anti-inflammation and antibacterial activities. We discovered that vitamin B2(VB2)modified iron oxide nanoparticles performed enhanced peroxidase-like, catalase-like, and superoxide dismutase(SOD)-like activities, acting as typical iron oxide nanozymes(IONzymes) with triad activities. In particular, VB2 modification significantly improved the SOD-like activity, thus providing a reactive oxygen species(ROS)-scavenging ability. Cellular antioxidant experiments showed that vitamin B2 modified IONzymes(VB2-IONzymes) protect human oral keratinocytes(HOK) and BALB/3 T3 cells from hydrogen peroxide(H2O2), and these cells have high biocompatibility to eukaryotic cells. In addition, VB2-IONzymes exerted an antibacterial activity against Streptococcus mutans, Staphylococcus aureus, and Escherichia coli. Importantly, VB2-IONzymes accelerated the recovery of mouth ulcer and reduced the local secretion of inflammatory factors in mouse ulcer model via ROS scavenging and antibacterial activity. Taken together, our work demonstrates that vitamin B2 modification endows iron oxide nanoparticles with enhanced enzyme-like activities and VB2-IONzymes may be a promising reagent in the treatment of mouth ulcer because of their intrinsic anti-inflammation and antibacterial capabilities. | Yunhao Gu Yixin Huang Zhiyue Qiu Zhuobin Xu Dandan Li Lei Chen Jing Jiang Lizeng Gao | 2020 | Science China(Life Sciences)2020，63，1： | 10 |
| 4 | A kind of coccoid dinoflagel-lates-like fossils gives a new explanation of source of dinosterane in the Early-Middle Cambrian显示文摘The coccoid fossils covered with thick gelatinous envelop containing several gametes are discovered in gyps and salt deposits of Cambrian, H4 well and chert bed of the base of Yuertus Formation (∈11) of Xiaoerbulake Section. The fossils are described and compared with coccoid dinoflagellates. These fossils may be a coccoid life-cycle stage (vegetative cyst) of coccoid dinoflagellates. If this identification is correct, the coccoid dinoflagellates-like fossils could give a reasonable explanation of the dinoflagellate-specific biomarkers from Cambrian, H4 well, Tarim Basin. | BIAN Lizeng, ZHANG Shuichang, ZHANG Baomin, MAO Shaozhi & YIN LeimingDepartment of Earth Sciences, Nanjing University, Nanjing 210093,China Key Laboratory of Petroleum Geochemistry, China National Petroleum Corporation, Beijing 100083, China Research Institute of Petroleum Exploration and Development, China National Petroleum Corporation, Beijing 100083, China China University of Geosciences, Beijing 100083, China Nanjing Institute of Geology and Palaeontology, Chinese Academy of Sciences, Nanjing 210008, China | 2001 | Chinese Science Bulletin2001，46，5： | 7 |
| 5 | Benthic macro red alga:A new possible bio-precursor of Jurassic mudstone source rocks in the northern Qaidam Basin,northwestern China显示文摘Whether benthic macroalga can be an important type of bio-precursor of source rocks is a contentious issue in source-rock studies,and has not been well understood.This paper represents a case study of Jurassic mudstone source rocks from the northern Qaidam Basin,northwestern China,in which the benthic macro red algae were recognized for the first time based on combined organic petrological and biomarker works.We found not only cystocarps in the algae,representative of rhodophyta,but also diahopanes,which are diagnostic biomarkers of such algae.Thus,as many reservoired oils in the northern Qaidam Basin contain abundant diahopanes,it may indicate that the red algae have contributed to hydrocarbon accumulation.This was confirmed by integrated geological and geochemical analyses.Hence,this study provides new evidence for macroalga-generated hydrocarbons. | CAO Jian BIAN LiZeng HU Kai LIU YunTian WANG LiQun YANG ShaoYong CHEN Yan PENG XiaoQun | 2009 | Science China Earth Sciences2009，52，5： | 5 |
| 6 | Developmental modes of the Neoproterozoic-Lower Paleozoic marine hydrocarbon source rocks in China显示文摘Based on the researches on rock type, the mode of occurrence, diagnostic minerals and creatures, the sedimentary geochemistry and organic facies of Chinese marine source rocks from wells and outcrops, and on the research findings of developmental modes of foreign marine source rock, the authors consider that it is impossible to objectively make clear the formation mechanism of hydrocarbon source rock with high organic matter abundance by either single mode of preservation or high organic matter productivity. According to the Chinese geological features, the formation mechanism of the Neoproterozoic-Lower Paleozoic marine source rock is generalized into four modes, namely, thermal water activity-upwelling flow-anoxic; carbonate gentle slope-upwelling flow; xerothermic climate-brine euxinic milieu; and humid climate-retained euxinic milieu; as the Lower Cambrian undercompensation basin organic facies (the Tarim Basin, South China and southwestern margin of North China), carbonate gentle lime mud bound organic facies (the Upper Ordovician in Tazhong region of the Tarim Basin and the Lower Silurian in the Upper Yangtze Platform), the Middle Cambrian evaporation laggon organic facies (the Tarim Basin and the Upper Yangtze Platform), enclosed undercompensation terrigenous bay organic facies (the Middle-Upper Ordovician in the west of the Tarim Basin, the Lower Silurian Longmaxi Formation in the Upper Yangtze platform). Chinese marine sedimentations with lower organic matter abundance are generalized into two modes of consumption-dilution mode of open epicontinental sea and depletion-dilution mode of supercompensation basin. | ZHANG BaoMin ZHANG ShuiChang BIAN LiZeng JIN ZhiJun WANG DaRui | 2007 | Chinese Science Bulletin2007，52，A01： | 4 |
| 7 | Discovery of branched tubular algae and microscopic tubes with annular-helical thickening from the Mesoproterozoic Ruyang Group of Shanxi,North China显示文摘Most previously reported Mesoproterozoic (1600-1000 Ma) fossils are from silicified carbonates, and they are commonly small in size (15-20 μm, ranging from coccoids to fila- ments in morphology. Many of them can be interpreted as cyanobacteria. Carbonaceous shales represent another source of palaeontological information of the Mesoproterozoic biosphere. Sphaeromorphic and acanthomorphic acritarchs, as well as filamentous fossils, are common in many Mesoproterozoic shales. Here we report an unusual assemblage of tubular fossils from the Meosproterozoic Ruyang Group in Shanxi, North China. Some of these tubes are branched. Others bear annular-helical thickening that might be represented by one extinct algae to adapt to a desiccating environment. | YIN Leiming BIAN Lizeng YUAN Xunlai | 2004 | Science China Earth Sciences2004，47，10： | 4 |
| 8 | Comparison between cryptospores from the Cambrian Log Cabin Member,Pioche Shale,Nevada,USA and similar specimens from the Cambrian Kaili Formation,Guizhou,China显示文摘Abundant cryptospore-like microfossils have been collected from a sample of the'Middle'Cambrian Log Cabin Member of the Pioche Shale in eastern Nevada,USA.Compared with organic-walled microfossils obtained from the Cambrian Kaili Formation in eastern Guizhou Province,China,some specimens of leiosphers may be inferred to be similar cryptospore-like microfossils.The new fossil record would be the oldest known specimens of cryptospore-like microfossils during the Cambrian Period. | YIN LeiMing ZHAO YuanLong BIAN LiZeng PENG Jin | 2013 | Science China Earth Sciences2013，56，5： | 4 |
| 9 | Numerical Study on the Effects of Equi-biaxial Residual Stress on Mechanical Properties of Nickel Film by Means of Nanoindentation显示文摘In this paper,mechanical properties of Nickel film under residual stress have been systematically examined by finite element method in nanoindentation.It was found that load-displacement curves shifted under elastic residual stress and residual stress exceeded the yield stress for fixed indentation depth.Indentation profiles changed monotonously with compressive and tensile stresses at peak force which determinates contact area observed directly by finite element modeling (FEM).The elastic residual stress has an effect slightly on the hardness but residual stress exceeded the yield stress shows a remarkable effect in nickel film.The hardness increased when residual stress exceeded the yield stress increased under tensile and compressive stress applied to specimen.The relationship between residual stress and hardness was linear.It was found that residual stresses didn't affect elastic modulus whether elastic residual stress or plastic stress was applied to specimen. | Lizeng Ling,Shiguo Long,Zengsheng Ma and Xu Liang Key Laboratory of Low Dimensional Materials and Application Technology of Ministry of Education,and Faculty of Materials,Optoelectronics and Physics,Xiangtan University,Xiangtan 411105,China | 2010 | Journal of Materials Science & Technology2010，26，11： | 3 |
| 10 | Intrinsic peroxidase-like activity of ferromagnetic nanoparticles and its application in immunoassay and environment treatment显示文摘Nanoparticles that contain magnetic materials, such as magnetite (Fe3O4), are particularly useful for imaging and separation techniques. Since these nanoparticles are | Lizeng Gao, Jie Zhuang, Xiyun Yan National Laboratory of Biomacromolecules and Institute of Biophysics, Chinese Academy of Sciences, 15 Datun Road, Beijing 100101, China. | 2009 | 生物物理学报2009，25，S1： | 3 |
| 11 | Features of the type Ill-like source rock and its generated natural gas显示文摘The mother matter of Ordovician source are mainly sapropelic and generate oil in mature stage, since the high plants did not appear in Ordovician period, which is well known by internal and external scholars. Now we find a kind of Orodovician source rock generating mainly light oil and gas in mature stage during appraising source rocks in the Tarim Basin. The organic matters of this source rock are chiefly constructed by benthic brown algae in organisms (showing as macro algae), and are similar to humic source in hydrocarbon generation. The natural gas generated by this kind of source matters is obviously different from the sapropelic gas. | ZHAO Mengjun, ZHANG Baomin, BIAN Lizeng, XIAO Zhongyao, LI Mei, PENG Yan & QIN Shengfei1. Research Center of Exploration of TPEDB, CNPC, Korla 841000, China 2. Research Institute of Petroleum Exploration & Development, CNPC, Beijing 100083, China 3. Department of Earth Science, Nanjing University, Nanjing 210002, China | 2000 | Chinese Science Bulletin2000，45，9： | 2 |
| 12 | A novel application of iron oxide nanoparticles for detection of hydrogen peroxide in acid rain显示文摘 | Zhuang jie Zhang jinbin Gao Lizeng | 2008 | Mater Lett2008，62，24： | 1 |
| 13 | A 1 H-NMR plasma metabonomic study of acute and chronic stress models of depression in rats 显示文摘 | Biyun S Junsheng T Huan X Xiaoqing G Lizeng Z Guan- hua D | 2012 | Behavioural brain research2012，241，： | 1 |
| 14 | Dynam,c and Antagonistic Allele-Specific Epigenetic Modifications Controlling the Expression of Imprinted Genes in Maize Endosperm显示文摘 | Xiaomei Dong Mei Zhang Jian Chen Lizeng Peng Nan Zhang Xin Wang Jinsheng Lai | 2017 | Molecular Plant2017，10，3： | 1 |
| 15 | Metabolomics study on the anti-depression effect of xiaoyaosan on rat model of chronic unpredictable mild stress显示文摘 | Yuntao Dai Zhenyu Li Liming Xue Chunyan Dou Yuzhi Zhou Lizeng Zhang Xuemei Qin | 2010 | Journal of Ethnopharmacology2010，，2： | 1 |
| 16 | Two new monascus red pigments produced by Shandong Zhonghui Food Company in China 显示文摘 | Xijun Lian Lizeng Liu Shirui Dong | 2015 | European Food Research and Technology2015，240，4： | 1 |
| 17 | Intrinsic peroxidase-like activity of ferromagnetic nanoparticles 显示文摘 | Gao Lizeng Zhuang Jie Nie Leng | 2007 | Nature Nanotechnology2007，2，9： | 1 |
| 18 | Decomposing phenol by the hidden talent of ferromagnetic nanoparticles显示文摘 | Jinbin Zhang Jie Zhuang Lizeng Gao Yu Zhang Ning Gu Jing Feng Dongling Yang Jingdong Zhu Xiyun Yan | 2008 | Chemosphere2008，，9： | 1 |
| 19 | Decomposing phenol by the hidden talent of ferromagnetic nanoparticles 显示文摘 | Zhang Jinbin Zhuang Jie Gao Lizeng | 2008 | Chemosphere2008，73，9： | 1 |
| 20 | Intrinsic peroxidase-like activity of ferromagnetic nanoparticles显示文摘 | Lizeng Gao Jie Zhuang Leng Nie | 2007 | Nature Nanotechnology2007，，2： | 1 |
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