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| 1 | 美国国立老化研究所与阿尔茨海默病协会诊断指南写作组:阿尔茨海默病临床前阶段的定义显示文摘阿尔茨海默病(AD)的病理生理过程在痴呆诊断的多年前就开始了。这一长期的AD“临床前”阶段是治疗干预的关键机会,但需进一步阐明AD的病理级联过程和临床症状出现之间的联系。美国国立老化研究所和AD协会召集了一个国际工作组对AD生物标志物、流行病学和神经心理学的证据进行综述并提出建议,以确定能够预测由“正常”认知到轻度认知功能障碍(MCI)及AD痴呆的最佳预测指标。根据目前已有的主要科学证据,我们提出了一个概念性的框架和用于操作的研究标准,以通过纵向临床研究来验证和改进这些模型。这些建议仅用于研究目的,目前不涉及临床应用。我们希望这些建议能提供一个共识,以推进临床前AD的研究,最终推动更早期治疗干预的进展,使得一些疾病减缓药物的疗效发挥最大。 | Sperling RA Aisen PS Beckett LA Bennett DA Craft S Fagan AM Iwatsubo T Jack CR Jr Kaye J Montine TJ Park DC Reiman EM Rowe CC Siemers E Stern Y Yaffe K Carrillo MC Thies B Morrison-Bogorad M Wagster MV Phelps CH 贾建平(译) 郭起浩(译) 黄丽(译) 陆璐(译) 张逸驰(译) 邢怡(译) | 2012 | 中华神经科杂志2012，45，5： | 22 |
| 2 | Three-dimensional perfused human in vitro model of nonalcoholic fatty liver disease显示文摘AIM To develop a human in vitro model of non-alcoholic fatty liver disease(NAFLD), utilising primary hepatocytes cultured in a three-dimensional(3D) perfused platform. METHODS Fat and lean culture media were developed to directly investigate the effects of fat loading on primary hepatocytes cultured in a 3D perfused culture system. Oil Red O staining was used to measure fat loading in the hepatocytes and the consumption of free fatty acids(FFA) from culture medium was monitored. Hepatic functions, gene expression profiles and adipokine release were compared for cells cultured in fat and lean conditions. To determine if fat loading in the system could be modulated hepatocytes were treated with known anti-steatotic compounds. RESULTS Hepatocytes cultured in fat medium were found to accumulate three times more fat than lean cells and fat uptake was continuous over a 14-d culture. Fat loading of hepatocytes did not cause any hepatotoxicity and significantly increased albumin production. Numerous adipokines were expressed by fatty cells and genes associated with NAFLD and liver disease were upregulated including: Insulin-like growth factorbinding protein 1, fatty acid-binding protein 3 and CYP7A1. The metabolic activity of hepatocytes cultured in fatty conditions was found to be impaired and the activities of CYP3A4 and CYP2C9 were significantlyreduced, similar to observations made in NAFLD patients. The utility of the model for drug screening was demonstrated by measuring the effects of known antisteatotic compounds. Hepatocytes, cultured under fatty conditions and treated with metformin, had a reduced cellular fat content compared to untreated controls and consumed less FFA from cell culture medium.CONCLUSION The 3D in vitro NAFLD model recapitulates many features of clinical NAFLD and is an ideal tool for analysing the efficacy of anti-steatotic compounds. | Tomasz Kostrzewski Terri Cornforth Sophie A Snow Larissa Ouro-Gnao Cliff Rowe Emma M Large David J Hughes | 2017 | World Journal of Gastroenterology2017，23，2： | 6 |
| 3 | Oxidative environments decrease tenderization of beef steaks through inactivation of μ-ealpain显示文摘 | Rowe L J Maddock K P Lonergan S M | 2004 | J Anita Sci2004，82，： | 1 |
| 4 | Antimicrobial activity and phytochemical studies of some lichens from south of Spain显示文摘 | SAENZ M T GARCIA M D ROWE J G | 2006 | Fitoterapia2006，77，： | 1 |
| 5 | Recent developments in acute myelogenous leukemia therapy 显示文摘 | King M E Rowe J M | 2007 | Oncologist2007，12，2： | 1 |
| 6 | Selected factors influencing GCL hydraulic conductivity显示文摘 | PETROV R J ROWE R K QUIGLEY R M | 1997 | Journal Geotechnical and Geoenvironmental Engineering1997，123，8： | 1 |
| 7 | Localization of mrna for vascular endothelial growth factor (Vegf), angio- poietins and their receptors during the peri-implanta- tion period and early pregnancy in marmosets (Cal- lithrix Jacchus) 显示文摘 | Rowe A J Wulff C Fraser H M | 2003 | Reproduction2003，126，2： | 1 |
| 8 | Cerebrospinal fluid leak after acoustic neuroma surgery:influence of tumor size and surgical approach on incidence and response to treatment显示文摘 | ROWED D W NEDZELSKI J M | 2001 | J Neurosurgery2001，94，2： | 1 |
| 9 | Operative intervention in delivery is associated with compromised early mother-infant interaction显示文摘 | Rowe M H J Fisher J R | 2001 | British Journal of Obstetrics and Gynaecology2001，108，10： | 1 |
| 10 | Latent membrane protein 1 of Epstein-Barr virus stimulates processing of NF-kappa B2p100 to p52显示文摘 | Atkinson PG Coope H J Rowe M | 2003 | J Biol Chem2003，278，51： | 1 |
| 11 | A randomized trial of washed red blood cell and platelet transfusions in adult acute leukemia显示文摘 | BLUMBERG N HEAL J M ROWE J M | 2004 | BMC Blood Disord2004，4，： | 1 |
| 12 | Transforming community members into diabetes cultural health brokers: The Neighborhood Health Talker project 显示文摘 | Cadzow RB Craig M Rowe J | 2013 | Diabetes Educ2013，39，1： | 1 |
| 13 | Viscosity-Elastic Analysis of Hot Mix Asphalt Pavement显示文摘 | Rowe B Sharrock S F Bouldin M J | 1995 | Transportation Research Record1995，，1482： | 1 |
| 14 | Progress in cystic fibrosis and the CF Therapeutics Development Network 显示文摘 | Rowe S M Borowitz D S Burns J L ct al | 2012 | Thorax2012，67，10： | 1 |
| 15 | Seeing red? Putting sportswear in context显示文摘 | ROWE C HARRIS J M ROBERTS S C | 2005 | Nature2005，437，： | 1 |
| 16 | Manufacturing Technology 显示文摘 | Alexander J M Brewer R C Rowe G W | 1999 | Tribology Transactions1999，59，2： | 1 |
| 17 | Modelling of thermally induced desiccation of geosynthetic clay liners显示文摘 | Southen J M Rowe R K | 2005 | Geotextiles and Geomembranes2005，23，： | 1 |
| 18 | Mix Rheology-a Tool for Predicting the High Temperature Performance of Hot Mix Asphalt显示文摘 | Bouldin G M Rowe J B Sousa M J Sharrock | 1994 | Journal of the Association Asphalt Paving Technologists1994，63，： | 1 |
| 19 | Early postmortem biochemical factors influence tenderness and water-holding capacity of three porcine muscles显示文摘 | MELODY J L LONERGAN S M ROWE L J | 2004 | J Anita Sci2004，，82： | 1 |
| 20 | Host status of agriculturally important plant families to the root-knot nematode Meloidogyne mayaguensis in Cuba 显示文摘 | Rodriguez M G Sanchez L Rowe J | 2004 | Nematropica2004，33，2： | 1 |
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