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| 1 | Clinicopathological predictors of long-term benefit in breast cancer treated with neoadjuvant chemotherapy显示文摘AIM To investigate the survival impact of clinicopathological factors, including pathological complete response(p CR) and tumor-infiltrating lymphocytes(s TIL) levels according to subtypes, in breast cancer(BC) patients who received neo-adjuvant chemotherapy(NAC).METHODS We evaluated 435 BC patients who presented and received NAC at the Instituto Nacional de Enfermedades Neoplasicas from 2003 to 2014. s TIL was analyzed as the proportion of tumor stroma occupied by lymphocytes, and was prospectively evaluated on hematoxylin and eosin-stained sections of the preN AC core biopsy. p CR was considered in the absence of infiltrating cancer cells in primary tumor and axillary lymph nodes. Analysis of statistical association between clinical pathological features, s TIL, p CR and survival were carried out using SPSSvs19.RESULTS Median age was 49 years(range 24-84 years) and the most frequent clinical stage was ⅢB(58.3%). Luminal A, Luminal B, HER2-enriched and(triple-negative) TN phenotype was found in 24.6%, 37.9%, 17.7% and 19.8%, respectively. p CR was observed in 11% and median percentage of s TIL was 40%(2%-95%) in the whole population. p CR was associated to Ct1-2(P = 0.045) and to high s TIL(P = 0.029) in the whole population. There was a slight trend towards significance for s TIL(P = 0.054) in Luminal A. s TIL was associated with grade Ⅲ(P < 0.001), no-Luminal A subtype(P < 0.001), RE-negative(P < 0.001), PgR-negative(P < 0.001), HER2-positive(P = 0.002) and p CR(P = 0.029) in the whole population. Longer disease-free survival was associated with grade Ⅰ-Ⅱ(P = 0.006), cN 0(P < 0.001), clinical stage Ⅱ(P = 0.004), ER-positive(P < 0.001), Pg R-positive(P < 0.001), luminal A(P < 0.001) and p CR(P = 0.002). Longer disease-free survival was associated with grade Ⅰ-Ⅱ in Luminal A(P < 0.001), N0-1 in Luminal A(P = 0.045) and TNBC(P = 0.01), clinical stage Ⅱ in Luminal A(P = 0.003) and TNBC(P = 0.038), and pC R in TNBC(P < 0.001). Longer overall survival was associated with grade Ⅰ-Ⅱ(P < 0.001), ER-positive(P < 0.001), PgR-positive(P < 0.001), Luminal A(P < 0.001), cN 0(P = 0.002) and p CR(P = 0.002) in the whole population. Overall survival was associated with clinical stage Ⅱ(P = 0.017) in Luminal A, older age(P = 0.042) in Luminal B, and pC R in TNBC(P = 0.005).CONCLUSION Predictive and prognostic values of clinicopathological features, like p CR and s TIL, differ depending on the evaluated molecular subtype. | Marco Galvez Carlos A Castaneda Joselyn Sanchez Miluska Castillo Lia Pamela Rebaza Gabriela Calderon Miguel De La Cruz Jose Manuel Cotrina Julio Abugattas Jorge Dunstan Henry Guerra Omar Mejia Henry L Gomez | 2018 | World Journal of Clinical Oncology2018，9，2： | 4 |
| 2 | Effect of Cyclosporine on Left Ventricular Remodeling After Reperfused Myocardial Infarction显示文摘 | Nathan Mewton Pierre Croisille Gerald Gahide Gilles Rioufol Eric Bonnefoy Ingrid Sanchez Thien Tri Cung Catherine Sportouch Denis Angoulvant Gérard Finet Xavier André-Fou?t Geneviève Derumeaux Christophe Piot Hélène Vernhet Didier Revel Michel Ovize | 2010 | Journal of the American College of Cardiology2010，，12： | 2 |
| 3 | Comparison of two clinical scales for causality assessment in hepatotoxicity显示文摘 | Ma Isabel Lucena Raquel Camargo Raúl J. Andrade Carlos J. Perez-Sanchez Felipe Sanchez De La Cuesta | 2001 | Hepatology2001，，1： | 2 |
| 4 | Non-steroidal anti-inflammatory drugs and risk of neoplastic progression in Barrett’s oesophagus: a prospective study显示文摘 | Thomas L Vaughan Linda M Dong Patricia L Blount Kamran Ayub Robert D Odze Carissa A Sanchez Peter S Rabinovitch Brian J Reid | 2005 | Lancet Oncology2005，，12： | 2 |
| 5 | Solitary keratoacanthoma:a self-healing proliferation that frequently becomes malignant显示文摘 | Sanchez Yus E Simon P Requena L | 2000 | Am J Dermatopathol2000，22，4： | 2 |
| 6 | Predictors of progression in Barrett’s esophagus II: baseline 17p (p53) loss of heterozygosity identifies a patient subset at increased risk for neoplastic progression显示文摘 | Brian J Reid Laura J Prevo Patricia C Galipeau Carissa A Sanchez Gary Longton Douglas S Levine Patricia L Blount Peter S Rabinovitch | 2001 | The American Journal of Gastroenterology2001，，10： | 2 |
| 7 | Multi-Centre European Experience with Intragastric Balloon in Overweight Populations: 13 Years of Experience显示文摘 | Alfredo Genco Gontrand López-Nava Christian Wahlen Roberta Maselli Massimiliano Cipriano Maria Mara Arenas Sanchez Chantal Jacobs Michele Lorenzo | 2013 | Obesity Surgery2013，，4： | 2 |
| 8 | Depression and poor sleep:the effect of monoaminergic antidepressants in a pre-clinical model in rats显示文摘 | SANCHEZ C BRENNUM L T STORUSTOVU S | 2007 | Pharmacol Biochem Behav2007，86，3： | 1 |
| 9 | Differentiating between malignant and idiopathic pleural effusions:the value of diagnostic procedures显示文摘 | Aleman C Sanchez L Alegre J | 2007 | QJM2007，100，： | 1 |
| 10 | The interaction of p62 with RIP links the atypical PKCs to NF-kappaB activation显示文摘 | Sanz L Sanchez P Lallena M J | 1999 | EMBO J1999，18，11： | 1 |
| 11 | Transcription factors in plant defense and stress responses 显示文摘 | Singh K Foley RC & Onate - Sanchez L | 2002 | Curr Opin Plant Biol2002，5，： | 1 |
| 12 | Enhanced production of lovastatin in a bubble column by Aspergillus terreus using a two-stage feeding strategy 显示文摘 | Rodriguez Porcel E M Casas Lepez J L Sanchez Perez J A | 2007 | Journal of Chemical Technology and Biotechnology2007，82，： | 1 |
| 13 | Primary intravitreal bevacizumab for diffuse diabetic macular edema: the Pan-American Collaborative Retina Study Group at 24 months 显示文摘 | Arevalo JF Sanchez JG W u L | 2009 | Ophthalmology2009，116，8： | 1 |
| 14 | Interception of the electron transport chain in bacteria with hydrophilic redox mediators显示文摘 | Lithgow A M Romero L Sanchez I C | 1986 | J Chem Res Synop1986，，5： | 1 |
| 15 | '98 Escherichia coli SWISS-2DPAGE database update 显示文摘 | Tonella L Walsh BJ Sanchez JC | 1998 | Electrophoresis1998，19，11： | 1 |
| 16 | The abi1-1 mutation blocks ABA signaling downstream of cADPR action显示文摘 | Wu Y Sanchez J P Lopez-Molina L | 2003 | Plant J2003，34，： | 1 |
| 17 | The 1999 SWISS-2DPAGE database update显示文摘 | Hoogland C Sanchez JC Tonella L | 2000 | Nucleic Acids Res2000，28，1： | 1 |
| 18 | An implantable carotid sinus stimulator for drug-resistant hypertension: surgical technique and short-term outcome from the muhicenter phase II Rheos feasibility trial显示文摘 | Illig KA Levy M Sanchez L | 2006 | J Vasc Surg2006，44，6： | 1 |
| 19 | Cryopreservation of chest- nut by vitrification of in vitro-grown shoot tips 显示文摘 | Vidal N Sanchez C Jorquera L | 2005 | In Vitro Cell Dev-P12005，41，1： | 1 |
| 20 | Heavy metals in sewage sludge amended soils determined by sequential extractions as afunction of incubation time of soils显示文摘 | SANCHEZ M J GARCfA D M LORENZO L F | 2007 | Geoderma2007，，142： | 1 |
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