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| 1 | 最新AD研究用诊断标准:IWG-2标准显示文摘在过去的8年中,国际工作组织(IWG)和美国国立老化研究院-阿尔茨海默协会(NIA-AA)建立了阿尔茨海默病(AD)诊断标准,它能更好地定义AD的临床表型,整合了生物标记物于诊断流程中,并覆盖了疾病的全程。本意见书充分地权衡了IWG标准的优缺点,建议改进诊断框架。依据这些改进,AD的诊断变得简单,只要有恰当的AD临床表型(典型或不典型)和与AD的病理相一致的病理生理学生物标志物出现。我们认为疾病的下游的定位性生物标志,如容积性磁共振成像(MRI)和氟脱氧葡萄糖-正电子发射型计算机断层成像(FDG-PET)等,适合更好地测量和监测疾病过程。本文还详述了非典型性AD、混合性AD和AD临床前期的特异诊断标准。 | 陈刚 曹雯炜 俞羚 糜建华 Dubois B Feldman HH Jacova C Hampel H Molinuevo JL Blennow K DeK osky ST Gauthier S Selkoe D Bateman R Cappa S Crutch S Engelborghs S Frisoni GB Fox NC Galasko D Habert MO Jicha GA Nordberg A Pasquier F Rabinovici G Robert P Rowe C Salloway S Sarazin M Epelbaum S de Souza LC Vellas B Visser PJ Schneider L Stern Y Scheltens P Cummings JL | 2014 | 神经病学与神经康复学杂志2014，11，3： | 31 |
| 2 | 美国国立老化研究所与阿尔茨海默病协会诊断指南写作组:阿尔茨海默病临床前阶段的定义显示文摘阿尔茨海默病(AD)的病理生理过程在痴呆诊断的多年前就开始了。这一长期的AD“临床前”阶段是治疗干预的关键机会,但需进一步阐明AD的病理级联过程和临床症状出现之间的联系。美国国立老化研究所和AD协会召集了一个国际工作组对AD生物标志物、流行病学和神经心理学的证据进行综述并提出建议,以确定能够预测由“正常”认知到轻度认知功能障碍(MCI)及AD痴呆的最佳预测指标。根据目前已有的主要科学证据,我们提出了一个概念性的框架和用于操作的研究标准,以通过纵向临床研究来验证和改进这些模型。这些建议仅用于研究目的,目前不涉及临床应用。我们希望这些建议能提供一个共识,以推进临床前AD的研究,最终推动更早期治疗干预的进展,使得一些疾病减缓药物的疗效发挥最大。 | Sperling RA Aisen PS Beckett LA Bennett DA Craft S Fagan AM Iwatsubo T Jack CR Jr Kaye J Montine TJ Park DC Reiman EM Rowe CC Siemers E Stern Y Yaffe K Carrillo MC Thies B Morrison-Bogorad M Wagster MV Phelps CH 贾建平(译) 郭起浩(译) 黄丽(译) 陆璐(译) 张逸驰(译) 邢怡(译) | 2012 | 中华神经科杂志2012，45，5： | 22 |
| 3 | Three-dimensional perfused human in vitro model of nonalcoholic fatty liver disease显示文摘AIM To develop a human in vitro model of non-alcoholic fatty liver disease(NAFLD), utilising primary hepatocytes cultured in a three-dimensional(3D) perfused platform. METHODS Fat and lean culture media were developed to directly investigate the effects of fat loading on primary hepatocytes cultured in a 3D perfused culture system. Oil Red O staining was used to measure fat loading in the hepatocytes and the consumption of free fatty acids(FFA) from culture medium was monitored. Hepatic functions, gene expression profiles and adipokine release were compared for cells cultured in fat and lean conditions. To determine if fat loading in the system could be modulated hepatocytes were treated with known anti-steatotic compounds. RESULTS Hepatocytes cultured in fat medium were found to accumulate three times more fat than lean cells and fat uptake was continuous over a 14-d culture. Fat loading of hepatocytes did not cause any hepatotoxicity and significantly increased albumin production. Numerous adipokines were expressed by fatty cells and genes associated with NAFLD and liver disease were upregulated including: Insulin-like growth factorbinding protein 1, fatty acid-binding protein 3 and CYP7A1. The metabolic activity of hepatocytes cultured in fatty conditions was found to be impaired and the activities of CYP3A4 and CYP2C9 were significantlyreduced, similar to observations made in NAFLD patients. The utility of the model for drug screening was demonstrated by measuring the effects of known antisteatotic compounds. Hepatocytes, cultured under fatty conditions and treated with metformin, had a reduced cellular fat content compared to untreated controls and consumed less FFA from cell culture medium.CONCLUSION The 3D in vitro NAFLD model recapitulates many features of clinical NAFLD and is an ideal tool for analysing the efficacy of anti-steatotic compounds. | Tomasz Kostrzewski Terri Cornforth Sophie A Snow Larissa Ouro-Gnao Cliff Rowe Emma M Large David J Hughes | 2017 | World Journal of Gastroenterology2017，23，2： | 6 |
| 4 | AJCN:过敏症来袭怎么办?新型益生菌组合疗法显神效显示文摘当进入过敏季节我们可能并不太会拿出手帕或者打喷嚏来预防过敏。日前,一项刊登在国际杂志The American Journal of Clinical Nutrition上的研究报告中。来自佛罗里达大学的研究人员通过研究发现。一种益生菌组合或许能够帮助减轻花粉症的症状。 | Jennifer C Dennis-Wall Tyler Culpepper Carmelo Nieves Jr. Cassie C Rowe Alyssa M Burns Carley T Rusch Ashton Federico Maria Ukhanova Sheldon Waugh Volker Mai Mary C Christman Bobbi Langkamp-Henken | 2017 | 现代生物医学进展2017，17，18： | 3 |
| 5 | Finite element modeling of the three-dimensional ground deformations due to tunnelling in son cohesive soils: pant Ⅰ -method of analysis显示文摘 | Lee K M Rowe R K | 1990 | Con'' puters and Geotechnics1990，，10： | 2 |
| 6 | Oxidative environments decrease tenderization of beef steaks through inactivation of μ-ealpain显示文摘 | Rowe L J Maddock K P Lonergan S M | 2004 | J Anita Sci2004，82，： | 1 |
| 7 | Antimicrobial activity and phytochemical studies of some lichens from south of Spain显示文摘 | SAENZ M T GARCIA M D ROWE J G | 2006 | Fitoterapia2006，77，： | 1 |
| 8 | Subsidence owing to unnelling (Ⅱ): Evaluztionof a prediction technique显示文摘 | Rowe R K Lo K Y | 1992 | Canadian Geotechnical Journal1992，29，： | 1 |
| 9 | Recent developments in acute myelogenous leukemia therapy 显示文摘 | King M E Rowe J M | 2007 | Oncologist2007，12，2： | 1 |
| 10 | Determination of Enrofloxacin and Ciprofloxacin in Milk Using Molecularly Imprinted Solid - phase Extraction显示文摘 | Yan H Y Tian M L Row K H | 2008 | J Sep Sci2008，31，： | 1 |
| 11 | Latent membrane protein 1 of Epstein - Barr virus stimulates processing of NF - κB2 p100 to p52 显示文摘 | Atkinson PGP Coople HJ Row M | 2003 | J Biol Chem2003，278，51： | 1 |
| 12 | Selected factors influencing GCL hydraulic conductivity显示文摘 | PETROV R J ROWE R K QUIGLEY R M | 1997 | Journal Geotechnical and Geoenvironmental Engineering1997，123，8： | 1 |
| 13 | Analysis of the three-dimensional ground movements,the Thunder Bay Tunnel显示文摘 | Lee K M Rowe R K | 1991 | Canadian Geotechnical Journal1991，，1： | 1 |
| 14 | Localization of mrna for vascular endothelial growth factor (Vegf), angio- poietins and their receptors during the peri-implanta- tion period and early pregnancy in marmosets (Cal- lithrix Jacchus) 显示文摘 | Rowe A J Wulff C Fraser H M | 2003 | Reproduction2003，126，2： | 1 |
| 15 | Cavernous malformation presenting as an extra-axial cerebellopontine angle mass: case re- port 显示文摘 | Kim M Rowed DW Cheung G | 1997 | Neurosurgery1997，40，1： | 1 |
| 16 | A Repeated Nested- logit Model of Atlantic Salmon Fishing 显示文摘 | MOREY R ROWE R WATSON M | 1993 | American Journal of Agricultural Economics1993，75，10： | 1 |
| 17 | Evidence-based treatments for acute asthma显示文摘 | ROWE B H EDMONDS M L SPOONER C H | 2001 | Respir Care2001，46，12： | 1 |
| 18 | Cerebrospinal fluid leak after acoustic neuroma surgery:influence of tumor size and surgical approach on incidence and response to treatment显示文摘 | ROWED D W NEDZELSKI J M | 2001 | J Neurosurgery2001，94，2： | 1 |
| 19 | High-temperature refractory metal-intermetallic composites显示文摘 | BEWLAY B P ROWE R G | 1996 | JOM1996，1996，： | 1 |
| 20 | An evaluation of simplified techniques for estimating three-dimensional undrained ground movements due to tunneling in soft soils显示文摘 | ROWE R K LEE K M | 1992 | Canadian Geotechnical Journal1992，29，： | 1 |
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