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1卒中存活者体力活动和锻炼建议:美国心脏协会/美国卒中协会针对医疗专业人员的声明显示文摘目的这份科学声明为卒中存活者的体力活动和锻炼建议提供了一份证据纵览。证据提示,卒中存活者会经历体力下降(physical deconditioning)并导致久坐的生活方式。因此,本更新版科学声明旨在为医务人员提供全面的指导,使其更好地理解体力活动的益处,并为卒中存活者各个恢复阶段的锻炼方案提供推荐意见。方法写作组成员由美国心脏协会(American Heart Association,AHA)卒中委员会的科学声明监督委员会和AHA手稿监督委员会任命。作者利用系统文献综述,参考公开发表的临床和流行病学研究、发病率和死亡率报告、临床与公共卫生指南、权威声明、个人文件以及专家意见,对现有的证据进行总结并指出目前的知识空白。结果卒中后体力活动不足非常普遍。大量证据明确支持对卒中存活者进行运动训练,包括有氧运动和力量训练。运动训练能改善功能能力、日常生活活动的执行能力以及生活质量,同时降低随后的心血管事件风险。卒中存活者的体力活动目标和锻炼方案需个体化制定以最大限度地增高长期依从性。结论写作组给出的推荐是,体力活动和锻炼方案应融入卒中存活者的治疗。卒中存活者体力活动的推动应强调低到中等强度的有氧活动、增强肌肉力量、减少久坐的生活方式以及对卒中二级预防的危险因素管理。Sandra A. Billinger Ross Arena Julie Bemhardt Janice J. Eng Barry A. Franklin Cheryl Mortag Johnson Marilyn MacKay-Lyons Richard F. Macko Gillian E. Mead Elliot J. Roth Marianne Shaughnessy Ada Tang 孙新亭 张通 2014国际脑血管病杂志2014,22,10:80
2Surgical outcome after docetaxel-based neoadjuvant chemotherapy in locally-advanced gastric cancer显示文摘AIM:To investigate feasibility,morbidity and surgical mortality of a docetaxel-based chemotherapy regimen randomly administered before or after gastrectomy in patients suffering from locally-advanced resectable gastric cancer.METHODS:Patients suffering from locally-advanced(T3-4 any N M0 or any T N1-3 M0)gastric carcinoma,staged with endoscopic ultrasound,bone scan,computed tomography,and laparoscopy,were assigned to receive four 21 d/cycles of TCF(docetaxel 75 mg/m 2 day 1,cisplatin 75 mg/m 2 day 1,and fluorouracil 300 mg/m 2 per day for days 1-14),either before(Arm A)or after(Arm B)gastrectomy.Operative morbidity,overall mortality,and severe adverse events were compared by intention-to-treat analysis.RESULTS:From November 1999 to November 2005,70 patients were treated.After preoperative TCF(Arm A),thirty-two(94%)resections were performed,85% of which were R0.Pathological response was complete in 4 patients(11.7%),and partial in 18(55%).No surgical mortality and 28.5%morbidity rate were observed,similar to those of immediate surgery arm(P= 0.86).Serious chemotherapy adverse events tended to be more frequent in arm B(23%vs 11%,P=0.07),with a single death per arm.CONCLUSION:Surgery following docetaxel-based chemotherapy was safe and with similar morbidity to immediate surgery in patients with locally-advanced resectable gastric carcinoma.Roberto Biffi Nicola Fazio Fabrizio Luca Antonio Chiappa Bruno Andreoni Maria Giulia Zampino Arnaud Roth Jan Christian Schuller Giancarla Fiori Franco Orsi Guido Bonomo Cristiano Crosta Olivier Huber 2010World Journal of Gastroenterology2010,16,7:43
3TREATMENT OF METALS, POLYMER FILMS, AND FABRICS WITHA ONE ATMOSPHERE UNIFORM GLOW DISCHARGE PLASMA(OAUGDP) FOR INCREASED SURFACE ENERGY AND DIRECTIONAL ETCHING显示文摘Direct exposure of samples to the active species of air generated by a One Atmosphere Uniform Glow Discharge Plasma (OAUGDP) has been used to etch and to increase the surface energy of metallic surfaces, photoresist, polymer films, and nonwoven fab- rics. The OAUGDP is a non-thermal plasma with the classical characteristics of a DC normal glow discharge that operates in air (and other gases) at atmospheric pres- sure. Neither a vacuum system nor batch processing is necessary. A wide range of applications to metals, photoresist, films, fabrics, and polymeric webs can be accom- modated by direct exposure of the workpiece to the plasma in parallel-plate reactors. This technolopy is simple, it produces effects that can be obtained in no other way at one atmosphere; it generates minimal pollutants or unwanted by-products; and it is suitable for individual sample or online treatment of metallic surfaces, wafers, films, and fabrics. Early exposures of solid materials to the OAUGDP required minutes to produce rela- tively small increases of surface energy. These durations appeared too long for com- mercial application to fast-moving webs. Recent improvements in OAUGDP gas com- position, power density, plasma quality, recireulating gas flow, and impedance match- ing of the power supply to the parallel plate plasma reactor have made it possible to raise the surface energy of a variety of polymeric webs (PP, PET PE etc.) to levels of 60 to 70 dynes/cm with one second of exposure. In air plasmas, the high surface ener- gies are not durable, and fall to 50 dynes/cm after periods of weeks to months. Here, we report the exposure of metallic surfaces, photoresist, polymeric films, and nonwo- ven fabrics made of PP and PET to an impedance matched parallel plate OAUGDP for durations ranging from one second to several tens of seconds. Data will be re- ported on the surface energy, wettability, wickability, and aging effect of polymeric films and fabrics as functions of time of exposure, and time after exposure; the rate and uniformity of photoresist etching; and the production of sub-micron structures by OAUGDP etching at one atmosphere.J. Reece Roth and Z. Y Chen (Plasma Sciences Laboratory, Department of Electrical and Computer Engineering, University of Tennessee, Knoxville, TN 37996-2100, USA) Peter P.- Y Tsai (Textiles and Nonwovens Development Center (TANDEC), University of Tenness 2001Acta Metallurgica Sinica(English Letters)2001,14,6:18
4铝合金的大功率扩散型CO_2激光粉末焊接技术显示文摘本试验研究采用 2 6 0 0W扩散型 (Slab)CO2 激光加工系统 ,利用喷射填充粉末激光焊接技术成功地进行了铝合金焊接 ;确定了试验材料激光焊接的能量阈值 ;通过工艺参数的优选获得了无明显焊接缺陷、正反两表面平滑连续的焊缝 ;焊接接头的力学性能检测表明 ,AA6 0 16铝合金 (厚度为 1 15mm)焊接接头抗拉强度不低于母材的可允许间隙可达 0 5mm(母材厚度的 44 % ) ;根据试验结果 ,推荐对于一定板厚的铝合金 ,应该经过试验确定不同激光功率时实现深熔焊的最小线能量 ,并且尽量选取较高的激光功率及较高的焊接速度 ,以确保取得最佳的焊接质量。陈铠 王智勇 肖荣诗 施定远 左铁钏 Roth G Opowe H 2000激光杂志2000,21,5:14
5响应面法优化白首乌多糖超声辅助提取工艺及其结构表征显示文摘为了提高白首乌多糖的得率,本文采用超声波辅助法提取白首乌中非淀粉多糖。在单因素实验基础上结合响应面法对超声波辅助法提取白首乌多糖工艺进行优化。结果表明,最优提取工艺参数为:液料比为22:1 mL/g、超声时间为44 min、超声功率为350 W及超声温度为52℃,在此条件下的多糖得率为1.35%±0.02%。该条件下提取的多糖的重均分子量集中在1.71×10~7、1.15×10~6、5.93×10~4 Da,由岩藻糖、鼠李糖、阿拉伯糖、半乳糖、葡萄糖、木糖、甘露糖、核糖、半乳糖醛酸以及葡萄糖醛酸组成,含量分别为0.17%、1.66%、7.40%、10.51%、74.41%、0.79%、0.85%、0.36%、3.28%、0.57%,具有一般多糖的红外光谱吸收峰以及良好的溶解性,为日后白首乌多糖的结构解析以及工业应用提供一定的参考。朱和权 冯进 李春阳 吴承东 张明 Chuon Mony Roth 2021食品工业科技2021,42,10:11
6松花粉对家猪粪便特性及肠道菌群的影响显示文摘目的:观察松花粉对家猪粪便特性及肠道菌群的影响。方法:9头雄性阉割猪,体重363kg,随机分为对照组(基础饲料,Ⅰ组)、麦麸添加组(基础饲料加3.5%麦麸,Ⅱ组)和松花粉添加组(基础饲料加3.5%松花粉,Ⅲ组),单笼饲养,用基础饲料喂养1w后,给予不同饲料2个周期、每个周期14d的代谢实验,测定肠道菌群和粪便特性参数。结果:三组动物饲料摄入量一致,但Ⅲ组日排出新鲜粪便量比Ⅰ组多1倍,比Ⅱ组多78%;粪便干重比Ⅰ组多64%,比Ⅱ组高52%;粪便含水量是Ⅰ组的2倍,Ⅱ组的2.16倍。Ⅲ组每日粪便中排出的甘油三酯是Ⅱ组的3.5倍、Ⅰ组的3倍;每日粪便排出胆固醇达735mg,是Ⅰ组的1.7倍、Ⅱ组的1.5倍;脂肪酸排出量为1506mg,而Ⅰ组和Ⅱ组分别为535mg和560mg;胆酸的排泄量也高于其他两组,且与Ⅱ组间有显著性差异。Ⅲ组粪便中粗蛋白、粗脂肪、各项含氮组分以及有关菌群(logCFUV/d)的排出量远高于其他两组。结论:松花粉对调整机体氮代谢、肠道菌群和抑制脂肪吸收有重要意义。赵霖 W Windisch FX Roth K Eder 2006营养学报2006,28,3:10
7光伏逆变器-市场、技术和发展趋势显示文摘光伏阵列和逆变器的市场正在以高达40%的年平均增长率迅猛发展。2007年总的市场大约为2.5GW,而且在2007年年末的总装机容量将达到约10Gw。光伏逆变器将阵列输出的直流电流转化成交流电流,并且反馈回电网。逆变器拓扑结构有三种基本形式:带低频(50/60Hz)变压器的逆变器、带高频变压器的逆变器、无变压器的逆变器。无变压器的逆变器在欧洲市场上占主导地位,市场份额约为80%,在日本市场上占有接近50%的份额,而在美国由于国家标准的要求,只能使用带变压器的逆变器。无变压器的逆变器的效率高达98%。高效率的无变压器逆变器这是一个国际的发展趋势。随着技术发展,通过采用中点钳位拓扑(NPC)和新型电力半导体器件材料如碳化硅,将使得逆变器效率达到98.5%。贺明智 冯轲 Bruno Burger Werner Roth 2008电力电子2008,,3:10
8Obese diet-induced mouse models of nonalcoholic steatohepatitis-tracking disease by liver biopsy显示文摘AIM:To characterize development of diet-induced nonalcoholic steatohepatitis(NASH)by performing live biopsy in wild-type and genetically obese mice.METHODS:Male wild-type C57BL/6J(C57)mice(DIO NASH)and male Lep ob/Lep ob(ob/ob)mice(ob/ob-NASH were maintained on a diet high in trans-fat(40%)fructose(22%)and cholesterol(2%)for 26 and 12 wk respectively.A normal chow diet served as control in C57 mice(lean chow)and ob/ob mice(ob/ob chow)After the diet-induction period,mice were liver biopsied and a blinded histological assessment of steatosis and fibrosis was conducted.Mice were then stratified into groups counterbalanced for steatosis score and fibrosi stage and continued on diet and to receive daily PO dosing of vehicle for 8 wk.Global gene expression in liver tissue was assessed by RNA sequencing and bioin formatics.Metabolic parameters,plasma liver enzyme and lipids(total cholesterol,triglycerides)as well a hepatic lipids and collagen content were measured b biochemical analysis.Non-alcoholic fatty liver disease activity score(NAS)(steatosis/inflammation/ballooningdegeneration)and fibrosis were scored.Steatosis and fibrosis were also quantified using percent fractional area.RESULTS:Diet-induction for 26 and 12 wk in DIONASH and ob/ob-NASH mice,respectively,elicited progressive metabolic perturbations characterized by increased adiposity,total cholesterol and elevated plasma liver enzymes.The diet also induced clear histological features of NASH including hepatosteatosis and fibrosis.Overall,the metabolic NASH phenotype was more pronounced in ob/ob-NASH vs DIO-NASH mice.During the eight week repeated vehicle dosing period,the metabolic phenotype was sustained in DIO-NASH and ob/ob-NASH mice in conjunction with hepatomegaly and increased hepatic lipids and collagen accumulation.Histopathological scoring demonstrated significantly increased NAS of DIO-NASH mice(0 vs4.7±0.4,P<0.001 compared to lean chow)and ob/ob-NASH mice(2.4±0.3 vs 6.3±0.2,P<0.001compared to ob/ob chow),respectively.Furthermore,fibrosis stage was significantly elevated for DIO-NASH mice(0 vs 1.2±0.2,P<0.05 compared to lean chow)and ob/ob NASH(0.1±0.1 vs 3.0±0.2,P<0.001compared to ob/ob chow).Notably,fibrosis stage was significantly(P<0.001)increased in ob/ob-NASH mice,when compared to DIO-NASH mice.CONCLUSION:These data introduce the obese dietinduced DIO-NASH and ob/ob-NASH mouse models with biopsy-confirmed individual disease staging as a preclinical platform for evaluation of novel NASH therapeutics.Maria Nicoline Baandrup Kristiansen Sanne Skovgard Veidal Kristoffer Tobias Gustav Rigbolt Kirstine Sloth Tolbol Jonathan David Roth Jacob Jelsing Niels Vrang Michael Feigh 2016World Journal of Hepatology2016,8,16:10
9松花粉对脂代谢影响的实验研究显示文摘目的:观察松花粉对家猪脂代谢的影响。方法:选用雄性阉割猪9头,体重(36±3)kg,随机分为3组:基础饲料组、松花粉添加组和麦麸添加组。分别饲养于单独的代谢笼中,先用普通饲料喂养1周,再给予不同饲料进行代谢实验,测定脂代谢的有关参数。结果:松花粉组粪便中甘油三酯浓度最高(7.43 mg/g),与其他两组差异显著,每日粪便排出的甘油三酯是麦麸组的3.5倍、基础饲料组的3倍。松花粉组粪便胆固醇浓度也名列第一,每日粪便排出胆固醇总量达735 mg,是基础饲料组(408 mg)的1.7倍、麦麸组(421 mg)的1.5倍。松花粉组每克粪便含脂肪酸总量为15.78 mg(基础饲料组和麦麸组分别为9.07 mg和8.81 mg),是基础饲料组的1.74倍,麦麸组的1.79倍;松花粉组粪便中每日脂肪酸排出总量为1 506 mg,基础饲料组和麦麸组分别为535 mg和560 mg。粪便中胆酸的排泄量松花粉组也高于其他两组,而且与麦麸组间有显著性差异。结论:食用添加3.5%松花粉饲料后不仅非常显著地增加了家猪粪便中甘油三酯、胆固醇及脂肪酸的排泄量,同时也促进了胆酸的排泄。这一性质对调整机体能量代谢和脂代谢,抑制脂肪的吸收具有重要意义。赵霖 Windisch W Roth FX Eder K 2006军医进修学院学报2006,27,6:9
10中德合作三江源区和甜水海地区多年冻土退化过程科学考察和研究进展显示文摘为准确了解青藏高原多年冻土退化过程及其环境效应,中国科学院寒区旱区环境与工程研究所和德国海德堡大学环境物理研究所共同组成科研小组,先后对我国三江源区、西昆仑甜水海地区进行了多年冻土退化过程的前期勘察研究工作.首次在人烟稀少的玉树-不冻泉沿线等地建立了3个长期综合观测研究站.在技术手段上,除应用常规的坑探、水土取样、水分现场观测、地面调查外,主要应用了最新的双天线、多回路探地雷达勘测技术,对不同地貌条件下的活动层结构特征、上限附近冻土结构、冷生组构等诸多方面进行了快速勘察,同时还进行了水分场分布规律、盐份迁移过程的初步研究.研究结果表明:地表景观特征对热质迁移规律、地温场具有重要影响;青藏高原新疆甜水海地区的低温(<-4℃)冻土与高原东部和腹地的高温(>-1℃)冻土在地质背景和地下冰发育情况等方面有所区别;甜水海地区生态环境在过去30多年的时间里已发生重大改变:地表植被发生大面积退化,地表普遍发生不同程度盐渍化;在该地区发现大量小型冻胀丘、石环等冰缘现象的存在.探地雷达勘察结果显示,地表地貌单元、植被分布、地表水分条件的变化均对多年冻土上限变化和地下冰的赋存产生重要影响.俞祁浩 Kurt Roth 金会军 潘喜才 Schiwek Philip Martin 盛煜 魏智 吴吉春 2006冰川冻土2006,28,6:9
11Hemoglobin in- fusion augments the tumor necrosis factor response to bacterial endotoxin ( 1 ipopolysaccharide ) in mice 显示文摘Su Dong Hui Roth R I Levin J 1999Crit Care Med1999,27,4:8
12INT-767 improves histopathological features in a dietinduced ob/ob mouse model of biopsy-confirmed nonalcoholic steatohepatitis显示文摘AIM To characterize the efficacy of the dual FXR/TGR5 receptor agonist INT-767 upon histological endpoints in a rodent model of diet-induced and biopsy-confirmed non-alcoholic steatohepatitis(NASH).METHODS The effects of INT-767 on histological features of NASH were assessed in two studies using Lep^(ob/ob)(ob/ob) NASH mice fed the AMLN diet(high fat with transfat, cholesterol and fructose). In a proof-of-conceptstudy, Lep^(ob/ob)(ob/ob) NASH mice were first dosed with INT-767(3 or 10 mg/kg for 8 wk). A second ob/ob NASH study compared INT-767(3 and 10 mg/kg) to obeticholic acid(OCA)(10 or 30 mg/kg; 16 wk). Primary histological endpoints included qualitative and quantitative assessments of NASH. Other metabolic and plasma endpoints were also assessed. A comparative assessment of INT-767 and OCA effects on drug distribution and hepatic gene expression was performed in C57 Bl/6 mice on standard chow. C57 Bl/6 mice were orally dosed with INT-767 or OCA(1-30 mg/kg) for 2 wk, and expression levels of candidate genes were assessed by RNA sequencing and tissue drug levels were measured by liquid chromatography tandem-mass spectrometry.RESULTS INT-767 dose-dependently(3 and 10 mg/kg, PO, QD, 8 wk) improved qualitative morphometric scores on steatohepatitis severity, inflammatory infiltrates and fibrosis stage. Quantitative morphometric analyses revealed that INT-767 reduced parenchymal collagen area, collagen fiber density, inflammation(assessed by Galectin-3 immunohistochemistry) and hepatocyte lipid droplet area following INT-767 treatment. In a comparative study(16 wk), the FXR agonists OCA(10 and 30 mg/kg) and INT-767(3 and 10 mg/kg) both improved NASH histopathology, with INT-767 exerting greater therapeutic potency and efficacy than OCA. Mechanistic studies suggest that both drugs accumulate similarly within the liver and ileum, however, the effects of INT-767 may be driven by enhanced hepatic, but not ileal, FXR function. CONCLUSION These findings confirm the potential utility of FXR and dual FXR/TGR5 activation as disease intervention strategies in NASH.Jonathan D Roth Michael Feigh Sanne S Veidal Louise KD Fensholdt Kristoffer T Rigbolt Henrik H Hansen Li C Chen Mathieu Petitjean Weslyn Friley Niels Vrang Jacob Jelsing Mark Young 2018World Journal of Gastroenterology2018,24,2:7
13Innate and adaptive immune responses in male and female reproductive tracts in homeostasis and following HIV infection显示文摘男、女的繁殖的道是有多样的功能的要求的复杂微型环境。当同时对潜在的病原体授与保护时,在繁殖的道的免疫系统举办为胎儿的 allograft 提供保护的环境的费力的任务。因此,它发展了改编的一个唯一的集合,首先在性荷尔蒙的影响下面,它从另外的 mucosal 地点使它不同。这里,我们讨论在男性和女繁殖的道是在场的免疫系统的各种各样的部件,包括在 homeostatic 条件下面的天生的可溶的因素和房间和体液、调停房间的适应免疫。我们考察在从全身的豁免展出区分并且讨论这些特征怎么被性荷尔蒙影响的男、女的繁殖的道显示出唯一的 phenotypic 和有免疫力的房间和回答的功能的特征的证据。我们也在跟随 HIV-1 感染的繁殖的道,性荷尔蒙和有免疫力的回答之中检验相互作用。男、女的繁殖的道的唯一的特征的改进理解将提供卓见进为性播送的感染的预防改进不孕的免疫学的原因和预防干预的设计的临床的处理。Philip V Nguyen Jessica K Kafka Victor H Ferreira Kristy Roth Charu Kaushic 2014Cellular & Molecular Immunology2014,11,5:7
14腹腔镜腹壁疝修补术SAGES指南显示文摘腹壁疝修补的目标是解除病人的症状和(或)治愈疝本身。近年来,越来越多的医生开展腹腔镜腹壁疝修补术,但是选择开放手术还是腹腔镜手术治疗腹壁疝仍有争议。该指南旨在为外科医生开展腹腔镜腹壁疝修补术时,在病人的选择、手术技术以及术后处理方面提供帮助。1方法用疝、腹壁、外科、腔镜、英语、人类等主题词,在Medline上进行文献检索。David Earle J.Scott Roth Alan Saber 陈大伟 2017中国微创外科杂志2017,17,11:7
15皮肤微生物学:常驻菌、生态学、感染显示文摘在正常人皮肤表面存在大量的对人体无害的微生物。Price 将其分为二类。一类为常驻菌群,较固定地寄生于皮肤,数量和菌种的组成保持相对稳定;另一类为暂驻菌群,主要存在于暴露部位皮肤,其数量和菌类有很大的变化。此外,尚有一些微生物偶尔存在于少数人体上,称为偶存菌,仅在短时期内附着于皮肤和增殖,此受环境及常驻菌群活性的影响。微生物的分类常驻菌群寄生在角质层表面和表皮的最外层中。常见的有:微球菌科(包括凝固酶阴性葡萄球菌、类球菌、微球菌属),棒状微生物(包括棒状杆菌属、短颈细菌属)、丙酸菌属,运动不能菌,糠秕孢子菌属。微球菌科:葡萄球菌(S):分为凝固酶阳性的金黄色葡萄球菌(Sa)Roth RR 吴晓初 1990国外医学(皮肤性病学分册)1990,16,6:6
16新型玻璃纤维增强复合材料——轻木夹心桥面板概念、设计及试验验证显示文摘描述了位于瑞士贝克斯(Bex)的阿旺松(Avancon)桥梁的概念、设计和试验验证。通过采用轻质玻璃纤维增强复合材料(GFRP)夹心桥面板与钢主梁进行胶黏结的方式,因施工造成的交通中断时间比传统混擬土现浇方式缩短了近40d(节省约80%的时间),且实现了双车道的扩展。通过半整体式的设计方案,可实现沥青层从桥台至桥面板的连续铺装,从而避免了伸缩缝的使用及简化了维护工作.带有轻木夹心的桥面板在结构性能上满足所有设计准则的要求,包括使用和承载能力极限状态和疲劳性能,然而桥面板尺寸很大程度上取决于选取和采用的设计准则。对于阿旺松桥,德国和英国准则提供了最保守的材料系数,而荷兰准则最不保守;欧洲准则介于两者之间。计算刚度时的材料系数选取会影响桥面板的组成和材料用量。李春生 周兴党 高雁波 颜美 Keller T. Rothe J. De Castro J. Osei-Antwi M. 2019中外公路2019,39,2:6
17响应面法优化纤维素酶辅助提取西蓝花萝卜硫素工艺研究显示文摘以西蓝花为试验原料,采用纤维素酶辅助溶剂法研究萝卜硫素的提取工艺,并通过优化酶解参数提高萝卜硫素的提取量。对酶解时间、pH值、温度和纤维素酶添加量等因素进行单因素实验,并进行响应面实验分析,得到萝卜硫素的最佳提取参数为:水解时间7.1 h、水解pH6.0、水解温度36.8 ℃、纤维素酶添加量2.5%,在此条件下,萝卜硫素的提取量可以达到(408.74±6.83)μg/g,与预测值(413.56 μg/g)接近。此外,扫描电镜的结果表明,纤维素酶可以水解细胞壁上的纤维素和半纤维素,从而更有效地破坏西蓝花的组织结构。张静 马永强 冯进 李春阳 CHUON Mony Roth SUN Sovath TAING Bunhok 2020食品科技2020,45,12:5
18审视马克思的工作室:马恩全集中的《资本论》及前期准备工作显示文摘本文以《资本论》及其手稿为例介绍了MEGA2即历史上第二次启动的马恩全集历史考证版的编纂工作和特征。作者指出,马克思和恩格斯之间的差异,以及马克思研究工作方式的开放性,是MEGA2这一历史考证版力图展现的两个重点,这一全集版本将开启通向马克思与恩格斯及其浩瀚著作的新入口。文章主体分三个部分,第一部分以《资本论》及其手稿的写作过程为例考察了马克思的工作方式,即他在研究写作中体现出的作为修改者和收集者的特征;第二部分以MEGA2中《资本论》及其手稿的编纂为例,介绍了这一历史考证版是如何展现马克思的工作方式,以及作者马克思和编者恩格斯之间差异的;第三部分介绍了目前网络空间里MEGA2的发布情况。Regina Roth 田园 2010现代哲学2010,,1:5
19Analytical formulation for the bend loss in single-ring hollow-core photonic crystal fibers显示文摘Understanding bend loss in single-ring hollow-core photonic crystal fibers(PCFs)is becoming of increasing importance as the fibers enter practical applications.While purely numerical approaches are useful,there is a need for a simpler analytical formalism that provides physical insight and can be directly used in the design of PCFs with low bend loss.We show theoretically and experimentally that a wavelength-dependent critical bend radius exists below which the bend loss reaches a maximum,and that this can be calculated from the structural parameters of a fiber using a simple analytical formula.This allows straightforward design of single-ring PCFs that are bend-insensitive for specified ranges of bend radius and wavelength.It also can be used to derive an expression for the bend radius that yields optimal higher-order mode suppression for a given fiber structure.MICHAEL H.FROSZ PAUL ROTH MEHMET C.GüNENDI PHILIP ST.J.RUSSELL 2017Photonics Research2017,5,2:5
20Irinotecan combined with fluorouracil compared with fluorouracil alone as first-line treatment for metastatic colorectal cancer: a multicentre randomised trial显示文摘JY Douillard D Cunningham AD Roth M Navarro RD James P Karasek P Jandik T Iveson J Carmichael M Alakl G Gruia L Awad P Rougier 2000The Lancet2000,,9209:4
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