|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | The role of gut microbiota(commensal bacteria)and the mucosal barrier in the pathogenesis of inflammatory and autoimmune diseases and cancer:contribution of germ-free and gnotobiotic animal models of human diseases显示文摘Metagenomic approaches are currently being used to decipher the genome of the microbiota(microbiome),and,in parallel,functional studies are being performed to analyze the effects of the microbiota on the host.Gnotobiological methods are an indispensable tool for studying the consequences of bacterial colonization.Animals used as models of human diseases can be maintained in sterile conditions(isolators used for germ-free rearing)and specifically colonized with defined microbes(including non-cultivable commensal bacteria).The effects of the germ-free state or the effects of colonization on disease initiation and maintenance can be observed in these models.Using this approach we demonstrated direct involvement of components of the microbiota in chronic intestinal inflammation and development of colonic neoplasia(i.e.,using models of human inflammatory bowel disease and colorectal carcinoma).In contrast,a protective effect of microbiota colonization was demonstrated for the development of autoimmune diabetes in non-obese diabetic(NOD)mice.Interestingly,the development of atherosclerosis in germ-free apolipoprotein E(ApoE)-deficient mice fed by a standard low-cholesterol diet is accelerated compared with conventionally reared animals.Mucosal induction of tolerance to allergen Bet v1 was not influenced by the presence or absence of microbiota.Identification of components of the microbiota and elucidation of the molecular mechanisms of their action in inducing pathological changes or exerting beneficial,disease-protective activities could aid in our ability to influence the composition of the microbiota and to find bacterial strains and components(e.g.,probiotics and prebiotics)whose administration may aid in disease prevention and treatment. | Helena Tlaskalova-Hogenova Renata Stepankova Hana Kozakova Tomas Hudcovic Luca Vannucci Ludmila Tuckova Pavel Rossmann TomasHrncır Miloslav Kverka Zuzana Zakostelska Klara Klimesova Jaroslava Pribylova Jirina Bartova Daniel Sanchez Petra Fundova Dana Borovska Dagmar Sru˚tkova Zdenek Zıdek Martin Schwarzer Pavel Drastich David P Funda | 2011 | Cellular & Molecular Immunology2011，8，2： | 47 |
| 2 | Structure of Dengue Virus显示文摘 | Richard J. Kuhn Wei Zhang Michael G. Rossmann Sergei V. Pletnev Jeroen Corver Edith Lenches Christopher T. Jones Suchetana Mukhopadhyay Paul R. Chipman Ellen G. Strauss Timothy S. Baker James H. Strauss | 2002 | Cell2002，，： | 2 |
| 3 | Detection of royal jelly adulteration using carbon and nitrogen stable isotope ratio analysis 显示文摘 | STOCKER A ROSSMANN A KETTRUP A | 2006 | Rapid Communications in Mass Spectrometry2006，20，2： | 1 |
| 4 | Variability in B-cell Antigen Expression: Implications for the Treatment of B-Cell Lymphomas and Leukemias With Monoclonal Antibodies显示文摘 | ROSSMANN ED LUNDIN J LENKEI R | 2001 | Hematol J2001，2，5： | 1 |
| 5 | Detection of royal jelly adulteration using carbon and nitrogen stable isotope ratio analysis显示文摘 | STOCKER A ROSSMANN A KETTRUP A | 2006 | Rapid Commun Mass Spectrom2006，20，2： | 1 |
| 6 | Interleukin 6 and its soluble receptor in serum and cerebrospinal fluid after cerebral- ma显示文摘 | Hans VH Rossmann T Joller H | 1999 | Neuroreport1999，10，2： | 1 |
| 7 | Measurement of stable isotope abundances in milk and milk ingredients- a possible tool for origin assignment and quality control 显示文摘 | Komexl BE Werner T Rossmann A | 1997 | Zeitschrift fur Lebensmitteluntersuchung und -Forschung A1997，205，1： | 1 |
| 8 | Influence of the distillation step on the ratiosof stable isotopes of ethanol in cherry brandies显示文摘 | BAUDLER R ADAM L ROSSMANN A | 2006 | Journal of Agricultural and Food Chemistry2006，54，3： | 1 |
| 9 | Expression of toll-like receptor 2 (TLR 2), TLR4, and CD 14 in biopsy samples of patients with inflammatory bowel diseases : upregulated expression of TLR 2 in terminal ileum of patients with ulcerative colitis显示文摘 | FrolovaL DrastichP Rossmann P | 2008 | J Histochem Cytochem2008，56，3： | 1 |
| 10 | Structure of dengue virus: implications for flavivirus organization, maturation, and fusion 显示文摘 | Kuhn RJ ZhangW Rossmann MG etal | 2002 | Cell2002，108，5： | 1 |
| 11 | Muhielement stable isotope ratio analysis of glycerol to determine its origin in wine显示文摘 | ROSSMANN A SCHMIDT H L HERMANN A | 1998 | Zeitschrift fur Lebensmittel- Untersuchung und Forschung A1998，207，3： | 1 |
| 12 | 14-3-3 zeta negatively regulates Raf-1 activity by interactions with the Raf-1 cysteine-rich domain显示文摘 | Clark G J Drugan J K Rossmann K L | 1997 | Journal of Biological Chemistry1997，272，20： | 1 |
| 13 | Isotope characteristics of vegetables andwheat from conventional and organic production显示文摘 | SCHMIDT H ROSSMANN A VOERKELIUS S | 2005 | Isotopes in Environmental and Health Stud- ies2005，41，3： | 1 |
| 14 | Oral administration of probiotic bacteria ( E. coli nissle, E. coli O83, Lactobacillus casei ) influences the severity of dextran sodium sulfate-induced colitis in BALB/c mice显示文摘 | A. Koke?ová L. Frolová M. Kverka D. Sokol P. Rossmann J. Bártová H. Tlaskalová-Hogenová | 2006 | Folia Microbiologica2006，，5： | 1 |
| 15 | Structure of dengue virus: implications for flavivirus organization, maturation and fusion显示文摘 | Kuhn R J Zhang W Rossmann MG | 2002 | Cell2002，108，5： | 1 |
| 16 | Determination of stable isotope rations in analysis显示文摘 | Rossmann A | 2001 | Food Reviews International2001，17，3： | 1 |
| 17 | Determination of stable isotope ratios in food analysis显示文摘 | ROSSMANN A | 2001 | Food Rev Int2001，17，3： | 1 |
| 18 | Chemical andbiological evolution of a nuceotide-binding protein显示文摘 | Rossmann M G Moras D Olsen K W | 1974 | Nature1974，250，5463： | 1 |
| 19 | Determination of Stable Isotope Ratios in Food Analysis显示文摘 | ROSSMANN A | 2001 | Food Reviews International2001，17，3： | 1 |
| 20 | Anticancer drugs induce caspase 8/FLICE activation and apoptosis in the absence of CD95 receptor/ligand interaction 显示文摘 | Wesselborg S Engels IH Rossmann E | 1999 | Blood1999，93，： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员