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| 1 | The role of gut microbiota(commensal bacteria)and the mucosal barrier in the pathogenesis of inflammatory and autoimmune diseases and cancer:contribution of germ-free and gnotobiotic animal models of human diseases显示文摘Metagenomic approaches are currently being used to decipher the genome of the microbiota(microbiome),and,in parallel,functional studies are being performed to analyze the effects of the microbiota on the host.Gnotobiological methods are an indispensable tool for studying the consequences of bacterial colonization.Animals used as models of human diseases can be maintained in sterile conditions(isolators used for germ-free rearing)and specifically colonized with defined microbes(including non-cultivable commensal bacteria).The effects of the germ-free state or the effects of colonization on disease initiation and maintenance can be observed in these models.Using this approach we demonstrated direct involvement of components of the microbiota in chronic intestinal inflammation and development of colonic neoplasia(i.e.,using models of human inflammatory bowel disease and colorectal carcinoma).In contrast,a protective effect of microbiota colonization was demonstrated for the development of autoimmune diabetes in non-obese diabetic(NOD)mice.Interestingly,the development of atherosclerosis in germ-free apolipoprotein E(ApoE)-deficient mice fed by a standard low-cholesterol diet is accelerated compared with conventionally reared animals.Mucosal induction of tolerance to allergen Bet v1 was not influenced by the presence or absence of microbiota.Identification of components of the microbiota and elucidation of the molecular mechanisms of their action in inducing pathological changes or exerting beneficial,disease-protective activities could aid in our ability to influence the composition of the microbiota and to find bacterial strains and components(e.g.,probiotics and prebiotics)whose administration may aid in disease prevention and treatment. | Helena Tlaskalova-Hogenova Renata Stepankova Hana Kozakova Tomas Hudcovic Luca Vannucci Ludmila Tuckova Pavel Rossmann TomasHrncır Miloslav Kverka Zuzana Zakostelska Klara Klimesova Jaroslava Pribylova Jirina Bartova Daniel Sanchez Petra Fundova Dana Borovska Dagmar Sru˚tkova Zdenek Zıdek Martin Schwarzer Pavel Drastich David P Funda | 2011 | Cellular & Molecular Immunology2011，8，2： | 47 |
| 2 | Expression of toll-like receptor 2 (TLR 2), TLR4, and CD 14 in biopsy samples of patients with inflammatory bowel diseases : upregulated expression of TLR 2 in terminal ileum of patients with ulcerative colitis显示文摘 | FrolovaL DrastichP Rossmann P | 2008 | J Histochem Cytochem2008，56，3： | 1 |
| 3 | Expression of Toll-like receptor 2 (TLR2) , TLR4, and CDI4 in biopsy samples of patients with inflammatory bowel diseases: upregulated expression of TLR2 in terminal ileum of patients with ulcerative colitis显示文摘 | FROLOVA L DRASTICH P ROSSMANN P | 2008 | J Histochem Cytochem2008，56，3： | 1 |
| 4 | Circulating endothelial ceils isolated together with platelets and the experimental modification of their counts in rats显示文摘 | Hladovee J Rossmann P | 1973 | Thrombosis Research1973，3，： | 1 |
| 5 | Common cold viruses显示文摘 | Rossmann M G Arnold E Griffith J P | 1987 | TIBS1987，12，： | 1 |
| 6 | Circulating endothelial cells isolated together with platelets and the experimental modification of their counts in rats 显示文摘 | Hladovec J Rossmann P | 1973 | Thromb Res1973，3，8： | 1 |
| 7 | The harlequin mouse mutation downregulates apoptosis-inducing factor显示文摘 | LONGO-GUESS C M ROSSMANN M P | 2002 | Nature2002，419，6905： | 1 |
| 8 | The taxonomy of binding sites in proteins显示文摘 | ROSSMANN M G ARGOS P | 1978 | Mol Cell Biochem1978，21，： | 1 |
| 9 | The combination of stable isotope abundance ratios of H, C, N and S with ^87 Sr/^86 Sr for geographical origin assignment of orange juices 显示文摘 | Stefan R S Horn H P Rossmann A Schlicht C | 2010 | Food Chemistry2010，118，： | 1 |
| 10 | Thermal stability and protein structure 显示文摘 | Argos P Rossmann M G Grau U M etal | 1979 | Biochemistry1979，18，： | 1 |
| 11 | Structural investigation of PsbO from plant and cyanobacterial photosys- tem II 显示文摘 | SLOWIK D ROSSMANN M KONAREV P V | 2011 | Journal of Molecular Biology2011，407，1： | 1 |
| 12 | Detection of ICAM-1 inexperimentally induced colitis of ICAM-1- deficient and wild-typemice: An immunohistochemical study显示文摘 | Bendjelloul F Rossmann P Mal'P | 2000 | Histochem J2000，32，： | 1 |
| 13 | Characterization of the antigenic sites on the refined 3-Aresolution structure of mouse testicular lactate dehydrogenase C4显示文摘 | Hogrefe H H Griffith J P Rossmann M G | 1987 | J Biol Chem1987，262，27： | 1 |
| 14 | Circulating endothelial cells isolated togerther with platelets and the experimental modification of their counts in rats显示文摘 | Hladovec J Rossmann P | 1973 | Thrombosis Res1973，3，6： | 1 |
| 15 | Combining isotopic signatures of n ( ^87 Sr)/n( ^86 Sr) and light stable elements ( C, N, O, S) with multi-elemental profiling for the authentication of provenance of European cereal samples显示文摘 | Asfaha D G Quatel C R Thomas F Horacek M Wimmer B Heiss G Dekant C Deters-hzelsberger P Hoelzl S Rummel S Brach-Papa C Bocxstaele M V Jamin E Baxter M Heinrich K Kelly S Bertoldi D Bontempo L Camin F Larcher R Perini M Rossmann A Schellenberg A Schlicht C Froeschl H Hoogewerff J Uechkermann H | 2011 | Journal of Cereal Science2011，53，2： | 1 |
| 16 | Surface modification of polyimide sheets for regenerative medi- cine application显示文摘 | Vlierberghe S V Sirova M Rossmann P | 2010 | Biomacromolecues2010，11，： | 1 |
| 17 | Detection of ICAM-1 in experimentally induced colitis of ICAM-l-deficient and wild-type mice: An immunohistochemical study显示文摘 | Bendjelloul F Rossmann P Maly P | 2000 | Histochem J2000，32，： | 1 |
| 18 | Structural studies of the Sputnik virophage 显示文摘 | Sun S La Scola B Bowman V D Ryan C M Whitelegge J P Raoult D Rossmann M G | 2010 | J Virol2010，84，2： | 1 |
| 19 | The potential of muhielement stable isotope analysis for regional origin assignment of butter显示文摘 | Rossmann A Haberhauer G Holzl S Heorn P Pichlmayer F Voerkelius S | 2000 | European Food Research and Technology2000，211，： | 1 |
| 20 | Downregulated in adenoma mediates apical Cl^-/HCO3^- exchange in rabbit, rat, and human duodenum 显示文摘 | JACOB P ROSSMANN H LAMPRECHT G | 2002 | Gastroenterology2002，122，3： | 1 |
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