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| 1 | European cooperation to tackle the legacies of hexachlorocyclohexane(HCH)and lindane显示文摘Hexachlorocyclohexane(HCH)waste isomers from lindane production are the largest single POPs legacy,with an estimated 4.8 to 7.4 million tonnes of disposed waste.The largest part of this waste e 1.8 to 3 million tonnes e was disposed in Europe,where most producers were located.This paper provides a short overview of projects supported by the European Union(EU)to address this waste legacy and to implement the Stockholm Convention for this group of POPs with associated protection of soil,ecosystems and human health.We report here particularly on the results of a project financed by the EU called the“HCH in EU project”,which aimed to develop a systematic inventory of sites where HCH was handled and potentially resulted in contamination.The compiled information provide guidance for competent authorities to further assess their national HCH inventory and to further develop a strategy to address this large POP legacy in future.The systematic inventory revealed that there were at least 299 sites where HCH was handled.These sites include 54 former production sites,76 pesticide processing plants that used lindane,59 uncontrolled HCH waste isomer deposits,29 landfills with HCH waste,34 former or current storage sites for stocks of obsolete pesticides including technical HCH or lindane,and 16 HCH treatment or disposal sites.Additionally,at 31 of the sites lindane/technical HCH was used in applications with significant risk of soil pollution,such as wood treatment.The number of sites in this latter category is likely higher and will need further assessment.In addition to this inventory,the“HCH in EU project”produced detailed country reports,a guidance document for how to find potentially HCHimpacted sites,and a strategy document for implementing the sustainable management of these sites EU-wide,with proposed actions at the EU,country,and site level.Furthermore,the project has facilitated information exchange and e together with other related EU projects e has led to sharing information and best practices among member states and to establishing a network of authorities and other stakeholders working on the lindane/HCH waste legacy.This collaboration will facilitate a more systematic and better coordinated process to further assess,secure,and remediate the large HCH waste legacy and reduce and control lindane/HCH releases in the EU and possibly beyond.Such a coordinated effort and exchange of information for inventorying and managing contaminated sites might also be useful for other POPs such as PFOS/PFOA or dioxins. | John Vijgen Boudewijn Fokke Guido van de Coterlet Katja Amstaetter Javier Sancho Carlo Bensaïah Roland Weber | 2022 | Emerging Contaminants2022，8，1： | 4 |
| 2 | Surface functionalized N-C-TiO_(2)/C nanocomposites derived from metal-organic framework in water vapour for enhanced photocatalytic H generation显示文摘Surface-functionalized nitrogen/carbon co-doped polymorphic TiO_(2) phase junction nanoparticles uniformly distributed in porous carbon matrix were synthesized by a simple one-step pyrolysis of titanium based metal-organic framework(MOF),NH_(2)-MIL^(-1)25(Ti) at 700℃ under water vapour atmosphere.Introducing water vapour during the pyrolysis of NH_(2)-MIL^(-1)25(Ti) not only functionalizes the derived porous carbon matrix with carboxyl groups but also forms additional oxygen-rich N like interstitial/intraband states lying above the valence band of TiO2 along with the self-doped carbo n,which further narrows the energy band gaps of polymorphic TiO2 nanoparticles that enhance photocatalytic charge transfer efficiency.Without co-catalyst,sample N-C-TiO2/CArW demonstrates H_(2) evolution activity of 426 μmol gcat-1h^(-1),which remarkably outperforms commercial TiO_(2)(P-25) and N-C-TiO_(2)/CAr with a 5-fold and 3-fold H_(2) generation,respectively.This study clearly shows that water vapour atmosphere during the pyrolysis increases the hydrophilicity of the Ti-MOF derived composites by functionalizing porous carbon matrix with carboxylic groups,as well as enhancing the electrical conductivity and charge transfer efficiency due to the formation of additional localized oxygen-rich N like interstitial/intraband states.This work also demonstrates that by optimizing the anatase-rutile phase composition of the TiO2 polymorphs,tuning the energy band gaps by N/C co-doping and functionalizing the porous carbon matrix in the N-C-TiO2/C nanocomposites,the photocatalytic H_(2) generation activity can be further enhanced. | Mian Zahid Hussain Zhuxian Yang Bart van der Linden Zheng Huang Quanli Jia Erik Cerrato Roland A.Fischer Freek Kapteijn Yanqiu Zhu Yongde Xia | 2021 | Journal of Energy Chemistry2021，30，6： | 3 |
| 3 | Cognitive performance in patients with COPD显示文摘 | Jeroen J.W Liesker Dirkje S Postma Rypko J Beukema Nick H.T ten Hacken Thys van der Molen Roland A Riemersma Ed H van Zomeren Huib A.M Kerstjens | 2003 | Respiratory Medicine2003，，4： | 3 |
| 4 | Inventory and action plan for PFOS and related substances in Suriname as basis for Stockholm Convention implementation显示文摘Within the framework of the Stockholm Convention implementation in Suriname,the first inventory of perfluorooctane sulfonic acid(PFOS)has been developed.The major stocks of PFOS are firefighting foams with minor stocks in pesticides(ant baits)and possibly carpets.The inventory of firefighting foams assessed the import,current stocks and major use sites and recent releases.Considerable amount of PFOS and potentially PFOS containing firefighting foams are stored at the military base,the oil company and small firefighting departments throughout the country.The total amount of stored PFAS firefighting foam in Suriname is estimated to be at least 275.6 tonnes,where the major stockpile of 206 tonnes is at the oil storage facilities.For some of these foams PFOS content is confirmed and for others it is not clear if the foam contains PFOS or other per-or polyfluorinated alkylated substances(PFAS).The upper estimate of PFOS content is 4133 kg in these foams.Additionally,PFOS or other PFAS has also been discovered in fire extinguishers in institutions.The total amount of PFOS related substance EtFOSA imported with the pesticide sulfluramid was 75 kg.The imports were banned in 2014 and is controlled.A considerable amount of synthetic carpets are in stores even produced before 2003 where main use of PFOS from 3 M took place possibly containing PFOS related substances.A compilation of potentially PFOS contaminated sites has been made.Potentially contaminated sites result from firefighting foam use,dumpsites and sulfluramid use.The airport where firefighting foam was applied is above a major drinking water reservoir,where an urgent assessment is needed.Due to the lack of analytical capacity for PFOS and precursors,drinking water,firefighting foam or impacted carpets,could not been analysed.An action plan for the control of PFOS and other PFAS has been developed considering the synergy of the Stockholm Convention and the Strategic Approach to International Chemicals Management(SAICM)addressing this emerging pollution issue for developing countries. | Victorine Pinas Carmen Van Dijk Roland Weber | 2020 | Emerging Contaminants2020，6，1： | 3 |
| 5 | 铸铁中碳测定方法的改进显示文摘碳是铸铁中最重要的元素。因此,在铸造过程中需要经常对碳进行监控。取样过程非常关键,冷凝速度过慢就会产生石墨夹杂。然而,火花直读光谱仪进行测定时需要完全不含石墨的样品才能得到精确的测量结果。本文对这种要求的原因进行了研究和讨论,并对一种测定碳新方法的原理和可行性进行了阐述。该方法改进了测定未达到最佳标准要求的铸铁样品中碳含量的准确性,并能提示取样过程是否恰当。 | VAN DRIEL Roland JOOSTEN Heinz-Gerd VAN STUIJVENBERG Bruno | 2012 | 冶金分析2012，32，9： | 3 |
| 6 | Arterial Stiffness and Risk of Coronary Heart Disease and Stroke: The Rotterdam Study显示文摘 | Francesco U.S. Mattace-Raso Tischa J.M. van der Cammen Albert Hofman Nicole M. van Popele Michiel L. Bos Maarten A.D.H. Schalekamp Roland Asmar Robert S. Reneman Arnold P.G. Hoeks Monique M.B. Breteler Jacqueline C.M. Witteman | 2006 | Circulation2006，，5： | 2 |
| 7 | Quantitative resistance against Bemisia tabaci in Solanum pennellii:Genetics and metabolomics显示文摘The whitefly Bemisia tabaci is a serious threat in tomato cultivation worldwide as all varieties grown today are highly susceptible to this devastating herbivorous insect.Many accessions of the tomato wild relative Solanum pennellii show a high resistance towards B. tabaci. A mapping approach was used to elucidate the genetic background of whiteflyresistance related traits and associated biochemical traits in this species. Minor quantitative trait loci(QTLs) for whitefly adult survival(AS) and oviposition rate(OR) were identified and some were confirmed in an F2BC1 population, where they showed increased percentages of explained variance(more than 30%). Bulked segregant analyses on pools of whiteflyresistant and-susceptible F2 plants enabled the identification of metabolites that correlate either with resistance or susceptibility. Genetic mapping of these metabolites showed that a large number of them co-localize with whiteflyresistance QTLs. Some of these whitefly-resistance QTLs are hotspots for metabolite QTLs. Although a large number of metabolite QTLs correlated to whitefly resistance or susceptibility, most of them are yet unknown compounds and further studies are needed to identify the metabolic pathways and genes involved. The results indicate a direct genetic correlation between biochemical-based resistance characteristics and reduced whitefly incidence in S. pennellii. | Floor van den Oever-van den Elsen Alejandro F.Lucatti Sjaak van Heusden Colette Broekgaarden Roland Mumm Marcel Dicke Ben Vosman | 2016 | Journal of Integrative Plant Biology2016，58，4： | 2 |
| 8 | Cognitive performance in patients with COPD显示文摘 | Jeroen J.W Liesker Dirkje S Postma Rypko J Beukema Nick H.T ten Hacken Thys van der Molen Roland A Riemersma Ed H van Zomeren Huib A.M Kerstjens | 2003 | Respiratory Medicine2003，，4： | 2 |
| 9 | The Global Rating Scale in clinical practice: A comprehensive quality assurance programme for endoscopy departments显示文摘 | Jerome Sint Nicolaas Vincent de Jonge Robert A. de Man Frank ter Borg Djuna L. Cahen Willem Moolenaar Mark F.J. Stolk Antonie J.P. van Tilburg Roland M. Valori Monique E. van Leerdam Ernst J. Kuipers | 2012 | Digestive and Liver Disease2012，，11： | 1 |
| 10 | Nonpancreatic primary tumors with metastasis to the pancreas显示文摘 | Roland CF van Heerden JA | | 0，，04： | 1 |
| 11 | Thealpha subunit of sodium pump could represent a novel target to combat non- small cell lung cancer 显示文摘 | MIJATOVIC T ROLAND I van QUAQUEBEKE E | 2007 | J Pathol2007，212，2： | 1 |
| 12 | A force velocity relationship and coordination patterns in overarm throwing显示文摘 | ROLAND VAN DEN TILLAAR GERTJAN | 2004 | J Sport Sci Med2004，，3： | 1 |
| 13 | Candidate colorectal cancer predisposing gene variants in Chinese early-onset and familial cases显示文摘AIM: To investigate whether whole-exome sequencing may serve as an efficient method to identify known or novel colorectal cancer(CRC) predisposing genes in early-onset or familial CRC cases.METHODS: We performed whole-exome sequencing in 23 Chinese patients from 21 families with nonpolyposis CRC diagnosed at ≤ 40 years of age, or from multiple affected CRC families with at least 1 firstdegree relative diagnosed with CRC at ≤ 55 years of age.Genomic DNA from blood was enriched for exome sequences using the Sure Select Human All Exon Kit, version 2(Agilent Technologies) and sequencing was performed on an Illumina Hi Seq 2000 platform.Data were processed through an analytical pipeline to search for rare germline variants in known or novel CRC predisposing genes.RESULTS: In total, 32 germline variants in 23 genes were identified and confirmed by Sanger sequencing.In 6 of the 21 families(29%), we identified 7 mutations in 3 known CRC predisposing genes including MLH1(5 patients), MSH2(1 patient), and MUTYH(biallelic, 1 patient), five of which were reported as pathogenic.Inthe remaining 15 families, we identified 20 rare and novel potentially deleterious variants in 19 genes, six of which were truncating mutations.One previously unreported variant identified in a conserved region of EIF2AK4(p.Glu738_Asp739insA rgA rg) was found to represent a local Chinese variant, which was significantly enriched in our early-onset CRC patient cohort compared to a control cohort of 100 healthy Chinese individuals scored negative by colonoscopy(33.3% vs 7%, P < 0.001).CONCLUSION: Whole-exome sequencing of early-onset or familial CRC cases serves as an efficient method to identify known and potential pathogenic variants in established and novel candidate CRC predisposing genes. | Jun-Xiao Zhang Lei Fu Richarda M de Voer Marc-Manuel Hahn Peng Jin Chen-Xi Lv Eugène TP Verwiel Marjolijn JL Ligtenberg Nicoline Hoogerbrugge Roland P Kuiper Jian-Qiu Sheng Ad Geurts van Kessel | 2015 | World Journal of Gastroenterology2015，21，14： | 1 |
| 14 | The alpha1 subunit of the sodium pump could represent a novel target to combat non-small cell lung cancers显示文摘 | Mijatovic T Roland I Van Quaquebeke E | 2007 | J Pathol2007，212，2： | 1 |
| 15 | Long-Term Antihypertensive Efficacy and Safety of the Oral Direct Renin Inhibitor Aliskiren: A 12-Month Randomized, Double-Blind Comparator Trial With Hydrochlorothiazide显示文摘 | Roland E. Schmieder Thomas Philipp Javier Guerediaga Manuel Gorostidi Beverly Smith Nicole Weissbach Mojdeh Maboudian Jaco Botha Hein van Ingen | 2009 | Circulation2009，，3： | 1 |
| 16 | Bitter taste receptor activation by flavonoids and isoflavonoids: modeled structural requirements for activation of hTAS2R14 and hTAS2R39 显示文摘 | Roland WS van Buren L Gruppen H | 2013 | JAgric Food Chem2013，61，10： | 1 |
| 17 | A rare congenital intranasal polyp: mesenchymal chondrosarcoma of the nasal region显示文摘 | Roland N J Khine M M Clarke R Van Velzen D | 1992 | J Laryngol Otol1992，106，12： | 1 |
| 18 | Hepatic perfusion parameters in chronic liver disease:dynamic CT measurements correlated with disease severity显示文摘 | Van Beers BE Leconte I Roland M | 2001 | AJR2001，176，： | 1 |
| 19 | Prevention and Management of Complications in Urological Laparoscopic Port Site Placement显示文摘 | Richard J. Pemberton David A. Tolley Roland F. van Velthoven | 2006 | European Urology2006，，5： | 1 |
| 20 | The alpha1 subunit of the sodium pump could represent a novel target to combat non-small cell lung cancers显示文摘 | Mijatovic T Roland I Van Quaquebeke E | 2007 | J Pathol2007，212，2： | 1 |
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