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| 1 | Quality of life, work productivity impairment and healthcare resources in inflammatory bowel diseases in Brazil显示文摘BACKGROUND Inflammatory bowel diseases(IBD)have been associated with a low quality of life(QoL)and a negative impact on work productivity compared to the general population.Information about disease control,patient-reported outcomes(PROs),treatment patterns and use of healthcare resources is relevant to optimizing IBD management.AIM To describe QoL and work productivity and activity impairment(WPAI),treatment patterns and use of healthcare resources among IBD patients in Brazil.METHODS A multicenter cross-sectional study included adult outpatients who were previously diagnosed with moderate to severe Crohn’s disease(CD)or ulcerative colitis(UC).At enrolment,active CD and UC were defined as having a Harvey Bradshaw Index≥8 or a CD Activity Index≥220 or calprotectin>200μg/g or previous colonoscopy results suggestive of inadequate control(per investigator criteria)and a 9-point partial Mayo score≥5,respectively.The PRO assessment included the QoL questionnaires SF-36 and EQ-5D-5L,the Inflammatory Bowel Disease Questionnaire(IBDQ),and the WPAI questionnaire.Information about healthcare resources and treatment during the previous 3 years was collected from medical records.Chi-square,Fisher’s exact and Student’s t-/Mann-Whitney U tests were used to compare PROs,treatment patterns and the use of healthcare resources by disease activity(α=0.05).RESULTS Of the 407 patients in this study(CD/UC:64.9%/35.1%,mean age 42.9/45.9 years,54.2%/56.6%female,38.3%/37.1%employed),44.7%/25.2%presented moderate-to-severe CD/UC activity,respectively,at baseline.Expressed in median values for CD/UC,respectively,the SF-36 physical component was 46.6/44.7 and the mental component was 45.2/44.2,the EQ-visual analog scale score was 80.0/70.0,and the IBDQ overall score was 164.0/165.0.Moderate to severe activity,female gender,being unemployed,a lower educational level and lower income were associated with lower QoL(P<0.05).Median work productivity impairment was 20%and 5%for CD and UC patients,respectively,and activity impairment was 30%,the latter being higher among patients with moderate to severe disease activity compared to patients with mild or no disease activity(75.0%vs 10.0%,P<0.001).For CD/UC patients,respectively,25.4%/2.8%had at least one surgery,38.3%/19.6%were hospitalized,and 70.7%/77.6%changed IBD treatment at least once during the last 3 years.The most common treatments at baseline were biologics(75.3%)and immunosuppressants(70.9%)for CD patients and 5-ASA compounds(77.5%)for UC patients.CONCLUSION Moderate to severe IBD activity,especially among CD patients,is associated with a substantial impact on QoL,work productivity impairment and an increased number of IBD surgeries and hospitalizations in Brazil. | Rogerio Serafim Parra Julio MF Chebli Heda MBS Amarante Cristina Flores Jose ML Parente Odery Ramos Milene Fernandes Jose JR Rocha Marley R Feitosa Omar Feres Antonio S Scotton Rodrigo B Nones Murilo M Lima Cyrla Zaltman Carolina D Goncalves Isabella M Guimaraes Genoile O Santana Ligia Y Sassaki Rogerio S Hossne Mauro Bafutto Roberto LK Junior Mikaell AG Faria Sender J Miszputen Tarcia NF Gomes Wilson R Catapani Anderson A Faria Stella CS Souza Rosana F Caratin Juliana T Senra Maria LA Ferrari | 2019 | World Journal of Gastroenterology2019，25，38： | 2 |
| 2 | Experimental implementation of the gyrator transform 显示文摘 | RODRIGO J A AIAEVA T CALVO M L | 2007 | Journal of Optics Society of America A2007，24，10： | 1 |
| 3 | Comparison of Radical Prostatectomy Techniques: Open, Laparoscopic and Robotic Assisted显示文摘 | Rodrigo F Burak T Rodrigo B | 2008 | Int Braz J Urol2008，34，3： | 1 |
| 4 | Phase-space tomography with a programmable Radon-Wigner display显示文摘 | Cámara A Alieva T Rodrigo J A | 2011 | Optics letters2011，36，13： | 1 |
| 5 | Cor-tactin and focal adhesion kinase as predictors of cancer risk in pa-tients with premalignant oral epithelial lesions 显示文摘 | de Vicente JC Rodrigo JP Rodriguez - Santaraarta T | 2012 | Oral Oncol2012，48，7： | 1 |
| 6 | Effects of supercritical carbon dioxide on waste banana peels for heavy metal removal显示文摘 | Juliana Q A Rodrigo B R Diego T S | 2011 | The Journal of Supercritical Fluids2011，58，： | 1 |
| 7 | In vitro mutation of Chrysanthemum with ethyl methane sulphonate in immature floral pedicels显示文摘 | RODRIGO R L ALVIS H A AUGUSTO T N | 2004 | Plant Cell Tissue Organ Cult2004，，77： | 1 |
| 8 | A new method for estimating driven pile static skin friction withat the top and bottom of the pile 显示文摘 | Khiem T T Michael M V Rodrigo H | 2011 | Soil Dynamics and Earthquake Engineering2011，，31： | 1 |
| 9 | Nitrous oxide (N2O) induces 2n gametes in sterile F1 hybrids between Oriental×Asiatic lily (Lilium) hybrids and leads to intergenomic recombination显示文摘 | RODRIGO BARBA-GONZALEZ MILLER CHAD T RAMANNA MUNIKOTE S | 2006 | Euphytica2006，148，： | 1 |
| 10 | Influence of lanthanum oxide as quality promoter on cathodes for MCFC显示文摘 | Escudero M J Novoa X R Rodrigo T | 2002 | Journal of Power Sources2002，106，12： | 1 |
| 11 | Materials Scienceand Engineering: 5显示文摘 | Femdndez S Pena R Rodrigo M T | 2007 | 2007, 143(1-3): 552007，143，13： | 1 |
| 12 | Better to be frustrated than bored: The incidence, persist- ence, and impact of learners'cognitive - affective states during interactions with three different computer- based learning environments 显示文摘 | Baker R S D'Mello S K Rodrigo M T Graesser A C | 2011 | International Journal of Human - Computer Studies2011，，68： | 1 |
| 13 | As- sociation between bone mineral density, lean mass, and fat mass among healthy middle-aged premenopausal women: a cross-sectional study in southern Sri Lanka 显示文摘 | Lekamwasam S Weerarathna T Rodrigo M | 2009 | J Bone Miner Metab2009，27，： | 1 |
| 14 | Easy gesture recognition for Kinect 显示文摘 | Rodrigo I Alvaro S Alfredo T | 2014 | Advances in Engineering Software2014，76，： | 1 |
| 15 | Treatment of articular cartilage defects in athletes:an analysis of functional outcome and lesion appearance显示文摘 | BLEVINS F T STEADMAN J R RODRIGO JJ | 1998 | Orthopedics1998，21，7： | 1 |
| 16 | Multi-site evaluation of IKONOS data for classification of tropical coral reef environments显示文摘 | Serge Andréfou?t Philip Kramer Damaris Torres-Pulliza Karen E Joyce Eric J Hochberg Rodrigo Garza-Pérez Peter J Mumby Bernhard Riegl Hiroya Yamano William H White Mayalen Zubia John C Brock Stuart R Phinn Abdulla Naseer Bruce G Hatcher Frank E Muller-Karg | 2003 | Remote Sensing of Environment2003，，1： | 1 |
| 17 | Performance enhancement of ohmic contact on n-GaN using Ti-W as metal barrier 显示文摘 | S Fernandez R Pefia M T Rodrigo | 2007 | Materials Science and Engineering: B2007，143，13： | 1 |
| 18 | NPY augments the proliferative effect of FGF2 and increases the expression of FGFR1 on nestin positive postnatal hippocampal precursor cells, via the Y1 receptor显示文摘 | Rodrigo C Zaben M Lawrence T | 2010 | J Neurochem2010，113，3： | 1 |
| 19 | Better to be frustrated than bored: The incidence, persistence, and impact of learners' cognitive-affective states during interactions with three different computer- based learning environments显示文摘 | Baker S J d R D'Mello S K Rodrigo M M T | 2010 | International Journal of Human-Computer Studies2010，68，： | 1 |
| 20 | Infection-triggered regulatory mechanisms override the role of STAT 4 in control of the immune response to influenza virus antigens显示文摘 | Bot A Rodrigo E Wolfe T | 2003 | J Virol2003，77，10： | 1 |
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