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| 1 | Intraoperative cell salvage with autologous transfusion in liver transplantation显示文摘Liver transplant(LT) is the primary treatment for patients with end-stage liver disease. About 25000 LTs are performed annually in the world. The potential for intraoperative bleeding is quite variable. However, massive bleeding is common and requires blood transfusion. Allogeneic blood transfusion has an immunosuppressive effect and an impact on recipient survival, in addition to the risk of transmission of viral infections and transfusion errors, among others.Techniques to prevent excessive bleeding or to use autologous blood have been proposed to minimize the negative effects of allogeneic blood transfusion.Intraoperative reinfusion of autologous blood is possible through previous selfdonation or blood collected during the operation. However, LT does not normally allow autologous transfusion by prior self-donation. Hence, using autologous blood collected intraoperatively is the most feasible option. The use of intraoperative blood salvage autotransfusion(IBSA) minimizes the perioperative use of allogeneic blood, preventing negative transfusion effects without negatively impacting other clinical outcomes. The use of IBSA in patients with cancer is still a matter of debate due to the theoretical risk of reinfusion of tumor cells. However, studies have demonstrated the safety of IBSA in several surgical procedures, including LT for hepatocellular carcinoma. Considering the literature available to date, we can state that IBSA should be routinely used in LT, both in patients with cancer and in patients with benign diseases. | Marcelo A Pinto Marcio F Chedid Leo Sekine Andre P Schmidt Rodrigo P Capra Carolina Prediger Jo?o E Prediger Tomaz JM Grezzana-Filho Cleber RP Kruel | 2019 | World Journal of Gastrointestinal Surgery2019，11，1： | 16 |
| 2 | Liver expression of steroid hormones and Apolipoprotein D receptors in hepatocellular carcinoma显示文摘AIM: To evaluate the tissular expression of Androgen (A), Estrogen (E) and Progesterone (Pg) receptors, and Apolipoprotein D (ApoD), in liver tumors from resected hepatocellular carcinoma (HCC) cases in order to assess their possible relationship to prognosis. METHODS: We performed an immunohistochemical study using tissue microarrays (containing more than 260 cancer specimens, from 31 HCC patients and controls) to determine the presence of specif ic antibodies against AR, ER, PgR and ApoD, correlating their findings with several clinico-pathological and biological variables. The staining results were categorized using a semi-quantitive score based on their intensity, and the percentage of immunostained cells was measured. RESULTS: A total of 21 liver tumors (67.7%) were positive for AR; 16 (51.6%) for ER; 26 (83.9%) for PgR and 12 (38.7%) stained for ApoD. We have found a wide variability in the immunostaining score values for each protein, with a median (range) of 11.5 (11.5-229.5) for AR; 11.1 (8.5-65) for ER; 14.2 (4-61) for PgR; and 37.7 (13.8-81.1) for ApoD. A history of heavy ethanol consumption, correlated positively with AR and PgR and negatively with ER status. HCV chronic infection also correlated positively with AR and PgR status. However, the presence of ApoD immunostaining did not correlate with any of these variables. Tumors with a positive immuno-staining for PgR showed a better prognosis. CONCLUSION: Our results indicate a moderate clinical value of the steroid receptor status in HCC, emphasizing the need to perform further studies in order to evaluate the possible role of new hormonal-based therapies. | FJ Vizoso M Rodriguez A Altadill ML González-Diéguez A Linares LO González S Junquera F Fresno-Forcelledo MD Corte L Rodrigo | 2007 | World Journal of Gastroenterology2007，13，23： | 11 |
| 3 | Usefulness of duodenal biopsy during routine upper gastrointestinal endoscopy for diagnosis of celiac disease显示文摘瞄准:在一张成年西班牙的人口在平淡的上面的胃肠的内视镜检查法期间在十二指肠的活体检视性能描述趋势,并且在临床的实践为乳糜泻的诊断分析它的值。方法:在当承担上面的胃肠的内视镜检查法时,执行的十二指肠的活体检视的 15 年趋势(1990 ~ 2004 ) 被学习。我们与贫血症或长期的腹泻在全面的组,并且在亚群分析了乳糜泻的流行。结果:十二指肠的活体检视在 13 678 上面的胃肠的内视镜检查法(7.6%) 中的 1033 个被执行;这的使用的增加在学习时期上被观察(1.9% 在 1990-1994, 5% 在 1995-1999 并且 12.8% 在 2000-2004 ) 。乳糜泻在 22 个病人(2.2%) 被诊断,这比在男人在女人是更经常的(3% 和 1% 分别地) 。十四从 514 (2.7%) 有贫血症的病人, 12 从 141 (8.5%) 与长期的腹泻并且 8 (19%) 从 42,与贫血症,正长期的腹泻有乳糜泻。一个古典临床的演讲在 55% 盒子中被观察, 23% 病人联系了疱疹样皮炎和 64% 介绍贫血症;9% 被家庭屏蔽诊断并且 5% 由秘密成员基因 hypertransaminasaemia。结论:在成年人在平淡的上面的胃肠的内视镜检查法期间承担的十二指肠的活体检视,逐渐地被合并了到临床的实践,并且是为在象有贫血症或长期的腹泻的那些那样的高风险组的乳糜泻的诊断的一个有用工具。 | S Riestra F Domínguez E Fernández-Ruiz E García-Riesco R Nieto E Fernández L Rodrigo | 2006 | World Journal of Gastroenterology2006，12，31： | 4 |
| 4 | Methylation of DAPK and THBS1 genes in esophageal gastric-type columnar metaplasia显示文摘AIM: To explore methylation of DAPK, THBS1, CDH-1, and p14 genes, and Helicobacter pylori(H. pylori) status in individuals harboring esophageal columnar metaplasia.METHODS: Distal esophageal mucosal samples obtained by endoscopy and histologically diagnosed as gastric-type(non-specialized) columnar metaplasia, were studied thoroughly. DNA was extracted from paraffin blocks, and methylation status of deathassociated protein kinase(DAPK), thrombospondin-1(THBS1), cadherin-1(CDH1), and p14 genes, was examined using a methyl-sensitive polymerase chain reaction(MS-PCR) and sodium bisulfite modification protocol. H. pylori cag A status was determined by PCR.RESULTS: In total, 68 subjects(33 females and 35 males), with a mean age of 52 years, were included. H. pylori cag A positive was present in the esophageal gastric-type metaplastic mucosa of 18 individuals. DAPK, THSB1, CDH1, and p14 gene promoters were methylated by MS-PCR in 40(58.8%), 33(48.5%), 46(67.6%), and 23(33.8%) cases of the 68 esophageal samples. H. pyloristatus was associated with methylation of DAPK(P = 0.003) and THBS1(P = 0.019).CONCLUSION: DNA methylation occurs in cases of gastric-type(non-specialized) columnar metaplasia of the esophagus, and this modification is associated with H. pylori cag A positive infection. | Roberto Herrera-Goepfert Luis F Onate-Ocana José Luis Mosqueda-Vargas Luis A Herrera Clementina Castro Julia Mendoza Rodrigo González-Barrios | 2016 | World Journal of Gastroenterology2016，22，18： | 3 |
| 5 | Double-layer graphene for enhanced tunable infrared plasmonics显示文摘Graphene is emerging as a promising material for photonic applications owing to its unique optoelectronic properties.Graphene supports tunable,long-lived and extremely confined plasmons that have great potential for applications such as biosensing and optical communications.However,in order to excite plasmonic resonances in graphene,this material requires a high doping level,which is challenging to achieve without degrading carrier mobility and stability.Here,we demonstrate that the infrared plasmonic response of a graphene multilayer stack is analogous to that of a highly doped single layer of graphene,preserving mobility and supporting plasmonic resonances with higher oscillator strength than previously explored single-layer devices.Particularly,we find that the optically equivalent carrier density in multilayer graphene is larger than the sum of those in the individual layers.Furthermore,electrostatic biasing in multilayer graphene is enhanced with respect to single layer due to the redistribution of carriers over different layers,thus extending the spectral tuning range of the plasmonic structure.The superior effective doping and improved tunability of multilayer graphene stacks should enable a plethora of future infrared plasmonic devices with high optical performance and wide tunability. | Daniel Rodrigo Andreas Tittl Odeta Limaj F Javier García de Abajo Valerio Pruneri Hatice Altug | 2017 | Light(Science & Applications)2017，6，1： | 3 |
| 6 | Quality of life, work productivity impairment and healthcare resources in inflammatory bowel diseases in Brazil显示文摘BACKGROUND Inflammatory bowel diseases(IBD)have been associated with a low quality of life(QoL)and a negative impact on work productivity compared to the general population.Information about disease control,patient-reported outcomes(PROs),treatment patterns and use of healthcare resources is relevant to optimizing IBD management.AIM To describe QoL and work productivity and activity impairment(WPAI),treatment patterns and use of healthcare resources among IBD patients in Brazil.METHODS A multicenter cross-sectional study included adult outpatients who were previously diagnosed with moderate to severe Crohn’s disease(CD)or ulcerative colitis(UC).At enrolment,active CD and UC were defined as having a Harvey Bradshaw Index≥8 or a CD Activity Index≥220 or calprotectin>200μg/g or previous colonoscopy results suggestive of inadequate control(per investigator criteria)and a 9-point partial Mayo score≥5,respectively.The PRO assessment included the QoL questionnaires SF-36 and EQ-5D-5L,the Inflammatory Bowel Disease Questionnaire(IBDQ),and the WPAI questionnaire.Information about healthcare resources and treatment during the previous 3 years was collected from medical records.Chi-square,Fisher’s exact and Student’s t-/Mann-Whitney U tests were used to compare PROs,treatment patterns and the use of healthcare resources by disease activity(α=0.05).RESULTS Of the 407 patients in this study(CD/UC:64.9%/35.1%,mean age 42.9/45.9 years,54.2%/56.6%female,38.3%/37.1%employed),44.7%/25.2%presented moderate-to-severe CD/UC activity,respectively,at baseline.Expressed in median values for CD/UC,respectively,the SF-36 physical component was 46.6/44.7 and the mental component was 45.2/44.2,the EQ-visual analog scale score was 80.0/70.0,and the IBDQ overall score was 164.0/165.0.Moderate to severe activity,female gender,being unemployed,a lower educational level and lower income were associated with lower QoL(P<0.05).Median work productivity impairment was 20%and 5%for CD and UC patients,respectively,and activity impairment was 30%,the latter being higher among patients with moderate to severe disease activity compared to patients with mild or no disease activity(75.0%vs 10.0%,P<0.001).For CD/UC patients,respectively,25.4%/2.8%had at least one surgery,38.3%/19.6%were hospitalized,and 70.7%/77.6%changed IBD treatment at least once during the last 3 years.The most common treatments at baseline were biologics(75.3%)and immunosuppressants(70.9%)for CD patients and 5-ASA compounds(77.5%)for UC patients.CONCLUSION Moderate to severe IBD activity,especially among CD patients,is associated with a substantial impact on QoL,work productivity impairment and an increased number of IBD surgeries and hospitalizations in Brazil. | Rogerio Serafim Parra Julio MF Chebli Heda MBS Amarante Cristina Flores Jose ML Parente Odery Ramos Milene Fernandes Jose JR Rocha Marley R Feitosa Omar Feres Antonio S Scotton Rodrigo B Nones Murilo M Lima Cyrla Zaltman Carolina D Goncalves Isabella M Guimaraes Genoile O Santana Ligia Y Sassaki Rogerio S Hossne Mauro Bafutto Roberto LK Junior Mikaell AG Faria Sender J Miszputen Tarcia NF Gomes Wilson R Catapani Anderson A Faria Stella CS Souza Rosana F Caratin Juliana T Senra Maria LA Ferrari | 2019 | World Journal of Gastroenterology2019，25，38： | 2 |
| 7 | Operative Versus Nonoperative Treatment for Stage 0 Distal Rectal Cancer Following Chemoradiation Therapy: Long-term Results显示文摘 | Angelita Habr-Gama Rodrigo Oliva Perez Wladimir Nadalin Jorge Sabbaga Ulysses Ribeiro Afonso Henrique Silva e Sousa Fábio Guilherme Campos Desidério Roberto Kiss Joaquim Gama-Rodrigues | 2004 | Annals of Surgery2004，，4： | 2 |
| 8 | Dev Cell:科学家阐明人类胚胎原生殖细胞发育的分子机制显示文摘近日,刊登于国际杂志Developmental Cell上的一项研究报道中,来自巴布拉汉研究所(Babraham Insdtute)的研究人员通过研究调查了原生殖细胞发育的早期阶段,同时他们在实验室开发了一种产生类似细胞的策略,这种酷似人类原始生殖细胞的产生对于未来生殖领域的研究,以及分析人类潜在的继代基因调控的遗传机制非常重要。 | Ferdinand von Meyenn Rebecca V. Berrens Simon Andrews Fátima Santos Amanda J. Collier Felix Krueger Rodrigo Osorno Wendy Dean Peter J. Rugg-Gunn Wolf Reik | 2016 | 现代生物医学进展2016，16，35： | 2 |
| 9 | Factors that impact health-related quality of life in adults with celiac disease:A multicenter study显示文摘AIM: To evaluate the factors involved in the impairment of health-related quality of life (HRQOL) in patients with celiac disease.METHODS: A multicenter, cross-sectional prospective study was performed in patients with celiac disease who completed two HRQOL questionnaires: the gastrointestinal quality of life index (GIQLI) and the EuroQol-5D (EQ).RESULTS: Three hundred and forty patients (163 controlled with a gluten-free diet, and 177 newly diagnosed with a normal diet) were included. The GIQLI score was significantly better in patients on a gluten-free diet (GFD) than in non-treated patients on their usual diet, both in terms of the overall score (3.3 vs 2.7, respectively; P < 0.001), as well as on the individual questionnaire dimensions. Both the preference value of the EQ as the visual analogue scale were significantly better in treated than in non-treated patients (0.93 vs 0.72 P < 0.001 and 80 vs 70 P < 0.001, respectively). Variables significantly associated with a worse HRQOL score were female gender, failure to adhere to a GFD, and symptomatic status.CONCLUSION: In untreated celiac disease, the most important factors that influence patient perception of health are the presence of symptoms and a normal diet. HRQOL improves to levels similar to those described in the general population in celiac disease patients well controlled with a GFD. | F Casellas L Rodrigo J López Vivancos S Riestra C Pantiga JS Baudet F Junquera V Puig Diví C Abadia M Papo J Gelabert JR Malagelada | 2008 | World Journal of Gastroenterology2008，14，1： | 2 |
| 10 | Peroxisome proliferator activated receptor up-regulates the bcl-2 anti- apoptosis protein in neurons and induces mitochondrial stabilization and protection against oxidative stress and apoptosis 显示文摘 | Karen F Rodrigo Q Patricio R | 2007 | J Biolcham2007，282，37： | 1 |
| 11 | Comparison of Radical Prostatectomy Techniques: Open, Laparoscopic and Robotic Assisted显示文摘 | Rodrigo F Burak T Rodrigo B | 2008 | Int Braz J Urol2008，34，3： | 1 |
| 12 | Characterization of Pinalate, a novel Citrus sinensis mutant with a fruit-specific alteration that results in yellow pigmentation and decreased ABA content显示文摘 | Rodrigo M J Marcos J F Alferez F | 2003 | J Exp Bot2003，54，： | 1 |
| 13 | Chinicopathologic significance of expression of CD4s and CD44v6 isoforms in squamous cell carcinoma of the supraglottic larynx显示文摘 | Rodrigo JP Dominguez F Alvarez C | 2002 | Am J Clin Pathol2002，118，1： | 1 |
| 14 | Alkaline proteinase from intestine of nile tilapia (Oreochromis Niloticus)显示文摘 | Ranilson S B Eduardo J F L Rodrigo B A | 2005 | Process Biochemistry2005，40，： | 1 |
| 15 | Coffee oil as a potential feedstock for biodiesel production显示文摘 | Leandro S O Adriana S F Rodrigo R S C | 2008 | Bioresource Technology2008，，99： | 1 |
| 16 | Channel plasmon-polaritons:modal shape,dispersion,and losses显示文摘 | Moreno E Garcia-Vidal F J Rodrigo S G | | 0，，23： | 1 |
| 17 | Direct synthesis of A2(Ti1-yZry)2O7(A=Gd3+,Y3+) solid solutions by ball milling constituent oxides显示文摘 | MORENO K J RODRIGO R S FUENTES A F | 2005 | J Alloys Compounds2005，390，12： | 1 |
| 18 | Long-term effects of continuing adjuvant tamoxifen to 10 years versus stopping at 5 years after diagnosis of oestrogen receptor-positive breast cancer: ATLAS, a randomised trial显示文摘 | Christina Davies Hongchao Pan Jon Godwin Richard Gray Rodrigo Arriagada Vinod Raina Mirta Abraham Victor Hugo Medeiros Alencar Atef Badran Xavier Bonfill Joan Bradbury Michael Clarke Rory Collins Susan R Davis Antonella Delmestri John F Forbes Peiman Hadd | 2012 | The Lancet2012，，： | 1 |
| 19 | Artifical vision through neuronal stinmlation 显示文摘 | Rodrigo A Brant F Bruno D | 2012 | Neuroscience letters2012，519，： | 1 |
| 20 | Intralesional recordings and epileptogenic zone in focal polymiemgyria显示文摘 | Chassoux F Landre E Rodrigo S | 2008 | Epilepsia2008，49，： | 1 |
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