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| 1 | Quality of life, work productivity impairment and healthcare resources in inflammatory bowel diseases in Brazil显示文摘BACKGROUND Inflammatory bowel diseases(IBD)have been associated with a low quality of life(QoL)and a negative impact on work productivity compared to the general population.Information about disease control,patient-reported outcomes(PROs),treatment patterns and use of healthcare resources is relevant to optimizing IBD management.AIM To describe QoL and work productivity and activity impairment(WPAI),treatment patterns and use of healthcare resources among IBD patients in Brazil.METHODS A multicenter cross-sectional study included adult outpatients who were previously diagnosed with moderate to severe Crohn’s disease(CD)or ulcerative colitis(UC).At enrolment,active CD and UC were defined as having a Harvey Bradshaw Index≥8 or a CD Activity Index≥220 or calprotectin>200μg/g or previous colonoscopy results suggestive of inadequate control(per investigator criteria)and a 9-point partial Mayo score≥5,respectively.The PRO assessment included the QoL questionnaires SF-36 and EQ-5D-5L,the Inflammatory Bowel Disease Questionnaire(IBDQ),and the WPAI questionnaire.Information about healthcare resources and treatment during the previous 3 years was collected from medical records.Chi-square,Fisher’s exact and Student’s t-/Mann-Whitney U tests were used to compare PROs,treatment patterns and the use of healthcare resources by disease activity(α=0.05).RESULTS Of the 407 patients in this study(CD/UC:64.9%/35.1%,mean age 42.9/45.9 years,54.2%/56.6%female,38.3%/37.1%employed),44.7%/25.2%presented moderate-to-severe CD/UC activity,respectively,at baseline.Expressed in median values for CD/UC,respectively,the SF-36 physical component was 46.6/44.7 and the mental component was 45.2/44.2,the EQ-visual analog scale score was 80.0/70.0,and the IBDQ overall score was 164.0/165.0.Moderate to severe activity,female gender,being unemployed,a lower educational level and lower income were associated with lower QoL(P<0.05).Median work productivity impairment was 20%and 5%for CD and UC patients,respectively,and activity impairment was 30%,the latter being higher among patients with moderate to severe disease activity compared to patients with mild or no disease activity(75.0%vs 10.0%,P<0.001).For CD/UC patients,respectively,25.4%/2.8%had at least one surgery,38.3%/19.6%were hospitalized,and 70.7%/77.6%changed IBD treatment at least once during the last 3 years.The most common treatments at baseline were biologics(75.3%)and immunosuppressants(70.9%)for CD patients and 5-ASA compounds(77.5%)for UC patients.CONCLUSION Moderate to severe IBD activity,especially among CD patients,is associated with a substantial impact on QoL,work productivity impairment and an increased number of IBD surgeries and hospitalizations in Brazil. | Rogerio Serafim Parra Julio MF Chebli Heda MBS Amarante Cristina Flores Jose ML Parente Odery Ramos Milene Fernandes Jose JR Rocha Marley R Feitosa Omar Feres Antonio S Scotton Rodrigo B Nones Murilo M Lima Cyrla Zaltman Carolina D Goncalves Isabella M Guimaraes Genoile O Santana Ligia Y Sassaki Rogerio S Hossne Mauro Bafutto Roberto LK Junior Mikaell AG Faria Sender J Miszputen Tarcia NF Gomes Wilson R Catapani Anderson A Faria Stella CS Souza Rosana F Caratin Juliana T Senra Maria LA Ferrari | 2019 | World Journal of Gastroenterology2019，25，38： | 2 |
| 2 | Experimental implementation of the gyrator transform 显示文摘 | RODRIGO J A AIAEVA T CALVO M L | 2007 | Journal of Optics Society of America A2007，24，10： | 1 |
| 3 | A new method for estimating driven pile static skin friction withat the top and bottom of the pile 显示文摘 | Khiem T T Michael M V Rodrigo H | 2011 | Soil Dynamics and Earthquake Engineering2011，，31： | 1 |
| 4 | Influence of lanthanum oxide as quality promoter on cathodes for MCFC显示文摘 | Escudero M J Novoa X R Rodrigo T | 2002 | Journal of Power Sources2002，106，12： | 1 |
| 5 | Materials Scienceand Engineering: 5显示文摘 | Femdndez S Pena R Rodrigo M T | 2007 | 2007, 143(1-3): 552007，143，13： | 1 |
| 6 | Better to be frustrated than bored: The incidence, persist- ence, and impact of learners'cognitive - affective states during interactions with three different computer- based learning environments 显示文摘 | Baker R S D'Mello S K Rodrigo M T Graesser A C | 2011 | International Journal of Human - Computer Studies2011，，68： | 1 |
| 7 | As- sociation between bone mineral density, lean mass, and fat mass among healthy middle-aged premenopausal women: a cross-sectional study in southern Sri Lanka 显示文摘 | Lekamwasam S Weerarathna T Rodrigo M | 2009 | J Bone Miner Metab2009，27，： | 1 |
| 8 | Performance enhancement of ohmic contact on n-GaN using Ti-W as metal barrier 显示文摘 | S Fernandez R Pefia M T Rodrigo | 2007 | Materials Science and Engineering: B2007，143，13： | 1 |
| 9 | NPY augments the proliferative effect of FGF2 and increases the expression of FGFR1 on nestin positive postnatal hippocampal precursor cells, via the Y1 receptor显示文摘 | Rodrigo C Zaben M Lawrence T | 2010 | J Neurochem2010，113，3： | 1 |
| 10 | Better to be frustrated than bored: The incidence, persistence, and impact of learners' cognitive-affective states during interactions with three different computer- based learning environments显示文摘 | Baker S J d R D'Mello S K Rodrigo M M T | 2010 | International Journal of Human-Computer Studies2010，68，： | 1 |
| 11 | Post-veraison sunlight exposure induces MYB-mediated transcriptional regulation of anthocyanin and flavonol synthesis in berry skins of Vitis vinifera显示文摘 | Jose T M Rodrigo L Andrea V | 2009 | Experimental Botany2009，60，3： | 1 |
| 12 | Dehydrin from citrus, which confers in vitro dehydration and freezing protection activity, is constitutive and highly expressed in the flavedo of fruit but responsive to cold and water stress in leaves 显示文摘 | Sanehez-Ballesta M T Rodrigo M J Zaearias L | 2004 | J Agric Food Chem2004，52，7： | 1 |
| 13 | Gyrator transform : properties and applications 显示文摘 | RODRIGO J A ALIEVA T CALVO M L | 2007 | Opt Express2007，15，： | 1 |
| 14 | Low resistance Ti/A1/Ti-W/Au Ohmic contact to n-GaN for high temperature applications 显示文摘 | S Fernandez R Pefia M T Rodrigo | 2007 | Applied Physics Letters2007，90，8： | 1 |
| 15 | DTI-MR tractography of white matter damage in stroke patients with neglect 显示文摘 | URBANSKI M DE SCHOTFEN M T RODRIGO S | 2011 | Experimental Brain Re- search2011，208，4： | 1 |
| 16 | Experimental implementation of the gyrator a'ansform 显示文摘 | Rodrigo J A Alieva T Calvo M L | 2007 | Journal of Optical Society of America A2007，24，10： | 1 |
| 17 | Applications of gyrator transform {or image processing显示文摘 | RODRIGO J A ALIEVA T CALVO M L | 2007 | Opt Comm2007，278，2： | 1 |
| 18 | Gyrator trans- form: properties and applications显示文摘 | RODRIGO J A ALIEVA T CALVO M L | 2007 | Opt Exp2007，15，5： | 1 |
| 19 | Experimental implementation of the gyrator transform显示文摘 | RODRIGO J A ALIEVA T CALVO M L | 2007 | Opt Soe Am A2007，24，10： | 1 |
| 20 | NPY augments the prolif- erative effect of FGF2 and increases the expression of FGFR1 on nestin positive postnatal hippocampal precursor cells, via the Y1 re- ceptor 显示文摘 | Rodrigo C Zaben M Lawrence T | 2010 | J Neurochem2010，113，： | 1 |
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