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| 1 | Quality of life, work productivity impairment and healthcare resources in inflammatory bowel diseases in Brazil显示文摘BACKGROUND Inflammatory bowel diseases(IBD)have been associated with a low quality of life(QoL)and a negative impact on work productivity compared to the general population.Information about disease control,patient-reported outcomes(PROs),treatment patterns and use of healthcare resources is relevant to optimizing IBD management.AIM To describe QoL and work productivity and activity impairment(WPAI),treatment patterns and use of healthcare resources among IBD patients in Brazil.METHODS A multicenter cross-sectional study included adult outpatients who were previously diagnosed with moderate to severe Crohn’s disease(CD)or ulcerative colitis(UC).At enrolment,active CD and UC were defined as having a Harvey Bradshaw Index≥8 or a CD Activity Index≥220 or calprotectin>200μg/g or previous colonoscopy results suggestive of inadequate control(per investigator criteria)and a 9-point partial Mayo score≥5,respectively.The PRO assessment included the QoL questionnaires SF-36 and EQ-5D-5L,the Inflammatory Bowel Disease Questionnaire(IBDQ),and the WPAI questionnaire.Information about healthcare resources and treatment during the previous 3 years was collected from medical records.Chi-square,Fisher’s exact and Student’s t-/Mann-Whitney U tests were used to compare PROs,treatment patterns and the use of healthcare resources by disease activity(α=0.05).RESULTS Of the 407 patients in this study(CD/UC:64.9%/35.1%,mean age 42.9/45.9 years,54.2%/56.6%female,38.3%/37.1%employed),44.7%/25.2%presented moderate-to-severe CD/UC activity,respectively,at baseline.Expressed in median values for CD/UC,respectively,the SF-36 physical component was 46.6/44.7 and the mental component was 45.2/44.2,the EQ-visual analog scale score was 80.0/70.0,and the IBDQ overall score was 164.0/165.0.Moderate to severe activity,female gender,being unemployed,a lower educational level and lower income were associated with lower QoL(P<0.05).Median work productivity impairment was 20%and 5%for CD and UC patients,respectively,and activity impairment was 30%,the latter being higher among patients with moderate to severe disease activity compared to patients with mild or no disease activity(75.0%vs 10.0%,P<0.001).For CD/UC patients,respectively,25.4%/2.8%had at least one surgery,38.3%/19.6%were hospitalized,and 70.7%/77.6%changed IBD treatment at least once during the last 3 years.The most common treatments at baseline were biologics(75.3%)and immunosuppressants(70.9%)for CD patients and 5-ASA compounds(77.5%)for UC patients.CONCLUSION Moderate to severe IBD activity,especially among CD patients,is associated with a substantial impact on QoL,work productivity impairment and an increased number of IBD surgeries and hospitalizations in Brazil. | Rogerio Serafim Parra Julio MF Chebli Heda MBS Amarante Cristina Flores Jose ML Parente Odery Ramos Milene Fernandes Jose JR Rocha Marley R Feitosa Omar Feres Antonio S Scotton Rodrigo B Nones Murilo M Lima Cyrla Zaltman Carolina D Goncalves Isabella M Guimaraes Genoile O Santana Ligia Y Sassaki Rogerio S Hossne Mauro Bafutto Roberto LK Junior Mikaell AG Faria Sender J Miszputen Tarcia NF Gomes Wilson R Catapani Anderson A Faria Stella CS Souza Rosana F Caratin Juliana T Senra Maria LA Ferrari | 2019 | World Journal of Gastroenterology2019，25，38： | 2 |
| 2 | Effects of supercritical carbon dioxide on waste banana peels for heavy metal removal显示文摘 | Juliana Q A Rodrigo B R Diego T S | 2011 | The Journal of Supercritical Fluids2011，58，： | 1 |
| 3 | Effect of Low-level Laser ( Ga-AlAs 655 nm) on Skeletal Muscle Fatigue Induced by Electrical Stimulation in Rats 显示文摘 | ALVARO R B LOPES-MARTINS RODRIGO L M | 2006 | J Appl Physiol2006，101，7： | 1 |
| 4 | Performance evaluation of collision-reaction interface and internal standardization in quadrupole ICP-MS measurements 显示文摘 | Rodrigo F S S Marcelo B B G Edenir R P | 2011 | Talanta2011，86，： | 1 |
| 5 | Data stream clustering: A survey显示文摘 | JONATHAN A S ELAINE R F~ RODRIGO C B | 2013 | ACM Computing Sur- veys2013，46，1： | 1 |
| 6 | CloudSim: a tool- kit for modeling and simulation of cloud computing envi- ronments and evaluation of resource provisioning algo- rithms 显示文摘 | Rodrigo C Rajiv R Anton B | 2001 | Software : Practice and Experience2001，41，1： | 1 |
| 7 | High-Harmonic Generation and Correlated Electron Emission from Relativistic Plasma Mirrors at 1 kHz Repetition Rate显示文摘We report evidence for the first generation of XUV spectra from relativistic surface high-harmonic generation(SHHG)on plasma mirrors at a kilohertz repetition rate,emitted simultaneously with energetic electrons.SHHG spectra and electron angular distributions are measured as a function of the experimentally controlled plasma density gradient scale length Lg for three increasingly short and intense driving pulses:24 fs and a0=1:1,8 fs and a0=1:6,and finally 4 fs and a0≈2:1,where a0 is the peak vector potential normalized by mec/e with the elementary charge e,the electron rest mass me,and the vacuum light velocity c.For all driver pulses,we observe correlated relativistic SHHG and electron emission in the range Lg∈½λ/20,λ/4,with an optimum gradient scale length of Lg≈λ/10.This universal optimal Lg-range is rationalized by deriving a direct intensity-independent link between the scale length Lg and an effective similarity parameter for relativistic laser-plasma interactions. | Stefan Haessler Marie Ouillé Jaismeen Kaur Maïmouna Bocoum Frederik Böhle Dan Levy Louis Daniault Aline Vernier Jérôme Faure Rodrigo Lopez-Martens | 2022 | Ultrafast Science2022，，3： | 1 |
| 8 | Detection of Ellipses Using Modified Hough Transform 显示文摘 | Patricia M B MANSO Rodrigo F PRESTES and Mariane R PETRAGLIA | 2003 | IEEE International Symposium2003，，2： | 1 |
| 9 | Inflammation and hepatic encephalopathy: ibuprofen restores learning ability in rats with portacaval shunts显示文摘 | Cauli O Rodrigo R Piedrafita B Boix J Felipo V | 2007 | Hepatology2007，46，： | 1 |
| 10 | Inflammation and hepatic encephalopathy: ibuprofen restores learning ability in rats with portacaval shunts 显示文摘 | Cauli O Rodrigo R Piedrafita B | 2007 | Hepatology2007，46，2： | 1 |
| 11 | CloudSim: a toolkit for modeling and simulation of cloud computing envi- ronments and evaluation of resource provisioning al- gorithms 显示文摘 | Rodrigo C Rajiv R Anton B | 2011 | Software: Practice and Experience2011，41，1： | 1 |
| 12 | Computer simulation and discrete-event models in the analysis of a mammography clinic patient flow显示文摘 | Fernando C Coelli Rodrigo B Ferreira Renan Moritz V R | 2007 | Computer Methods and Programs in Biomedicine2007，87，： | 1 |
| 13 | Simulation in primitive variables of incompressible flow with pressure Neumann condition显示文摘 | JULIO R CLAEYSSEN RODRIGO B PLATTE ELBA BRAVO | 1999 | International Journal for Numerical Method in Fluids1999，30，： | 1 |
| 14 | Inflammation and hepatic encephalopathy: ibuprofen restores learning ability in rats with portacaval shunts显示文摘 | Cauli O Rodrigo R Piedrafita B Boix J Felipo V | 2007 | Hepatology2007，46，： | 1 |
| 15 | Isolation and characterization of a eDNA encoding a serine proteinase from the root-knot nematode Meloidogyne incognita 显示文摘 | Rodrigo R F Joao A N B Osmundo B O N | 2005 | Experimental Parasitology2005，110，： | 1 |
| 16 | Validation ofa HPLC method for simultaneous determination of main organicacids in fruits and juices显示文摘 | RODRIGO S ANA C P R CRISTIANO A B | 2012 | Food Chemistry2012，135，： | 1 |
| 17 | Druginduced hver injury: an analysis of 461 incidences submitted to the Spanish registry over a 10 - year period显示文摘 | Andrade RJ Lucena MI Fernandez MC Pelaez G Pachkofia K Garcia- Ruiz E Garcia- Munoz B Gonzalez- Grande R Hzarro A Duran JA Jimenez M Rodrigo L Romero- Gomez M Navarro JM Hanas R Costa J Borras A Soler A Salmeron J Martin-Vivaldi R | 2005 | Gastroenterology2005，129，： | 1 |
| 18 | Development of a citrus genomewide EST collection and cDNA microarray as resources for genomic studies显示文摘 | FORMENT J GADEA J HUERTA L ABIZANDA L AGUSTI J ALAMAR S ALOS E ANDRES F ARRIBAS R BELTRAN J P BERBEL A BLAZQUEZ M A BRUMOS J CANAS L A CERCOS M COLMENERO-FLORES J M CONESA A ESTABLES B GANDIA M GARCIA-MARTINEZ J L GIMENO J GISBERT A GOMEZ G GONZALEZ-CANDELAS L GRANELL A GUERRI J LAFUENTE M T MADUENO F MARCOS J F MARQUES M C MARTINEZ F MARTINEZ-GODOY M A MIRALLES S MORENO P NAVARRO L PALLAS V PEREZ-AMADOR M A PEREZ-VALLE J PONS C RODRIGO I RODRIGUEZ P L ROYO C SERRANO R SOLER G TADEO F TALON M TEROL J TRENOR M VAELLO L VICENTE O VIDAL C ZACARIAS L CONEJERO V | 2005 | Plant Molecular Biology2005，57，3： | 1 |
| 19 | Evaluation of two bioadsorbents for removing paracetamol from aqueous media显示文摘 | ARACELI V F N R MARCIELA B RODRIGO M G et aI | 2011 | Electronic Journal of Biotechnology2011，14，6： | 1 |
| 20 | A Mechanistic Model for Internal Bone Remodeling Exhibits Different Dynamics Responses in Disuse and Overload显示文摘 | HAZELWOOD S J MARTIN R B RASHID M M RODRIGO J J | 2001 | Journal of Biomechanics2001，34，3： | 1 |
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