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| 1 | Consecutive fecal calprotectin measurements for predicting relapse in pediatric Crohn's disease patients显示文摘BACKGROUND Asymptomatic children with Crohn's disease(CD) require ongoing monitoring to ensure early recognition of a disease exacerbation.AIM In a cohort of pediatric CD patients, we aimed to assess the utility of serial fecal calprotectin measurements to detect intestinal inflammatory activity and predict disease relapse.METHODS In this prospective longitudinal cohort study, children with CD on infliximab therapy in clinical remission were included. Fecal calprotectin levels were assessed at baseline and at subsequent 2-5 visits. Clinical and biochemical disease activity were assessed using the Pediatric Crohn's Disease Activity Index, Creactive protein and erythrocyte sedimentation rate at baseline and at visits over the following 18 mo.RESULTS 53 children were included and eighteen patients(34%) had a clinical disease relapse during the study. Baseline fecal calprotectin levels were higher in patients that developed symptomatic relapse [median(interquartile range), relapse 723μg/g(283-1758) vs 244 μg/g(61-627), P = 0.02]. Fecal calprotectin levels > 250μg/g demonstrated good predictive accuracy of a clinical flare within 3 mo(area under the receiver operator curve was 0.86, 95% confidence limits 0.781 to 0.937).CONCLUSION Routine fecal calprotectin testing in children with CD in clinical remission is useful to predict relapse. Levels > 250 μg/g are a good predictor of relapse in the following 3 mo. This information is important to guide monitoring standards used in this population. | Alice Jane Foster Matthew Smyth Alam Lakhani Benjamin Jung Rollin F Brant Kevan Jacobson | 2019 | World Journal of Gastroenterology2019，25，10： | 3 |
| 2 | Human exposure to heavy metals in the vicinity of Portuguese solid waste incinerators- Part 1: Biomonitoring of Pb, Cd and Hg in blood of the general population 显示文摘 | Reis M F Sampaio C Brantes A | 2007 | International Journal of Hygiene and Environmental Health2007，210，34： | 1 |
| 3 | Artifical vision through neuronal stinmlation 显示文摘 | Rodrigo A Brant F Bruno D | 2012 | Neuroscience letters2012，519，： | 1 |
| 4 | IL-23 receptor regulation by Let-7f in human CD4+ memory T cells显示文摘 | Li Z Wu F Brant SR | 2011 | J Immunol2011，186，： | 1 |
| 5 | Use of Micellar-Enhanced Ultrafiltration at low Surfactant Concentrations and with Anionic-Nonionic Surfaction Mixtrues 显示文摘 | Bita R Fillipi Loriw Brant John F Scamehom | 1999 | Journal of Colloid and Interface Science1999，213，： | 1 |
| 6 | Intake of conjugated linoleic acid,fat,and other fatty acids in relation to postmenopausal breast cancer:the Netherlands cohort study on diet and cancer显示文摘 | VOORRIPS L E BRANTS H A KARDINAAL A F M | 2002 | Am J Clin Nutr2002，76，4： | 1 |
| 7 | Epidermal growth factor-related peptidesand their receptors in human malignances显示文摘 | Salomon DS Brant R Ciardiello F | 1995 | Crit Rev Oncol haematol1995，19，： | 1 |
| 8 | In- take of conjugated linoleic acid, fat, and other fatty acids in relation to postmenopausal breast cancer, the Netherlands Cohort Study on Diet and Cancer显示文摘 | Voorrips L E Brants H A Kardinaal A F | 2002 | Am J Clin Nutr2002，76，4： | 1 |
| 9 | Resource availability and plant antiherbivore defense显示文摘 | Coley P D Brant J P Chapin F S | 1985 | Science1985，230，： | 1 |
| 10 | Microsatellite evidence for sperm storage and multiple paternity in the marine gastropod Crepidula coquimbensis 显示文摘 | Brante A Ferndndez M Viard F | 2011 | J Exp Mar Biol Ecol2011，396，： | 1 |
| 11 | Towards a systems-based umderstanding of plant desiccation tolerance显示文摘 | MOORE J P LE N T BRANT W F | 2009 | Trends Plant Sci2009，14，： | 1 |
| 12 | Treatment options for erectile dysfunction显示文摘 | BRANT W O BELLA A J LUE T F | 2007 | Endocrinol Metab Clin North Am2007，36，2： | 1 |
| 13 | Pathogenesis of Chagas disease:time to move on显示文摘 | MACHADO F S TYLER K M BRANT F | | 0，，： | 1 |
| 14 | Resource availability and plant antiherbivore defense 显示文摘 | Coley P D Brant J P Chapin F S | 1985 | Science1985，230，： | 1 |
| 15 | A simple approximation for semivariance显示文摘 | Choobineh F Branting D | 1986 | European Journal of Operational Research1986，27，1： | 1 |
| 16 | Roll-gap temperature models for hot mills显示文摘 | Heselton M O | 1982 | Metall Technol1982，9，： | 1 |
| 17 | Intake of conjugated linoleic acid, fat, and other fatty acids in relation to postmenopausal breast cancer: the Netherlands Cohort Study on Diet and Cancer显示文摘 | Voorrips L E Brants H A Kardinaal A F | 2002 | Am J Clin Nutr2002，76，4： | 1 |
| 18 | Semicrys- talline blends of polyethylene and isotactic polypropylene: improving mechanical performance by enhancing the interfa- cial structure 显示文摘 | CHAFFIN K A BATES F S BRANT P | 2000 | J Appl Polym Sci2000，38，： | 1 |
| 19 | Intake of conjugated linoleic acid, fat, and other fatty acids in relation to postmenopausal breast cancer: the Netherlands Cohort Study on Diet and Cancer显示文摘 | VOORRIPS L E BRANTS H A KARDINAAL A F | 2002 | Am J Clin Nutr2002，76，4： | 1 |
| 20 | Human exposure to heavy metals in the vicinity of Portuguese solid waste incinerators-Part 1:Biomonitoring of Pb,Cd and Hg in blood of the general population显示文摘 | Reis M F Sampaio C Brantes A | | 0，，3： | 1 |
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