|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Increased expression of tumor necrosis factor-a is associated with advanced colorectal cancer stages显示文摘AIM:To detect the expression of tumor necrosis factor-a(TNF-a)in colorectal cancer(CRC)cells among Saudi patients,and correlate its expression with clinical stages of cancer.METHODS:Archival tissue specimens were collected from 30 patients with CRC who had undergone surgical intervention at King Khalid University Hospital.Patient demographic information,including age and gender,tumor sites,and histological type of CRC,was recorded.To measure TNF-a m RNA expression in CRC,total RNA was extracted from tumor formalin-fixed,paraffinembedded,and adjacent normal tissues.Reverse transcription and reverse transcription polymerase chain reaction were performed.Colorectal tissue microarrays were constructed to investigate the protein expression of TNF-a by immunohistochemistry.RESULTS:The relative expression of TNF-a m RNA in colorectal cancer was significantly higher than that seen in adjacent normal colorectal tissue.High TNF-a gene expression was associated with StageⅢandⅣneoplasms when compared with earlier tumor stages(P=0.004).Eighty-three percent of patients(25/30)showed strong TNF-a positive staining,while only 10%(n=3/30)of patients showed weak staining,and 7%(n=2/30)were negative.We showed the presence of elevated TNF-a gene expression in cancer cells,which strongly correlated with advanced stages of tumor.CONCLUSION:High levels of TNF-a expression could be an independent diagnostic indicator of colorectal cancer,and targeting TNF-a might be a promising prognostic tool by assessment of the clinical stages of CRC. | Omar A Al Obeed Khayal A Alkhayal Abdulmalik Al Sheikh Ahmad M Zubaidi Mansoor-Ali Vaali-Mohammed Robin Boushey James H Mckerrow Maha-Hamadien Abdulla | 2014 | World Journal of Gastroenterology2014，20，48： | 8 |
| 2 | RTOG 0211:a phase 1/2 study of radiation therapy with concurrent gefitinib for newly diagnosed glioblastoma patients显示文摘PURPOSE: To determine the safety and efficacy of gefitinib,an epidermal growth factor receptor(EGFR) tyrosine kinase inhibitor,in combination with radiation for newly diagnosed glioblastoma(GBM) patients.METHODS AND MATERIALS: Between March 21,2002,and May 3,2004,Radiation Therapy Oncology Group(RTOG) 0211 enrolled 31 and 147GBM patients in the phase 1 and 2 arms,respectively.Treatment consisted of daily oral gefinitnib started at the time of conventional cranial radiation therapy(RT) and continued post RT for 18 months or until progression.Tissue microarrays from 68 cases were analyzed for EGFR expression.RESULTS: The maximum tolerated dose(MTD) of gefitinib was determined to be 500 mg in patients on non-enzyme-inducing anticonvulsant drugs(non-EIAEDs).All patients in the phase 2 component were treated at a gefitinib dose of 500 mg;patients receiving EIADSs could be escalated to 750 mg.The most common side effects of gefitinib in combination with radiation were dermatologic and gastrointestinal.Median survival was 11.5 months for patients treated per protocol.There was no overall survival benefit for patients treated with gefitinib + RT when compared with a historical cohort of patients treated with RT alone,matched by RTOG recursive partitioning analysis(RPA) class distribution.Younger age was significantly associated with better outcome.Per protocol stratification,EGFR expression was not found to be of prognostic value for gefitinib + RT-treated patients.CONCLUSIONS: The addition of gefitinib to RT is well tolerated.Median survival of RTOG 0211 patients treated with RT with concurrent and adjuvant gefitinib was similar to that in a historical control cohort treated with radiation alone. | Chakravarti A Wang M Robins HI Lautenschlaeger T Curran WJ Brachman DG Schultz CJ Choucair A Dolled-Filhart M Christiansen J Gustavson M Molinaro A Mischel P Dicker AP Bredel M Mehta M | 2013 | 中国神经肿瘤杂志2013，11，1： | 8 |
| 3 | Preassembly and ligand-induced restructuring of the chains of the IFN-γ receptor complex: the roles of Jak kinases, Statl and the receptor chains显示文摘 | Christopher D Krause Natasha Lavnikova Junxia Xie Erwen Mei Olga V Mirochnitchenko Yiwei Jia Robin M Hochstrasser Sidney Pestka | 2006 | Cell Research2006，16，1： | 7 |
| 4 | Serotonin type 3 receptor subunit gene polymorphisms associated with psychosomatic symptoms in irritable bowel syndrome:A multicenter retrospective study显示文摘BACKGROUND Single-nucleotide polymorphisms(SNPs)of the serotonin type 3 receptor subunit(HTR3)genes have been associated with psychosomatic symptoms,but it is not clear whether these associations exist in irritable bowel syndrome(IBS).AIM To assess the association of HTR3 polymorphisms with depressive,anxiety,and somatization symptoms in individuals with IBS.METHODS In this retrospective study,623 participants with IBS were recruited from five specialty centers in Germany,Sweden,the United States,the United Kingdom,and Ireland.Depressive,anxiety,and somatization symptoms and sociodemographic characteristics were collected.Four functional SNPs—HTR3A c.-42C>T,HTR3B c.386A>C,HTR3C c.489C>A,and HTR3E c.*76G>A—were genotyped and analyzed using the dominant and recessive models.We also performed separate analyses for sex and IBS subtypes.SNP scores were calculated as the number of minor alleles of the SNPs above.The impact of HTR3C c.489C>A was tested by radioligand-binding and calcium influx assays.RESULTS Depressive and anxiety symptoms significantly worsened with increasing numbers of minor HTR3C c.489C>A alleles in the dominant model(F_(depressive)=7.475,P_(depressive)=0.006;F_(anxiety)=6.535,P_(anxiety)=0.011).A higher SNP score(range 0-6)was linked to a worsened depressive symptoms score(F=7.710,P-linear trend=0.006)in IBS.The potential relevance of the HTR3C SNP was corroborated,showing changes in the expression level of 5-HT3AC variant receptors.CONCLUSION We have provided the first evidence that HTR3C c.489C>A is involved in depressive and anxiety symptoms in individuals with IBS.The SNP score indicated that an increasing number of minor alleles is linked to the worsening of depressive symptoms in IBS. | Sabrina Berens Yuanjun Dong Nikola Fritz Jutta Walstab Mauro D'Amato Tenghao Zheng Verena Wahl Felix Boekstegers Justo Lorenzo Bermejo Cristina Martinez Stefanie Schmitteckert Egbert Clevers Felicitas Engel Annika Gauss Wolfgang Herzog Robin Spiller Miriam Goebel-Stengel Hubert Mönnikes Viola Andresen Frieling Thomas Jutta Keller Christian Pehl Christoph Stein-Thöringer Gerard Clarke Timothy G Dinan Eamonn M Quigley Gregory Sayuk Magnus Simrén Jonas Tesarz Gudrun Rappold Lukas van Oudenhove Rainer Schaefert Beate Niesler | 2022 | World Journal of Gastroenterology2022，28，21： | 2 |
| 5 | Precision atomic gravimeter based on Bragg diffraction显示文摘 | P A Altin M T Johnsson V Negnevitsky G R Dennis R P Anderson J E Debs S S Szigeti K S Hardman S Bennetts G D McDonald L D Turner J D Close N P Robins | 2013 | New Journal of Physics2013，，2： | 2 |
| 6 | A novel tunnd structure containing enclathrated hydrogen peroxide:4Na2SO4 · 2H2O2· NaCl显示文摘 | ADAMS JOHN M PRITCHARD ROBIN G THOMAS JOHN M | 1978 | Journal of Chemical Society Chem Conm1978，，3： | 1 |
| 7 | A Resource-Based Approach to the Multibusiness Firm: Empirical Analysis of Portfolio Interrelationships and Corporate Financial Performance显示文摘 | Robins J M F Wiersema | 1995 | Strategic Management Journal1995，16，： | 1 |
| 8 | Low self-esteem is related to aggression, antisocial behavior, and delinquency 显示文摘 | o Donnellan M B Trzesniewski K H Robins R W | 2005 | Psychol Sci2005，16，4： | 1 |
| 9 | Free-ranging automatic guided-vehicle system显示文摘 | ROBINS M P | 1986 | GEC Review1986，2，2： | 1 |
| 10 | Plasma membrane cytochromes P450 as neoantigens and autoimmune targets in drug-induced hepatitis显示文摘 | Robin MA LeRoy M Descatoire V | 1997 | J Hepatol1997，26，1： | 1 |
| 11 | Systemic hyperthermia and ICE chemotherapy for sarcoma patients:rationale and clinical status 显示文摘 | Wiedemann G J Robins H I Katschinski D M | 1997 | Anticancer Res1997，17，4： | 1 |
| 12 | Bimodal targeting of microsomal CYP2E1 tomitochondria through activation of an N-terminalchimeric signal by cAMP-mediated phosphorylation显示文摘 | ROBIN M A ANANDATHEERTHAVARADA H K BISWAS G | 2002 | J Biol Chem2002，277，40： | 1 |
| 13 | National Science Training Policy andEarly Scientific Careers in France and the United States 显示文摘 | Gaughan M Robin S | 2004 | Research Policy2004，33，4： | 1 |
| 14 | Biochemical attributes of tea flowers (Camellia sinensis)at different developmental stages in the Kangra region of India显示文摘 | ROBIN J POONA M ASHU G | 2011 | Scientia Horticulturaef2011，130，： | 1 |
| 15 | Maximum likelihood from incomplete data via the EM algorithm显示文摘 | Dempster A P Laird N M Robin D B | 1977 | Journal of the Royal Statistical Society1977，39，1： | 1 |
| 16 | Long term outcome after bone marrow transplantation for severe aplastic anemia显示文摘 | Ades L mary JY robin M | 2004 | Blood2004，103，7： | 1 |
| 17 | Newall-vanadium redox cell显示文摘 | SKYLLAS-KAZACOS M RYCHCIK M ROBINS R G | 1986 | J Electrochem Soc1986，133，： | 1 |
| 18 | 20,26-Dihydro-xyecdysone, a new steroid with moulting hormone activity from the tobacco homworm, Manduca sexta (Johannson) 显示文摘 | Thompson M J Kaplanis J N Robins W E | 1967 | Chem Comm1967，38，： | 1 |
| 19 | The epidemology of schizophrenia replacing dog- ma with knowledge 显示文摘 | Simona A Robin M | 2010 | Dialogues Clin Neurosci2010，12，： | 1 |
| 20 | The Role of Environmental Factors in Growth Accounting显示文摘 | Jeon Byung M Robin C Sickles | 2004 | Joumal of Applied Econometrics2004，19，5： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员