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| 1 | FAIR Principles:Interpretations and Implementation Considerations显示文摘The FAIR principles have been widely cited,endorsed and adopted by a broad range of stakeholders since their publication in 2016.By intention,the 15 FAIR guiding principles do not dictate specific technological implementations,but provide guidance for improving Findability,Accessibility,Interoperability and Reusability of digital resources.This has likely contributed to the broad adoption of the FAIR principles,because individual stakeholder communities can implement their own FAIR solutions.However,it has also resulted in inconsistent interpretations that carry the risk of leading to incompatible implementations.Thus,while the FAIR principles are formulated on a high level and may be interpreted and implemented in different ways,for true interoperability we need to support convergence in implementation choices that are widely accessible and(re)-usable.We introduce the concept of FAIR implementation considerations to assist accelerated global participation and convergence towards accessible,robust,widespread and consistent FAIR implementations.Any self-identified stakeholder community may either choose to reuse solutions from existing implementations,or when they spot a gap,accept the challenge to create the needed solution,which,ideally,can be used again by other communities in the future.Here,we provide interpretations and implementation considerations(choices and challenges)for each FAIR principle. | Annika Jacobsen Ricardo de Miranda Azevedo Nick Juty Dominique Batista Simon Coles Ronald Cornet Melanie Courtot Merce Crosas Michel Dumontier Chris T.Evelo Carole Goble Giancarlo Guizzardi Karsten Kryger Hansen Ali Hasnain Kristina Hettne Jaap Heringa Rob W.W.Hooft Melanie Imming Keith G.Jeffery Rajaram Kaliyaperumal Martijn GKersloot Christine R.Kirkpatrick Tobias Kuhn Ignasi Labastida Barbara Magagna PeterMcQuilton Natalie Meyers Annalisa Montesanti Mirjam van Reisen Philippe Rocca-Serra Robert Pergl Susanna-Assunta Sansone Luiz Olavo Bonino da Silva Santos Juliane Schneider George Strawn Mark Thompson Andra Waagmeester Tobias Weigel Mark D.Wilkinson Egon L.Willighagen Peter Wittenburg Marco Roos Barend Mons Erik Schultes | 2020 | Data Intelligence2020，2，1： | 26 |
| 2 | FAIR Convergence Matrix:Optimizing the Reuse of Existing FAIR-Related Resources显示文摘The FAIR principles articulate the behaviors expected from digital artifacts that are Findable,Accessible,Interoperable and Reusable by machines and by people.Although by now widely accepted,the FAIR Principles by design do not explicitly consider actual implementation choices enabling FAIR behaviors.As different communities have their own,often well-established implementation preferences and priorities for data reuse,coordinating a broadly accepted,widely used FAIR implementation approach remains a global challenge.In an effort to accelerate broad community convergence on FAIR implementation options,the GO FAIR community has launched the development of the FAIR Convergence Matrix.The Matrix is a platform that compiles for any community of practice,an inventory of their self-declared FAIR implementation choices and challenges.The Convergence Matrix is itself a FAIR resource,openly available,and encourages voluntary participation by any self-identified community of practice(not only the GO FAIR Implementation Networks).Based on patterns of use and reuse of existing resources,the Convergence Matrix supports the transparent derivation of strategies that optimally coordinate convergence on standards and technologies in the emerging Internet of FAIR Data and Services. | Hana Pergl Sustkova Kristina Maria Hettne Peter Wittenburg Annika Jacobsen Tobias Kuhn Robert Pergl Jan Slifka Peter McQuilton Barbara Magagna Susanna-Assunta Sansone Markus Stocker Melanie Imming Larry Lannom Mark Musen Erik Schultes | 2020 | Data Intelligence2020，2，1： | 4 |
| 3 | Abdominal incision tumor implantation following pneumoperitoneum laparoscopic procedurevs. Standard open incision in a syngeneic rat model显示文摘 | Peter S. Paik M.D. Takeyuki Misawa M.D. Mimi Chiang Ph.D. Jeffrey Towson B.A. Samuel Im B.A. Adrian Ortega M.D. Dr. Robert W. Beart M.D | 1998 | Diseases of the Colon & Rectum1998，，4： | 1 |
| 4 | Retardation of atheroscleros is by overexpression of catalase or both Cu/Zn-superoxile dismutase and catalase in mice lacking apolipoprotein E显示文摘 | Yang H Roberts LJ Sh IM J | | 0，，11： | 1 |
| 5 | A prospec- tive double-blind randomized controlled trial of radioffe- quency versus laser treatment of the great saphenous vein in patients with varicose veins 显示文摘 | Nordon IM Robert FJ Hinchliffe F | 2011 | Ann Surg2011，254，6： | 1 |
| 6 | Ras mediates nerve growth Factor receptor modulation of three signal-transducing protein kinases:MAPkinase,Raf-1 and RSK显示文摘 | Wood KW Sarnecki C Roberts IM | 1992 | Cell1992，68，6： | 1 |
| 7 | T lymphocytes mediating protectionand cellular cytolysis during the course of Mycobacterium tuberculosisinfection显示文摘 | Miller ES Roberts AD | 1992 | Immunol1992，148，： | 1 |
| 8 | Cetuximab plus irinotecan in pretreated metastatic colorectal cancer patients:The ELSIE study显示文摘AIM:To evaluate the efficacy and safety of cetuxim-ab plus irinotecan in irinotecan-refractory metastatic colorectal cancer (mCRC) patients from South-East Asia and Australia. METHODS:In this open-label,phase Ⅱ study,the main eligibility criteria were epidermal growth factor receptor-positive mCRC with progressive disease within 3 mo of an irinotecan-based regimen as the most recent chemotherapy. Patients received cetuximab 400 mg/m2 initially,then 250 mg/m2 every week,with the same regimen of irinotecan on which the patients had progressed (4 pre-defined regim-ens allowed). The prim-ary objective was evaluation of progression-free survival (PFS) at 12 wk. Secondary objectives included a further investigation of PFS,and an assessment of the overall response rate (ORR),duration of response,time to treatment failure (TTF),overall survival and the safety profile. RESULTS:One hundred and twenty nine patients were enrolled from-25 centers in the Asia-Pacific region and of these 123 received cetuximab plus irinotecan. The most common recent irinotecan regimen used was 180 mg/m2 every 2 wk which had been used in 93 patients (75.6%). The PFS rate at 12 wk was 50% (95% confidence interval (CI,41-59) and m-edian PFS tim-e was 12.1 wk (95% CI:9.7-17.7). The ORR was 13.8% (95% CI:8.3-21.2) and disease control rate was 49.6% (95% CI:40.5-58.8). Median duration of response was 31.1 wk (95% CI:18.0-42.6) and median overall survival was 9.5 mo (95% CI,7.5-11.7). The median TTF was 11.7 wk (95% CI:9.1-17.4). Treatment was generally well tolerated. The most common grade 3/4 adverse events were diarrhea (13.8%),neutropenia (8.9%),rash (5.7%) and vomiting (5.7%).CONCLUSION:In patients from Asia and Australia,this study confirm-s the activity and safety of cetuxim-ab plus irinotecan observed in previous studies in Europe and South America. | Robert Lim Yan Sun Seock-Ah Im Ruey-Kuen Hsieh Tsz Kok Yau Anthony Bonaventura Arkom Cheirsilpa Regina Esser Matthias Mueser Suresh Advani | 2011 | World Journal of Gastroenterology2011，17，14： | 1 |
| 9 | Some recent advances in the chemistry and biology of transforming growth factor-β显示文摘 | Roberts AB Wakefield IM | 1987 | J Cell Biol1987，105，： | 1 |
| 10 | Some recent advances in the chemistry and biology of transforming growth factor-β显示文摘 | Sporn MB Roberts AB Warkerfield IM de Crombrugghe B | 1987 | J Cell Bio11987，105，： | 1 |
| 11 | The Role of Oxygen-free Radicals in Ischemic Tissue Injury in Island Skin Flaps显示文摘 | PAUL N. MANSON ROBERT M. ANTHENELLI MICHAEL J. IM GREGORY B. BULKLEY JOHN E. HOOPES | 1983 | Annals of Surgery1983，，： | 1 |
| 12 | Growth in extremelylow birth weight infants up to three years显示文摘 | Jordan IM Robert A Francart J | 2005 | Biol Neonate2005，88，1： | 1 |
| 13 | Transforming growth factor-β receptor mutations and pulmonary arterial hypertension in childhood显示文摘 | Rachel EH Rolf BE Sheila GH Robert TU Christoph IM Nicholas WM | 2005 | Circulation2005，111，： | 1 |
| 14 | Association of virus-likeparticles with the foregut of the aphid Cavariella aegopodiitransmitting the semipersistent viruses anthriscus yellows andparsnip yellow fleck 显示文摘 | Murant AF Roberts IM Einag ar S | 1976 | J Gen Virol1976，，31： | 1 |
| 15 | Expression of tobacco mosaic virus coat protein and assembly of pseudovirus particles in Escherichia coli 显示文摘 | Hwang DJ Roberts IM Wilson TM | 1994 | Proc Natl Acad Sci U S A1994，91，19： | 1 |
| 16 | Posterior sternoclavicular joint dislocation in children-role of spiral computed tomography显示文摘 | Doss A Lang IM Roberts I | | 0，，05： | 1 |
| 17 | Direct on-line hyphenation of capillary liquid chromatography to nuclear magnetic resonance spectroscopy:Practical aspects and application to drug metabolite identification显示文摘 | Sandvoss M Roberts AD Ismail IM | 2004 | J Chromatogr A2004，1028，2： | 1 |
| 18 | Growth in extremely low birth weight infants up to three years显示文摘 | Jordan IM Robert A Francart J | 2005 | Biol Neonate2005，88，1： | 1 |
| 19 | Mortality in older people with diabetes mellitus显示文摘 | Sinclair AJ Robert IM Croxson SCM | 1996 | Diabet Med1996，14，： | 1 |
| 20 | Interaction of milk α- and β-caseins with tea polyphenols显示文摘 | Imed Hasni Philippe Bourassa Saber Hamdani Guy Samson Robert Carpentier Heidar-Ali Tajmir-Riahi | 2010 | Food Chemistry2010，，2： | 1 |
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