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| 1 | Small intestinal bacterial overgrowth syndrome显示文摘Human intestinal microbiota create a complex polymi-crobial ecology. This is characterised by its high population density, wide diversity and complexity of interaction. Any dysbalance of this complex intestinal microbiome, both qualitative and quantitative, might have serious health consequence for a macro-organism, including small intestinal bacterial overgrowth syndrome (SIBO).SIBO is defined as an increase in the number and/or alteration in the type of bacteria in the upper gastro-intestinal tract. There are several endogenous defence mechanisms for preventing bacterial overgrowth: gastric acid secretion, intestinal motility, intact ileo-caecal valve, immunoglobulins within intestinal secretion and bacte-riostatic properties of pancreatic and biliary secretion. Aetiology of SIBO is usually complex, associated with disorders of protective antibacterial mechanisms (e.g. achlorhydria, pancreatic exocrine insuff iciency, immuno-deficiency syndromes), anatomical abnormalities (e.g. small intestinal obstruction, diverticula, f istulae, surgical blind loop, previous ileo-caecal resections) and/or motility disorders (e.g. scleroderma, autonomic neuropathy in diabetes mellitus, post-radiation enteropathy, small intestinal pseudo-obstruction). In some patients more than one factor may be involved. Symptoms related to SIBO are bloating, diarrhoea, malabsorption, weight loss and malnutrition. The gold standard for diagnosing SIBO is still microbial investigation of jejunal aspirates. Noninvasive hydrogen and methane breath tests are most commonly used for the diagnosis of SIBO using glucose or lactulose. Therapy for SIBO must be com-plex, addressing all causes, symptoms and complica-tions, and fully individualised. It should include treatment of the underlying disease, nutritional support and cyclical gastro-intestinal selective antibiotics. Prognosis is usually serious, determined mostly by the underlying disease that led to SIBO. | Jan Bures Jiri Cyrany Darina Kohoutova Miroslav Frstl Stanislav Rejchrt Jaroslav Kvetina Viktor Vorisek Marcela Kopacova | 2010 | World Journal of Gastroenterology2010，16，24： | 52 |
| 2 | Peutz-Jeghers syndrome:Diagnostic and therapeutic approach显示文摘Peutz-Jeghers syndrome(PJS)is an inherited,autosomal dominant disorder distinguished by hamartomatous polyps in the gastrointestinal tract and pigmented mucocutaneous lesions.Prevalence of PJS is estimated from 1 in 8300 to 1 in 280 000 individuals.PJS predisposes sufferers to various malignancies(gastrointestinal,pancreatic,lung,breast,uterine,ovarian and testicular tumors).Bleeding,obstruction and intussusception are common complications in patients with PJS.Double balloon enteroscopy(DBE)allows examination and treatment of the small bowel.Polypectomy using DBE may obviate the need for repeated urgent operations and small bowel resection that leads to short bowel syndrome.Prophylaxis and polypectomy of the entire small bowel is the gold standard in PJS patients.Intraoperative enteroscopy(IOE)was the only possibility for endoscopic treatment of patients with PJS before the DBE era.Both DBE and IOE facilitate exploration and treatment of the small intestine. DBE is less invasive and more convenient for the pa- tient.Both procedures are generally safe and useful. An overall recommendation for PJS patients includes not only gastrointestinal multiple polyp resolution,but also regular lifelong cancer screening(colonoscopy, upper endoscopy,computed tomography,magnetic resonance imaging or ultrasound of the pancreas, chest X-ray,mammography and pelvic examinationwith ultrasound in women,and testicular examination in men).Although the incidence of PJS is low,it is important for clinicians to recognize these disorders to prevent morbidity and mortality in these patients,and to perform presymptomatic testing in the first-degree relatives of PJS patients. | Marcela Kopacova Ilja Tacheci Stanislav Rejchrt Jan Bures | 2009 | World Journal of Gastroenterology2009，15，43： | 45 |
| 3 | Double balloon enteroscopy and acute pancreatitis显示文摘Double balloon enteroscopy(DBE)is a new technique, first published and introduced into clinical practice in 2001 by Yamamoto,the inventor of this outstanding method.DBE allows complete visualization,biopsy and treatment of the small bowel.Nowadays,we have some experience of this method for evaluation of the complica- tion rate.Severe complications are described in 1%-1.7% of patients.Acute pancreatitis is a rare complication of the investigation.The incidence of acute pancreatitis after diagnostic DBE is 0.3%in most studies.More than 50 cases of acute pancreatitis have been described in the literature so far.On the contrary,hyperamylasemia after DBE seems to be a rather common condition.Association with acute pancreatitis is supposed to be possible,but not obligatory.The causal mechanism of post-DBE acute pancreatitis is uncertain,and there are several theories in the literature.The most probable cause seems to be a mechanical straining of the endoscope with over-tube on the pancreas or in the papillary area. | Marcela Kopacova Ilja Tacheci Stanislav Rejchrt Jolana Bartova Jan Bures | 2010 | World Journal of Gastroenterology2010，16，19： | 18 |
| 4 | Blood pressure and stature in Helicobacter pylori positive and negative persons显示文摘To evaluate vital signs and body indices in Helicobacter pylori(H.pylori)positive and negative persons.A total of 22 centres entered the study.They were spread over the whole country,corresponding well to the geographical distribution of the Czech population.A total of 1818 subjects(aged 5-98 years)took part in the study,randomly selected out of 38147 subjects.H.pylori infection was investigated by means of a 13Curea breath test.Data on height,weight,systolic and diastolic blood pressure and heart rate were collected at the clinics of general practitioners.The overall prevalence of H.pylori infection was 30.4%(402/1321)in adults(≥18 year-old)and 5.2%(26/497)in children and adolescents(≤17 year-old).Once adjusted for age and gender,only a difference in body mass index remained statistically significant with H.pylori positive adults showing an increase of 0.6 kg/m2 in body mass index.Once adjusted for age and gender,we found a difference in height between H.pylori positive and H.pylori negative children and adolescents.On further adjustment for place of residence,this difference became statistically significant,with H.pylori positive children and adolescents being on average 3.5 cm shorter.H.pylori positive adults were significantly older compared to H.pylori negative subjects.Once adjusted for age and gender,H.pylori infection had no impact on body weight,body mass index and vital signs either in adults or children and adolescents.Chronic H.pylori infection appeared to be associated with short stature in children.H.pylori infection did not influence blood pressure,body weight and body mass index either in adults or children and adolescents. | Marcela Kopacova Ilona Koupil Bohumil Seifert Miluska Skodova Fendrichova Jana Spirkova Viktor Vorisek Stanislav Rejchrt Tomas Douda Ilja Tacheci Jan Bures | 2014 | World Journal of Gastroenterology2014，20，19： | 9 |
| 5 | Buried bumper syndrome:A complication of percutaneousendoscopic gastrostomy显示文摘Percutaneous endoscopic gastrostomy(PEG) is a widely used method of nutrition delivery for patients with longterm insufficiency of oral intake. The PEG complication rate varies from 0.4% to 22.5% of cases, with minor complications being three times more frequent. Buried bumper syndrome(BBS) is a severe complication of this method, in which the internal fixation device migrates alongside the tract of the stoma outside the stomach. Excessive compression of tissue between the external and internal fixation device of the gastrostomy tube is considered the main etiological factor leading to BBS. Incidence of BBS is estimated at around 1%(0.3%-2.4%). Inability to insert, loss of patency and leakage around the PEG tube are considered to be a typical symptomatic triad. Gastroscopy is indicated in all cases in which BBS is suspected. The depth of disc migration in relation to the lamina muscularis propria of the stomach is critical for further therapy and can be estimated by endoscopic or transabdominal ultrasound. BBS can be complicated by gastrointestinal bleeding, perforation, peritonitis, intra-abdominal and abdominal wall abscesses, or phlegmon, and these complications can lead to fatal outcomes. The most important preventive measure is adequate positioning of the external bolster. A conservative approach should be applied only in patients with high operative risk and dismal prognosis. Choice of the method of release is based on the type of the PEG set and depth of disc migration. A disc retained inside the stomach and completely covered by the overgrowing tissue can be released using some type of endoscopic dissection technique(needle knife, argon plasma coagulation, or papillotome through the cannula). Proper patient selection and dissection of the overgrowing tissue are the major determinants for successful endoscopic therapy. A disc localized out of the stomach(lamina muscularis propria) should be treated by a surgeon. | Jiri Cyrany Stanislav Rejchrt Marcela Kopacova Jan Bures | 2016 | World Journal of Gastroenterology2016，22，2： | 9 |
| 6 | Significant decrease in prevalence ofHelicobacter pylori in the Czech Republic显示文摘AIM:To study possible decrease in prevalence of Helicobacter pylori(H.pylori) infection in the Czech Republic within a 10-year period.METHODS:A total of 22 centres entered the study.The catchment areas of these centres covered cities and towns with more than 20 000 inhabitants,smaller towns(≤ 20 000 inhabitants) with surrounding villages and rural areas,and were spread over the whole country,corresponding well to the geographical distribution of the Czech population.A total of 1 837 subjects(aged 5-98 years) took part in the study,randomly selected out of 38 147 people from the general population.H.pylori infection was investigated by means of a 13 C-urea breath test.Breath samples in duplicates were analysed using isotope ratio mass spectrometry.The cut-off point was 3.5.Social and demographic characteristics were based on data from self-completed questionnaires.RESULTS:The overall prevalence of H.pylori infection was 23.5%(430/1826),and 4.8%(20/420) in children aged 15 or less.There was no statistically significant difference in prevalence between males(24.3%;208/857) and females(22.9%,222/969,P = 0.494).H.pylori infection was strongly associated with higher age,among subjects aged 55+ years,prevalence of H.pylori infection was 39.8%(252/633,P < 0.001).The highest prevalence of H.pylori infection was found among persons aged 55-64 years(43.9%,97/221) and 75+ years(37.9%,58/153).Among study subjects aged 15+ years,prevalence of H.pylori infection was significantly increased in those with lowest education(odds risk 3.19,95% CI 1.87-5.47).Compared to never married(14.1%),the prevalence of H.pylori infection was statistically significantly higher among married(35.4%,246/694,P < 0.001),divorced(36.8%,49/133,P < 0.001) and widowed study subjects(40.2%,45/112,P < 0.001),both in minimally and fully adjusted analysis.There was no significant difference in the prevalence of H.pylori infection between married and widowed subjects(35.4%,246/694 vs 40.2%,45/112,P = 0.389).There was little variation in smoking prevalence across categories of smoking and there was no evidence of an increased risk ofH.pylori infection among current or past smokers in our data(odds risk 1.04 with 95% CI 0.78-1.40 for current smokers;odds ratio 0.83 with 95% CI 0.60-1.16 for former smokers).The current prevalence of H.pylori in 2011 was significantly lower compared to the prevalence reported from identical geographical areas in 2001(23.5%vs 41.7%,P < 0.001).CONCLUSION:The overall prevalence of H.pylori infection in the general population has fallen substantially in the Czech Republic over the past 10 years. | Jan Bure Marcela Kopáová Ilona Koupil Bohumil Seifert Miluka kodová Fendrichová Jana pirková Viktor Voíek Stanislav Rejchrt TomáDouda Norbert Král Ilja Tachecí | 2012 | World Journal of Gastroenterology2012，18，32： | 8 |
| 7 | 女性整体心血管风险的改良评估方法的确立和验证:Reynolds风险评分 | Ridker P.M. Buring J.E. Rifai N. Cook N.R. 刘少伟 | 2007 | 世界核心医学期刊文摘(心脏病学分册)2007，0，8： | 6 |
| 8 | Multiple haploids, triploids, and tetraploids found in modern-day “living fossil” Ginkgo biloba显示文摘Ginkgo biloba,the last extant representative of a lineage of Mesozoic gymnosperms,is one of the few seed plants with an exceptionally long(~300 Myr)evolutionary history free of genome-wide duplications(polyploidy).Despite this genome conservatism,we have recently found a viable spontaneous tetraploid Ginkgo sapling during routine screening of several plants,demonstrating that natural polyploidy is possible in Ginkgo.Here we provide a much wider flow cytometry survey of ploidy in some European Ginkgo collections,and own seedlings(>2200 individuals and~200 cultivars).We found a surprisingly high level of ploidy variation in modern-day Ginkgo and documented altogether 13 haploid,3 triploid,and 10 tetraploid Ginkgo plants or cultivars,most of them being morphologically distinct from common diploids.Haploids frequently produced polyploid(dihaploid)buds or branches.Tetraploids showed some genome size variation.The surveyed plants provide a unique resource for future Ginkgo research and breeding,and they might be used to accelerate the modern diversification of this nearly extinct plant lineage. | PetrŠmarda Lucie Horová Ondřej Knápek Heidi Dieck Martin Dieck Katarína Ražná Pavel Hrubík Laszlo Orlóci Laszlo Papp Kristýna Veselá Pavel Veselý Petr Bureš | 2018 | Horticulture Research2018，5，1： | 4 |
| 9 | 不同铁磁性粉末和酚醛树脂设计的软磁复合材料的比较(英文)显示文摘Soft magnetic composites(SMCs) were prepared from three different ferromagnetic powder particles: iron powder ASC 100.29, spherical Fe Si particles and vitroperm(Fe73Cu1Nb3Si16B7) flakes. Two types of hybrid organic–inorganic phenolic resins modified with either silica nanoparticles or boron were used to design a thin insulating layer perfectly covering the ferromagnetic particles. Fourier transform infrared(FTIR) spectrometry confirmed an incorporation of silica or boron into the polymer matrix, which manifested itself through an improved thermal stability of the hybrid resins verified by thermogravimetric-differential scanning calorimetry(TG-DSC) analysis. The core-shell particles prepared from the ferromagnetic powder particles and the modified hybrid resins were further compacted to the cylindrical and toroidal shapes for the mechanical, electrical and magnetic testing. A uniform distribution of the resin between the ferromagnetic particles was evidenced by scanning electron microscope(SEM) analysis,which was also reflected in a rather high value of the electrical resistivity. A low porosity and extraordinary high values of mechanical hardness and flexural strength were found in SMC consisting of the iron powder and phenolic resin modified with boron. The coercive fields of the prepared samples were comparable with the commercial SMCs. | Magdalena Streckova Radovan Bures Maria Faberova Lubomir Medvecky Jan Fuzer Peter Kollar | 2015 | Chinese Journal of Chemical Engineering2015，23，4： | 3 |
| 10 | 非高密度脂蛋白胆固醇、载脂蛋白A-I及B100、标准脂质测量、脂质比值以及CRP作为女性心血管病危险因素的临床用途显示文摘背景:关于不同脂质测定、非高密度脂蛋白胆固醇(non-HDL-C)、脂质比值、载脂蛋白和C-反应蛋白(CRP)的临床应用,现行心血管危险检测指南仍有争议。
目的:直接比较总胆固醇(totalcholesterol,TC)、低密度脂蛋白胆固醇(LDL-C)、HDL-C、non-HDL-C、载脂蛋白A-I(apoA-I)及B100(apoB100)、高敏C-反应蛋白(高敏CRP)以及TC与HDL-C、LDL-C与HDL-C、apoB100与apoA-I、apoB100与HDL-C比值,在妇女作为将来心血管事件预测指标的临床用途。
设计、地点及参试者:于15 632例起始健康美国妇女进行的前瞻性队列研究。1992年11月至1995年7月人组时年龄≥45岁(4分位范围48~59岁)。所有参试者均经10年随访,观察将来心血管事件的发生情况。
主要观测指标:按照各项生化指标不同基线值而确定的首次主要心血管事件(n=4 764)的风险比(hazard ratios,HRs)及95%可信区间(confidence intervals,CIs)。
结果:在校正年龄、吸烟状况、血压、糖尿病及体重指数后,测量结果在最高5分位者将来发生心血管事件的风险比LDL-C为1.62(95%CI,1.17~2.25),apoA-I为1.75(95%CI,1.30~2.38),TC为2.08(95%CI,1.45~2.97),HDL-C为2.32(95%CI,1.64~3.33),apoB100为2.50(95%CI,1.68~3.72),non-HDL-C为2.51(95%CI,1.69~3.72),高敏CRP为2.98(95%CI,1.90~4.67)(P<0.001,趋势贯穿所有5分位)。脂质比值风险比,apoBl00与apoA-I为3.01(95%CI,2.01~4.50),LDL-C与HDL-C为3.18(95%CI,2.12~4.75),apoB100与HDL-C为3.56(95%CI,2.31~5.47),TC与HDL-C为3.81(95%CI,2.47~5.86)(P<0.001,趋势贯穿所有5分位)。高敏CRP与脂质参数的相关系数范围为-0.33到0.15,以CRP<1、1~3和>3 ms/L为临床分割点,可对每项脂质测量及脂质比值水平增加提供预后危险信息。
结论:non-HDL-C以及TC与HDL-C比值对将来心血管事件的预测效果与载脂蛋白相同或者更好。校正年龄、血压、吸烟、糖尿病和肥胖后,高敏CRP提供的预后信息超越各项脂质测量。 | Paul M Ridker Nader Rifai Nancy R.Cook Gary Bradwin Julie E Buring 徐成斌(译) | 2006 | 美国医学会杂志(中文版)2006，25，3： | 3 |
| 11 | 空腹与餐后甘油三酯预测女性心血管事件风险的比较显示文摘背景:关于甘油三酯(TG)与新发心血管事件的关系尚无定论。尽管通常是检测空腹TG,然而餐后高甘油三酯血症可能是动脉粥样硬化(AS)的重要相关因素。目的:研究TG水平(空腹vs餐后)与未来心血管事件的相关性。设计。 | Bansal S. Buring J.E. Rifai N. P.M. Ridker 吴超能 | 2007 | 世界核心医学期刊文摘(心脏病学分册)2007，，11： | 3 |
| 12 | Hydrogels in pharmaceutical formulation显示文摘 | Peppas NA Bures P Leobandung W | 2000 | Eur J Pharm Biopharm2000，50，1： | 2 |
| 13 | Effects of Random Allocation to Vitamin E Supplementation on the Occurrence of Venous Thromboembolism: Report From the Women’s Health Study显示文摘 | Robert J. Glynn Paul M Ridker Samuel Z. Goldhaber Robert Y.L. Zee Julie E. Buring | 2007 | Circulation2007，，13： | 2 |
| 14 | 健康女性隔日给予阿司匹林预防癌症、心血管疾病和胃肠道出血风险的个体化预测显示文摘阿司匹林在癌症和心血管疾病(cardiovascular disease,CVD)一级预防中的作用仍不清楚。该研究旨在确定女性使用阿司匹林治疗是否能改善发生癌症、CVD和重大消化道出血的风险。方法:对女性健康研究(一项随机试验,隔日服用阿司匹林100mg/安慰剂的临床实验)中拥有血浆样本的健康女性27 939人进行长期随访,个体化预测使用阿司匹林是否降低合并CVD、癌症和主要消化道出血的绝对风险。 | 刘莉 叶鹏 van Kruijsdijk RC Visseren FL Ridker PM Dorresteijn JA Buring JE van der Graaf Y Cook NR | 2014 | 中华高血压杂志2014，22，12： | 2 |
| 15 | Longitudinal molecular characterization of endoscopic specimens from colorectal lesions显示文摘AIM: To compare molecular profiles of proximal colon, distal colon and rectum in large adenomas, early and late carcinomas. To assess feasibility of testing directed at molecular markers from this study in routine clinical practice. METHODS: A prospective 3-year study has resulted in the acquisition of samples from 159 large adenomas and 138 carcinomas along with associated clinical parameters including localization, grade and histological type for adenomas and localization and stage for carcinomas. A complex molecular phenotyping has been performed using multiplex ligation-dependent probe amplification technique for the evaluation of Cp G-islandmethylator phenotype(CIMP), PCR fragment analysis for detection of microsatellite instability and denaturing capillary electrophoresis for sensitive detection of somatic mutations in KRAS, BRAF, TP53 and APC genes.RESULTS: Molecular types according to previously introduced Jass classification have been evaluated for large adenomas and early and late carcinomas. An increase in CIMP+ type, eventually accompanied with KRAS mutations, was notable between large adenomas and early carcinomas. As expected, the longitudinal observations revealed a correlation of the CIMP+/BRAF + type with proximal location. CONCLUSION: Prospective molecular classification of tissue specimens is feasible in routine endoscopy practice. Increased frequency of some molecular types corresponds to the developmental stages of colorectal tumors. As expected, a clear distinction is notable for tumors located in proximal colon supposedly arising from the serrated(methylation) pathway. | Petra Minarikova Lucie Benesova Tereza Halkova Barbora Belsanova Stepan Suchanek Jiri Cyrany Inna Tuckova Jan Bures Miroslav Zavoral Marek Minarik | 2016 | World Journal of Gastroenterology2016，22，20： | 2 |
| 16 | Ear-fill effects on field and quality of silage corn显示文摘 | Coors J G Bures E J | 1997 | Crop Sci1997，37，： | 2 |
| 17 | Dietary Intake of Dairy Products, Calcium, and Vitamin D and the Risk of Hypertension in Middle-Aged and Older Women显示文摘 | Lu Wang JoAnn E. Manson Julie E. Buring I-Min Lee Howard D. Sesso | 2008 | Hypertension ( Part Suppl)2008，，4： | 2 |
| 18 | 关于小剂量阿司匹林用于女性心血管疾病一级预防的随机试验 | Ridker P.M. Cook N.R. Lee I.-M. J.E. Buring 任付先 | 2005 | 世界核心医学期刊文摘(心脏病学分册)2005，0，9： | 2 |
| 19 | Hyperglycemia, Insulin Resistance, Impaired Pancreatic β-Cell Function, and Risk of Pancreatic Cancer显示文摘 | Brian M. Wolpin Ying Bao Zhi Rong Qian Chen Wu Peter Kraft Shuji Ogino Meir J. Stampfer Kaori Sato Jing Ma Julie E. Buring Howard D. Sesso I-Min Lee John Michael Gaziano Anne McTiernan Lawrence S. Phillips Barbara B. Cochrane Michael N. Pollak JoAnn E. Ma | 2013 | JNCI Journal of the National Cancer Institute2013，，14： | 2 |
| 20 | 1977~1997:文化建筑20年显示文摘在法国,20世纪产生了一系列新奇又切合实际的创造,涉及到各种各样的学科.从吉马尔设计的地铁入口到协和式飞机,从柯布西埃到斯塔尔克,从米其林指南到雪铁龙DS19型汽车,从佩里昂设计的家具到塔隆的高速火车车厢,从南锡学校到'原始'风格,从拉利克的花瓶到萃萃们(Tsé Tsé)设计的花瓶,在这一个世纪里,法国不断地将设计调节成一面'世纪的镜子'. | Gilles de Bure Rik Gadella 傅杰 | 2004 | 国外城市规划2004，19，5： | 2 |
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