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| 1 | AGNP精神科治疗药物监测共识指南:2011显示文摘治疗药物监测(Therapeutic drug monitoring,TDM),如通过定量测定血清或血浆药物浓度指导用药剂量优化,已经成为对患者进行精神药物治疗的很有价值的工具。在患者用药依从性难以判断、药物耐受性不佳、治疗剂量下无效以及可能存在药代动力学药物-药物相互作用等情况下,测定药物浓度是很有用的。在精神科,有可能明显获益于TDM的主要患者群体包括儿童、孕妇、老年患者、智力障碍患者、涉及司法的患者、已知或怀疑携带药代动力学相关基因变异的患者,以及合并躯体疾病影响药代动力学的患者。然而,只有将TDM充分整合到临床治疗过程中去,才能发挥其优化药物治疗的潜在优势。为了促进TDM的合理应用,神经精神药理学与药物精神病学协会(Arbeitsgemeinschaft für Neuropsychopharmakologie und Pharmakopsychiatrie,AGNP)的TDM专家组在2004年发表了精神药物治疗药物监测指南。之后,随着知识不断更新,又有许多可能需要进行TDM的新药上市。因此,本次更新将神经精神药物的种类扩展到了128种,并将其TDM必要性划分为从'强烈推荐'到'可能有用'的四个等级。经过大量细致且全面的文献检索与分门别类的汇总整理,将基于循证医学理念的'治疗参考浓度范围'和'剂量相关参考浓度范围'呈现给大家。本共识指南引入了'实验室警戒浓度'的新概念,即实验室需要马上告知治疗医生的药物浓度上限。本共识指南还给出了诸如药物作为细胞色素P450酶的底物和抑制剂的性质,代谢物与母药浓度比值的常见范围,以及与结果解释相关的内容,还提供了何时将TDM与遗传药理学检测相结合的建议。遵循本指南,有助于改善许多患者精神药物治疗的效果,特别是那些存在药代动力学异常的患者。TDM是一门交叉学科,有时针对看起来不一致的数据,需要多学科坦诚地讨论,只有这样,患者才能从这种合作中获益。 | Hiemke C Baumann P Bergemann N Conca A Dietmaier O Egberts K Fric M Gerlach M Greiner C Gründer G Haen E Havemann-Reinecke U Jaquenoud Sirot E Kirchherr H Laux G Lutz UC Messer T Müller MJ Pfuhlmann B Rambeck B Riederer P Schoppek B Stingl J Uhr M Ulrich S Waschgler R Zernig G 李文标(译) 果伟(译) 阮灿军(译) 贺静(译) 汤宜朗(审校) 王传跃(审校) | 2016 | 实用药物与临床2016，19，10： | 37 |
| 2 | Cellular and molecular mechanisms of intestinal fibrosis显示文摘Fibrosis is a chronic and progressive process characterized by an excessive accumulation of extracellular matrix (ECM) leading to stiffening and/or scarring of the involved tissue. Intestinal fibrosis may develop in several different enteropathies, including inflammatory bowel disease. It develops through complex cell, extracellular matrix, cytokine and growth factor interactions. Distinct cell types are involved in intestinal fibrosis, such as resident mesenchymal cells (fibroblasts, myofibroblasts and smooth muscle cells) but also ECM-producing cells derived from epithelial and endothelial cells (through a process termed epithelialand endothelial-mesenchymal transition), stellate cells, pericytes, local or bone marrow-derived stem cells. The most important soluble factors that regulate the activation of these cells include cytokines, chemokines, growth factors, components of the renin-angiotensin system, angiogenic factors, peroxisome proliferator-activated receptors, mammalian target of rapamycin, and products of oxidative stress. It soon becomes clear that although inflammation is responsible for triggering the onset of the fibrotic proc-ess, it only plays a minor role in the progression of this condition, as fibrosis may advance in a self-perpetuating fashion. Definition of the cellular and molecular mechanisms involved in intestinal fibrosis may provide the key to developing new therapeutic approaches. | Silvia Speca Ilaria Giusti Florian Rieder Giovanni Latella | 2012 | World Journal of Gastroenterology2012，18，28： | 32 |
| 3 | H pylori infection causes chronic pancreatitis in Mongolian gerbils显示文摘AIM: To investigate whether chronic H pylori infection has the potential to induce pancreatitis in the Mongolian gerbil model, and whether it is dependent on an intact type Ⅳ secretion system. METHODS: Mongolian gerbils were infected with wild type (WT) H pylori typeⅠstrain B128 or its isogenic mutant B128 ?cagY (defective type Ⅳ secretion). After seven months of infection, H pylori was reisolated from antrum and corpus and H pylori DNA was analyzed by semi- nested polymerase chain reaction (PCR). Inflammation and histological changes were documented in the gastric antrum, corpus, and pancreas by immunohistochemistry. Cytokine mRNA, gastric pH, plasma gastrin, amylase, lipase, and glucose levels were determined. RESULTS: The H pylori infection rate was 95%. Eight infected animals, but none of the uninfected group, developed transmural inflammation and chronic pancreatitis. Extensive interstitial fibrosis and inflammation of the pancreatic lobe adjacent to the antrum was confirmed by trichrome stain, and immuno- histochemically. Pro-inflammatory cytokine mRNA was significantly increased in the antral mucosa of all infected gerbils. In the corpus, only cytokine levels of WT-infected animals and those developing transmural inflammation and pancreatitis were significantly increased. Levels of lipase, but not glucose or amylase levels, were significantly reduced in the pancreatitis group. H pylori DNA was detected in infected antral and corpus tissue,but not in the pancreas. CONCLUSION: H pylori infection is able to induce chronic pancreatitis in Mongolian gerbils independently of the type Ⅳ secretion system, probably by an indirect mechanism associated with a penetrating ulcer. | Gabriele Rieder Arno Karnholz Mechthild Stoeckelhuber Juanita L Merchant Rainer Haas | 2007 | World Journal of Gastroenterology2007，13，29： | 10 |
| 4 | B7-H7 (HHLA2) inhibits T-cell activation and proliferation in the presence of TCR and CD28 signaling显示文摘Modulation of T-cell responses has played a key role in treating cancers and autoimmune diseases.Therefore,understanding how different receptors on T cells impact functional outcomes is crucial.The influence of B7-H7(HHLA2)and CD28H(TMIGD2)on T-cell activation remains controversial.Here we examined global transcriptomic changes in human T cells induced by B7-H7.Stimulation through TCR with OKT3 and B7-H7 resulted in modest fold changes in the expression of select genes;however,these fold changes were significantly lower than those induced by OKT3 and B7-1 stimulation.The transcriptional changes induced by OKT3 and B7-H7 were insufficient to provide functional stimulation as measured by evaluating T-cell proliferation and cytokine production.Interestingly,B7-H7 was coinhibitory when simultaneously combined with TCR and CD28 stimulation.This inhibitory activity was comparable to that observed with PD-L1.Finally,in physiological assays using T cells and APCs,blockade of B7-H7 enhanced T-cell activation and proliferation,demonstrating that this ligand acts as a break signal.Our work defines that the transcriptomic changes induced by B7-H7 are insufficient to support full costimulation with TCR signaling and,instead,B7-H7 inhibits T-cell activation and proliferation in the presence of TCR and CD28 signaling. | Sadiye Amcaoglu Rieder Jingya Wang Natalie White Ariful Qadri Catherine Menard Geoffrey Stephens Jodi LKarnell Christopher ERudd Roland Kolbeck | 2021 | Cellular & Molecular Immunology2021，18，6： | 9 |
| 5 | 云母的命名显示文摘定义云母为层状硅酸盐。其结构单元由两个相向排列的四面体片(Ts)和夹于其间的一个八面体片(Os)组成。这些片构成一个单元层,层与层之间被非水化层间阳离子(I)分开,其顺序是:非水化阳离子层、四面体片、八面体片、四面体片、非水化阳离子层、四面体片、八面... | Milan Rieder,Giancarlo Cavazzini,Yurii S.D’yakonov, Viktor A.Frank Kamenetskii,Glauco Gottardi,Stephen Guggenheim,Pavel V.Koval′, Georg Muller,Ana M.R.Neiva,Edward W.Radoslovich,Jean Louis Robert, Francesco P.Sassi,Hiroshi Takeda,Zdenek Weiss,Davi | 1999 | 矿物岩石地球化学通报1999，18，3： | 8 |
| 6 | Combination of corticosteroids and 5-aminosalicylates or corticosteroids alone for patients with moderate-severe active ulcerative colitis:A global survey of physicians'practice显示文摘AIM To examine treatment decisions of gastroenterologists regarding the choice of prescribing 5-aminosalycilates(5ASA) with corticosteroids(CS) versus corticosteroids alone for patients with active ulcerative colitis(UC). METHODS A cross-sectional questionnaire exploring physicians' attitude toward 5ASA + CS combination therapy vs CS alone was developed and validated. The questionnaire was distributed to gastroenterology experts in twelve countries in five continents. Respondents' agreement with stated treatment choices were assessed by standardized Likert scale. Background professional characteristics of respondents were analyzed for correlation with responses. RESULTS Six hundred and sixty-four questionnaires were distributed and 349 received(52.6% response rate). Of 340 eligible respondents, 221(65%) would continue 5ASA in a patient hospitalized for intravenous CS treatment due to a moderate-severe UC flare, while 108(32%) would stop the 5ASA(P < 0.001), and 11(3%) are undecided. Similarly, 62% would continue 5ASA in an out-patient starting oral CS. However, only 140/340(41%) would proactively start 5ASA in a hospitalized patient not receiving 5ASA before admission. Most(94%) physicians consider the safety profile of 5ASA as very good. Only 52% consider them inexpensive, 35% perceive them to be expensive and 12% are undecided. On multi-variable analysis, less years of practice and perception of a plausible additive mechanistic effect of 5ASA + CS were positively associated with the decision to continue 5ASA with CS. CONCLUSION Despite the absence of data supporting its benefit, most gastroenterologists endorse combination of 5ASA + CS for patients with active moderate-to-severe UC. Randomized controlled trials are needed to assess if 5ASA confer any benefit for these patients. | Shomron Ben-Horin Jane M Andrews Konstantinos H Katsanos Florian Rieder Flavio Steinwurz Konstantinos Karmiris Jae Hee Cheon Gordon William Moran Monica Cesarini Christian D Stone Doron Schwartz Marijana Protic Xavier Roblin Giulia Roda Min-Hu Chen Ofir Har-Noy Charles N Bernstein | 2017 | World Journal of Gastroenterology2017，23，16： | 3 |
| 7 | 针织物超声波熔接显示文摘 | H.-H. Bttcher E. Rothermel O. Rieder H. Planck 徐载熊 | 2005 | 国际纺织导报2005，33，7： | 3 |
| 8 | A Comparative Study on Comprehensive, Objective Outcomes of Laparoscopic Heller Myotomy With Per-Oral Endoscopic Myotomy (POEM) for Achalasia显示文摘 | Neil H. Bhayani Ashwin A. Kurian Christy M. Dunst Ahmed M. Sharata Erwin Rieder Lee L. Swanstrom | 2014 | Annals of Surgery2014，，6： | 2 |
| 9 | Pilot trial of autologous dendritic cells loaded with tumor lysate(s)from allogeneic tumor cell lines in patients with metastatic medullary thyroidcarcinoma显示文摘 | Thomas Bachleitner-Hofmann Josef Friedl Michaela Hassler Hubert Hayden Peter Dubsky Monika Sachet Erwin Rieder Roswitha Pfragner Christine Brostjan Stefan Riss Bruno Niederle Michael Gnant Anton Stift | 2009 | Oncology Reports2009，，6： | 2 |
| 10 | HCl-induced and ATP-dependent upregulation of TRPV1 receptor expression and cytokine production by human esophageal epithelial cells显示文摘 | Jie Ma Annamaria Altomare Michele Guarino Michele Cicala Florian Rieder Claudio Fiocchi Dan Li Weibiao Cao Jose Behar Piero Biancani Karen M. Harnett | 2012 | AJP: Gastrointestinal and Liver Physiology2012，，5： | 2 |
| 11 | Long-Term Outcomes of an Endoscopic Myotomy for Achalasia: The POEM Procedure显示文摘 | Lee L. Swanstrom Ashwin Kurian Christy M. Dunst Ahmed Sharata Neil Bhayani Erwin Rieder | 2012 | Annals of Surgery2012，，4： | 2 |
| 12 | Acromio-humer- al distance variation measured by ultrasonography and its as- sociation with the outcome of rehabilitation for shoulder im- pingement syndrome显示文摘 | Desmeules F Minville L Riederer B | 2004 | Clin J Sport Med2004，14，： | 1 |
| 13 | Genetically engineered foot-and-mouth disease viruses with poly(C) tracts of two nucleotides are virulent in mice 显示文摘 | Rieder E Bunch T Brown F | 1993 | Journal of Virology1993，67，： | 1 |
| 14 | Improved centric phase encoding orders for three-dimensional magnetization-prepared MR angiography显示文摘 | Wilman AH Riederer SJ | 1996 | Magn Reson Med1996，36，3： | 1 |
| 15 | Plasmid DNA encoding replicating Foot-and-mouth disease virus genomes induces antiviral immune response in swine显示文摘 | Ward G Rieder E Mason P W | 1997 | J Virol1997，71，： | 1 |
| 16 | Automating theidentification of DNA variations using quality-basedfluorescence re-sequencing:analysis of the human mitocho-ndrial genome显示文摘 | Rieder MJ Taylor SL Tobe VO | 1998 | Nucleic Acids Res1998，26，4： | 1 |
| 17 | Interinstitutional and intrainstitutional transmission of a strain of Acineto- bacter baumanniidetected by molecular analysis: compari- son of pulsed-field gel electrophoresis and repetitive se- quence-based polymerase chain reaction 显示文摘 | Saeed S Fakih M G Riederer K | 2006 | Infect Con- trol Hosp Epidemiol2006，27，9： | 1 |
| 18 | Epicuticular crystals of nonacosan-10-ol: In-vitro reconstitution and factors influencing crystal habits显示文摘 | R. Jetter M. Riederer | 1994 | Planta1994，，2： | 1 |
| 19 | CYP4F2 is a vitamin K1 oxidase: an explanation for altered warfarin dose in carriers of the V433M variant显示文摘 | MCDDNALD MG RIEDER MJ NAKANO M | 2009 | Mol Pharmacol2009，75，6： | 1 |
| 20 | 萋尼氏染色:理论与实践显示文摘世界卫生组织、国际防痨与肺病联盟的指南所提供的萋尼氏染色内容,在某些方面缺乏实用性,本文给出的建议意在对指南加以补充。这些建议是建立在有关碱性复红染色和染色液的试验以及实际经验基础之上的。 | A. Van Deun M. A. Hossain M. Gumusboga H.L. Rieder 姜广路(译) 黄海荣(校) 何广学(审) | 2008 | 国际结核病与肺部疾病杂志2008，3，2： | 1 |
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