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| 1 | AGNP精神科治疗药物监测共识指南:2011显示文摘治疗药物监测(Therapeutic drug monitoring,TDM),如通过定量测定血清或血浆药物浓度指导用药剂量优化,已经成为对患者进行精神药物治疗的很有价值的工具。在患者用药依从性难以判断、药物耐受性不佳、治疗剂量下无效以及可能存在药代动力学药物-药物相互作用等情况下,测定药物浓度是很有用的。在精神科,有可能明显获益于TDM的主要患者群体包括儿童、孕妇、老年患者、智力障碍患者、涉及司法的患者、已知或怀疑携带药代动力学相关基因变异的患者,以及合并躯体疾病影响药代动力学的患者。然而,只有将TDM充分整合到临床治疗过程中去,才能发挥其优化药物治疗的潜在优势。为了促进TDM的合理应用,神经精神药理学与药物精神病学协会(Arbeitsgemeinschaft für Neuropsychopharmakologie und Pharmakopsychiatrie,AGNP)的TDM专家组在2004年发表了精神药物治疗药物监测指南。之后,随着知识不断更新,又有许多可能需要进行TDM的新药上市。因此,本次更新将神经精神药物的种类扩展到了128种,并将其TDM必要性划分为从'强烈推荐'到'可能有用'的四个等级。经过大量细致且全面的文献检索与分门别类的汇总整理,将基于循证医学理念的'治疗参考浓度范围'和'剂量相关参考浓度范围'呈现给大家。本共识指南引入了'实验室警戒浓度'的新概念,即实验室需要马上告知治疗医生的药物浓度上限。本共识指南还给出了诸如药物作为细胞色素P450酶的底物和抑制剂的性质,代谢物与母药浓度比值的常见范围,以及与结果解释相关的内容,还提供了何时将TDM与遗传药理学检测相结合的建议。遵循本指南,有助于改善许多患者精神药物治疗的效果,特别是那些存在药代动力学异常的患者。TDM是一门交叉学科,有时针对看起来不一致的数据,需要多学科坦诚地讨论,只有这样,患者才能从这种合作中获益。 | Hiemke C Baumann P Bergemann N Conca A Dietmaier O Egberts K Fric M Gerlach M Greiner C Gründer G Haen E Havemann-Reinecke U Jaquenoud Sirot E Kirchherr H Laux G Lutz UC Messer T Müller MJ Pfuhlmann B Rambeck B Riederer P Schoppek B Stingl J Uhr M Ulrich S Waschgler R Zernig G 李文标(译) 果伟(译) 阮灿军(译) 贺静(译) 汤宜朗(审校) 王传跃(审校) | 2016 | 实用药物与临床2016，19，10： | 37 |
| 2 | Antibacterial approaches in tissue engineering using metal ions and nanoparticles:From mechanisms to applications显示文摘Bacterial infection of implanted scaffolds may have fatal consequences and,in combination with the emergence of multidrug bacterial resistance,the development of advanced antibacterial biomaterials and constructs is of great interest.Since decades ago,metals and their ions had been used to minimize bacterial infection risk and,more recently,metal-based nanomaterials,with improved antimicrobial properties,have been advocated as a novel and tunable alternative.A comprehensive review is provided on how metal ions and ion nanoparticles have the potential to decrease or eliminate unwanted bacteria.Antibacterial mechanisms such as oxidative stress induction,ion release and disruption of biomolecules are currently well accepted.However,the exact antimicrobial mechanisms of the discussed metal compounds remain poorly understood.The combination of different metal ions and surface decorations of nanoparticles will lead to synergistic effects and improved microbial killing,and allow to mitigate potential side effects to the host.Starting with a general overview of antibacterial mechanisms,we subsequently focus on specific metal ions such as silver,zinc,copper,iron and gold,and outline their distinct modes of action.Finally,we discuss the use of these metal ions and nanoparticles in tissue engineering to prevent implant failure. | Maria Godoy-Gallardo Ulrich Eckhard Luis M.Delgado Yolanda J.D.de Roo Puente Mireia Hoyos-Nogués F.Javier Gil Roman A.Perez | 2021 | Bioactive Materials2021，6，12： | 14 |
| 3 | CaMKII in cerebral ischemia显示文摘神经原上的 Ischemic 侮辱触发引起 Ca 导致 neuronal 房间死亡(excitotoxicity ) 的 2+ 超载的过多的、病理学的 glutamate 版本。Ca 2+/calmodulin (凸轮) 依赖者蛋白质 kinase II (CaMKII ) 是位于 neuronal 粘性下面并且学习的生理的有刺激性的 glutamate 信号的一个主要调停人。Glutamate 刺激在 T286 触发 CaMKII 的 autophosphorylation,使 kinase 成为 “ 的一个过程; autonomous”(从 Ca 2+ 刺激的部分活跃的独立人士) 并且那为 synaptic 的形式被要求粘性。最近的研究为侮辱以后的 neuroprotection 作为潜在的药目标也建议了自治 CaMKII 活动,在在 neuronal 文化的 glutamate 侮辱以后并且在在 vivo 的焦点的服的局部缺血以后。然而, CaMKII 和凸轮 kinase 家庭的另外的成员在 neuronal 死亡和幸存的规定被含有。这里,我们在 excitotoxicity 和服的局部缺血讨论过去的调查结果和凸轮 kinase 功能的可能的机制,与 CaMKII 和它的规定的一个焦点。 | Steven J COULTRAP Rebekah S VEST Nicole M ASHPOLE Andy HUDMON K Ulrich BAYEF | 2011 | Acta Pharmacologica Sinica2011，32，7： | 6 |
| 4 | Impact of mobile health and medical applications on clinical practice in gastroenterology显示文摘Mobile health apps (MHAs) and medical apps (MAs) are becoming increasinglypopular as digital interventions in a wide range of health-related applications inalmost all sectors of healthcare. The surge in demand for digital medical solutionshas been accelerated by the need for new diagnostic and therapeutic methods inthe current coronavirus disease 2019 pandemic. This also applies to clinicalpractice in gastroenterology, which has, in many respects, undergone a recentdigital transformation with numerous consequences that will impact patients andhealth care professionals in the near future. MHAs and MAs are considered tohave great potential, especially for chronic diseases, as they can support the selfmanagementof patients in many ways. Despite the great potential associated withthe application of MHAs and MAs in gastroenterology and health care in general,there are numerous challenges to be met in the future, including both the ethicaland legal aspects of applying this technology. The aim of this article is to providean overview of the current status of MHA and MA use in the field ofgastroenterology, describe the future perspectives in this field and point out someof the challenges that need to be addressed. | Sven Kernebeck Theresa S Busse Maximilian D Bottcher Jurgen Weitz Jan Ehlers Ulrich Bork Didactics Educational Research in Health | 2020 | World Journal of Gastroenterology2020，26，29： | 2 |
| 5 | The Constitution and Properties of Cubic Boron Nitride Thin Films:a Comparative Study on the Influence of Bombarding Ion Energy显示文摘 | K Sell S Ulrich E Nold | 2003 | Surf Coat Technol2003，，： | 1 |
| 6 | Stroke-induced immundepression: experimental evidence and clinical relevance显示文摘 | Ulrich D Juliane K Johann S | 2007 | Stroke2007，38，2： | 1 |
| 7 | Pcroxisome proliferator-activated receptor gamma as a molecular target of resveratrol-induced modulation of polyamine metabolism 显示文摘 | Ulrich S Loitsch SM Ran O | 2006 | Cancer Res2006，66，14： | 1 |
| 8 | Fighting restenosis after coronary angioplasty: contemporary and future treatment options显示文摘 | MARC H ULRICH S JOSEF N | 2002 | Int J Cardiol2002，83，3： | 1 |
| 9 | PPARgamma is a key target of butyrate-induced Casepase-3-3 activation in the colorectal cancer cell line Caco-2 显示文摘 | Schwab M Reynders V Ulrich S | 2006 | Apoptosis2006，11，10： | 1 |
| 10 | The incidence of infectious complications of central venous catheters at the subclavian,internal jugular,and femoral sites in an intensive care unit population显示文摘 | Deshpande K S Hatem C Ulrich H L | 2005 | Crit Care Med2005，33，1： | 1 |
| 11 | Subplantation effect in magnetron sputtered superhard boron carbide thin films 显示文摘 | Ulrich S Ehrhardt H Schwan J | 1998 | Diamond and Related Materials1998，6，7： | 1 |
| 12 | Investigating the five facet mindfulness questionnaire (FFMQ):construction of a short form and evidence of a two-factor higher order structure of mindfulness显示文摘 | ULRICH S TRAN TOBIAS M GLUCK INGO W NADER | 2013 | Journal of Clinical Psychology2013，69，9： | 1 |
| 13 | Validation of theWHO p roposalfor a new classifications of p rimarymyelodysp lastic syndromes:aretrospective analysis of 1600 patients显示文摘 | Ulrich G Norben G Corinna S | 2000 | Leuk a Res2000，25，12： | 1 |
| 14 | Measurement of dynamic electrical and mechanical properties of resistance spot welding显示文摘 | GEDEON S A SORENSEN C D ULRICH K T | 1987 | Welding Journal1987，66，12： | 1 |
| 15 | 显示文摘 | Ulrich S Scherer J Schwan J | 1996 | Appl Phys Lett1996，68，： | 1 |
| 16 | New developments of polymeric dental composites 显示文摘 | Norbert M Ulrich S | 2001 | Dent Mater2001，26，4： | 1 |
| 17 | Braun stroke-induced immunodepression: experimental evidence and clinical relevance显示文摘 | Ulrich D Juliane K Johann S | 2007 | Stroke2007，38，2： | 1 |
| 18 | Tissue engineering of pulmonary heart valves on anogenic acellular matrix con duits 显示文摘 | Gustav S Ulrich S Najibulla K | 2000 | Circulation2000，102，： | 1 |
| 19 | Definition and grading of anastomotic leakage following anterior resection of the rectum: A proposal by the International Study Group of Rectal Cancer显示文摘 | Nuh N. Rahbari Jürgen Weitz Werner Hohenberger Richard J. Heald Brendan Moran Alexis Ulrich Torbj?rn Holm W. Douglas Wong Emmanuel Tiret Yoshihiro Moriya S?ren Laurberg Marcel den Dulk Cornelis van de Velde Markus W. Büchler | 2010 | Surgery2010，，3： | 1 |
| 20 | Free radical and thermal curing of terpyridine modified terpolymers 显示文摘 | Harald H Abdelkrim E Ulrich S S | 2004 | Journal of Polymer Science Part A:Polymer Chemistry2004，42，40： | 1 |
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