|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | In vivo radiometric analysis of glucose uptake and distribution in mouse bone显示文摘Bone formation and remodeling occurs throughout life and requires the sustained activity of osteoblasts and osteoclasts,particularly during periods of rapid bone growth.Despite increasing evidence linking bone cell activity to global energy homeostasis,little is known about the relative energy requirements or substrate utilization of bone cells.In these studies,we measured the uptake and distribution of glucose in the skeleton in vivo using positron-emitting^(18)F-fluorodeoxyglucose([^(18)F]-FDG) and non-invasive,high-resolution positron emission tomography/computed tomography(PET/CT) imaging and ex vivo autoradiography.Assessment of [^(18)F]-FDG uptake demonstrated that relative to other tissues bone accumulated a significant fraction of the total dose of the glucose analog.Skeletal accumulation was greatest in young mice undergoing the rapid bone formation that characterizes early development.PET/CT imaging revealed that [^(18)F]-FDG uptake was greatest in the epiphyseal and metaphyseal regions of long bones,which accords with the increased osteoblast numbers and activity at this skeletal site.Insulin administration significantly increased skeletal accumulation of [^(18)F]-FDG,while uptake was reduced in mice lacking the insulin receptor specifically in osteoblasts or fed a high-fat diet.Our results indicated that the skeleton is a site of significant glucose uptake and that its consumption by bone cells is subject to regulation by insulin and disturbances in whole-body metabolism. | Meredith L Zoch Diane S Abou Thomas L Clemens Daniel LJ Thorek Ryan C Riddle | 2016 | Bone Research2016，4，1： | 9 |
| 2 | A Study of electrocardiographic patterns in a population of commercial broiler chickens 显示文摘 | Olkowski A A Classen H L Riddle C | 1997 | Veterinary Research Communications1997，21，： | 2 |
| 3 | Hypoxia-inducible factor-1a restricts the anabolic actions of parathyroid hormone显示文摘The hypoxia inducible factors(Hifs) are evolutionarily conserved transcriptional factors that control homeostatic responses to low oxygen. In developing bone, Hif-1 generated signals induce angiogenesis necessary for osteoblast specification, but in mature bone, loss of Hif-1 in osteoblasts resulted in a more rapid accumulation of bone. These findings suggested that Hif-1 exerts distinct developmental functions and acts as a negative regulator of bone formation. To investigate the function of Hif-1a in osteoanabolic signaling, we assessed the effect of Hif-1a loss-of-function on bone formation in response to intermittent parathyroid hormone(PTH). Mice lacking Hif-1a in osteoblasts and osteocytes form more bone in response to PTH, likely through a larger increase in osteoblast activity and increased sensitivity to the hormone. Consistent with this effect, exposure of primary mouse osteoblasts to PTH resulted in the rapid induction of Hif-1a protein levels via a post-transcriptional mechanism. The enhanced anabolic response appears to result from the removal of Hif-1a-mediated suppression of b-catenin transcriptional activity. Together, these data indicate that Hif-1a functions in the mature skeleton to restrict osteoanabolic signaling. The availability of pharmacological agents that reduce Hif-1a function suggests the value in further exploration of this pathway to optimize the therapeutic benefits of PTH. | Julie L Frey David P Stonko Marie-Claude Faugere Ryan C Riddle | 2014 | Bone Research2014，2，1： | 2 |
| 4 | In search of the molecular basis of heterosis显示文摘 | BIRCHLER J A AUGER D L RIDDLE N C | | 0，，： | 1 |
| 5 | Contri-butions of descending and ascending pathways to corticomus-cular coherence in humans 显示文摘 | WITHAM C L RIDDLE C N BAKER M R | 2011 | J Physiol2011，589，15： | 1 |
| 6 | In search of the molecular basis of heterosis显示文摘 | BIRCHLER J A AUGER D L RIDDLE N C | 2003 | Plant Cell2003，15，10： | 1 |
| 7 | Fission product extraction(FPEX):development of a novel solvent for the simultaneous separation of strontium and cesium from acidic solutions显示文摘 | Riddle C L Baker J D Magrath C A | 2007 | Solvent Extraction and Ion Exchange2007，23，3： | 1 |
| 8 | In search of the molecular basis of heterosis 显示文摘 | BIRCHLER J A AUGER D L RIDDLE N C | 2003 | Plant Ce112003，15，10： | 1 |
| 9 | Marine introductions in the southern ocean: An unrecognised hazard to biodiversity 显示文摘 | Lewis P N Hewitt C L Riddle M | 2003 | Marine Pollution Bull2003，46，： | 1 |
| 10 | Fission Product Extraction (FPEX):Development of a Novel Solvent for the Simultaneous Separation of Strontium and Cesium From Acidic Solutions显示文摘 | Riddle C L Baker J D Law J D | 2005 | Solvent Extr Ion Exch2005，23，3： | 1 |
| 11 | In search of the molecular basis of heterosis显示文摘 | Birchler J A Auger D L Riddle N C | 2003 | Plant Cell2003，15，： | 1 |
| 12 | In search of the molecular basis of heterosis显示文摘 | Birchler J A Auger D L Riddle N C | | 0，，： | 1 |
| 13 | In search of the molecular basis of heterosis显示文摘 | Birchler J A Auger D L Riddle N C | 2003 | Plant Cell2003，15，： | 1 |
| 14 | The tomato genome sequence provides insights into fleshy fruit evolution 显示文摘 | Sato S Tabata S Hirakawa H Asamizu E Shlrasawa K Isobe S Kaneko T Nakamura Y Shibata D Aoki K Egholm M Knight J Bogden R Li C Shuang Y Xu X Pan S Cheng S Liu X Ren Y Wang J Albiero A Dal Pero F Todesco S Van Eck J Buels R M Bombarely A Gosselin J R Huang M Leto J A Menda N Strickler S Mao L Gao S Tecle I Y York T Zheng Y Vrebalov JT Lee J Zhong S Mueller L A Stiekema W J Ribeca P Alioto T Yang W Huang S Du Y Zhang Z Gao J Guo Y Wang X Li Y He J Li C Cheng Z Zuo J Ren J Zhao J Yan L Jiang H Wang B Li H Li Z Fu F Chen B Feng Q Fan D Wang Y Ling H Xue Y Ware D McCombie W R Lippman Z B Chia J M Jiang K Pasternak S Gelley L Kramer M Anderson L K Chang S B Royer S M Shearer L A Stack S M Rose J K Xu Y Eannetta N Matas A J McQuinn R Tanksley S D Camara F Guiga R Rombauts S Fawcett J Van de Peer Y Zamir D Liang C Spannagl M Gundlach H Bruggmann R Mayer K Jia Z Zhang J Ye Z Bishop G J Butcher S Lopez-Cobollo R Buchan D Filippis I Abbott J Dixit R Singh M Singh A Pal J K Pandit A Singh P K Mahato A K Gaikwad V D Sharma R R Mohapatra T Singh N K Causse M Rothan C Schiex T Noirot C Bellec A Klopp C Delalande C Berges H Mariette J Frasse P Vautrin S Zouine M Latch6 A Rousseau C Regad F Pech J C Philippot M Bouzayen M Pericard P Osorio S Fernandez del Carmen A Monforte A Granell A Fernandez-Mufioz R Conte M Lichtenstein G Carrari F De Bellis G Fuligni F Peano C Grandillo S Termolino P Pietrella M Fantini E Falcone G Fiore A Giuliano G Lopez L Facella P Perotta G Daddiego L Bryan G Orozco M Pastor X Torrents D van Schriek M G Feron R M van Oeveren J de Heer P daPonte L Jacobs-Oomen S Cariaso M Prins M van Eijk M J Janssen A van Haaren M J Jungeun Kim S H Kwon S Y Kim S Koo D H Lee S Hur C G Clouser C Rico A Hallab A Gebhardt C Klee K Jocker A Warfsmann J Gobel U Kawamura S Yano K Sherman J D Fukuoka H Negoro S Bhutty S Chowdhury P Chattopadhyay D Datema E Smit S Schijlen E G van de Belt J van Haarst J C Peters S A van Staveren M A Henkens M H Mooyman P J Hesselink T van Ham R C Jiang G Droege M Choi D Kang B C Kim B D Park M Kim S Yeom SI Lee YH Choi Y D Li G Gao J Liu Y Huang S Fernandez-Pedrosa V Collado C Zufiiga S Wang G Cade R Dietrich R A Rogers J Knapp S Fei Z White R A Thannhauser T W Giovannoni J J Botella M A Gilbert L Gonzalez R Goieoechea J L Yu Y Kudrna D Collura K Wissotski M Wing R Meyers BC Gurazada AB Green P J Vyas S M Solanke A U Kumar R Gupta V Sharma A K Khurana P Khurana J P Tyagi A K Dalmay T Mohorianu 1 Waits B Chamala S Barbazuk W B Li J Guo H Lee T H Wang Y Zhang D Paterson A H Wang X Tang H Barone A Chiusano M L Ereolano M R D' Agostino N Di Filippo M Traini A Sanseverino W Frusciante L Seymour G B Elharam M Fu Y Hua A Kenton S Lewis J Lin S Najar F Lai H Qin B Qu C Shi R White D White J Xing Y Yang K Yi J Yao Z Zhou L Roe B A Vezzi A D' Angelo M Zimbello R Sehiavon R Caniato E Rigobello C Campagna D Vitulo N Valle G Nelson D R De Paoli E Szinay D de Jong H H Bai Y Visser R G Klein R Beasley H McLaren K Nicholson C Riddle C Gianese G | 2012 | Nature2012，485，7400： | 1 |
| 15 | In Search of the Molecular Basis of Heterosis显示文摘 | Birchler J A Auger D L Riddle N C | 2003 | The Plant Cell2003，15，： | 1 |
| 16 | Fission product extraction (FPEX): development of a novel solvent for the simultaneous separation of strontium and cesium from acidic solutions 显示文摘 | Riddle C L Baker J D Law J D McGrath C A Meikrantz D H Mincher B J Peterman D R Todd T A | 2005 | Solvent Extraction and lon Exchange2005，23，： | 1 |
| 17 | In search of the molecu- lar basis of heterosis显示文摘 | Birchler J A Auger D L Riddle N C | 2003 | Plant Cell2003，15，： | 1 |
| 18 | In search of the molecular basis of heterosis显示文摘 | Birchler J A Auger D L Riddle N C | 2003 | Plant Cell2003，15，： | 1 |
| 19 | In search of the molecular basis of heterosis显示文摘 | BIRCHLER J A AUGER D L RIDDLE N C | 2003 | The Plant Cell2003，15，： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员