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| 1 | Bone Morphogenetic Protein (BMP) signaling in development and human diseases显示文摘Bone Morphogenetic Proteins(BMPs)are a group of signaling molecules that belongs to the Transforming Growth Factor-b(TGF-b)superfamily of proteins.Initially discovered for their ability to induce bone formation,BMPs are now known to play crucial roles in all organ systems.BMPs are important in embryogenesis and development,and also in maintenance of adult tissue homeostasis.Mouse knockout models of various components of the BMP signaling pathway result in embryonic lethality or marked defects,highlighting the essential functions of BMPs.In this review,we first outline the basic aspects of BMP signaling and then focus on genetically manipulated mouse knockout models that have helped elucidate the role of BMPs in development.A significant portion of this review is devoted to the prominent human pathologies associated with dysregulated BMP signaling. | Richard N.Wang Jordan Green Zhongliang Wang Youlin Deng Min Qiao Michael Peabody Qian Zhang Jixing Ye Zhengjian Yan Sahitya Denduluri Olumuyiwa Idowu Melissa Li Christine Shen Alan Hu Rex C.Haydon Richard Kang James Mok Michael J.Lee Hue L.Luu Lewis L.Shi | 2014 | Genes & Diseases2014，1，1： | 47 |
| 2 | Energycentric enabling technologies for wireless sensor networks显示文摘 | Rex Min Manish Bhardwaj Seong-Hwan Cho | 2002 | IEEE Wireless Communications2002，，8： | 1 |
| 3 | Energy-Centric Enabling Technologies for Wireless Sensor Networks显示文摘 | Min Rex Bhardwaj Manish Cho Seong-Hwan Ickes Nathan Shih Eugene Sinha Amit Wang Alice Chandrakasan Anantha | 2002 | IEEE Wireless Communications (S1536-1284)2002，8，： | 1 |
| 4 | Energy-Centric Enabling Technologies for Wireless Sensor Networks显示文摘 | Min Rex Bhardwaj Manish Cho Seong-Hwan | 2002 | IEEE Wireless Communications (S1536-1284)2002，8，： | 1 |
| 5 | Erectile dysfunction and radiation dose to penile base structures: a lack of correlation 显示文摘 | Ugur Selek Rex Cheung Min Gfwu Lii | 2004 | Int J Radiat Oncol Biol Phys2004，59，4： | 1 |
| 6 | Energy-Centric Enabling Tech-nologies for Wireless Sensor Networks显示文摘 | Rex Min Manish Bhardwaj | 2002 | IEEE Wireless Communications2002，，8： | 1 |
| 7 | Energy-Centric enabling technologies for wireless sensor networks显示文摘 | Rex Min Manish Bhardwaj Seong-Hwan Cho Nathan Ickes Eugene Shih Amit Sinlia Alice Wang Anantha Chandrakasan | 2002 | IEEE Wireless Communications2002，，8： | 1 |
| 8 | Bone morphogenetic protein 2 inhibits the proliferation and growth ofhuman colorectal cancer cells显示文摘 | Yunyuan Zhang Xian Chen Min Qiao Bing-Qiang Zhang Ning Wang Zhonglin Zhang Zhan Liao Liyi Zeng Youlin Deng Fang Deng Junhui Zhang Liangjun Yin Wei Liu Qian Zhang Zhengjian Ya Jixing Ye Zhongliang Wang Lan Zhou Hue Luu Rex Haydon Tong-Chuan He Hongyu Zhang | 2014 | Oncology Reports2014，，3： | 1 |
| 9 | Modeling colorectal tumorigenesis using the organoids derived from conditionally immortalized mouse intestinal crypt cells (ciMICs)显示文摘Intestinal cancers are developed from intestinal epithelial stem cells(ISCs)in intestinal crypts through a multi-step process involved in genetic mutations of oncogenes and tumor suppressor genes.ISCs play a key role in maintaining the homeostasis of gut epithelium.In 2009,Sato et al established a three-dimensional culture system,which mimicked the niche microenvironment by employing the niche factors,and successfully grew crypt ISCs into organoids or Mini-guts in vitro.Since then,the intestinal organoid technology has been used to delineate cellular signaling in ISC biology.However,the cultured organoids consist of heterogeneous cell populations,and it was technically challenging to introduce genomic changes into three-dimensional organoids.Thus,there was a technical necessity to develop a twodimensional ISC culture system for effective genomic manipulations.In this study,we established a conditionally immortalized mouse intestinal crypt(ciMIC)cell line by using a piggyBac transposon-based SV40 T antigen expression system.We showed that the ciMICs maintained long-term proliferative activity under two-dimensional niche factor-containing culture condition,retained the biological characteristics of intestinal epithelial stem cells,and could form intestinal organoids in three-dimensional culture.While in vivo cell implantation tests indicated that the ciMICs were non-tumorigenic,the ciMICs overexpressing oncogenic b-catenin and/or KRAS exhibited high proliferative activity and developed intestinal adenoma-like pathological features in vivo.Collectively,these findings strongly suggested that the engineered ciMICs should be used as a valuable tool cell line to dissect the genetic and/or epigenetic underpinnings of intestinal tumorigenesis. | Xiaoxing Wu Zhaoxia Li Hongyu Zhang Fang He Min Qiao Huaxiu Luo Jing Zhang Meng Zhang Yukun Mao William Wagstaff Yongtao Zhang Changchun Niu Xia Zhao Hao Wang Linjuan Huang Deyao Shi Qing Liu Na Ni Kai Fu Rex C.Haydon Russell R.Reid Hue H.Luu Tong-Chuan He Ziwei Wang Houjie Liang Bing-Qiang Zhang Ning Wang | 2021 | Genes & Diseases2021，8，6： | 1 |
| 10 | Energy-Centric Enabling Technologies for Witless Sensor Networks显示文摘 | Min Rex Bhardwaj Manish Cho Seonghwan | 2002 | IEEE Witless Communications (S1536-1284)2002，8，： | 1 |
| 11 | Corrigendum to ‘Modeling colorectal tumorigenesis using the organoids derived from conditionally immortalized mouse intestinal crypt cells (ciMICs)’ [Genes Dis 8 (2021) 814-826]显示文摘The authors regret that an image assembly(copy/paste)error in Figure 3D,in which the image for the organoid of'Primary MiCs'group was erroneously duplicated with an image of primary MICs that was previously published.The corrected figure is shown below.As shown in the corrected Figure 3D,this error does not adversely impact the conclusion of the original work.The authors would like to apologise forany inconvenience caused. | Xiaoxing Wu Zhaoxia Li Hongyu Zhang Fang He Min Qiao Huaxiu Luo Jing Zhang Meng Zhang Yukun Mao William Wagstaff Yongtao Zhang Changchun Niu Xia Zhao Hao Wang Linjuan Huang Deyao Shi Qing Liu Na Ni Kai Fu Rex C. Haydon Russell R. Reid Hue H. Luu Tong-Chuan He Ziwei Wang Houjie Liang Bing-Qiang Zhang Ning Wang | 2023 | Genes & Diseases2023，10，2： | 0 |
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