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| 1 | Role of bacterial and genetic factors in gastric cancer in Costa Rica显示文摘AIM: To evaluate several risk factors for gastric cancer (GC) in Costa Rican regions with contrasting GC incidence rate (GCIR). METHODS: According to GCIR, 191 Helicobacter pylori (H pylori)-positive patients were classified into groups A (high GCIR, n = 101) and B (low GCIR, n = 90). Human DNA obtained from biopsy specimens was used in the determination of polymorphisms of the genes coding for interleukin (IL)-1β and IL-10 by PCR-RFLP, and IL-1RN by PCR. H pylori DNA extractions obtained from clinical isolates of 83 patients were used for PCR-based genotyping of H pylori cagA, vacA and babA2. Human DNA from gastric biopsies of 52 GC patients was utilized for comparative purposes. RESULTS: Cytokine polymorphisms showed no association with GCIR variability. However, gastric atrophy, intestinal metaplasia and strains with different vacA genotypes in the same stomach (mixed strain infection) were more frequently found in group A than in group B, and cagA and vacA s1b were signif icantly associated with high GCIR (P = 0.026 and 0.041, respectively). IL- 1β+3954_T/C (OR 2.1, 1.0-4.3), IL-1RN*2/L (OR 3.5, 1.7-7.3) and IL-10-592_C/A (OR 3.2, 1.5-6.8) were individually associated with GC, and a combination of these cytokine polymorphisms with H pylori vacA s1b and m1 further increased the risk (OR 7.2, 1.4-36.4). CONCLUSION: Although a proinflammatory cytokine genetic profile showed an increased risk for developing GC, the characteristics of H pylori infection, in particular the status of cagA and vacA genotype distribution seemed to play a major role in GCIR variability in Costa Rica. | Sergio A Con Hiroaki Takeuchi Gil R Con-Chin Vicky G Con-Chin Nobufumi Yasuda Reinaldo Con-Wong | 2009 | World Journal of Gastroenterology2009，15，2： | 9 |
| 2 | Device-associated infec-tion rates in intensive care units of Brazilian hospitals:findingsof the international nosocomial infection control consortium显示文摘 | Reinaldo S Victor R Gorki G | 2008 | Pan Am J Public Health2008，24，3： | 1 |
| 3 | Apolipoprotein E polymorphism influences orthotopic liver transplantation outcomes in patients with hepatitis C virus-induced liver cirrhosis显示文摘BACKGROUND Hepatitis C virus(HCV)infection is responsible for a chronic liver inflammation,which may cause end-stage liver disease and hepatocellular carcinoma.Apolipoprotein E(protein:ApoE,gene:APOE),a key player in cholesterol metabolism,is mainly synthesized in the liver and APOE polymorphisms may influence HCV-induced liver damage.AIM To determine whether APOE alleles affect outcomes in HCV-infected patients with liver cirrhosis following orthotopic liver transplantation(OLT).METHODS This was a cohort study in which 179 patients,both genders and aged 34-70 years,were included before or after(up to 10 years follow-up)OLT.Liver injury severity was assessed using different criteria,including METAVIR and models for endstage liver disease.APOE polymorphisms were analyzed by quantitative real-time polymerase chain reaction.RESULTS The APOE3 allele was the most common(67.3%).In inflammation severity of biopsies from 89 OLT explants and 2 patients in pre-transplant,the degree of severe inflammation(A3F4,0.0%)was significantly less frequent than in patients with minimal and moderate degree of inflammation(≤A2F4,16.2%)P=0.048,in patients carrying the APOE4 allele when compared to non-APOE4.In addition,a significant difference was also found(≤A2F4,64.4%vs A3F4,0.0%;P=0.043)and(A1F4,57.4%vs A3F4,0.0%;P=0.024)in APOE4 patients when compared to APOE3 carriers.The fibrosis degree of the liver graft in 8 of 91 patients and the lack of the E4 allele was associated with more moderate fibrosis(F2)(P=0.006).CONCLUSION Our results suggest that the E4 allele protects against progression of liver fibrosis and degree of inflammation in HCV-infected patients. | José Carlos Rodrigues Nascimento Lianna C Pereira Juliana Magalhães C Rêgo Ronaldo P Dias Paulo Goberlânio B Silva Silvio Alencar C Sobrinho Gustavo R Coelho Ivelise Regina C Brasil Edmilson F Oliveira-Filho James S Owen Pierluigi Toniutto Reinaldo B Oriá | 2021 | World Journal of Gastroenterology2021，27，11： | 1 |
| 4 | Water level dynamics in the Amazon flood plain显示文摘 | IVAN B T L REINALDO R R FERNANDO M R | 2003 | Advances in Water Resources2003，26，7： | 1 |
| 5 | Designing systems-on-chip using cores显示文摘 | Reinaldo A B William R L | 2000 | Annual ACM IEEE Design Automation Conference Proceedings of 37th conference on design automation2000，，： | 1 |
| 6 | Accelerating autonomous learning by using heuristic selection of actions显示文摘 | Reinaldo A C Bianchi Carlos H C Ribeiro Anna H R Costa | 2008 | Journal of Heuristics2008，14，2： | 1 |
| 7 | Computational evaluation of effective material properties of composites reinforced by randomly distributed spherical particles 显示文摘 | Sreedhar K Harald B Reinaldo R Ulrich G | 2007 | Composite Structures2007，77，2： | 1 |
| 8 | Device-associated infection rates in intensive care units of Brazilian hospitals:findings of the international nosocomial infection control consortium 显示文摘 | Reinaldo S Victor R Gorki G | 2008 | Pan Am Public Health2008，24，3： | 1 |
| 9 | Antenatal corticosteroids: are incomplete courses beneficial?显示文摘 | Andrew Elimian Reinaldo Figueroa Alan R Spitzer Paul L Ogburn Vandy Wiencek J.Gerald Quirk | 2003 | Obstetrics & Gynecology2003，，2： | 1 |
| 10 | Fuzzy switchingtechnique applied to PWM boostconverter operating in mixedconduction mode for PV systems显示文摘 | Agorreta J L Reinaldos L Gonzalez R | 2009 | IEEE Transactions2009，56，11： | 1 |
| 11 | Device-associated infection rates in intensive care units of brazlian hospitals:findings of the international nosocomial infection control consortium显示文摘 | Reinaldo S Victor R Gorki G | 2008 | Pan Am J Public Health2008，24，3： | 1 |
| 12 | Cadmium uptake by hydroxyapatite synthesized in different conditions and submitted to thermal treatment 显示文摘 | Nilce C C Reinaldo C DE Alexandre M R | 2002 | Environmental Science & Technology2002，36，7： | 1 |
| 13 | Value-at-risk and Tsallis statistics : risk analysis of the aerospace sector显示文摘 | ADRIANA P FERNANDO M REINALDO R | 2004 | Physica A2004，344，： | 1 |
| 14 | Computational evaluation of effective material properties of composites reinforced by randomly distributed spherical particles显示文摘 | Sreedhar K Harald B Reinaldo R Ulrich G | | 0，，02： | 1 |
| 15 | Two and three- dimensionalsimulation of sound generated by flow around acircular cylinder 显示文摘 | Reinaldo M O Julio R M Fabio S | 2009 | AIAA Paper2009，3270，： | 1 |
| 16 | Loading optimization of palletized products on trucks显示文摘 | Reinaldo M Silvia R M Joao A W | 2000 | Transportation Research Part E2000，，36： | 1 |
| 17 | Substitution of Y2O3 by a rare earth oxide mixture as sintering additive of Si3N4 ceramics显示文摘 | Kurt S Reinaldo G Sebastiao R | 2000 | Materials Letters2000，45，： | 1 |
| 18 | 查看详情显示文摘 | Flaviane A S Anna I G C Maria E L R Q Reinaldo F T Ant(o)nio A N Gevany P P | | 0，，01： | 1 |
| 19 | Simulation modeling of polyamide-6,6 polymerization in a continuous two-phase flow coiled tubular reactor显示文摘 | Renata O Pimentel Reinaldo Giudici R | | 0，，： | 1 |
| 20 | Extreme event dynamics in methane ebullition fluxes from tropical reservoirs 显示文摘 | Fernado M Ramas Ivan B T Lima Reinaldo R Rosa | 2006 | Geophysical Research Letters2006，33，21： | 1 |
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