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| 1 | Role of bacterial and genetic factors in gastric cancer in Costa Rica显示文摘AIM: To evaluate several risk factors for gastric cancer (GC) in Costa Rican regions with contrasting GC incidence rate (GCIR). METHODS: According to GCIR, 191 Helicobacter pylori (H pylori)-positive patients were classified into groups A (high GCIR, n = 101) and B (low GCIR, n = 90). Human DNA obtained from biopsy specimens was used in the determination of polymorphisms of the genes coding for interleukin (IL)-1β and IL-10 by PCR-RFLP, and IL-1RN by PCR. H pylori DNA extractions obtained from clinical isolates of 83 patients were used for PCR-based genotyping of H pylori cagA, vacA and babA2. Human DNA from gastric biopsies of 52 GC patients was utilized for comparative purposes. RESULTS: Cytokine polymorphisms showed no association with GCIR variability. However, gastric atrophy, intestinal metaplasia and strains with different vacA genotypes in the same stomach (mixed strain infection) were more frequently found in group A than in group B, and cagA and vacA s1b were signif icantly associated with high GCIR (P = 0.026 and 0.041, respectively). IL- 1β+3954_T/C (OR 2.1, 1.0-4.3), IL-1RN*2/L (OR 3.5, 1.7-7.3) and IL-10-592_C/A (OR 3.2, 1.5-6.8) were individually associated with GC, and a combination of these cytokine polymorphisms with H pylori vacA s1b and m1 further increased the risk (OR 7.2, 1.4-36.4). CONCLUSION: Although a proinflammatory cytokine genetic profile showed an increased risk for developing GC, the characteristics of H pylori infection, in particular the status of cagA and vacA genotype distribution seemed to play a major role in GCIR variability in Costa Rica. | Sergio A Con Hiroaki Takeuchi Gil R Con-Chin Vicky G Con-Chin Nobufumi Yasuda Reinaldo Con-Wong | 2009 | World Journal of Gastroenterology2009，15，2： | 9 |
| 2 | Stable two-sided matching of slot allocation in airport collaborative decision making by top trading cycles mechanism显示文摘The problem of capacity shortage in some airports needs to be dealt with sustainable solutions including a more efficient use of the existing runway slots at the airports. The Collaborative Decision Making(CDM) is an important approach applied to Air Traffic Management(ATM)to achieve this efficient use of the slots allocation. Using the Matching approach for two-sided markets of Game theory, the Top Trading Cycle CDM(TTC-CDM) algorithm developed in this research is an extension of the CDM approach aggregating the Ground Delay Program(GDP)of the air sector. The paper compared the developed TTC-CDM model to the existing models such as the conventional Compression algorithm in CDM, the Trade Cycle algorithm and the Deferred Acceptance CDM(DA-CDM) model to evaluate the performance of the proposed model. Through a case study, the results show the effective application of TTC-CDM model to slot allocation in ATM and also presents the advantage of considering the preferences of airport managers beside ATC controllers and airlines in the decision processing. | Marcio Augusto DA SILVA SOUZA Weigang LI Reinaldo Crispiniano GARCIA | 2018 | Chinese Journal of Aeronautics2018，31，3： | 5 |
| 3 | Clinical relevance of Helicobacter pylori babA2 and babA2/B in Costa Rica and Japan显示文摘AIM:To evaluate the prevalence of Helicobacter pylori(H.pylori ) babA2 ,babB and a recombinant gene between babA2 and babB(babA2/B ),and their role in the development of atrophic gastritis in Costa Rican and Japanese clinical isolates.METHODS:A total of 95 continuous H.pylori-positive Costa Rican(41 males and 54 females;mean age,50.65 years;SD,± 13.04 years) and 95 continuous H.pylori-positive Japanese(50 males and 45 females;mean age,63.43;SD,± 13.21 years) patients underwent upper endoscopy from October 2005 to July 2006.They were enrolled for the polymerase chain reaction(PCR)-based genotyping of the H.pylori babA2 ,babB and babA2/B genes.Statistical analysis was performed using the χ2 test and the Fisher's exact probability test and multivariate analysis was performed by logistic regression adjusting for gender and age.P < 0.05 was regarded as statistically significant.RESULTS:The PCR-based genotyping of 95 Costa Rican and 95 Japanese isolates showed a higher prevalence of babA2 in Japan(96.8%) than in Costa Rica(73.7%),while that of babA2/B was higher in Costa Rica(11.6%) than in Japan(1.1%).In Costa Rican isolates only,babA2 was significantly associated with atrophic gastritis(P = 0.01).CONCLUSION:These results suggest that the status of babA2 and babA2/B shows geographic differences,and that babA2 has clinical relevance in Costa Rica. | Sergio A Con Hiroaki Takeuchi Mitsuaki Nishioka Norihito Morimoto Tetsuro Sugiura Nobufumi Yasuda Reinaldo Con-Wong | 2010 | World Journal of Gastroenterology2010，16，4： | 4 |
| 4 | Specific and cross-reactive immune response against Mycobacterium tuberculosis antigens in mice immunized with proteoliposomes from Mycobacterium bovis BCG显示文摘Objective: To characterize the immunogenicity and the induction of cross-reactive responses against Mycobacterium tuberculosis(M. tuberculosis) of a proteoliposome(PL)from Mycobacterium bovis Bacillus Calmette–Guerin(BCG) with and without alum hydroxide(AL) as adjuvant(PLBCG-AL and PLBCG, respectively) in BALB/c mice.Methods: BALB/c mice were inoculated with phosphate buffer solution, BCG, PLBCG and PLBCG-AL. The humoral immunogenicity was determined by ELISA [immunoglobulin G(Ig G), Ig G1 and Ig G2a] and the cellular immunogenicity was evaluated in vivo by delayed type hypersensitivity. The humoral cross-reactive response against M. tuberculosis was determined by Western blot.Results: Sera from animals immunized with PLBCG-AL and PLBCG showed significant increase in specific total Ig G and Ig G1 antibodies and the presence of cross-reactive antibodies against M. tuberculosis antigens, which were more intense with the use of alum as adjuvant. Mice immunized with PLBCG and PLBCG-AL also showed a specific cellular response in vivo.Conclusions: The cellular and humoral immunogenicity of PLBCG and the capacity to induce cross-reactive responses against M. tuberculosis is in agreement with the protective capacity previously demonstrated by this vaccine candidate and supports the continuation of its evaluation in further stages. | Nadine Alvarez DaymíSerpa Ramlah Kadir Yanely Tirado Reinier Borrero Sonsire Fernández Rubén Cabrera Yolanda Valdes Caridad Zayas Reinaldo Acevedo Luis Izquierdo María Elena Sarmiento Mohd-Nor Norazmi JoséLuis Pérez Armando Acosta | 2017 | Asian Pacific Journal of Tropical Biomedicine2017，7，3： | 3 |
| 5 | 相似性分析:地震属性信息综合分析的一种新方法显示文摘地震属性分析通常是把各种地震属性与储层特征相关来进行的。尽管有经验的解释员会直观地发现这些地震属性与特定的储层特征之间常常存在良好的相关关系,但这种相关关系不能从一个油藏外推到另一个油藏中去。随着属性数量的增大,分析变得更加困难; | Reinaldo J.Michelena 马秀兰 | 1998 | 石油物探译丛1998，，4： | 2 |
| 6 | Online Learning Control for Harmonics Reduction Based on Current Controlled Voltage Source Power Inverters显示文摘Nonlinear loads in the power distribution system cause non-sinusoidal currents and voltages with harmonic components.Shunt active filters(SAF) with current controlled voltage source inverters(CCVSI) are usually used to obtain balanced and sinusoidal source currents by injecting compensation currents.However,CCVSI with traditional controllers have a limited transient and steady state performance.In this paper,we propose an adaptive dynamic programming(ADP) controller with online learning capability to improve transient response and harmonics.The proposed controller works alongside existing proportional integral(PI) controllers to efficiently track the reference currents in the d-q domain.It can generate adaptive control actions to compensate the PI controller.The proposed system was simulated under different nonlinear(three-phase full wave rectifier) load conditions.The performance of the proposed approach was compared with the traditional approach.We have also included the simulation results without connecting the traditional PI control based power inverter for reference comparison.The online learning based ADP controller not only reduced average total harmonic distortion by 18.41%,but also outperformed traditional PI controllers during transients. | Naresh Malla Ujjwol Tamrakar Dipesh Shrestha Zhen Ni Reinaldo Tonkoski | 2017 | IEEE/CAA Journal of Automatica Sinica2017，4，3： | 2 |
| 7 | Nuclear factor–kappaB: a main regulator of inflammation and cell survival in endometriosis pathophysiology显示文摘 | Reinaldo González-Ramos Sylvie Defrère Luigi Devoto | 2012 | Fertility and Sterility2012，，3： | 2 |
| 8 | Aqueous extract of Ocimum tenuiflorum decreases levels of blood glucose in induced hyperglycemic tilapia(Oreochromis niloticus)显示文摘Objective:To evaluate,in hyperglycemic tilapia[Oreochromis niloticus(O.niloticus)].the effect of this aqueous extract on blood glucose levels.Methods:The hyperglycemia in O.niloticus was induced by adding glucose to fish pond water.An aqueous extract of Ocimum tenuiflorum (O.tenuiflorum) was prepared by boiling fresh leaves and the doses of 0,40,80,200 and 400 mg per liter of pond water were tested.Results:The blood sugar concentration for tilapia with hyperglycemic induced was an average of 50%higher than the control group.The blood glucose levels in tilapia after the induction of hyperglycemia were higher than the control group for 90 min after the treatment.The treatment with the aqueous extract of O.tenuiflorum dropped the serum glucose level of hyperglycemic tilapia until it was similar to that of the control group and was dose dependent.Conclusions:The results indicated that O.tenuiflorum was endowed with anti-hyperglycemic activity.To our knowledge,this is the first report on the use of fish as a diabetes model to test natural extracts from plants. | Amilcar Arenal Leonardo Martín Nestor M Castillo Dainier de la Torre Ubaldo Torres Reinaldo Gonzlez | 2012 | Asian Pacific Journal of Tropical Medicine2012，5，8： | 2 |
| 9 | Cadmium uptake byhydroxyapatite synthesized in different conditions and submittedto thermal treatment显示文摘 | Nilce CC Reinaldo C Rossi AM’ | 2002 | Environ Sci Technol2002，36，7： | 1 |
| 10 | Results, status and future activities of the coal-seq consortium显示文摘 | Scott Reeves Reinaldo Gonzalez Satya Harpalani | 2009 | Energy Procedia2009，1，1： | 1 |
| 11 | Temporal increases in plasma markers of oxidized low - density lipoprotein strongly reflect the presence of acute coronary syndromes显示文摘 | Sotirios Tsimikas Claes B Reinaldo WB | 2003 | J Am Coll Cardiol2003，41，3： | 1 |
| 12 | Solid phase microextraction capillary gas chromatography combined with furnace atomization plasma emission spectrometry for speciation of mercury in fish tissues显示文摘 | Patricia G Reinaldo C C Zoltan M | 2003 | Spectrochimica Acta Part B2003，，58： | 1 |
| 13 | Iridium as permanent modifier in the determination of lead in whole and urine by electrothermal atomic absorption spectrometry 显示文摘 | Grinberg P Reinaldo Calixto de Campos | 2001 | Specrchim Acta2001，56，： | 1 |
| 14 | Discrete-time singular observers: H2/H∞ Optimality and Unknown inputs 显示文摘 | Ricardo H C Takahashi Reinaldo M | 1999 | International Journal of Control1999，72，6： | 1 |
| 15 | Fracture detection in a carbonate reservoir using a variety of seismic methods显示文摘 | Maria A P Vladimir G Reinaldo J M | 1999 | Geophysics1999，64，4： | 1 |
| 16 | Loading optimization of palletized products on trucks显示文摘 | Reinaldo Morabito Silvia Regina Morales | 2000 | Transportation Research Part E Logistics and Transportation Review2000，36，4： | 1 |
| 17 | Quantification of endometriotic lesions in a murine model by fluorimetric and morphometric analyses 显示文摘 | Sylvle D Anne VL Reinaldo GR | 2006 | Hum Reprod2006，21，3： | 1 |
| 18 | Device-associated infec-tion rates in intensive care units of Brazilian hospitals:findingsof the international nosocomial infection control consortium显示文摘 | Reinaldo S Victor R Gorki G | 2008 | Pan Am J Public Health2008，24，3： | 1 |
| 19 | Effectiveness of a multidimensional approach for prevention of ventilator-associated pneumonia in adult intensive care units from 14 developing countries of four continents: Findings of the International Nosocomial Infection Control Consortium*显示文摘 | Victor D. Rosenthal Camilla Rodrigues Carlos álvarez-Moreno Naoufel Madani Zan Mitrev Guxiang Ye Reinaldo Salomao Fatma Ulger Humberto Guanche-Garcell Souha S. Kanj Luis E. Cuéllar Francisco Higuera Trudell Mapp Rosalía Fernández-Hidalgo | 2012 | Critical Care Medicine2012，，： | 1 |
| 20 | Neural network based approach for optimization of industrial chemical processes 显示文摘 | Laudio Augusto Oiler Nascimento Reinaldo Giudici | 2000 | Computers and Chemical Engineering2000，24，： | 1 |
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